PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34142866-2 2021 The selective expression of diacylglycerol lipase-beta (DAGL-beta), the 2-arachidonylglycerol biosynthetic enzyme, on resident immune cells of the brain (microglia) and the role of this pathway in neuroinflammation, suggest that this enzyme may contribute to TBI-induced neuroinflammation. glyceryl 2-arachidonate 72-93 diacylglycerol lipase, alpha Mus musculus 56-65 34970803-3 2022 Recently, we showed that tanycytes produce diacylglycerol lipase alpha (DAGLalpha), the synthesizing enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG) that inhibits the release of TRH from the hypophysiotropic terminals in median eminence explants. glyceryl 2-arachidonate 131-153 diacylglycerol lipase, alpha Mus musculus 43-70 34970803-3 2022 Recently, we showed that tanycytes produce diacylglycerol lipase alpha (DAGLalpha), the synthesizing enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG) that inhibits the release of TRH from the hypophysiotropic terminals in median eminence explants. glyceryl 2-arachidonate 131-153 diacylglycerol lipase, alpha Mus musculus 72-81 34970803-3 2022 Recently, we showed that tanycytes produce diacylglycerol lipase alpha (DAGLalpha), the synthesizing enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG) that inhibits the release of TRH from the hypophysiotropic terminals in median eminence explants. glyceryl 2-arachidonate 155-159 diacylglycerol lipase, alpha Mus musculus 43-70 34970803-3 2022 Recently, we showed that tanycytes produce diacylglycerol lipase alpha (DAGLalpha), the synthesizing enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG) that inhibits the release of TRH from the hypophysiotropic terminals in median eminence explants. glyceryl 2-arachidonate 155-159 diacylglycerol lipase, alpha Mus musculus 72-81 31127001-1 2019 Diacylglycerol lipase-alpha (DAGL-alpha), the principal biosynthetic enzyme of the endogenous cannabinoid 2-arachidonylglycerol (2-AG) on neurons, plays a key role in CB1 receptor-mediated synaptic plasticity and hippocampal neurogenesis, but its contribution to global hippocampal-mediated processes remains unknown. glyceryl 2-arachidonate 106-127 diacylglycerol lipase, alpha Mus musculus 0-27 34099188-6 2021 RESULTS: DAGLalpha modulated dendritic spine size and density, but the effects of changes in its protein level versus enzymatic activity were different, implicating either a 2-arachidonoylglycerol (2-AG)-dependent or -independent mechanism. glyceryl 2-arachidonate 174-196 diacylglycerol lipase, alpha Mus musculus 9-18 34099188-6 2021 RESULTS: DAGLalpha modulated dendritic spine size and density, but the effects of changes in its protein level versus enzymatic activity were different, implicating either a 2-arachidonoylglycerol (2-AG)-dependent or -independent mechanism. glyceryl 2-arachidonate 198-202 diacylglycerol lipase, alpha Mus musculus 9-18 34099188-7 2021 The 2-AG-independent effects were mediated by the interaction of DAGLalpha with ankyrin-G, a multifunctional scaffold protein implicated in psychiatric disorders. glyceryl 2-arachidonate 4-8 diacylglycerol lipase, alpha Mus musculus 65-74 35615929-12 2022 These results indicate that maintaining the physiological level of 2-AG in the blood by targeting DAGLbeta may be a novel and effective approach to treat pain in SCD. glyceryl 2-arachidonate 67-71 diacylglycerol lipase, alpha Mus musculus 98-106 33398893-0 2021 In situ localization of diacylglycerol lipase alpha and beta producing an endocannabinoid 2-arachidonoylglycerol and of cannabinoid receptor 1 in the primary oocytes