PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31186081-7	2019	Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	102-110	hexokinase 2	Homo sapiens	71-74	
31309931-13	2019	LY294002 also attenuated the increase in Nrf2 protein by apigenin in high glucose-treated HK-2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	hexokinase 2	Homo sapiens	90-94	
22298254-5	2012	The enhancement of HKII levels and lactate production in MM cells by OCs were mostly abrogated by the PI3K inhibitor LY294002, suggesting activation of glycolysis in MM cells by OCs via the PI3K-Akt-HKII pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	hexokinase 2	Homo sapiens	19-23	
22298254-5	2012	The enhancement of HKII levels and lactate production in MM cells by OCs were mostly abrogated by the PI3K inhibitor LY294002, suggesting activation of glycolysis in MM cells by OCs via the PI3K-Akt-HKII pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	117-125	hexokinase 2	Homo sapiens	199-203	
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	hexokinase 2	Homo sapiens	74-77	
34974760-3	2022	Moreover, Akt activation is followed by the upregulation of Cyclin D1 and HK2 expression in L-02-As cells, since inhibition of Akt activity by Ly294002 attenuated the colony formation in soft agar and decreased the levels of Cyclin D1 and HK2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	143-151	hexokinase 2	Homo sapiens	239-242	
33856720-5	2021	Furthermore, AKT inhibitor LY294002 blocked the expression of p-AKT, c-Myc, HK2, PKM2, and pro-cas3 in HepG2 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	27-35	hexokinase 2	Homo sapiens	76-79	
29956736-13	2018	The combined administration of LY294002 with DCA significantly decreased lactate concentration, promoted the depolarisation of the DeltaPsim and repressed HIF-1alpha upregulation and HK-2 activation in PASMCs treated with PDGF, which was attributed to the potentiation of DCA-induced PDK-1 inhibition by LY294002 via blockade of the Akt/GSK-3beta/HIF-1alpha signalling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	hexokinase 2	Homo sapiens	183-187