PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31872059-2 2019 The diacylglycerol lipases (diacylglycerol lipase alpha and diacylglycerol lipase beta) not only synthesize essentially all the 2-AG in the body but also generate other monoacylglycerols, including 2-linoleoylglycerol (2-LG). glyceryl 2-arachidonate 128-132 diacylglycerol lipase beta Homo sapiens 60-86 35217685-3 2022 Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation of the endocannabinoid 2-AG (2-arachidonoylglycerol), as a cargo of AP-4 vesicles. glyceryl 2-arachidonate 104-108 diacylglycerol lipase beta Homo sapiens 17-22 35217685-3 2022 Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation of the endocannabinoid 2-AG (2-arachidonoylglycerol), as a cargo of AP-4 vesicles. glyceryl 2-arachidonate 104-108 diacylglycerol lipase beta Homo sapiens 24-50 35217685-3 2022 Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation of the endocannabinoid 2-AG (2-arachidonoylglycerol), as a cargo of AP-4 vesicles. glyceryl 2-arachidonate 110-132 diacylglycerol lipase beta Homo sapiens 17-22 35217685-3 2022 Here we identify DAGLB (diacylglycerol lipase-beta), a key enzyme for generation of the endocannabinoid 2-AG (2-arachidonoylglycerol), as a cargo of AP-4 vesicles. glyceryl 2-arachidonate 110-132 diacylglycerol lipase beta Homo sapiens 24-50 35217685-4 2022 During normal development, DAGLB is targeted to the axon, where 2-AG signalling drives axonal growth. glyceryl 2-arachidonate 64-68 diacylglycerol lipase beta Homo sapiens 27-32 35217685-5 2022 We show that DAGLB accumulates at the trans-Golgi network of AP-4-deficient cells, that axonal DAGLB levels are reduced in neurons from a patient with AP-4 deficiency, and that 2-AG levels are reduced in the brains of AP-4 knockout mice. glyceryl 2-arachidonate 177-181 diacylglycerol lipase beta Homo sapiens 13-18 23748223-0 2013 Diacylglycerol lipasealpha (DAGLalpha) and DAGLbeta cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons. glyceryl 2-arachidonate 93-116 diacylglycerol lipase beta Homo sapiens 43-51 31105063-1 2019 Diacylglycerol lipase-beta (DAGLbeta) hydrolyzes arachidonic acid (AA)-esterified diacylglycerols to produce 2-arachidonoylglycerol (2-AG) and downstream prostanoids that mediate inflammatory responses of macrophages. glyceryl 2-arachidonate 109-131 diacylglycerol lipase beta Homo sapiens 0-26 31105063-1 2019 Diacylglycerol lipase-beta (DAGLbeta) hydrolyzes arachidonic acid (AA)-esterified diacylglycerols to produce 2-arachidonoylglycerol (2-AG) and downstream prostanoids that mediate inflammatory responses of macrophages. glyceryl 2-arachidonate 109-131 diacylglycerol lipase beta Homo sapiens 28-36 31105063-1 2019 Diacylglycerol lipase-beta (DAGLbeta) hydrolyzes arachidonic acid (AA)-esterified diacylglycerols to produce 2-arachidonoylglycerol (2-AG) and downstream prostanoids that mediate inflammatory responses of macrophages. glyceryl 2-arachidonate 133-137 diacylglycerol lipase beta Homo sapiens 0-26 31105063-1 2019 Diacylglycerol lipase-beta (DAGLbeta) hydrolyzes arachidonic acid (AA)-esterified diacylglycerols to produce 2-arachidonoylglycerol (2-AG) and downstream prostanoids that mediate inflammatory responses of macrophages. glyceryl 2-arachidonate 133-137 diacylglycerol lipase beta Homo sapiens 28-36 27115711-1 2016 The diacylglycerol lipases (DAGLalpha and DAGLbeta) hydrolyze DAG to generate 2-arachidonoylglycerol (2-AG), the principal endocannabinoid and main precursor of arachidonic acid (AA). glyceryl 2-arachidonate 78-100 diacylglycerol lipase beta Homo sapiens 42-50 27115711-1 2016 The diacylglycerol lipases (DAGLalpha and DAGLbeta) hydrolyze DAG to generate 2-arachidonoylglycerol (2-AG), the principal endocannabinoid and main precursor of arachidonic acid (AA). glyceryl 2-arachidonate 102-106 diacylglycerol lipase beta Homo sapiens 42-50 26702404-8 2015 The second messenger lipid molecule diacylglycerol is implicated in the regulation of Nox activity and diacylglycerol lipase beta (DAGLbeta) is a key