of postnatal mice. glyceryl 2-arachidonate 90-112 diacylglycerol lipase, alpha Mus musculus 24-51 33398893-2 2021 For this purpose, diacylglycerol lipase (DGL) alpha and beta are involved in the synthesis of an eCB 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 101-123 diacylglycerol lipase, alpha Mus musculus 18-51 33398893-2 2021 For this purpose, diacylglycerol lipase (DGL) alpha and beta are involved in the synthesis of an eCB 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 125-129 diacylglycerol lipase, alpha Mus musculus 18-51 32876968-6 2021 Targeted lipidomics revealed that astrocytic DAGLa only accounts for a minor percentage of the steady-state brain 2-AG levels and other arachidonic acid derived lipids like prostaglandins. glyceryl 2-arachidonate 114-118 diacylglycerol lipase, alpha Mus musculus 45-50 31849602-5 2019 Surprisingly, CRISPR/Cas9-mediated knockdown of DAGLalpha and DAGLbeta in Neuro-2a cells did not reduce 2-AG levels, suggesting another enzyme capable of producing 2-AG in this cell line. glyceryl 2-arachidonate 164-168 diacylglycerol lipase, alpha Mus musculus 48-57 31682822-2 2019 2-arachidonoylglycerol, a major endocannabinoid produced by diacylglycerol lipase-alpha (DGLalpha), is released from postsynaptic neurons, retrogradely activates presynaptic CB1 cannabinoid receptors, and induces short-term or long-term synaptic plasticity. glyceryl 2-arachidonate 0-22 diacylglycerol lipase, alpha Mus musculus 60-87 31682822-2 2019 2-arachidonoylglycerol, a major endocannabinoid produced by diacylglycerol lipase-alpha (DGLalpha), is released from postsynaptic neurons, retrogradely activates presynaptic CB1 cannabinoid receptors, and induces short-term or long-term synaptic plasticity. glyceryl 2-arachidonate 0-22 diacylglycerol lipase, alpha Mus musculus 89-97 35022487-2 2022 This is demonstrated by the disruption of adult neurogenesis under two experimental conditions: (1) NSPC-specific deletion of cannabinoid receptors and (2) constitutive deletion of the enzyme diacylglycerol lipase alpha (DAGLa) which produces the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 263-285 diacylglycerol lipase, alpha Mus musculus 192-219 35022487-2 2022 This is demonstrated by the disruption of adult neurogenesis under two experimental conditions: (1) NSPC-specific deletion of cannabinoid receptors and (2) constitutive deletion of the enzyme diacylglycerol lipase alpha (DAGLa) which produces the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 263-285 diacylglycerol lipase, alpha Mus musculus 221-226 35022487-2 2022 This is demonstrated by the disruption of adult neurogenesis under two experimental conditions: (1) NSPC-specific deletion of cannabinoid receptors and (2) constitutive deletion of the enzyme diacylglycerol lipase alpha (DAGLa) which produces the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 287-291 diacylglycerol lipase, alpha Mus musculus 192-219 35022487-2 2022 This is demonstrated by the disruption of adult neurogenesis under two experimental conditions: (1) NSPC-specific deletion of cannabinoid receptors and (2) constitutive deletion of the enzyme diacylglycerol lipase alpha (DAGLa) which produces the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 287-291 diacylglycerol lipase, alpha Mus musculus 221-226 32876968-1 2021 Genetic deletion of cannabinoid CB1 receptors or diacylglycerol lipase alpha (DAGLa), the main enzyme involved in the synthesis of the endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG), produced profound phenotypes in animal models of depression-related behaviors. glyceryl 2-arachidonate 