PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28975647-0	2017	Effect of metformin and celecoxib on cytotoxicity and release of GDF-15 from human mesenchymal stem cells in high glucose condition.	Celecoxib	24-33	growth differentiation factor 15	Homo sapiens	65-71	
28975647-5	2017	The cytotoxicity and secretion of GDF-15 were further tested in MSCs treated with metformin and celecoxib in various glucose concentrations.	Celecoxib	96-105	growth differentiation factor 15	Homo sapiens	34-40	
28975647-11	2017	Moreover, celecoxib treatment in diabetic condition can reduce the viability of MSCs to proliferate and regenerate perhaps via change in release of GDF-15.	Celecoxib	10-19	growth differentiation factor 15	Homo sapiens	148-154	
22615612-0	2010	The effect of full length and mature NAG-1 protein overexpression on cytotoxicity of celecoxib, tamoxifen and doxorubicin in HT1080.	Celecoxib	85-94	growth differentiation factor 15	Homo sapiens	37-42	
20937742-10	2010	Celecoxib induced NAG-1 mRNA levels and apoptosis in cultured HESCs, with the effects dependent on drug concentrations and duration of treatment.	Celecoxib	0-9	growth differentiation factor 15	Homo sapiens	18-23	
20067113-1	2009	OBJECTIVE: To investigate the effect of cyclooxygenase2 inhibitor celecoxib on the suppression of human gastric cancer (GC) growth and the induction of nonsteroidal anti-inflammatory drug activated gene (NAG-1) expression.	Celecoxib	66-75	growth differentiation factor 15	Homo sapiens	204-209	
20067113-9	2009	NAG-1 mRNA expression was higher in celecoxib group (0.22 +/- 0.13) than in the control (0.12 +/- 0.08, P < 0.05).	Celecoxib	36-45	growth differentiation factor 15	Homo sapiens	0-5	
20067113-11	2009	CONCLUSION: Celecoxib can enhance apoptosis of GC cell by induction of NAG-1 gene transcription in human.	Celecoxib	12-21	growth differentiation factor 15	Homo sapiens	71-76	
17257745-0	2007	Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway.	Celecoxib	0-9	growth differentiation factor 15	Homo sapiens	95-100	
19375854-4	2009	Furthermore, PGE(2) reduces NAG-1 while celebrex induces NAG-1 expression.	Celecoxib	40-48	growth differentiation factor 15	Homo sapiens	57-62	
18089846-9	2008	Celecoxib treatment resulted in highly significant increases in the mRNA expression of the smooth muscle component desmin, the detoxification enzyme glutathione S-transferase pi (GSTpi), and nonsteroidal anti-inflammatory response gene (NAG-1) in the LNCaPCOX-2 cell line compared with LNCaPneo cells.	Celecoxib	0-9	growth differentiation factor 15	Homo sapiens	237-242	
17959037-10	2007	The upregulation of NAG-1 was displayed both in the celecoxib and combination groups.	Celecoxib	52-61	growth differentiation factor 15	Homo sapiens	20-25	
17959037-13	2007	NAG-1 and SSTR-2 might be the molecular targets for celecoxib or octreotide.	Celecoxib	52-61	growth differentiation factor 15	Homo sapiens	0-5	
17257745-3	2007	Celecoxib inhibited Ser473 Akt and Ser9 GSK3beta phosphorylation and induced upregulation of nonsteroidal anti-inflammatory drugs-activated gene-1 (NAG-1) expression.	Celecoxib	0-9	growth differentiation factor 15	Homo sapiens	93-146	
17257745-3	2007	Celecoxib inhibited Ser473 Akt and Ser9 GSK3beta phosphorylation and induced upregulation of nonsteroidal anti-inflammatory drugs-activated gene-1 (NAG-1) expression.	Celecoxib	0-9	growth differentiation factor 15	Homo sapiens	148-153	
17257745-4	2007	The effects of celecoxib on NAG-1 expression were abolished by pretreatment with GSK3beta inhibitor, SB216763.	Celecoxib	15-24	growth differentiation factor 15	Homo sapiens	28-33	
17257745-5	2007	Furthermore, GSK3beta gene silencing by siRNA inhibited the celecoxib-induced NAG-1 expression.	Celecoxib	60-69	growth differentiation factor 15	Homo sapiens	78-83	
17257745-6	2007	Our study demonstrated that Akt/GSK3beta/NAG-1 signal pathway may represent as the major mechanism of the COX-2-independent effects of celecoxib on gastric cancer cells.	Celecoxib	135-144	growth differentiation factor 15	Homo sapiens	41-46