PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23831366-7	2013	The results showed that the 2 mg/kg/d late donepezil treatment was the optimal dosage and could ameliorate clinical and pathological parameters, improve magnetic resonance imaging outcomes, reduce the permeability of BBB, inhibit the production of MMP-2 and MMP-9, modulate the expression of NGF and proNGF, increase Th2 bias and the phosphorylation of Akt in the brains of EAE mice.	Donepezil	43-52	matrix metallopeptidase 9	Mus musculus	258-263	
21750701-4	2011	METHODS AND RESULTS: In isolated and activated macrophages, donepezil significantly reduced intra- and extracellular matrix metalloproteinase-9 (MMP-9).	Donepezil	60-69	matrix metallopeptidase 9	Mus musculus	117-143	
21750701-4	2011	METHODS AND RESULTS: In isolated and activated macrophages, donepezil significantly reduced intra- and extracellular matrix metalloproteinase-9 (MMP-9).	Donepezil	60-69	matrix metallopeptidase 9	Mus musculus	145-150	
21750701-6	2011	Immunohistochemistry revealed that MMP-9 was localized at the infarct area where a large number of inflammatory cells including macrophages infiltrated, and the expression and the enzymatic activity of MMP-9 at the left ventricular infarct area was significantly reduced in the donepezil-treated group.	Donepezil	278-287	matrix metallopeptidase 9	Mus musculus	35-40	
21750701-6	2011	Immunohistochemistry revealed that MMP-9 was localized at the infarct area where a large number of inflammatory cells including macrophages infiltrated, and the expression and the enzymatic activity of MMP-9 at the left ventricular infarct area was significantly reduced in the donepezil-treated group.	Donepezil	278-287	matrix metallopeptidase 9	Mus musculus	202-207	
21750701-7	2011	CONCLUSION: The present study suggests that donepezil inhibits the MMP-9-related acute inflammatory tissue injury in the infarcted myocardium, thereby reduces the risk of left ventricular free wall rupture during the acute phase of MI.	Donepezil	44-53	matrix metallopeptidase 9	Mus musculus	67-72	
32333532-13	2020	CONCLUSION: EA can enhance the effect of Donepezil in improving learning-memory ability in AD mice possibly by regulating expression of MMP-9, LRP-1, Pgp and Claudin-5 mRNAs and strengthening the effect of Donepezil in transporting Abeta via BBB.	Donepezil	41-50	matrix metallopeptidase 9	Mus musculus	136-141