157-179 diacylglycerol lipase, alpha Mus musculus 49-76 32876968-1 2021 Genetic deletion of cannabinoid CB1 receptors or diacylglycerol lipase alpha (DAGLa), the main enzyme involved in the synthesis of the endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG), produced profound phenotypes in animal models of depression-related behaviors. glyceryl 2-arachidonate 157-179 diacylglycerol lipase, alpha Mus musculus 78-83 32876968-1 2021 Genetic deletion of cannabinoid CB1 receptors or diacylglycerol lipase alpha (DAGLa), the main enzyme involved in the synthesis of the endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG), produced profound phenotypes in animal models of depression-related behaviors. glyceryl 2-arachidonate 181-185 diacylglycerol lipase, alpha Mus musculus 49-76 32876968-1 2021 Genetic deletion of cannabinoid CB1 receptors or diacylglycerol lipase alpha (DAGLa), the main enzyme involved in the synthesis of the endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG), produced profound phenotypes in animal models of depression-related behaviors. glyceryl 2-arachidonate 181-185 diacylglycerol lipase, alpha Mus musculus 78-83 31127001-1 2019 Diacylglycerol lipase-alpha (DAGL-alpha), the principal biosynthetic enzyme of the endogenous cannabinoid 2-arachidonylglycerol (2-AG) on neurons, plays a key role in CB1 receptor-mediated synaptic plasticity and hippocampal neurogenesis, but its contribution to global hippocampal-mediated processes remains unknown. glyceryl 2-arachidonate 106-127 diacylglycerol lipase, alpha Mus musculus 29-39 31127001-1 2019 Diacylglycerol lipase-alpha (DAGL-alpha), the principal biosynthetic enzyme of the endogenous cannabinoid 2-arachidonylglycerol (2-AG) on neurons, plays a key role in CB1 receptor-mediated synaptic plasticity and hippocampal neurogenesis, but its contribution to global hippocampal-mediated processes remains unknown. glyceryl 2-arachidonate 129-133 diacylglycerol lipase, alpha Mus musculus 0-27 31127001-1 2019 Diacylglycerol lipase-alpha (DAGL-alpha), the principal biosynthetic enzyme of the endogenous cannabinoid 2-arachidonylglycerol (2-AG) on neurons, plays a key role in CB1 receptor-mediated synaptic plasticity and hippocampal neurogenesis, but its contribution to global hippocampal-mediated processes remains unknown. glyceryl 2-arachidonate 129-133 diacylglycerol lipase, alpha Mus musculus 29-39 29477030-3 2018 This study investigated the involvement of the 2-AG biosynthesizing enzyme diacylglycerol lipase alpha (DAGLA) in the pathogenesis of alcoholism. glyceryl 2-arachidonate 47-51 diacylglycerol lipase, alpha Mus musculus 75-102 29458998-3 2018 METHODS: Using conditional knockout mice, we examined the electrophysiological, biochemical, and behavioral effects of 2-AG deficiency by deleting its primary synthetic enzyme, diacylglycerol lipase alpha (DGLalpha), from dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (MSNs) to determine the role of 2-AG signaling in striatal direct or indirect pathways, respectively. glyceryl 2-arachidonate 119-123 diacylglycerol lipase, alpha Mus musculus 177-204 29458998-3 2018 METHODS: Using conditional knockout mice, we examined the electrophysiological, biochemical, and behavioral effects of 2-AG deficiency by deleting its primary synthetic enzyme, diacylglycerol lipase alpha (DGLalpha), from dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (MSNs) to determine the role of 2-AG signaling in striatal direct or indirect pathways, respectively. glyceryl 2-arachidonate 119-123 diacylglycerol lipase, alpha Mus musculus 206-214 29477030-3 2018 This study