PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30137220-2 2019 In this study, we first examined whether rosiglitazone, an agonist of the peroxisome proliferator-activated receptor-gamma (PPARgamma), protects the human trophoblast from oxidative injury by regulating key antioxidant proteins, catalase (CAT) and the superoxide dismutases (SOD1 and SOD2). Rosiglitazone 41-54 superoxide dismutase 2 Homo sapiens 284-288 30137220-5 2019 Treatment with rosiglitazone dose-dependently upregulated anti-oxidative CAT and SOD2, and rescued hypoxic injury in first trimester villous explants and JEG-3 cells, strongly suggesting the involvement of the PPARgamma in regulating their expressions. Rosiglitazone 15-28 superoxide dismutase 2 Homo sapiens 81-85 28964868-6 2017 The stimulation of mitochondrial function and anti-oxidative stress by rosiglitazone was associated with activation of the PGC1alpha pathway by up-regulation of mitochondrial (NRF-1 and Tfam) and oxidative defense (SOD1, SOD2 and Gpx1) genes. Rosiglitazone 71-84 superoxide dismutase 2 Homo sapiens 221-225