PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20590600-4	2010	EXPERIMENTAL APPROACH: Effects of the selective cyclooxygenase-2 inhibitor celecoxib on the response to the P-glycoprotein substrate, phenobarbital, was evaluated in a chronic model of drug-resistant temporal lobe epilepsy in rats.	Celecoxib	75-84	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	108-122	
18482683-0	2008	Can celecoxib affect P-glycoprotein-mediated drug efflux?	Celecoxib	4-13	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	21-35	
18482683-3	2008	The anti-inflammatory drug celecoxib potentiates the efficacy of several cytostatic and neurotropic drugs that are known Pgp substrates.	Celecoxib	27-36	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	121-124	
18482683-4	2008	To clarify whether Pgp is involved in the sensitizing effect of celecoxib, we investigated in vivo whether celecoxib is a substrate of Pgp and whether it can affect the efflux activity of the pump.	Celecoxib	64-73	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	19-22	
18482683-5	2008	METHODS: In control rats and in rats treated with the Pgp modulator cyclosporin A (CsA), cerebral accumulation of radiolabeled [(11)C]celecoxib was investigated by ex vivo biodistribution and micro-positron emission tomography imaging.	Celecoxib	134-143	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	54-57	
18482683-12	2008	Therefore, celecoxib-induced augmentation of the efficacy of chemotherapeutic and neurotropic drugs must be due to another mechanism than modulation of Pgp-mediated drug efflux.	Celecoxib	11-20	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	152-155	
19371577-5	2009	Importantly, consistent with this, the COX-2 inhibitor, celecoxib, blocked seizure-induced up-regulation of P-glycoprotein expression in brain capillaries of rats in vivo.	Celecoxib	56-65	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	108-122