investigated the involvement of the 2-AG biosynthesizing enzyme diacylglycerol lipase alpha (DAGLA) in the pathogenesis of alcoholism. glyceryl 2-arachidonate 47-51 diacylglycerol lipase, alpha Mus musculus 104-109 28970359-1 2017 Diacylglycerol lipase (DAGL) alpha and beta, the major biosynthetic enzymes of the endogenous cannabinoid (endocannabinoid) 2-arachidonylglycerol (2-AG), are highly expressed in the nervous system and immune system, respectively. glyceryl 2-arachidonate 124-145 diacylglycerol lipase, alpha Mus musculus 0-34 29467679-6 2018 Quantitative polymerase chain reaction was conducted to assess mRNA levels of cannabinoid receptor 1 (CB1R) and enzymes for the synthesis and breakdown of the endocannabinoid 2-arachidonoylglycerol [i.e., diacylglycerol lipase alpha (DAGLalpha), monoglyceride lipase (MGLL), and alpha/beta-hydrolase domain-containing 6 (ABHD6)]. glyceryl 2-arachidonate 175-197 diacylglycerol lipase, alpha Mus musculus 205-232 28970359-1 2017 Diacylglycerol lipase (DAGL) alpha and beta, the major biosynthetic enzymes of the endogenous cannabinoid (endocannabinoid) 2-arachidonylglycerol (2-AG), are highly expressed in the nervous system and immune system, respectively. glyceryl 2-arachidonate 147-151 diacylglycerol lipase, alpha Mus musculus 0-34 26668358-1 2016 Diacylglycerol lipases (DAGLalpha and DAGLbeta) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. glyceryl 2-arachidonate 94-116 diacylglycerol lipase, alpha Mus musculus 24-33 28377876-9 2017 Furthermore, we identified CB1R in close apposition to the endocannabinoid (2-arachidonoylglycerol)-synthesizing enzyme diacylglycerol lipase-alpha at AgRP/NPY neurons. glyceryl 2-arachidonate 76-98 diacylglycerol lipase, alpha Mus musculus 120-147 26731274-3 2016 METHODS: ApoE-deficient mice were sublethally irradiated and reconstituted with bone marrow from mice with a myeloid-specific knockout of the 2-AG synthesising enzyme diacylglycerol lipase alpha (Dagla) or control bone marrow with an intact 2-AG biosynthesis. glyceryl 2-arachidonate 142-146 diacylglycerol lipase, alpha Mus musculus 167-194 26083464-1 2015 Diacylglycerol lipase (DAGL)-alpha and -beta are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 113-135 diacylglycerol lipase, alpha Mus musculus 0-44 26278494-6 2015 We hypothesize that the observed decrease of 2-AG levels is probably caused by changes in DAGLalpha expression and MAGL activity. glyceryl 2-arachidonate 45-49 diacylglycerol lipase, alpha Mus musculus 90-99 26083464-1 2015 Diacylglycerol lipase (DAGL)-alpha and -beta are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 137-141 diacylglycerol lipase, alpha Mus musculus 0-44 25684407-3 2015 Here, we examined the expression, localization and function of the enzyme diacylglycerol lipase-alpha (DAGLalpha), which is involved in biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 172-194 diacylglycerol lipase, alpha Mus musculus 74-101 25929688-11 2015 In contrast, the protein levels of cannabinoid CB2 receptors and diacylglycerol lipase alpha, the enzyme that synthesizes endocannabinoid 2-arachidonoylglycerol, in the amygdala did not differ between non-diabetic and STZ-induced diabetic mice. glyceryl 2-arachidonate 138-160 diacylglycerol lipase, alpha Mus musculus 65-92 25684407-3 2015 Here, we examined the expression, localization and function of the enzyme diacylglycerol lipase-alpha (DAGLalpha), which is involved in biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 172-194 diacylglycerol lipase, alpha Mus musculus 103-112 25684407-3 2015 Here, we examined the expression, localization and function