PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23922700-14 2013 The expressions of prostaglandin E2 (PGE2), phosphorylated extracellular signal-regulated kinase (p-ERK), hypoxia-inducible factor-1alpha (HIF-1alpha), and c-fos were also down-regulated after celecoxib treatment. Celecoxib 193-202 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 106-137 27380212-6 2016 Celecoxib and octreotide exerted their anti-angiogenesis effect via an axis of cyclooxygenase-2/prostaglandin E2/EP-2/somatostatin receptor-2, which consequently down-regulated phosphorylation of extracellular signal-regulated kinase (p-ERK)-hypoxia-inducible factor-1alpha (HIF-1alpha)-vascular endothelial growth factor (VEGF) integrated signaling pathways. Celecoxib 0-9 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 275-285 23922700-16 2013 The anti-angiogenesis effect afforded by celecoxib may attribute to its modulation on VEGF/VEGFR-2 through the down-regulation of integrated signal pathways involving PGE2- HIF-1alpha- VEGF and p-ERK- c-fos- VEGFR-2. Celecoxib 41-50 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 173-183