PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28934275-11 2017 Thus, the combination of sorafenib and MK-2206 led to significant reversion of the EMT phenotype and P-gp-mediated MDR by downregulating phosphorylated AKT. MK 2206 39-46 ATP binding cassette subfamily B member 1 Homo sapiens 101-105 29130495-8 2018 Matrine was more likely to reduce the expression of P-gp, MRP1, and p-AKT at the same inhibition radio of Matrine, (0.6 mg/mL) and MK2206 (0.05 mumol/L). MK 2206 131-137 ATP binding cassette subfamily B member 1 Homo sapiens 52-56 27486760-0 2016 Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma. MK 2206 32-38 ATP binding cassette subfamily B member 1 Homo sapiens 92-106 27486760-6 2016 Inhibition of Akt activity using MK2206 decreased GRP78 expression in OS cells, which enhanced the inhibitory effect of MK2206 on P-gp expression. MK 2206 33-39 ATP binding cassette subfamily B member 1 Homo sapiens 130-134 27486760-6 2016 Inhibition of Akt activity using MK2206 decreased GRP78 expression in OS cells, which enhanced the inhibitory effect of MK2206 on P-gp expression. MK 2206 120-126 ATP binding cassette subfamily B member 1 Homo sapiens 130-134