of the enzyme diacylglycerol lipase-alpha (DAGLalpha), which is involved in biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 196-200 diacylglycerol lipase, alpha Mus musculus 74-101 25684407-3 2015 Here, we examined the expression, localization and function of the enzyme diacylglycerol lipase-alpha (DAGLalpha), which is involved in biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG). glyceryl 2-arachidonate 196-200 diacylglycerol lipase, alpha Mus musculus 103-112 25484252-2 2015 However, mechanisms involved in the synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) by diacylglycerol lipase alpha (DGLalpha) are poorly understood. glyceryl 2-arachidonate 69-91 diacylglycerol lipase, alpha Mus musculus 102-129 25684760-1 2015 The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase alpha (DAGL-alpha) in the CNS. glyceryl 2-arachidonate 20-42 diacylglycerol lipase, alpha Mus musculus 90-117 25684760-1 2015 The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase alpha (DAGL-alpha) in the CNS. glyceryl 2-arachidonate 20-42 diacylglycerol lipase, alpha Mus musculus 119-129 25684760-1 2015 The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase alpha (DAGL-alpha) in the CNS. glyceryl 2-arachidonate 44-48 diacylglycerol lipase, alpha Mus musculus 90-117 25684760-1 2015 The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase alpha (DAGL-alpha) in the CNS. glyceryl 2-arachidonate 44-48 diacylglycerol lipase, alpha Mus musculus 119-129 25684760-2 2015 Selective inhibitors of DAGL-alpha will provide valuable insights in the role of 2-AG in endocannabinoid signaling processes and are potential therapeutics for the treatment of obesity and neurodegenerative diseases. glyceryl 2-arachidonate 81-85 diacylglycerol lipase, alpha Mus musculus 24-34 25484252-2 2015 However, mechanisms involved in the synthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) by diacylglycerol lipase alpha (DGLalpha) are poorly understood. glyceryl 2-arachidonate 93-97 diacylglycerol lipase, alpha Mus musculus 102-129 25466252-5 2014 Importantly, acute pharmacological normalization of 2-AG levels reverses both phenotypes of DAGLalpha-deficient mice. glyceryl 2-arachidonate 52-56 diacylglycerol lipase, alpha Mus musculus 92-101 23426686-2 2013 The 2-arachidonoylglycerol (2-AG) produced by diacylglycerol lipase alpha (DGLalpha) is regarded as the major endocannabinoid that causes retrograde synaptic suppression. glyceryl 2-arachidonate 4-26 diacylglycerol lipase, alpha Mus musculus 46-73 23502535-2 2013 Here we identify a functional interaction between the 2-AG synthetic enzyme diacylglycerol lipase-alpha (DGLalpha) and calcium/calmodulin dependent protein kinase II (CaMKII). glyceryl 2-arachidonate 54-58 diacylglycerol lipase, alpha Mus musculus 76-103 23502535-2 2013 Here we identify a functional interaction between the 2-AG synthetic enzyme diacylglycerol lipase-alpha (DGLalpha) and calcium/calmodulin dependent protein kinase II (CaMKII). glyceryl 2-arachidonate 54-58 diacylglycerol lipase, alpha Mus musculus 105-113 24012970-3 2014 The primary pathway for 2-AG generation is believed to be conversion from the diacylglycerols (DAGs) by two sn-1-specific lipases, DAGLalpha and DAGLbeta. glyceryl 2-arachidonate 24-28 diacylglycerol lipase, alpha Mus musculus 131-140 24012970-8 2014 As demonstrated by LC/MS/MS, this pool of 2-AG was generated via tetrahydrolipstatin-sensitive enzymatic pathways distinct from DAGLalpha or DAGLbeta. glyceryl 2-arachidonate 42-46 diacylglycerol lipase, alpha Mus musculus 128-137 23892011-17 2013 The protein levels of cannabinoid CB1 