PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33991313-4	2021	Therefore, 4-HPR or celecoxib appear to stimulate the de novo ceramide pathway (with the exception of C24:0 ceramide), using native Degs1, and thereby promote PARP cleavage and LC3B-I/II processing (autophagy/apoptosis).	Celecoxib	20-29	poly(ADP-ribose) polymerase 1	Homo sapiens	159-163	
17461495-7	2007	Western blot analyses for caspase-3 and poly (ADP-ribose) polymerase (PARP) cleavage showed that celecoxib attenuated 5-FU induced apoptosis.	Celecoxib	97-106	poly(ADP-ribose) polymerase 1	Homo sapiens	70-74	
24520227-10	2014	Pretreatment with celecoxib also increased activation of caspase-9, -3 and cleaved PARP following paclitaxel-treatment.	Celecoxib	18-27	poly(ADP-ribose) polymerase 1	Homo sapiens	83-87	
18202791-5	2008	Only celecoxib induced apoptosis of the KB cells, as detected on the basis of DNA fragmentation, caspase-3/7 activation and cleaved poly(ADP-ribose) polymerase (PARP) fragmentation.	Celecoxib	5-14	poly(ADP-ribose) polymerase 1	Homo sapiens	132-159	
18202791-5	2008	Only celecoxib induced apoptosis of the KB cells, as detected on the basis of DNA fragmentation, caspase-3/7 activation and cleaved poly(ADP-ribose) polymerase (PARP) fragmentation.	Celecoxib	5-14	poly(ADP-ribose) polymerase 1	Homo sapiens	161-165	
24968832-6	2014	RESULTS: Celecoxib treatment significantly increased the IC50 of carboplatin, suppressed carboplatin-induced caspase-3 and PARP cleavage and caspase-3 activity in EC109 and EC109/CDDP cells.	Celecoxib	9-18	poly(ADP-ribose) polymerase 1	Homo sapiens	123-127	
15911099-11	2005	Celecoxib thus potentiates apoptosis as shown by MTT assay, cytochrome c leakage, PARP cleavage, DNA fragmentation, Bcl-2 downregulation and possibly by inhibiting NF-kB activation.	Celecoxib	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	82-86	
12499282-9	2002	Treatment of BxPC-3 cells with a higher dose (50 micro M) of celecoxib for 24 h resulted in the induction of apoptosis, as assayed by flow cytometry and poly(ADP-ribose) polymerase cleavage.	Celecoxib	61-70	poly(ADP-ribose) polymerase 1	Homo sapiens	153-180