biosynthetic enzyme in the biosynthesis eCB ligand 2-arachidonylglycerol (2-AG). glyceryl 2-arachidonate 201-222 diacylglycerol lipase beta Homo sapiens 103-129 26702404-8 2015 The second messenger lipid molecule diacylglycerol is implicated in the regulation of Nox activity and diacylglycerol lipase beta (DAGLbeta) is a key biosynthetic enzyme in the biosynthesis eCB ligand 2-arachidonylglycerol (2-AG). glyceryl 2-arachidonate 201-222 diacylglycerol lipase beta Homo sapiens 131-139 26702404-8 2015 The second messenger lipid molecule diacylglycerol is implicated in the regulation of Nox activity and diacylglycerol lipase beta (DAGLbeta) is a key biosynthetic enzyme in the biosynthesis eCB ligand 2-arachidonylglycerol (2-AG). glyceryl 2-arachidonate 224-228 diacylglycerol lipase beta Homo sapiens 103-129 26702404-8 2015 The second messenger lipid molecule diacylglycerol is implicated in the regulation of Nox activity and diacylglycerol lipase beta (DAGLbeta) is a key biosynthetic enzyme in the biosynthesis eCB ligand 2-arachidonylglycerol (2-AG). glyceryl 2-arachidonate 224-228 diacylglycerol lipase beta Homo sapiens 131-139 23748223-3 2013 Both diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta can produce 2-AG in vitro, but evidence from knockout animals argues strongly for a predominant, even exclusive, role for DAGLalpha in regulation of 2-AG-mediated synaptic plasticity. glyceryl 2-arachidonate 70-74 diacylglycerol lipase beta Homo sapiens 49-57 23748223-3 2013 Both diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta can produce 2-AG in vitro, but evidence from knockout animals argues strongly for a predominant, even exclusive, role for DAGLalpha in regulation of 2-AG-mediated synaptic plasticity. glyceryl 2-arachidonate 207-211 diacylglycerol lipase beta Homo sapiens 49-57 23748223-8 2013 Surprisingly, DAGLbeta knockdown diminishes DSE as much or more (ED(50) 6.4 seconds), suggesting that DAGLbeta is also responsible for a portion of 2-AG production in autaptic neurons. glyceryl 2-arachidonate 148-152 diacylglycerol lipase beta Homo sapiens 14-22 23748223-8 2013 Surprisingly, DAGLbeta knockdown diminishes DSE as much or more (ED(50) 6.4 seconds), suggesting that DAGLbeta is also responsible for a portion of 2-AG production in autaptic neurons. glyceryl 2-arachidonate 148-152 diacylglycerol lipase beta Homo sapiens 102-110 20878765-6 2010 Likewise, 2-AG synthesis disruption using specific siRNAs against DAGLalpha and DAGLbeta significantly reduced myelin protein expression in vitro, whereas a pharmacological gain-of-function approach by using cannabinoid agonists or MAGL inhibition had the opposite effects. glyceryl 2-arachidonate 10-14 diacylglycerol lipase beta Homo sapiens 80-88 22103420-2 2011 However, the identification of two diacylglycerol lipases (DAGLalpha and DAGLbeta) responsible for the synthesis of 2-arachidonoylglycerol (2-AG) has increased the understanding of where this eCB is synthesised in relationship to the expression of cannabinoid receptor (CB)1 and CB2. glyceryl 2-arachidonate 116-138 diacylglycerol lipase beta Homo sapiens 73-81 21459826-6 2011 Hippocampal protein concentrations for the sn-1-diacylglycerol lipase alpha and beta isoforms, synthesizing 2-arachidonoyl glycerol, significantly increased in definite Alzheimer"s (Braak stage VI), with ectopic sn-1-diacylglycerol lipase beta expression found in microglia accumulating near senile plaques and apposing CB(1) cannabinoid receptor-positive presynapses. glyceryl 2-arachidonate 108-131 diacylglycerol lipase beta Homo sapiens 217-243 19798744-1 2010 The diacylglycerol lipases (DAGLalpha and DAGLbeta) synthesize 2-arachidonoylglycerol (2-AG), a full agonist at cannabinoid receptors. glyceryl 2-arachidonate 63-85 diacylglycerol lipase beta Homo sapiens 42-50 19798744-1 2010 The diacylglycerol lipases (DAGLalpha and DAGLbeta) synthesize 2-arachidonoylglycerol (2-AG), a full agonist at cannabinoid receptors. glyceryl 2-arachidonate 87-91 diacylglycerol lipase beta Homo sapiens 42-50