receptors, CB2 receptors and diacylglycerol lipase alpha (DGL-alpha), the enzyme that synthesizes endocannabinoid 2-arachidonoylglycerol, in the spinal cord were examined using Western blotting. glyceryl 2-arachidonate 152-174 diacylglycerol lipase, alpha Mus musculus 96-105 23426686-2 2013 The 2-arachidonoylglycerol (2-AG) produced by diacylglycerol lipase alpha (DGLalpha) is regarded as the major endocannabinoid that causes retrograde synaptic suppression. glyceryl 2-arachidonate 4-26 diacylglycerol lipase, alpha Mus musculus 75-83 23426686-2 2013 The 2-arachidonoylglycerol (2-AG) produced by diacylglycerol lipase alpha (DGLalpha) is regarded as the major endocannabinoid that causes retrograde synaptic suppression. glyceryl 2-arachidonate 28-32 diacylglycerol lipase, alpha Mus musculus 46-73 23426686-2 2013 The 2-arachidonoylglycerol (2-AG) produced by diacylglycerol lipase alpha (DGLalpha) is regarded as the major endocannabinoid that causes retrograde synaptic suppression. glyceryl 2-arachidonate 28-32 diacylglycerol lipase, alpha Mus musculus 75-83 21613483-3 2011 First, we showed by electrophysiology that 2-AG produced by diacylglycerol lipase alpha (DGLalpha) mediated both depolarization-induced suppression of excitation and its enhancement by group I metabotropic glutamate receptor activation at MC-GC synapses, as they were abolished in DGLalpha-knock-out mice. glyceryl 2-arachidonate 43-47 diacylglycerol lipase, alpha Mus musculus 60-87 23806960-4 2013 Here, we first show that cholinergic innervation of CA1 pyramidal cells of the hippocampus is sensitive to the genetic disruption of 2-AG signaling in DAGLalpha null mice. glyceryl 2-arachidonate 133-137 diacylglycerol lipase, alpha Mus musculus 151-160 23055515-2 2012 Here, we show that parvalbumin- and somatostatin/metabotropic glutamate receptor 1(a) (mGlu(1a))-positive GABAergic interneurons express diacylglycerol lipase-alpha (DGL-alpha), a synthesizing enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG), albeit at lower levels than principal cells. glyceryl 2-arachidonate 223-245 diacylglycerol lipase, alpha Mus musculus 166-175 23055515-2 2012 Here, we show that parvalbumin- and somatostatin/metabotropic glutamate receptor 1(a) (mGlu(1a))-positive GABAergic interneurons express diacylglycerol lipase-alpha (DGL-alpha), a synthesizing enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG), albeit at lower levels than principal cells. glyceryl 2-arachidonate 247-251 diacylglycerol lipase, alpha Mus musculus 166-175 23011134-4 2012 In these mutants, the macromolecular complex that links metabotropic glutamate receptor-5 to the 2-arachidonoyl-sn-glycerol-producing enzyme, diacylglycerol lipase-alpha (endocannabinoid signalosome), is disrupted and metabotropic glutamate receptor-5-dependent 2-arachidonoyl-sn-glycerol formation is compromised. glyceryl 2-arachidonate 97-123 diacylglycerol lipase, alpha Mus musculus 142-169 21807615-15 2011 Moreover, the close agreement between our pharmacological and genetic studies indicates that 2-AG synthesized by postsynaptic DAGLalpha mediates DSI in PFC neurons. glyceryl 2-arachidonate 93-97 diacylglycerol lipase, alpha Mus musculus 126-135 23103940-1 2012 The endocannabinoid 2-arachidonoylglycerol (2-AG) is biosynthesized by diacylglycerol lipases DAGLalpha and DAGLbeta. glyceryl 2-arachidonate 20-42 diacylglycerol lipase, alpha Mus musculus 94-103 23103940-1 2012 The endocannabinoid 2-arachidonoylglycerol (2-AG) is biosynthesized by diacylglycerol lipases DAGLalpha and DAGLbeta. glyceryl 2-arachidonate 44-48 diacylglycerol lipase, alpha Mus musculus 94-103 21613483-3 