PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33673103-1 2021 This study evaluated the effect of anandamide (AEA) on interleukin (IL)-1beta synthesis and gene expression of IL-1beta, its type I (IL-1R1) and II (IL-1R2) receptors, and IL-1 receptor antagonist (IL-1RN) in the hypothalamic structures, involved in the central control of reproduction, during inflammation. aea 47-50 interleukin 1 alpha Homo sapiens 55-77 33673103-6 2021 AEA injection (p < 0.05) suppressed LPS-induced expression of IL-1beta protein in the hypothalamus. aea 0-3 interleukin 1 alpha Homo sapiens 62-70 33673103-7 2021 The gene expression of IL-1beta, IL-1RN, and IL-1R2 in the hypothalamic structures was higher (p < 0.05) in animals treated with both LPS and AEA in comparison to other experimental groups. aea 142-145 interleukin 1 alpha Homo sapiens 23-31 33673103-9 2021 Our study shows that AEA suppressed IL-1beta synthesis in the hypothalamus, likely affecting posttranscriptional levels of this cytokine synthesis. aea 21-24 interleukin 1 alpha Homo sapiens 36-44