2011 First, we showed by electrophysiology that 2-AG produced by diacylglycerol lipase alpha (DGLalpha) mediated both depolarization-induced suppression of excitation and its enhancement by group I metabotropic glutamate receptor activation at MC-GC synapses, as they were abolished in DGLalpha-knock-out mice. glyceryl 2-arachidonate 43-47 diacylglycerol lipase, alpha Mus musculus 89-97 21613483-3 2011 First, we showed by electrophysiology that 2-AG produced by diacylglycerol lipase alpha (DGLalpha) mediated both depolarization-induced suppression of excitation and its enhancement by group I metabotropic glutamate receptor activation at MC-GC synapses, as they were abolished in DGLalpha-knock-out mice. glyceryl 2-arachidonate 43-47 diacylglycerol lipase, alpha Mus musculus 281-289 21411643-4 2011 We now show that mouse migratory neuroblasts express cannabinoid receptors, diacylglycerol lipase alpha (DAGLalpha), the enzyme that synthesizes the endocannabinoid 2-arachidonoylglycerol (2-AG), and monoacylglycerol lipase, the enzyme responsible for its degradation. glyceryl 2-arachidonate 165-187 diacylglycerol lipase, alpha Mus musculus 76-103 21411643-4 2011 We now show that mouse migratory neuroblasts express cannabinoid receptors, diacylglycerol lipase alpha (DAGLalpha), the enzyme that synthesizes the endocannabinoid 2-arachidonoylglycerol (2-AG), and monoacylglycerol lipase, the enzyme responsible for its degradation. glyceryl 2-arachidonate 165-187 diacylglycerol lipase, alpha Mus musculus 105-114 21411643-4 2011 We now show that mouse migratory neuroblasts express cannabinoid receptors, diacylglycerol lipase alpha (DAGLalpha), the enzyme that synthesizes the endocannabinoid 2-arachidonoylglycerol (2-AG), and monoacylglycerol lipase, the enzyme responsible for its degradation. glyceryl 2-arachidonate 189-193 diacylglycerol lipase, alpha Mus musculus 76-103 21411643-4 2011 We now show that mouse migratory neuroblasts express cannabinoid receptors, diacylglycerol lipase alpha (DAGLalpha), the enzyme that synthesizes the endocannabinoid 2-arachidonoylglycerol (2-AG), and monoacylglycerol lipase, the enzyme responsible for its degradation. glyceryl 2-arachidonate 189-193 diacylglycerol lipase, alpha Mus musculus 105-114 20159446-7 2010 We conclude that 2-AG produced by DGLalpha, but not by DGLbeta, mediates retrograde suppression at central synapses. glyceryl 2-arachidonate 17-21 diacylglycerol lipase, alpha Mus musculus 34-42 20147530-3 2010 Diacylglycerol lipase-alpha (DAGLalpha) and -beta (DAGLbeta) synthesize 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in the brain. glyceryl 2-arachidonate 72-95 diacylglycerol lipase, alpha Mus musculus 0-49 20147530-3 2010 Diacylglycerol lipase-alpha (DAGLalpha) and -beta (DAGLbeta) synthesize 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in the brain. glyceryl 2-arachidonate 97-101 diacylglycerol lipase, alpha Mus musculus 0-49 20147530-5 2010 In the present study, we show approximately 80% reductions in 2-AG levels in the brain and spinal cord in DAGLalpha(-/-) mice and a 50% reduction in the brain in DAGLbeta(-/-) mice. glyceryl 2-arachidonate 62-66 diacylglycerol lipase, alpha Mus musculus 106-115 20147530-6 2010 In contrast, DAGLbeta plays a more important role than DAGLalpha in regulating 2-AG levels in the liver, with a 90% reduction seen in DAGLbeta(-/-) mice. glyceryl 2-arachidonate 79-83 diacylglycerol lipase, alpha Mus musculus 55-64 20147530-10 2010 These findings provide the first evidence that DAGLalpha is the major biosynthetic enzyme for 2-AG in the nervous system and reveal an essential role for this enzyme in regulating retrograde synaptic plasticity and adult neurogenesis. glyceryl 2-arachidonate 94-98 diacylglycerol lipase, alpha Mus musculus 47-56 17584991-4 2007 DGL-alpha overexpression in mouse neuroblastoma Neuro-2a cells increased baseline 2-AG levels. glyceryl 2-arachidonate 82-86 diacylglycerol lipase, alpha Mus musculus 0-9 17584991-9 2007 DGL-alpha mutants that do not bind Homer maintained their ability to generate 2-AG in intact cells but failed to associate with the plasma membrane. glyceryl 2-arachidonate 78-82 diacylglycerol lipase, alpha Mus musculus 0-9 16672646-0 2006 Localization of diacylglycerol lipase-alpha around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. glyceryl 2-arachidonate 142-165 diacylglycerol lipase, alpha Mus musculus 16-43 16672646-2 2006 To understand the mechanisms of the 2-AG-mediated retrograde modulation, we investigated subcellular localization of a major 2-AG biosynthetic enzyme, diacylglycerol lipase-alpha (DAGLalpha), by using immunofluorescence and immunoelectron microscopy in the mouse brain. glyceryl 2-arachidonate 36-40 diacylglycerol lipase, alpha Mus musculus 151-178 16672646-2 2006 To understand the mechanisms of the 2-AG-mediated retrograde modulation, we investigated subcellular localization of a major 2-AG biosynthetic enzyme, diacylglycerol lipase-alpha (DAGLalpha), by using immunofluorescence and immunoelectron microscopy in the mouse brain. glyceryl 2-arachidonate 36-40 diacylglycerol lipase, alpha Mus musculus 180-189 20837870-7 2010 Hippocampal DSI is absent in DAGL-alpha knockout mice, pointing to a key role for 2-AG in DSI. glyceryl 2-arachidonate 82-86 diacylglycerol lipase, alpha Mus musculus 29-39 20159446-0 2010 The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. glyceryl 2-arachidonate 20-42 diacylglycerol lipase, alpha Mus musculus 55-82 20159446-5 2010 The basal 2-AG content was markedly reduced and stimulus-induced elevation of 2-AG was absent in DGLalpha knockout brains, whereas the 2-AG content was normal in DGLbeta knockout brains. glyceryl 2-arachidonate 78-82 diacylglycerol lipase, alpha Mus musculus 97-105 20159446-5 2010 The basal 2-AG content was markedly reduced and stimulus-induced elevation of 2-AG was absent in DGLalpha knockout brains, whereas the 2-AG content was normal in DGLbeta knockout brains. glyceryl 2-arachidonate 78-82 diacylglycerol lipase, alpha Mus musculus 97-105 19675536-3 2009 Here, we show that the synthetic enzyme for the eCB 2-arachidonoylglycerol (2-AG), diacylglycerol (DAG) lipase alpha, is heterogeneously expressed in the amygdala, and that levels of 2-AG and precursor DAGs are increased in the basolateral amygdala (BLA) after 10 days, but not 1 day, of restraint stress. glyceryl 2-arachidonate 52-74 diacylglycerol lipase, alpha Mus musculus 83-116 19675536-3 2009 Here, we show that the synthetic enzyme for the eCB 2-arachidonoylglycerol (2-AG), diacylglycerol (DAG) lipase alpha, is heterogeneously expressed in the amygdala, and that levels of 2-AG and precursor DAGs are increased in the basolateral amygdala (BLA) after 10 days, but not 1 day, of restraint stress. glyceryl 2-arachidonate 76-80 diacylglycerol lipase, alpha Mus musculus 83-116 19675536-3 2009 Here, we show that the synthetic enzyme for the eCB 2-arachidonoylglycerol (2-AG), diacylglycerol (DAG) lipase alpha, is heterogeneously expressed in the amygdala, and that levels of 2-AG and precursor DAGs are increased in the basolateral amygdala (BLA) after 10 days, but not 1 day, of restraint stress. glyceryl 2-arachidonate 183-187 diacylglycerol lipase, alpha Mus musculus 83-116