PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26389892-6 2015 LY294002 completely inhibited the GA-activated phosphorylation of Akt, while only partially inhibiting eNOS. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 66-69 30952195-2 2019 PI3K/AKT signaling is frequently activated in GC, and its inhibitor LY294002 exerts potent antitumor effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 68-76 thymoma viral proto-oncogene 1 Mus musculus 5-8 33804171-7 2021 In addition, co-treatment with LY294002 noticeably blocked the effect of dieckol on Abeta production, demonstrating that dieckol promoted the PI3K/Akt signaling pathway, which in turn inactivated GSK-3beta, resulting in the reduction in Abeta levels. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31-39 thymoma viral proto-oncogene 1 Mus musculus 147-150 28347821-7 2017 The enhanced phospho-eNOS was inhibited by LY294002, indicating that the effects of LED-T on the ischemic brain could be attributed to the upregulation of eNOS phosphorylation through the phosphoinositide 3-kinase (PI3K)/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 thymoma viral proto-oncogene 1 Mus musculus 221-224 34543169-9 2021 LY294002 further inhibited cell viability, increased apoptosis, and down-regulated p-Akt/Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 85-88 34522005-6 2022 The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 80-88 thymoma viral proto-oncogene 1 Mus musculus 93-96 34900083-20 2021 LY294002 inhibited the upregulation of NRF2 activated by BHD through inhibiting the phosphorylation of the AKT/GSK3beta pathway (P < 0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 107-110 34874107-5 2022 Moreover, AOF was able to protect neurons through the PI3K/AKT signaling pathway and significantly decrease NF-kappaB, IL-6, IL-1beta, and TNF-alpha levels in the hippocampal and cortex tissues, which were reversed through the use of LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 234-242 thymoma viral proto-oncogene 1 Mus musculus 59-62 34425525-10 2021 LY294002 was used to block the PI3K/AKT/mTOR signalling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 36-39 34865170-10 2022 Moreover, administration of the PI3K/AKT inhibitor LY294002 abolished amelioration by SOMCL-668 of chronic PCP-induced schizophrenia-related behaviors by inhibition of BDNF expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 51-59 thymoma viral proto-oncogene 1 Mus musculus 37-40 34543169-9 2021 LY294002 further inhibited cell viability, increased apoptosis, and down-regulated p-Akt/Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 89-92 34537206-9 2021 Importantly, treatment of LY294002 (an inhibitor of the PI3K/Akt pathway) attenuated miR-17-5p-mediated osteoclastogenesis effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26-34 thymoma viral proto-oncogene 1 Mus musculus 61-64 34755491-9 2021 2-F-L-a also reduced PI3K, Akt, and p-Akt protein expression in NIH/3T3 cells, while the PI3K antagonist LY294002 increased this expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 105-113 thymoma viral proto-oncogene 1 Mus musculus 27-30 34597809-7 2022 Hirsutine exhibited the effects on enhancing glucose consumption and uptake in IR cell models via activating phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which was blocked by PI3K inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 195-203 thymoma viral proto-oncogene 1 Mus musculus 146-149 34689241-8 2021 RESULTS: After pretreatment with LY294002, Triciribine and Rapamycin, the p-Akt/Akt ratio of pathway protein in Triciribine and Rapamycin groups decreased (P < 0.05), while the autophagy protein LC3-II/LC3-I in the Rapamycin group was upregulated obviously (P < 0.001). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 thymoma viral proto-oncogene 1 Mus musculus 76-79 34689241-8 2021 RESULTS: After pretreatment with LY294002, Triciribine and Rapamycin, the p-Akt/Akt ratio of pathway protein in Triciribine and Rapamycin groups decreased (P < 0.05), while the autophagy protein LC3-II/LC3-I in the Rapamycin group was upregulated obviously (P < 0.001). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 thymoma viral proto-oncogene 1 Mus musculus 80-83 34332284-8 2021 DMBQ increased the phosphorylation of protein kinase B (AKT) and p70 ribosomal protein S6 kinase (S6K), whereas the phosphorylation of these proteins was abolished by the phosphoinositide 3-kinase inhibitor LY294002 in C2C12 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 207-215 thymoma viral proto-oncogene 1 Mus musculus 56-59 34663382-9 2021 FGF-2-mediated anti-apoptosis was impaired by inactivating the PI3K/AKT pathway with LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 85-93 thymoma viral proto-oncogene 1 Mus musculus 68-71 34635126-9 2021 We also cultured motor neuron-like NSC-34 cells transfected with a plasmid to overexpress mutant SOD1G93A and starved them in serum-free medium for 24 h with and without bpV(pic) and downstream inhibitor of Akt signaling, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 222-230 thymoma viral proto-oncogene 1 Mus musculus 207-210 34358859-8 2021 LY294002, an inhibitor of PI3K/Akt signaling, was used to elucidate the relationship between ME and PI3K/Akt signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 31-34 34358859-8 2021 LY294002, an inhibitor of PI3K/Akt signaling, was used to elucidate the relationship between ME and PI3K/Akt signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 105-108 34698101-4 2021 This increase in GU was partially, but significantly canceled by TXF treatment in combination with either LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K), which phosphorylates protein kinase B (Akt) or Compound C, an inhibitor of 5"-adenosine monophosphate-activated protein kinase (AMPK). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 209-212 34553450-7 2021 Finally, the potential downstream mechanisms were investigated, and we expectedly found that METTL3 activated the PI3K/Akt pathway in H/R-treated cardiomyocytes through modulating miR-25-3p and miR-873-5p, and the PI3K/Akt pathway inhibitor (LY294002) abrogated the protective effects of METTL3 overexpression in cardiomyocytes with H/R treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 242-250 thymoma viral proto-oncogene 1 Mus musculus 119-122 34553450-7 2021 Finally, the potential downstream mechanisms were investigated, and we expectedly found that METTL3 activated the PI3K/Akt pathway in H/R-treated cardiomyocytes through modulating miR-25-3p and miR-873-5p, and the PI3K/Akt pathway inhibitor (LY294002) abrogated the protective effects of METTL3 overexpression in cardiomyocytes with H/R treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 242-250 thymoma viral proto-oncogene 1 Mus musculus 219-222 34553399-9 2022 PI3K/Akt inactivation by LY294002 resisted the effects of fraxetin on isoflurane-induced autophagy and autophagy-modulated neurotoxicity in HT22 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 5-8 34521048-2 2021 METHODS: GDM mice models were established and treated with Apelin-13 and/or PI3K/AKT inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 95-103 thymoma viral proto-oncogene 1 Mus musculus 81-84 34275490-7 2021 In vitro organotypic culture-induced activation of the PI3K/PTEN/Akt pathway is counteracted by cryopreservation with rapamycin and in vitro culture in the presence of LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 168-176 thymoma viral proto-oncogene 1 Mus musculus 65-68 34416638-10 2021 Moreover, Akt and mTOR inhibition by using LY294002 and rapamycin, respectively, blocked inflammatory cytokine overexpression induced by TCS. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 thymoma viral proto-oncogene 1 Mus musculus 10-13 34349085-10 2022 The effect of CIB1 knockdown on Ang II-induced cellular injury was comparable to that of LY294002, a specific inhibitor of the PI3K/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 89-97 thymoma viral proto-oncogene 1 Mus musculus 132-135 35575872-11 2022 We used LY294002 to block PI3K and the results showed that CTS exerted neuroprotective effects through regulation of the PI3K/Akt/GSK3beta signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 8-16 thymoma viral proto-oncogene 1 Mus musculus 126-129 34118791-6 2021 However, these effects were largely attenuated by LY294002 (a specific Akt signaling blocker) administration. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 50-58 thymoma viral proto-oncogene 1 Mus musculus 71-74 35582997-12 2022 In vitro study from 5% IMQ-induced mouse splenic mononuclear cells presented that high dose of LY294002 exerted more obviously regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 95-103 thymoma viral proto-oncogene 1 Mus musculus 165-168 35533447-10 2022 Moreover, inhibiting PI3K-AKT by LY294002 abrogated nicotine-mediated beta-catenin level increase and thymopoiesis abnormalities, and an alpha7 nAChR antagonist (alpha-btx) also reversed nicotine-induced PI3K-AKT activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 thymoma viral proto-oncogene 1 Mus musculus 26-29 35359221-7 2022 Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 100-108 thymoma viral proto-oncogene 1 Mus musculus 95-98 35359221-7 2022 Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 100-108 thymoma viral proto-oncogene 1 Mus musculus 211-214 35582997-3 2022 The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 195-203 thymoma viral proto-oncogene 1 Mus musculus 114-117 35582997-3 2022 The present study aimed to evaluate the regulatory effect of the Notch1/hairy and enhancer of split 1 (Hes1)-PTEN/AKT/IL-17A feedback loop on Th17 cell differentiation via the PI3K/AKT inhibitor LY294002 in a mouse model of psoriasis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 195-203 thymoma viral proto-oncogene 1 Mus musculus 181-184 35582997-8 2022 Additionally, splenic mononuclear cells from model mice were treated by 10 and 50 microM LY294002 to further evaluate its regulatory effect on Notch1/Hes1-PTEN/AKT/IL-17A feedback loop. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 89-97 thymoma viral proto-oncogene 1 Mus musculus 160-163 35582997-11 2022 In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 thymoma viral proto-oncogene 1 Mus musculus 137-140 35582997-11 2022 In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 thymoma viral proto-oncogene 1 Mus musculus 144-147 35487953-8 2022 PI3K-AKT pathway inhibitor LY294002 reversed the excessive activation and phagocytosis of microglia caused by sTREM-1 in vivo and in vitro, which in turn improved the hippocampus damage. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 27-35 thymoma viral proto-oncogene 1 Mus musculus 5-8 35550264-7 2022 Moreover, the potential underlying mechanisms were uncovered, and we illustrated that sevoflurane promoted GSK-3beta activation in LPS-treated ALI mice lung tissues, and re-activation of GSK-3beta by the PI3K/Akt pathway inhibitor LY294002 suppressed LPS-induced pyroptotic cell death in vivo. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 231-239 thymoma viral proto-oncogene 1 Mus musculus 209-212 35503228-10 2022 Moreover, PI3K/AKT signaling inhibitor LY294002 reversed KAT5 overexpression-mediated phenotypes and inflammatory response after induction AC in vivo. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 thymoma viral proto-oncogene 1 Mus musculus 15-18 35378205-7 2022 Inhibition of autophagy or Akt pathways by chloroquine (CQ), 3-Methyladenine (3-MA) or LY294002 promoted colistin-induced mitochondrial damage, and caspase-dependent cellular apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 87-95 thymoma viral proto-oncogene 1 Mus musculus 27-30 35261236-8 2022 When the AKT pathway was inhibited by LY294002, the neurogenerative and antioxidant effects of melatonin were significantly limited in the hippocampus of miR-144/451-/- mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 38-46 thymoma viral proto-oncogene 1 Mus musculus 9-12 35394554-5 2022 In cultured podocytes, we used plasmids to knockdown FKN and treated the podocytes with PI3K/Akt inhibitor (LY294002). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 108-116 thymoma viral proto-oncogene 1 Mus musculus 93-96 35394554-10 2022 FKN knockdown reduced podocyte apoptosis by regulating the Bcl-2 family; however, this protective effect was reversed by the co-administration of a PI3K/Akt inhibitor (LY294002). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 168-176 thymoma viral proto-oncogene 1 Mus musculus 153-156 35201262-10 2022 Inhibition of AKT by its inhibitor LY294002 abolishes eHsp90alpha-induced migration and proliferation of corneal epithelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 thymoma viral proto-oncogene 1 Mus musculus 14-17 35066448-13 2022 Moreover, activated PI3K/AKT signaling in HK-2 cells was inhibited by PK and the PI3K inhibitor, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 97-105 thymoma viral proto-oncogene 1 Mus musculus 25-28 35354939-6 2022 The following mechanisms were explored using a specific PI3K/AKT pathway inhibitor (Ly294002). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 84-92 thymoma viral proto-oncogene 1 Mus musculus 61-64 35132190-9 2022 Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 38-41 35132190-9 2022 Using ERK1/2 inhibitor U0126 and PI3K/AKT inhibitor LY294002, we revealed that the amount of Nurr1 in the nucleus was upregulated through beta-arrestin2/ERK1/2 and PI3K/AKT/GSK-3beta signaling pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 169-172 35130910-11 2022 In addition, 24A could up-regulate the expression of phosphorylated phosphoinositide 3-kinases (p-PI3K) and phosphorylated protein kinase B (p-AKT) in GCI/R mice brain, and all the morphological, neurological, and biochemical changes of 24A treatment were abolished by the application of PI3K/AKT pathway inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 315-323 thymoma viral proto-oncogene 1 Mus musculus 143-146 35165685-8 2022 The reduction in the expression of PI3K/Akt/mTOR was enhanced by the use of the PI3K inhibitor, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 96-104 thymoma viral proto-oncogene 1 Mus musculus 40-43 35484750-11 2022 The functionality of PI3K/Akt signaling pathway was tested using LY294002, an inhibitor of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 65-73 thymoma viral proto-oncogene 1 Mus musculus 26-29 35484750-15 2022 However, LY294002 inhibited the shikonin-mediated PI3K/Akt signaling pathway and affected the wound healing process. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 thymoma viral proto-oncogene 1 Mus musculus 55-58 35069549-9 2021 These effects of SMS were inhibited when PI3K/Akt activation was blocked by LY294002 in the macrophages. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 46-49 35053144-10 2022 LY294002 infusion revealed the PI3K/Akt involvement in the warm-RIC protection. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 36-39 35282120-12 2022 Moreover, AS downregulated the expression of apoptotic protein, and promoted phosphorylation of PI3K, AKT, and GSK3beta, which was reversed by PI3K inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 102-105 34038756-8 2021 Expectedly, inhibition of Akt signaling with LY294002 obviously enhanced As3+-triggered autophagy and apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 thymoma viral proto-oncogene 1 Mus musculus 26-29 35355710-9 2022 Moreover, the PI3K/AKT and Wnt/beta-catenin signaling inhibitors, LY294002 and XAV-939, ameliorated BLM-meditated PF in vivo and relieved EMT in vivo and in vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 66-74 thymoma viral proto-oncogene 1 Mus musculus 19-22 33999329-10 2021 Meanwhile, treatment with Akt inhibitor LY294002 reversed the protective effects of isorhamnetin against HG-aggravated OGD/R injury in HT22 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 40-48 thymoma viral proto-oncogene 1 Mus musculus 26-29 33607158-8 2021 Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3beta/beta-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 89-92 33607158-8 2021 Mechanism studies revealed that XQ-1H exerted angiogenesis promoting effect via the PI3K/Akt/GSK3beta/beta-catenin/VEGF signal pathway, which was reversed by LY294002 (the specific inhibitor of PI3K/Akt). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 199-202 33860870-10 2021 Metformin, metformin and ketamine, triciribine, LY294002, and torin2 reduced Akt and PI3K expression, peribronchial and perivascular inflammation, and increased expression of Foxp3. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 thymoma viral proto-oncogene 1 Mus musculus 77-80 33986917-6 2021 These beneficial effects of SPostC were abolished by either TOPK kinase inhibitor HI-TOPK-032 or PI3K/Akt inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 thymoma viral proto-oncogene 1 Mus musculus 102-105 33645479-11 2021 Furthermore, fisetin activated the phosphoinositide-3-kinase/protein kinase B (PI3K-AKT) signaling pathway, and blocking this pathway by the inhibitor LY-294002 could impair fisetin"s functions on proliferation, differentiation and OPG/RANKL expression ratio in the MC3T3-E1 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-160 thymoma viral proto-oncogene 1 Mus musculus 84-87 33710186-9 2021 Western blot analysis results also implied that active-constituent pretreatment reversed the diminished expression of the PI3K/Akt/mTOR pathway mediated by oxygen glucose deprivation/reperfusion (OGD/R); further experimental evidence showed that the protective role was limited in the PI3K inhibitor (LY294002) treatment group. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 301-309 thymoma viral proto-oncogene 1 Mus musculus 127-130 33537812-11 2021 It was found that the PI3K/Akt signaling pathway was activated in high glucose-stimulated HKC cells, and inhibition of PI3K/Akt pathway using LY294002 increased FBXW7 expression and decreased SREBP-1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 142-150 thymoma viral proto-oncogene 1 Mus musculus 124-127 33537834-8 2021 The PI3K inhibitor, LY294002, blocked BMP2-induced osteoblastogenesis, suggesting that the PI3K/AKT pathway is critically required for BMP2 to initiate osteoblastogenesis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 thymoma viral proto-oncogene 1 Mus musculus 96-99 33632134-5 2021 Mice were treated with MaR1 (5-20 ng/mouse), Boc2 (Lipoxin A4 receptor antagonist), LY294002 (Akt inhibitor) or corresponding controls just prior to liver I/R or at the beginning of reperfusion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 84-92 thymoma viral proto-oncogene 1 Mus musculus 94-97 32668051-9 2021 Then the antagonist of Akt phosphorylation (LY294002) was used to treat AD mice, which could rescue the expression of CLDN1 through inhibiting the Akt phosphorylation in skin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 thymoma viral proto-oncogene 1 Mus musculus 23-26 33432947-11 2021 The PI3K inhibitor LY294002 dramatically decreased the p-Akt expression and activated FoxO1 by dephosphorylation, thus diminishing the inhibitory effects of Rsv on dapagliflozin-induced PEPCK and G6Pase expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 57-60 32942336-10 2021 Inhibition of PI3K/AKT/mTOR signalling with LY294002 activated autophagy in clusterin-overexpressing GC-1 spg cells under high glucose conditions. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 thymoma viral proto-oncogene 1 Mus musculus 19-22 33603340-9 2021 Finally, AKT blockage by 10 muM LY294002 or Nrf2 inhibition by10 mu M ML385 were utilized to prove the involvement of AKT and Nrf2/HO-1 pathway in AKI during sepsis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 32-40 thymoma viral proto-oncogene 1 Mus musculus 9-12 33456508-7 2021 Further study demonstrated that a pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, inhibited the expression of NF-kappaB p65 in the nuclear fraction and decreased the production of inflammatory cytokines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 113-121 thymoma viral proto-oncogene 1 Mus musculus 100-103 33414476-5 2021 Furthermore, HDAC5 expression was regulated by PI3K/Akt signaling pathway and inhibition of PI3K/Akt pathway by LY294002 treatment or Akt phosphorylation mutation reduced HDAC5 and TGF-beta1 expression in vitro high glucose-cultured HK2 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 thymoma viral proto-oncogene 1 Mus musculus 97-100 33414476-5 2021 Furthermore, HDAC5 expression was regulated by PI3K/Akt signaling pathway and inhibition of PI3K/Akt pathway by LY294002 treatment or Akt phosphorylation mutation reduced HDAC5 and TGF-beta1 expression in vitro high glucose-cultured HK2 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 thymoma viral proto-oncogene 1 Mus musculus 97-100 32668051-9 2021 Then the antagonist of Akt phosphorylation (LY294002) was used to treat AD mice, which could rescue the expression of CLDN1 through inhibiting the Akt phosphorylation in skin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 44-52 thymoma viral proto-oncogene 1 Mus musculus 147-150 33193844-13 2020 Moreover, miR-342-5p mimics partially activated the Akt signaling pathway inhibited by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 87-95 thymoma viral proto-oncogene 1 Mus musculus 52-55 33349309-8 2020 These effects were inversed after pretreatment of the PI3K/Akt inhibitor LY294002 or overexpression of constitutively active Akt1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 73-81 thymoma viral proto-oncogene 1 Mus musculus 59-62 33343353-9 2020 The use of the specific PI3K/AKT pathway inhibitor LY294002 regressed the cardio-protection of GSPE. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 51-59 thymoma viral proto-oncogene 1 Mus musculus 29-32 33039957-3 2020 LY294002 was used as an inhibitor of PI3K/AKT signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 42-45 33039957-11 2020 Blockade of p-FoxO3a activation by LY294002 suppressed PI3K/Akt/FoxO3a pathway and the subsequent upregulation of FoxO3a in the nucleus resulting in the severity of inflammation and fibrosis in the kidney of MRL/lpr mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 thymoma viral proto-oncogene 1 Mus musculus 60-63 33372619-12 2020 Additionally, treatment with LY294002 inhibitor revealed the involvement of the Akt/FOXO1/Bim signaling pathway in folate deficiency-induced apoptosis, rather than the ERK pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 thymoma viral proto-oncogene 1 Mus musculus 80-83 33145952-12 2020 The PI3K/AKT inhibitor LY294002 prevented SLC1A3-induced glucose metabolism and cell proliferation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 thymoma viral proto-oncogene 1 Mus musculus 9-12 33174025-14 2020 Most importantly, treatment with the Akt inhibitor LY294002 in WT mice blocked the hepatoprotective effects of HDN in liver I/R injury. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 51-59 thymoma viral proto-oncogene 1 Mus musculus 37-40 33162828-11 2020 Inhibition of VEGFR2 by siRNA or XL184 (cabozantinib) and inhibition of downstream signaling by LY294002 (inhibits AKT activation) and L-NAME (eNOS inhibitor) remarkably abolished proangiogenic effects of CD137 signaling both in vitro and ex vivo. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 96-104 thymoma viral proto-oncogene 1 Mus musculus 115-118 33173334-5 2020 The PI3K/AKT signaling pathway was interfered with L740Y-P (activator of the PI3K/AKT pathway) and LY294002 (inhibitor of the PI3K/AKT pathway) in BC cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99-107 thymoma viral proto-oncogene 1 Mus musculus 9-12 32777676-6 2020 Furthermore, LY294002, an inhibitor for PI3K, abrogated serum-induced phosphorylation of Akt, and decreased the proliferation of ASMCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 thymoma viral proto-oncogene 1 Mus musculus 89-92 33305726-5 2020 LY294002, a PI3K inhibitor, is used to inhibit the activity of the PI3K/Akt signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 72-75 32698024-11 2020 Furthermore, the increase in ALP activity, LRP5 and phospho-Akt/Akt expression by 8PG and genistein were abolished by co-treatment with LY294002 (10-5 M, a PI3K pathway inhibitor). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 136-144 thymoma viral proto-oncogene 1 Mus musculus 60-63 32698024-11 2020 Furthermore, the increase in ALP activity, LRP5 and phospho-Akt/Akt expression by 8PG and genistein were abolished by co-treatment with LY294002 (10-5 M, a PI3K pathway inhibitor). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 136-144 thymoma viral proto-oncogene 1 Mus musculus 64-67 33123919-2 2020 Here we analyze the effect of a specific PI3K/Akt pathway inhibitor (LY 294002) on the antidiabetic effect of the BDNF loop 1 mimetic GSB-214. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-78 thymoma viral proto-oncogene 1 Mus musculus 46-49 32725369-8 2020 The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway was blocked by LY294002 and related protein levels were detected via western blot. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 thymoma viral proto-oncogene 1 Mus musculus 55-58 32885795-11 2020 The specific PI3K/Akt inhibitor LY294002, however, reversed these effects of ICA on UA-treated Min6 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 32-40 thymoma viral proto-oncogene 1 Mus musculus 18-21 32982299-10 2020 OLR1 inhibition and LY294002 treatment significantly weakened the effects HSPA12B on activating the PI3K/Akt/mTOR signaling and M2 marker expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 thymoma viral proto-oncogene 1 Mus musculus 105-108 32534061-5 2020 To address these issues, we establish a stabilized fracture model in mice and show that PI3K inhibitor LY294002 substantially inhibits the bone healing process, suggesting that PI3K/AKT promotes fracture repair. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 thymoma viral proto-oncogene 1 Mus musculus 182-185 32863960-9 2020 The PI3K/Akt inhibitor LY294002 was utilized to identify the effects of the PI3K-Akt/Nrf2 signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 thymoma viral proto-oncogene 1 Mus musculus 9-12 32584135-9 2020 Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 38-41 32584135-9 2020 Additionally, we also found that PI3K/AKT inhibitor LY294002 abolished the downregulation of PUMA mRNA by FSH in vitro, In conclusion, FSH inhibit the expression of PUMA induced by ROS through PI3K/AKT pathway in vivo and vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 198-201 31280345-11 2020 delta-TT prevention of oxidative damage was completely removed by combined treatment with the specific inhibitors of PI3K/AKT (LY294002) and Nrf2 (ML385). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 127-135 thymoma viral proto-oncogene 1 Mus musculus 122-125 32803867-9 2020 PD98059 (an ERK1/2 inhibitor) and LY294002 (an AKT inhibitor) both inhibited BDNF-induced migration and integrin beta1 expression while integrin beta1 blocking antibody only suppressed cell migration. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 thymoma viral proto-oncogene 1 Mus musculus 47-50 32209778-9 2020 However, an Akt inhibitor LY294002, which was injected at 15 nmol/kg via the tail vein, attenuated the protective effects of IL-4. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26-34 thymoma viral proto-oncogene 1 Mus musculus 12-15 32811251-5 2021 At concentrations as low as 3.12 microM, LY294002 abolished Akt phosphorylation induced by 2MeSADP and SFLLRN, but not by AYPGKF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 thymoma viral proto-oncogene 1 Mus musculus 60-63 32811251-6 2021 It required much higher concentrations of LY294002 (12.5-25 microM) to abolish AYPGKF-induced Akt phosphorylation, both in wild type and P2Y12 null mouse platelets. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 42-50 thymoma viral proto-oncogene 1 Mus musculus 94-97 32811251-7 2021 We propose that 3.12 microM LY294002 is sufficient to inhibit PI3 kinase isoforms in platelets and higher concentrations might inhibit other pathways regulating Akt phosphorylation by AYPGKF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 thymoma viral proto-oncogene 1 Mus musculus 161-164 32863960-9 2020 The PI3K/Akt inhibitor LY294002 was utilized to identify the effects of the PI3K-Akt/Nrf2 signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 thymoma viral proto-oncogene 1 Mus musculus 81-84 32600449-10 2020 These effects were associated with increased levels of phosphorylated Akt and eNOS, which could be abolished by PI3K inhibitor (LY294002) or Ras inhibitor (NSC 23766). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 128-136 thymoma viral proto-oncogene 1 Mus musculus 70-73 32144792-6 2020 LY294002, a PI3K inhibitor, could inhibit the phosphorylation of Akt and reduce the expression of TLR4, thus reduce the foam cell source and lipid volume in the unstable plaque tissue. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 65-68 32067282-8 2020 Additionally, the Akt signaling pathway was blocked with an Akt inhibitor, LY294002, to investigate its involvement in the regulatory effect of miR30a. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 thymoma viral proto-oncogene 1 Mus musculus 18-21 32414166-9 2020 These were blocked by LY294002, which is an Akt inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 22-30 thymoma viral proto-oncogene 1 Mus musculus 44-47 32181480-12 2020 Notably, PI3K/AKT inhibitor LY294002 significantly inhibited the effects of HER4 via the downregulation of pAKT, Ki67, and MMP9. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 thymoma viral proto-oncogene 1 Mus musculus 14-17 32150448-7 2020 The protective effect of canagliflozin was diminished by the phosphatidylinositol 3-kinase/Akt inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 105-113 thymoma viral proto-oncogene 1 Mus musculus 91-94 32215984-7 2020 The PI3K inhibitor LY294002 and PI3K agonist 740Y-P were used to regulate the PI3K/Akt pathway in EMSCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 83-86 32527040-9 2020 Specific inhibitors of Akt/GSK-3beta (LY294002) and MEK/ERK (PD98059) signaling prevented the inhibition of melanogenesis by NBI. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 38-46 thymoma viral proto-oncogene 1 Mus musculus 23-26 32458633-9 2020 Moreover, EHF inactivated the PI3K/Akt signaling pathway and LY294002, a PI3K/Akt inhibitor, increased the apoptosis-inducing effect of EHF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 61-69 thymoma viral proto-oncogene 1 Mus musculus 78-81 32049549-9 2020 In addition, the capacity of NIC to protect CECs was fully reversed in the presence of the AKT inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 105-113 thymoma viral proto-oncogene 1 Mus musculus 91-94 32067282-8 2020 Additionally, the Akt signaling pathway was blocked with an Akt inhibitor, LY294002, to investigate its involvement in the regulatory effect of miR30a. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 thymoma viral proto-oncogene 1 Mus musculus 60-63 32256089-12 2020 Moreover, PI3K inhibitor LY294002 effectively inhibited activation of PI3K and AKT, and further repressed RAGE overexpression-induced cell proliferation and apoptosis inhibition. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 79-82 31535378-11 2020 LY294002, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT pathway inhibitor, attenuated the decline in pAKT, but enhanced the decline in pmTOR and the increase in pULK1 following OPG treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 66-69 31918274-12 2020 The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 53-56 31918274-12 2020 The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 468-476 thymoma viral proto-oncogene 1 Mus musculus 53-56 31918274-12 2020 The in vitro data showed that pre-treatment of PI3 K/AKT specific inhibitor LY294002 remarkably abrogated GPR174 over-expression-accelerated expression levels of Iba-1, tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in lipopolysaccharide (LPS)-incubated retinal microglial cells.Furthermore, in LPS-exposed retinal microglial cells, PI3 K/AKT and NF-kappaB pathways were further promoted by GPR174 over-expression, which were significantlyabolished by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 355-358 31642978-10 2019 PI3K and p-Akt were much higher after insulin exposure and the compromised decidualization by high insulin treatment was rescued by PI3K/Akt inhibitor LY294002 both in vitro and in vivo. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-159 thymoma viral proto-oncogene 1 Mus musculus 11-14 32055597-13 2020 Western blot results showed that the expression of P-AKT increased after EA treatment and decreased after LY294002, an inhibitor of the PI3K/AKT pathway, treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 53-56 31829201-4 2019 Under the simulation of TNF-alpha, with or without PI3K/Akt inhibitor LY294002, Cadherin-11 expression was detected by real-time PCR and Western blot, as well as the migration and invasive capacity changes of OA FLS. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 70-78 thymoma viral proto-oncogene 1 Mus musculus 56-59 31642978-10 2019 PI3K and p-Akt were much higher after insulin exposure and the compromised decidualization by high insulin treatment was rescued by PI3K/Akt inhibitor LY294002 both in vitro and in vivo. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-159 thymoma viral proto-oncogene 1 Mus musculus 137-140 31638199-5 2019 Cells were treated with 10-6 mol/l of Ang II and/or LY294002 (inhibitor of Akt) or 740Y-P (activator of PI3K) for 48 h to detect Akt, phosphorylated (phospho)-Akt, p65 NF-kappaB, and phospho-p65 NF-kappaB, nephrin, podocin and caspase-9 expression, and podocyte apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 75-78 31586450-11 2019 In addition, application of the PI3K/Akt antagonist LY294002 counteracted the effect of G-1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 37-40 31570770-10 2019 Notably, LY294002, a PI3K inhibitor, or knockdown of PI3K by small interfering RNA significantly suppressed Akt phosphorylation, attenuated HO-1 induction, and further reversed these beneficial effects evoked by hemin pretreatment in RAW264.7 cells or rats received LPS, indicating a direct involvement of PI3K/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 thymoma viral proto-oncogene 1 Mus musculus 108-111 31638199-8 2019 LY294002 further enhanced Ang II-induced downregulation of Akt and p65 NF-kappaB activation, as well as upregulation of caspase-9 mRNA and protein, and promoted the apoptosis of podocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 59-62 31894002-5 2019 The AKT pathway inhibitor LY294002 (50 mumol/L) was used for investigating the role of AKT pathway in the autophagy in RAW264.7 cells treated by oxLDL/beta2GPI/anti-beta2GPI antibody complex. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26-34 thymoma viral proto-oncogene 1 Mus musculus 4-7 31176760-12 2019 Finally, we found naringenin promoted AKT phosphorylation; PI3K inhibitor LY294002 treatment increased nuclear ATF6 and reduced naringenin-enhanced ABCA1 expression and cholesterol efflux. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 74-82 thymoma viral proto-oncogene 1 Mus musculus 38-41 31260867-9 2019 In addition, the inhibition of AKT with a pharmacological inhibitor (LY294002) demonstrated more synergic anti-proliferative effects than in the TM3 and TM4 cell lines treated only with alpha-solanine. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-77 thymoma viral proto-oncogene 1 Mus musculus 31-34 31377156-6 2019 Inhibition of ERK1/2 or PI-3K/Akt by PD98059 and LY294002 restored the decreased tyrosinase activity and MITF expression via resveratrol-mediated down-regulation of COX-2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 49-57 thymoma viral proto-oncogene 1 Mus musculus 30-33 31723054-14 2019 Furthermore, the Akt agonist, insulin-like growth factor-1 (IGF-1), prevented I/R injury in TSLPR-/- mice and an Akt inhibitor, LY294002, blocked the protective effects of TSLP in WT mice subjected to I/R. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 128-136 thymoma viral proto-oncogene 1 Mus musculus 113-116 31120172-5 2019 In addition, AKT, which is an upstream protein kinase of mTORC1 and is downstream of mTORC2, is inhibited by LY294002 (a phosphatidylinositol 3-kinase inhibitor), but not by rapamycin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 109-117 thymoma viral proto-oncogene 1 Mus musculus 13-16 31482900-5 2019 The inhibition of Akt signaling by LY294002 or TrkB activity by K252a eliminated the neuroprotective effects of THSG. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 thymoma viral proto-oncogene 1 Mus musculus 18-21 31132356-11 2019 Furthermore, administration of PI3K/Akt/mTOR signaling pathway inhibitor LY294002 abolished the beneficial effects of ginsenoside Rg1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 73-81 thymoma viral proto-oncogene 1 Mus musculus 36-39 31270250-11 2019 Overexpressed RECK and LY294002 could decrease p-AKT and PI3K-p85 expression accompanied with unchanged expression of total protein of AKT. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 thymoma viral proto-oncogene 1 Mus musculus 49-52 31270250-11 2019 Overexpressed RECK and LY294002 could decrease p-AKT and PI3K-p85 expression accompanied with unchanged expression of total protein of AKT. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 thymoma viral proto-oncogene 1 Mus musculus 135-138 31308811-6 2019 Rb1 also increased Akt phosphorylation, which was suppressed by LY294002, a phosphoinositide 3-kinase inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 64-72 thymoma viral proto-oncogene 1 Mus musculus 19-22 31120192-6 2019 Inhibition of PI3K/Akt pathway by specific inhibitor, LY294002, partially reduced the protective effect of SDX. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 54-62 thymoma viral proto-oncogene 1 Mus musculus 19-22 31189740-9 2019 Moreover, overexpressed miR-613, silenced FN1 or LY294002 treatment suppressed proliferation, invasion, migration, and angiogenesis in NPC cells, which was indicated by reduced expression of AKT, mTOR, MMP-2, MMP-9, VEGF, and CD31 as well as decreased ratio of Bcl-2/Bax and increased expression of Cleaved-caspase3. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 49-57 thymoma viral proto-oncogene 1 Mus musculus 191-194 31189740-10 2019 Furthermore, cell apoptosis was promoted and tumorigenesis and MVD in nude mice were inhibited with overexpression of miR-613, silenced FN1 or LY294002 treatment.Conclusion: Taken together, miR-613 inhibits angiogenesis in NPC cells through inactivating FN1-dependent AKT signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 143-151 thymoma viral proto-oncogene 1 Mus musculus 268-271 31456644-6 2019 CCA cell lines QBC-939 and RBE were selected and treated with siRNA against GATA1 or/and a PI3K/AKT pathway inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 118-126 thymoma viral proto-oncogene 1 Mus musculus 96-99 31006055-6 2019 The bLF-mediated proliferation was significantly blocked by the Erk phosphorylation inhibitor PD98059 or the Akt phosphorylation inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 139-147 thymoma viral proto-oncogene 1 Mus musculus 109-112 31115571-6 2019 Furthermore, 10 micromol/PI3K inhibitor (LY294002) was applied to inhibit the PTEN/PI3K/Akt signal transduction pathway and 100 micromol/l FA was selected for treatment; alteration in the cell cycle were analyzed. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 thymoma viral proto-oncogene 1 Mus musculus 88-91 31115571-9 2019 Following the application of LY294002 to inhibit the PTEN/PI3K/Akt signal transduction pathway, the numbers of cells arrested in the G0/G1 phase were significantly increased in the PI3K inhibitor group compared with the control (P<0.01); however, no significant change in the number of G0/G1 cells compared with FA group was observed (P>0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 thymoma viral proto-oncogene 1 Mus musculus 63-66 30877761-8 2019 Moreover, MV reduced ROS level and restored overexpressed HO-1 and AP-1 to basal level, which can be markedly reversed by AKT1 inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 137-145 thymoma viral proto-oncogene 1 Mus musculus 122-126 31137461-7 2019 In addition, treatment with a phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, LY294002, suppressed the mineralization and the expression of osteoblast differentiation markers other than ALP. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 82-90 thymoma viral proto-oncogene 1 Mus musculus 67-70 30335670-6 2019 Pretreatment with either Akt inhibitor LY294002 or Sp1 inhibitor mithramycin A (MTM) could inhibit melatonin-induced P4Halpha1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 thymoma viral proto-oncogene 1 Mus musculus 25-28 30760865-6 2019 Treating mouse lung fibroblasts with LPS resulted in mTOR and Akt phosphorylation, p62 up-regulation, and significant down-regulation of autophagosomes, which could be reversed by PI3K-Akt inhibitors (Ly294002) or mTOR inhibitors (rapamycin, RAPA). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 201-209 thymoma viral proto-oncogene 1 Mus musculus 185-188 31261859-7 2019 The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 thymoma viral proto-oncogene 1 Mus musculus 98-101 31261859-7 2019 The inhibitor of LY294002 inhibited S1P-stimulated activation of phosphorylated protein kinase B (AKT) (p-AKT) and endothelial nitric oxide synthase (eNOS) (p-eNOS), and down-regulated the level of eNOS significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 thymoma viral proto-oncogene 1 Mus musculus 106-109 30891787-0 2019 Adiponectin and Serine/Threonine Kinase Akt Modulation by Triiodothyronine and/or LY294002 in 3T3-L1 Adipocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 82-90 thymoma viral proto-oncogene 1 Mus musculus 40-43 29372310-12 2019 D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 148-156 thymoma viral proto-oncogene 1 Mus musculus 96-99 29372310-12 2019 D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 148-156 thymoma viral proto-oncogene 1 Mus musculus 165-168 30629471-6 2019 Furthermore, pretreatment of the PI3K/Akt inhibitor LY294002 reverses all the SC79-induced hepatoprotective effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 38-41 30637828-7 2019 Importantly, EX527, SIRT1 siRNA, and LY294002, Akt siRNA, remarkably abolished the antiapoptotic effects of TASAES. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 thymoma viral proto-oncogene 1 Mus musculus 47-50 30816216-7 2019 Treatment with Akt inhibitor LY294002 or mTOR inhibitor rapamycin rescued the social deficit, but had no effect on hyperactivity and repetitive behavior/restricted behavior in Cntnap2-/- mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 thymoma viral proto-oncogene 1 Mus musculus 15-18 30554658-11 2019 The attenuated relaxation and the augmented Akt-p were ameliorated by LY294002, a specific inhibitor of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 70-78 thymoma viral proto-oncogene 1 Mus musculus 44-47 30719047-8 2019 We also found that G-CSF significantly increased the CXCR4 expression and AKT phosphorylation in BM-MSCs, and the AKT pathway inhibitor LY294002 significantly diminished the ability of G-CSF to upregulate the CXCR4 expression in BM-MSCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 136-144 thymoma viral proto-oncogene 1 Mus musculus 74-77 30662396-6 2018 Intriguingly, the neuroprotective effects of hUC-MSCs with HDAC1 silence on behavioral performance of TBI mice was markedly attenuated by LY294002, an inhibitor of the PI3K/AKT pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 138-146 thymoma viral proto-oncogene 1 Mus musculus 173-176 30719047-8 2019 We also found that G-CSF significantly increased the CXCR4 expression and AKT phosphorylation in BM-MSCs, and the AKT pathway inhibitor LY294002 significantly diminished the ability of G-CSF to upregulate the CXCR4 expression in BM-MSCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 136-144 thymoma viral proto-oncogene 1 Mus musculus 114-117 30173054-7 2018 Additionally, a pharmacological inhibitor of PI3K/AKT, LY294002, also restrained the phosphorylation levels of IkappaBalpha and NF-kappaB p65 and thereby decreased the expression of pro-inflammatory cytokines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 thymoma viral proto-oncogene 1 Mus musculus 50-53 30404729-9 2018 LY294002 not only attenuated differentiation of C3H10T1/2 MSCs into brown adipocytes, but also reduced phosphorylated AKT and mTOR levels. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 118-121 30404729-10 2018 However, co-treatment with liraglutide and LY294002 decreased the expression of adipogenic and mitochondrial genes, mtDNA, and phosphorylated AKT and mTOR levels compared to C3H10T1/2 MSCs treated with liraglutide 100 nM. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 thymoma viral proto-oncogene 1 Mus musculus 142-145 30745820-13 2019 However, this beneficial effect of ICA was abolished by PI3K/AKT inhibitor LY294002 in vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 thymoma viral proto-oncogene 1 Mus musculus 61-64 30323140-10 2018 The PI3K/Akt signaling pathway inhibitor LY294002 (10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 thymoma viral proto-oncogene 1 Mus musculus 9-12 30323140-10 2018 The PI3K/Akt signaling pathway inhibitor LY294002 (10 mM) inhibited Akt phosphorylation, as well as Nrf2 and HO-1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 thymoma viral proto-oncogene 1 Mus musculus 68-71 30479372-7 2018 The PI3K/AKT inhibitor LY294002 inhibited KLF8-induced VEGFA expression, whereas PI3K/AKT signaling pathway proteins, such as P-PDK1(Ser241) and P-AKT(Thr308), were decreased significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 thymoma viral proto-oncogene 1 Mus musculus 9-12 29932247-7 2018 Moreover, expression of Nrf2 HupA-mediated was significant attenuated by AKT inhibitor (LY294002), p38 MAPK inhibitor (SB202190) and ERK inhibitor (PD98059). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 88-96 thymoma viral proto-oncogene 1 Mus musculus 73-76 29663377-13 2018 Besides, the neuroprotective effect of UBIAD1 was correlated with the PI3K/AKT pathway, which was demonstrated using the PI3K inhibitor LY294002 and perifosion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 136-144 thymoma viral proto-oncogene 1 Mus musculus 75-78 30201908-7 2018 Furthermore, TSG activated the phosphoinosmde-3-kinase/protein kinase B (also known as PI3K/Akt) pathway, and blocking this pathway by the inhibitor LY-294002 could impair TSG"s functions in relation to the MC3T3-E1 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 149-158 thymoma viral proto-oncogene 1 Mus musculus 92-95 30032334-8 2018 Furthermore, the process of TM4 cells promoting the proliferation of ADSCs was significantly inhibited by the administration of the PI3K/AKT inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-159 thymoma viral proto-oncogene 1 Mus musculus 137-140 30140630-0 2018 Inhibition of LY294002 in retinal neovascularization via down-regulation the PI3K/AKT-VEGF pathway in vivo and in vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 14-22 thymoma viral proto-oncogene 1 Mus musculus 82-85 30140630-5 2018 HUVECs treating with LY294002 were exposed to hypoxia; the expression of PI3K, AKT and VEGF were examined by Western blot and RT-PCR analyses. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 21-29 thymoma viral proto-oncogene 1 Mus musculus 79-82 30140630-8 2018 Intravitreal injection of LY294002 (in the LY294002 treatment group) markedly decreased PI3K/AKT-VEGF expression compared with the OIR-control group by immunohistochemistry, Western blotting and RT-PCR (all P<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26-34 thymoma viral proto-oncogene 1 Mus musculus 93-96 30140630-8 2018 Intravitreal injection of LY294002 (in the LY294002 treatment group) markedly decreased PI3K/AKT-VEGF expression compared with the OIR-control group by immunohistochemistry, Western blotting and RT-PCR (all P<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 thymoma viral proto-oncogene 1 Mus musculus 93-96 30140630-9 2018 In HUVECs treated with hypoxia, expression of PI3K, AKT and VEGF were downregulated in the hypoxia-LY294002 group (all P<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99-107 thymoma viral proto-oncogene 1 Mus musculus 52-55 30140630-10 2018 CONCLUSION: The PI3K inhibitor LY294002 can inhibit RNV by downregulating PI3K, AKT, and VEGF expression in vivo and in vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31-39 thymoma viral proto-oncogene 1 Mus musculus 80-83 30127597-5 2018 LY294002 (LY) (a commonly used PI3K/Akt pathway inhibitor) was injected into the left ventricle at 30 minutes before TBI. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 36-39 29738849-8 2018 LY341495 increased the phosphorylation of Akt in the mPFC, which was blocked by both intra-mPFC injection of WAY100635 and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-131 thymoma viral proto-oncogene 1 Mus musculus 42-45 29323710-4 2018 We revealed a significant increase in PI3K/AKT signaling activation which was associated with aberrant bone formation in tibial subchondral bone following destabilizing the medial meniscus (DMM), which was effectively prevented by treatment with PI3K/AKT signaling inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 275-283 thymoma viral proto-oncogene 1 Mus musculus 43-46 29323710-4 2018 We revealed a significant increase in PI3K/AKT signaling activation which was associated with aberrant bone formation in tibial subchondral bone following destabilizing the medial meniscus (DMM), which was effectively prevented by treatment with PI3K/AKT signaling inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 275-283 thymoma viral proto-oncogene 1 Mus musculus 251-254 29660433-8 2018 This effect was abrogated by LY294002, a PI3K/Akt pathway inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 thymoma viral proto-oncogene 1 Mus musculus 46-49 29678744-11 2018 When PI3K/Akt pathway was blocked by LY294002, the inhibitor of PI3K, the effect of lncARSR on SREBP-2 and HMGCR disappeared. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 thymoma viral proto-oncogene 1 Mus musculus 10-13 29805476-8 2018 Sal suppressed inflammatory reactions in serum and liver tissues, and activated the PI3K/Akt signaling pathway to inhibit apoptosis and autophagy in vivo and in vitro, which could be reversed by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 195-203 thymoma viral proto-oncogene 1 Mus musculus 89-92 29790749-6 2018 The anti-inflammatory activity of 8-OHD was attenuated by the HO-1 inhibitor zinc protoporphyrin (Znpp) but augmented by the PI3K/Akt inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 thymoma viral proto-oncogene 1 Mus musculus 130-133 29447944-8 2018 Furthermore, both LY294002, an inhibitor for phosphoinositide-3-kinase (PI3K), and short hairpin RNAs for LXRbeta knockdown, abrogated GW3965-induced Akt phosphorylation, and therefore abolished GW3965-mediated proliferation-promoting of NPCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 18-26 thymoma viral proto-oncogene 1 Mus musculus 150-153 29673487-6 2018 All of the SC79-induced hepatoprotective and DISC-interruptive effects were confirmed to have been reversed by the Akt inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 129-137 thymoma viral proto-oncogene 1 Mus musculus 115-118 29450644-0 2018 PI3K/Akt inhibitor LY294002 potentiates homoharringtonine antimyeloma activity in myeloma cells adhered to stromal cells and in SCID mouse xenograft. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 5-8 29450644-3 2018 This study aimed to investigate whether PI3K/Akt inhibitor LY294002 could potentiate the antimyeloma activity of HHT against MM cells adhered to BM stromal cells and in vivo xenograft models. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-67 thymoma viral proto-oncogene 1 Mus musculus 45-48 29450644-9 2018 LY294002 induced apoptosis in MM cells and potentiated the antimyeloma effects of HHT by inhibiting the PI3K/Akt signal pathway which was abnormally activated during adhesion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 109-112 29169284-5 2018 VEGFC stimulated the proliferation and DNA synthesis of GC-1 cells and enhanced the phosphorylation of PI3K-AKT and MAPK, whereas LY294002 (an inhibitor for AKT) and CI-1040 (an inhibitor for MAPK) blocked the effect of VEGFC on GC-1 cell proliferation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 130-138 thymoma viral proto-oncogene 1 Mus musculus 157-160 29472543-8 2018 PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 thymoma viral proto-oncogene 1 Mus musculus 5-8 29472543-8 2018 PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 thymoma viral proto-oncogene 1 Mus musculus 225-228 29467020-9 2018 The activities of the phosphoinositol 3-kinase (PI3K)/AKT signaling pathway and DNA methyltransferases (DNMTs) were enhanced, and their respective inhibitors LY294002 and 5-azacytidine (5-AZA) blunted c-kit expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 54-57 28940008-5 2018 Moreover, LY294002, an inhibitor of the PI3K/Akt pathway enhanced the Dex-induced apoptosis of osteoblasts. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10-18 thymoma viral proto-oncogene 1 Mus musculus 45-48 29789792-9 2018 LY294002 significantly attenuated RIPostC-increased levels of Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 62-65 29605032-11 2018 At the cellular level, PHLPP-1 siRNA attenuated cellular injury, and this was associated with increased p-Akt and nuclear Nrf2 protein, whereas the decrement of Akt phosphorylation induced by LY294002 augmented cellular injury and decreased nuclear Nrf2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 192-200 thymoma viral proto-oncogene 1 Mus musculus 161-164 29467759-6 2018 However, MG suspended the activation of PPARalpha expression and was thus blocked by pretreatment with LY294002 and compound c (specific inhibitors of AKT and AMPK). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 thymoma viral proto-oncogene 1 Mus musculus 151-154 27844286-13 2017 Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, inhibited M1 marker expression; moreover, LY294002, an Akt inhibitor, enhanced M1 marker expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 94-102 thymoma viral proto-oncogene 1 Mus musculus 107-110 28780388-10 2018 p-AKT and p-S6 activation by Mn is almost completely blocked upon addition of NU7441(5muM) or LY294002(7muM), supporting PI3K"s upstream role in the AKT/mTOR pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 94-102 thymoma viral proto-oncogene 1 Mus musculus 2-5 28780388-10 2018 p-AKT and p-S6 activation by Mn is almost completely blocked upon addition of NU7441(5muM) or LY294002(7muM), supporting PI3K"s upstream role in the AKT/mTOR pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 94-102 thymoma viral proto-oncogene 1 Mus musculus 149-152 29075038-4 2017 PPD activated both PI3K/Akt/mTOR and Raf/MEK/ERK signaling pathways in HUVECs, which were abrogated by LY294002 and PD98059. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 thymoma viral proto-oncogene 1 Mus musculus 24-27 28798142-9 2017 Using LY294002, a PI3K/Akt inhibitor, we found that PI3K/Akt-mediated Mdm2 phosphorylation and activation was inhibited in senescent or SM22alpha-overexpressed VSMCs, in parallel with decreased p53 ubiquitination. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6-14 thymoma viral proto-oncogene 1 Mus musculus 23-26 28798142-9 2017 Using LY294002, a PI3K/Akt inhibitor, we found that PI3K/Akt-mediated Mdm2 phosphorylation and activation was inhibited in senescent or SM22alpha-overexpressed VSMCs, in parallel with decreased p53 ubiquitination. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6-14 thymoma viral proto-oncogene 1 Mus musculus 57-60 29163781-6 2017 SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 118-126 thymoma viral proto-oncogene 1 Mus musculus 52-55 28256185-8 2017 These effects were inversed after pretreatment of the PI3K/Akt inhibitor LY294002 or overexpression of constitutively active Akt1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 73-81 thymoma viral proto-oncogene 1 Mus musculus 59-62 28408345-8 2017 Interestingly, DKK1, an inhibitor of Wnt/beta-catenin signaling inhibitor, and LY294002, an inhibitor of PI3K/Akt signaling, abolished the induction of DEC1 by icariin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 79-87 thymoma viral proto-oncogene 1 Mus musculus 110-113 28075049-7 2017 Again, either the M90-SHIP plasmid or the PI3K/Akt pathway inhibitor LY294002 could significantly prevent the high glucose-induced increase in TGF-beta1, alpha-SMA, and secreted Col 3 and decreased E-cadherin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-77 thymoma viral proto-oncogene 1 Mus musculus 47-50 28627590-7 2017 Furthermore, the blockade of the PI3K/Akt signaling pathway by intranasal administration of LY294002, significantly reduced the SHH-associated neuroprotective effects on dopaminergic neurons, improved motor functions, and increased the microglial activation and inflammatory response in a mouse model of PD induced using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 92-100 thymoma viral proto-oncogene 1 Mus musculus 38-41 28734031-12 2017 Interestingly, LY294002, an inhibitor of PI3K/Akt signaling, aggravated, whereas LiCl, an activator of Wnt/beta-catenin signaling, abolished the reduction in DEC1 by MPP+ . 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 thymoma viral proto-oncogene 1 Mus musculus 46-49 28292218-8 2017 What"s more, Akt was phosphorylated at the eighth hour stimulated by high glucose medium, and LY294002 inhibited the expression of Arg-1 and CD206 by blocking the phosphorylation of Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 94-102 thymoma viral proto-oncogene 1 Mus musculus 182-185 28528862-13 2017 Importantly, preconditioning with antagonist of LY294002 (for PI3K/AKT) or NG-monomethyl-l-arginine (for eNOS) antagonized the beneficial effect of crocetin on diabetic EPC dysfunction. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 thymoma viral proto-oncogene 1 Mus musculus 67-70 28273403-9 2017 Meanwhile we treated BMDMs from emphysematous mice and CSE-treated RAW264.7 cells with the phosphoinositide 3-kinase (PI3K)/Akt inhibitor (LY294002), we observed a reduction in RNA levels of M2 macrophage-related markers and cytokines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 139-147 thymoma viral proto-oncogene 1 Mus musculus 124-127 28365917-12 2017 HBSP activated the PI3K/Akt/mTORC1 pathway, which was confirmed by the PI3K inhibitor LY294002 both in vivo and in vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 thymoma viral proto-oncogene 1 Mus musculus 24-27 27808000-10 2017 The effects were abolished by using pharmacological inhibition of PI3K/Akt with LY294002 and paralleled by transfecting DCs with klotho siRNA. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 80-88 thymoma viral proto-oncogene 1 Mus musculus 71-74 29029396-9 2017 Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 thymoma viral proto-oncogene 1 Mus musculus 86-89 28343995-8 2017 The protection of UA was abolished by LY294002, a PI3K/Akt-inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 38-46 thymoma viral proto-oncogene 1 Mus musculus 55-58 28302560-8 2017 Furthermore, LY294002, an Akt inhibitor, significantly attenuated TCDD-triggered HSC activation through blocking Akt phosphorylation and NF-kappaB activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 thymoma viral proto-oncogene 1 Mus musculus 26-29 28302560-8 2017 Furthermore, LY294002, an Akt inhibitor, significantly attenuated TCDD-triggered HSC activation through blocking Akt phosphorylation and NF-kappaB activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 thymoma viral proto-oncogene 1 Mus musculus 113-116 27943011-8 2017 In contrast, the phosphorylated Akt concentration in macrophages treated with endotoxin plus vasopressin was significantly higher than that in macrophages treated with endotoxin or in macrophages treated with endotoxin plus vasopressin plus LY294002, TGX-221, IC-87114, or AS-252424, but not PIK-75. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 241-249 thymoma viral proto-oncogene 1 Mus musculus 32-35 28238066-10 2017 Moreover, using the PI3K/Akt inhibitor LY294002, we revealed that PI3K/Akt signaling plays a significant role in blocking oxidative stress, suppressing the pro-inflammatory response, and maintaining the neuroprotective effects of crocin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 thymoma viral proto-oncogene 1 Mus musculus 25-28 28238066-10 2017 Moreover, using the PI3K/Akt inhibitor LY294002, we revealed that PI3K/Akt signaling plays a significant role in blocking oxidative stress, suppressing the pro-inflammatory response, and maintaining the neuroprotective effects of crocin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 thymoma viral proto-oncogene 1 Mus musculus 71-74 28303030-8 2017 Moreover, it was found that the activation of FPRs increased the generation of reactive oxygen species (ROS) and phosphorylation of AKT in the NSCs, while N-acetylcysteine and LY294002 inhibited the FPRs-stimulated increase in ROS generation and AKT phosphorylation, and blocked the FPRs-stimulated neural differentiation into neurons. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 176-184 thymoma viral proto-oncogene 1 Mus musculus 246-249 27779177-4 2016 In addition, mouse neuroblastoma NG108-15 cells were treated ethanol for 3 days and subsequently treated with AKT inhibitor LY294002 for 2-12 h. The in vitro kinase assay was performed for determining mTOR activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 124-132 thymoma viral proto-oncogene 1 Mus musculus 110-113 27991908-8 2017 Treatment with HSC-CM promoted AHPCs proliferation and resulted in increased pAkt expression in vitro, and this effect was abolished by the PI3K/Akt inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 159-167 thymoma viral proto-oncogene 1 Mus musculus 78-81 28122344-10 2017 LY294002, a PI3K/Akt inhibitor, significantly suppressed the CGA-induced Nrf2 nuclear translocation and HO-1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 17-20 28078613-7 2017 Those effects were blocked by the specific PI3K inhibitor, LY294002, indicating the involvement of Akt/GSK-3beta pathway in the neuroprotective effect of L-F001. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-67 thymoma viral proto-oncogene 1 Mus musculus 99-102 27940357-10 2017 Moreover, the Akt inhibitor LY294002 reversed the anti-apoptotic effects of high insulin in the ovary tissues in early pregnancy mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 thymoma viral proto-oncogene 1 Mus musculus 14-17 27911877-4 2017 Akt inhibitors (LY294002, perifosine and MK-2206) almost abolished icariside II-induced osteoblast cytoprotection against dexamethasone. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 thymoma viral proto-oncogene 1 Mus musculus 0-3 27639645-6 2016 Moreover, Western blot analysis showed that the decreased PI3K and AKT phosphorylation, increased the epithelial maker E-cadherin, and upregulation level of RARbeta while decreased the mesenchymal markers N-cadherin and downregulation level of RARalpha by incubation with LY294002 in mouse melanoma B16 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 272-280 thymoma viral proto-oncogene 1 Mus musculus 67-70 27784964-8 2016 The expression of glucose glycolysis-related proteins and ECM components decreased remarkably when the PI3K/Akt signaling was blocked by Ly294002 in the activated HSCs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 137-145 thymoma viral proto-oncogene 1 Mus musculus 108-111 28190476-11 2017 Blockade of PI3K/Akt or MEK/ERK signaling pathway by LY294002 or PD98059 could attenuate the increase of DA content in the striatum and TH-IR in the SNpc induced by icariin in PD mice model. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 53-61 thymoma viral proto-oncogene 1 Mus musculus 17-20 28095306-7 2017 Additionally, Ly294002, a chemical inhibitor of PI3K/Akt, could dramatically down-regulate the hallmarks of M2 macrophages. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 14-22 thymoma viral proto-oncogene 1 Mus musculus 53-56 28034780-4 2017 The inhibitory effects of Form were associated with PI3K/Akt signaling pathway as PI3K inhibitor (LY294002) or ERalpha specific inhibitor (MPP) blocked the effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 98-106 thymoma viral proto-oncogene 1 Mus musculus 57-60 27982695-12 2017 However, the Akt inhibitor, LY294002, partially hampered the effects of 17-DMAG on the expression of p-Akt, nuclear Nrf2, and HO-1 and cell viability, as well as cell apoptosis induced by H/R in HT22 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 thymoma viral proto-oncogene 1 Mus musculus 13-16 27982695-12 2017 However, the Akt inhibitor, LY294002, partially hampered the effects of 17-DMAG on the expression of p-Akt, nuclear Nrf2, and HO-1 and cell viability, as well as cell apoptosis induced by H/R in HT22 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 thymoma viral proto-oncogene 1 Mus musculus 103-106 27614310-6 2016 Akt inhibitors (LY294002, perifosine and MK-2206) blocked SC79-induced Akt activation and abolished its anti-Dex actions in osteoblasts. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 thymoma viral proto-oncogene 1 Mus musculus 0-3 27614310-6 2016 Akt inhibitors (LY294002, perifosine and MK-2206) blocked SC79-induced Akt activation and abolished its anti-Dex actions in osteoblasts. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 thymoma viral proto-oncogene 1 Mus musculus 71-74 26956696-8 2016 In co-treatment Zn with PI3K/Akt/GSK-3beta signaling pathway, inhibitor LY294002 prevented HG/hypoxic-induced HIF-1alpha increase and EMT changes, suggesting that Zn may mediate HG/hypoxic-induced EMT through PI3K/Akt/GSK-3beta pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 72-80 thymoma viral proto-oncogene 1 Mus musculus 214-217 27779177-10 2016 Compared with NG108-15 cells treated without both ethanol and LY294002, ethanol increased the expression level of P-AKT, P-S6K, and P-S6, whereas LY294002 had opposite effects on expression levels of these proteins. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 62-70 thymoma viral proto-oncogene 1 Mus musculus 116-119 27497988-9 2016 Importantly, blockade of Akt/mTOR signaling pathway with LY294002, a specific PI3K inhibitor, replicated these effects of thioredoxin-interacting protein silencing. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 57-65 thymoma viral proto-oncogene 1 Mus musculus 25-28 27599586-9 2016 The phosphoinositide 3-kinase (PI3K)/AKT pathway inhibitor LY294002 significantly suppressed IL-21-induced osteoclastogenesis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-67 thymoma viral proto-oncogene 1 Mus musculus 37-40 27450812-11 2016 Conversely, treatment with LY294002 (a selective inhibitor of Akt1) reversed the effects of quercetin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 27-35 thymoma viral proto-oncogene 1 Mus musculus 62-66 27685463-8 2016 LY294002, a specific PI3K/Akt inhibitor, abolished agmatine-induced HO-1 up-regulation and ROS suppression significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 26-29 26374551-5 2016 A PI3K inhibitor LY294002 significantly decreased the levels of phospho-Akt, phospho-mTOR, phospho-p70S6K, and AChE protein expression in HG-cultured HT-22 cells, and an mTOR inhibitor rapamycin markedly reduced the levels of phospho-mTOR, phospho-p70S6K, and AChE expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 thymoma viral proto-oncogene 1 Mus musculus 72-75 27161366-5 2016 To further certain the effectiveness of Akt signaling to the final outcome of cerebral ischemia, the animals were treated with LY294002, an inhibitor of the Akt pathway, which aggravated the ischemic injury in db/+ mice but not in db/db mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 127-135 thymoma viral proto-oncogene 1 Mus musculus 40-43 27161366-5 2016 To further certain the effectiveness of Akt signaling to the final outcome of cerebral ischemia, the animals were treated with LY294002, an inhibitor of the Akt pathway, which aggravated the ischemic injury in db/+ mice but not in db/db mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 127-135 thymoma viral proto-oncogene 1 Mus musculus 157-160 27003241-10 2016 However, the synergistic effect was efficiently abolished by the phosphoinositide 3-kinase (PI3K)/AKT inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 thymoma viral proto-oncogene 1 Mus musculus 98-101 26440805-8 2016 Additionally, after treating with LY294002 or wortmannin [the selective inhibitors of phosphatidylinositol 3 kinase (PI3K)], HupA dramatically prevented the down-regulations of p-Akt, p-mTOR, and p-p70s6 kinase in HT22 cells under oxidative toxicity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 thymoma viral proto-oncogene 1 Mus musculus 179-182 27156691-9 2016 Moreover, blockade of PI3K/Akt activation by LY294002 significantly reduced inflammation response and NF-kappaB p65 nuclear translocation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 thymoma viral proto-oncogene 1 Mus musculus 27-30 27323812-8 2016 The proliferation, cellular growth and glucose consumption of ARID1A-deficient GC cells were efficiently prohibited by allosteric inhibitors mk2206 and LY294002, which targeting AKT and PI3K, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 152-160 thymoma viral proto-oncogene 1 Mus musculus 178-181 27177125-5 2016 The cells in the Akt pathway blockage group were treated with 25 microM LY294002 for 1 h, followed by ginsenoside Rg1 + H2O2 treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 72-80 thymoma viral proto-oncogene 1 Mus musculus 17-20 26447680-10 2016 The treatment of LY294002 inhibited phospho-Akt (Ser 473) and phospho-Akt (Thr 308) expression followed by decreased CTGF, secretory fibronectin and secretory Col 3 in high glucose-treated HKC cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 thymoma viral proto-oncogene 1 Mus musculus 44-47 26787540-4 2016 The effects of B7-H3 on activation of the PI3K/Akt pathway and elevation of TS expression could be blocked by LY294002, a specific inhibitor of the PI3K signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 110-118 thymoma viral proto-oncogene 1 Mus musculus 47-50 26884348-9 2016 Additionally, inactivation of Akt by LY294002 offset the exacerbated hypertrophic response induced by AB in TRIM32-deficient mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 thymoma viral proto-oncogene 1 Mus musculus 30-33 27060196-7 2016 The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 78-86 thymoma viral proto-oncogene 1 Mus musculus 18-21 27060196-7 2016 The inhibition of AKT-FoxO3a signalings by a PI3K (PI3-kinase)/AKT inhibitor (LY294002) or the transfection of ERK5-siRNA led to the nuclear translocation of non-phosphorylated FoxO3a, and increased the protein expression of FasL and Bim. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 78-86 thymoma viral proto-oncogene 1 Mus musculus 63-66 27194135-15 2016 Preincubation with beta2AR inhibitor (ICI118,551), Akt inhibitor (ly294002), or eNOS inhibitor (L-NAME) significantly attenuated the enhanced in vitro function and in vivo re-endothelialization capacity of EPCs induced by beta2AR overexpression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 66-74 thymoma viral proto-oncogene 1 Mus musculus 51-54 27044523-9 2016 Blocking the PI3K-Akt pathway by LY294002 led to an enhancement of IL-12 production. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 thymoma viral proto-oncogene 1 Mus musculus 18-21 26447680-10 2016 The treatment of LY294002 inhibited phospho-Akt (Ser 473) and phospho-Akt (Thr 308) expression followed by decreased CTGF, secretory fibronectin and secretory Col 3 in high glucose-treated HKC cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 thymoma viral proto-oncogene 1 Mus musculus 70-73 26873077-10 2016 It markedly reduced the level of p-NF-kappaB, as also p-Akt, which was partly blocked by Ly294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 89-97 thymoma viral proto-oncogene 1 Mus musculus 56-59 26647806-11 2016 The PI3K inhibitor, LY294002, reversed the activation of the Akt/CDC2/survivin cascade in the Smad4-deficient cells, while it had little effect on cells with high Smad4 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 thymoma viral proto-oncogene 1 Mus musculus 61-64 26887589-10 2016 To determine whether the conditioned rewarding effects of phentermine were mediated through the PI3K/Akt pathway, we assessed the effects of the Akt inhibitor LY294002 on phentermine-induced place preference and climbing behavior. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 159-167 thymoma viral proto-oncogene 1 Mus musculus 145-148 26887589-14 2016 Further, LY294002 decreased the phentermine-increased levels of DAT protein and phosphorylation of Akt in the NAc of CPP mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 thymoma viral proto-oncogene 1 Mus musculus 99-102 26822343-6 2016 The TLR2 neutralization antibody and LY294002 both reduced the MMC proliferation levels induced by HMGB1 and also blocked the HMGB1-dependent phosphorylation of the Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 thymoma viral proto-oncogene 1 Mus musculus 165-168 26719016-8 2016 LY294002 was used to specifically block the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homologue (PI3K/Akt) pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 126-129 26930476-7 2016 These losartan-mediated protective effects were inhibited by the phosphatidyl-inositol-3-kinase (PI3K) inhibitor LY294002, indicating that losartan provides significant protection from cocaine-induced renal toxicity through PI3K/Akt signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 113-121 thymoma viral proto-oncogene 1 Mus musculus 229-232 27143997-8 2016 The interaction between Shh and PI3K/Akt pathways was clarified by specific PI3K inhibitor LY294002 or Shh inhibitor GDC-0449. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 91-99 thymoma viral proto-oncogene 1 Mus musculus 37-40 26492242-10 2015 Pretreatment with PI3K/AKT inhibitor LY294002 strikingly ameliorated the inhibitory effects of miR-223 on the activation of TLR4 and p65, concomitant with the increase in lipid deposition and inflammatory cytokine production. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 thymoma viral proto-oncogene 1 Mus musculus 23-26 26459773-5 2015 The cells exposed to hypoxia were also treated with the PI3K/AKT inhibitor, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 61-64 26441085-6 2015 Additionally, Reelin treatment led to increased phosphorylation of AKT, GSK3beta, and JNK, which were all effectively blocked by the PI3K inhibitor, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 149-157 thymoma viral proto-oncogene 1 Mus musculus 67-70 26226221-11 2015 However, KLF14"s ability to increase glucose uptake and Akt activation was significantly attenuated by LY294002, a PI3-kinase inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 thymoma viral proto-oncogene 1 Mus musculus 56-59 26187353-11 2015 In contrast, LY294002, the PI3k/Akt pathway inhibitor, abolished SAL-induced phosphorylation and expression of eNOS. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 thymoma viral proto-oncogene 1 Mus musculus 32-35 26279331-8 2015 Consistent with these results, nicorandil-mediated neuroprotection was reduced in the Akt1+/- mutant mice and inhibited by LY294002, a PI3K inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-131 thymoma viral proto-oncogene 1 Mus musculus 86-90 26408613-7 2015 The effect of OST on p-Akt phosphorylation in HT22 cells was attenuated in the presence of PI3K specific inhibitor (LY294002). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 thymoma viral proto-oncogene 1 Mus musculus 23-26 26310574-9 2015 Folic acid also promoted the activation of the Akt pathway, and this effect was inhibited by treatment of the C2C12 cells with LY294002 (Akt inhibitor). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 127-135 thymoma viral proto-oncogene 1 Mus musculus 47-50 26310574-9 2015 Folic acid also promoted the activation of the Akt pathway, and this effect was inhibited by treatment of the C2C12 cells with LY294002 (Akt inhibitor). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 127-135 thymoma viral proto-oncogene 1 Mus musculus 137-140 26356837-7 2015 Inhibition of MEK1/2/ERK1/2 (1 muM U0126) and PI-3K/Akt (10 muM LY294002) signaling showed that the MEK1/2/ERK1/2 pathway via GSK-3beta exclusively was responsible for cardioprotection as an addition of U0126 prevented estrogen-induced GSK-3beta increased phosphorylation, resistance to mitochondrial Ca2+-overload, functional recovery and protection against infarction. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 64-72 thymoma viral proto-oncogene 1 Mus musculus 52-55 25487790-7 2015 Tumor migration and GDNF-RET-AKT activation was inhibited by the RET small-molecule inhibitor pyrazolopyrimidine-1 (PP1) and by the AKT inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 146-154 thymoma viral proto-oncogene 1 Mus musculus 29-32 25487790-7 2015 Tumor migration and GDNF-RET-AKT activation was inhibited by the RET small-molecule inhibitor pyrazolopyrimidine-1 (PP1) and by the AKT inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 146-154 thymoma viral proto-oncogene 1 Mus musculus 132-135 25934572-8 2015 Treatment with LY294002, a specific Akt inhibitor, restored baicalin-induced melanogenesis inhibition and abolished MITF and tyrosinase downregulation by baicalin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 thymoma viral proto-oncogene 1 Mus musculus 36-39 26146542-7 2015 In C2C12 myogenic cells, blocking the IGF1/PI3K/Akt pathway using LY294002 inhibitor reduced MSY3 phosphorylation levels resulting in its accumulation in the nuclei. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 66-74 thymoma viral proto-oncogene 1 Mus musculus 48-51 25604781-9 2015 The Akt was also activated by hyperbaric oxygen preconditioning but suppressed by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 82-90 thymoma viral proto-oncogene 1 Mus musculus 4-7 25951933-7 2015 LY294002 and U0126 inhibited activation of p-PI-3K/Akt and p-Erk expression by Western blot and attenuated the expression of inflammation factors in BV2 cells by fluorescence staining. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 51-54 26020972-4 2015 AICAR increased phosphorylation of Akt, but the inhibition of PI3K/Akt activity using LY294002 did not affect the AICAR-induced changes in efferocytosis in macrophages. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 thymoma viral proto-oncogene 1 Mus musculus 67-70 25968579-7 2015 Incubation with parthenolide abolished LIF-induced glucose uptake and STAT3 Tyr(705) P, whereas incubation with LY-294002 and wortmannin suppressed both basal and LIF-induced glucose uptake and Akt Ser(473) P, indicating that JAK and PI 3-kinase signaling is required for LIF-stimulated glucose uptake. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-121 thymoma viral proto-oncogene 1 Mus musculus 194-197 25547390-8 2015 Blocking Akt activation using the selective inhibitor LY294002 partially reversed the CDPPB-induced protection against SO2-induced neurotoxicity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 54-62 thymoma viral proto-oncogene 1 Mus musculus 9-12 24777577-5 2015 By contrast, The PI3K/Akt inhibitor LY294002 inhibited phosphorylation of Akt and differentiation of NSCs in the SGZ and SVZ, resulting in no change in the proliferation of NSCs and ERK1/2 phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-44 thymoma viral proto-oncogene 1 Mus musculus 22-25 25712622-5 2015 PI3K/AKT pathway was activated by MCD and triggered gene deregulation causing either activation or inhibition of all studied genes as demonstrated through cell incubation with the PI3K-inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 195-203 thymoma viral proto-oncogene 1 Mus musculus 5-8 24777577-5 2015 By contrast, The PI3K/Akt inhibitor LY294002 inhibited phosphorylation of Akt and differentiation of NSCs in the SGZ and SVZ, resulting in no change in the proliferation of NSCs and ERK1/2 phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-44 thymoma viral proto-oncogene 1 Mus musculus 74-77 25621554-6 2015 Furthermore, these effects were significantly inhibited by PI3K/Akt inhibitor LY294002 at a glucose concentration of 15.5 mM, which was the optimum. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 78-86 thymoma viral proto-oncogene 1 Mus musculus 64-67 25680461-9 2015 LY294002 and MK-2206, two established Akt inhibitors, alleviated K6PC-5- or S1P-mediated osteoblast protection against Dex. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 38-41 25394413-8 2015 Additionally, treatment with LY294002 (10 microM), a specific inhibitor of phosphatidylinositol 3-kinase/Akt signaling, eliminated the omentin-induced increase in neurosphere size and cell viability. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 thymoma viral proto-oncogene 1 Mus musculus 105-108 25885904-6 2015 These changes were reversed with the treatment of a PI3K/Akt inhibitor LY294002 in vivo or in cells transfected with Akt dominant-negative (Akt-DN) plasmids in vitro. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 71-79 thymoma viral proto-oncogene 1 Mus musculus 57-60 26045735-7 2015 Phosphorylation of Akt, PI3K, and endothelial nitricoxide synthase (eNOS) were up-regulated by Ad-SIRT1, which was attenuated by LY294002, sc-221226, and L-NAME. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 129-137 thymoma viral proto-oncogene 1 Mus musculus 19-22 25048007-4 2015 LY294002, the PI3K inhibitor, blocked the protection as well as the up-regulation of Akt phosphorylation of BBR. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 85-88 24975165-7 2015 LY294002 and IC87114 prevented Akt phosphorylation as expected and down-regulated the expression of inflammatory factors IL-6, MCP-1,TNFalpha and iNOS. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 31-34 25591759-7 2015 TSLP increased Akt phosphorylation, an effect that was abrogated by the PI3K inhibitors wortmannin and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 thymoma viral proto-oncogene 1 Mus musculus 15-18 25802931-6 2015 Blocking PI3K/Akt signaling with LY-294002 enhanced DLK kinase activity dramatically. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-42 thymoma viral proto-oncogene 1 Mus musculus 14-17 25542689-12 2014 Moreover, intra-hippocampus infusion of LY294002 significantly abolished the antidepressant-like effects and upregulation on phosphatidylinositol 3-kinase/AKT/mTOR/VGF signaling of GLYX-13. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 40-48 thymoma viral proto-oncogene 1 Mus musculus 155-158 25352364-5 2015 The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 222-230 thymoma viral proto-oncogene 1 Mus musculus 261-264 25352364-7 2015 In the measurement of histone acetylation levels, the LPS-stimulated acetylation of histone H4 was significantly attenuated by veratric acid, and was also reduced following the inhibition of PI3K/Akt with LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 205-213 thymoma viral proto-oncogene 1 Mus musculus 196-199 23147834-5 2014 We demonstrate that pharmacological inhibition via LY294002 results in abrogation of CNTF-mediated viability, suggesting that the CNTF-mediated MPC viability benefit occurs via the PI3-Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 51-59 thymoma viral proto-oncogene 1 Mus musculus 185-188 25450677-6 2014 The enhanced myoblast differentiation by THP treatment can be blocked by inhibition of p38MAPK or Akt by SB203580 or LY294002, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 117-125 thymoma viral proto-oncogene 1 Mus musculus 98-101 25425962-5 2014 RESULTS: Our results demonstrate that treatment of LacZ+, GFAP + and PCNA + (12) V-Ras Tg transformed astrocytes with SF1126 and LY294002 blocked the activation of AKT as well as EGF-induced phospho-ERK. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 129-137 thymoma viral proto-oncogene 1 Mus musculus 164-167 25454762-9 2014 The functional aspects of the PI3K/Akt signaling pathway were analyzed with LY294002, which is a specific PI3K/Akt inhibitor that attenuated LPS-induced iNOS and COX-2 expression by suppressing NF-kappaB activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 35-38 25454762-9 2014 The functional aspects of the PI3K/Akt signaling pathway were analyzed with LY294002, which is a specific PI3K/Akt inhibitor that attenuated LPS-induced iNOS and COX-2 expression by suppressing NF-kappaB activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 111-114 25228694-11 2014 More importantly, the palmitic acid-stimulated proliferation was further enhanced in the Akt-overexpressed melanoma cells and was reduced by LY294002 or knockdown of endogenous Akt or overexpression of Akt mutants. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 141-149 thymoma viral proto-oncogene 1 Mus musculus 89-92 25179784-7 2014 The elevated Akt/mTOR signaling was likely responsible for increased production of TNF-alpha protein at the translational level, as suppression of this pathway by LY294002, an inhibitor of the upstream phosphatidylinositol 3-kinase (PI3K), abrogated such an enhancement of TNF-alpha protein expression even though its mRNA levels were conversely increased. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 163-171 thymoma viral proto-oncogene 1 Mus musculus 13-16 25374071-6 2014 Western blotting demonstrated that after the PI3K/AKT signal pathway was inhibited by LY294002 for 24 hours, the levels of B7-H4 in cell membrane and cytoplasm decreased significantly (P<0.05), while the expression in nuclear increased significantly (P<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 thymoma viral proto-oncogene 1 Mus musculus 50-53 25142024-14 2014 LY294002, an Akt activation inhibitor, attenuated the isoflurane effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 13-16 25181477-4 2014 Interestingly, the CCC treatment of the 3T3-L1 adipocytes suppressed the insulin-stimulated Akt and GSK3beta phosphorylation, and these effects were stronger in the presence of an inhibitor of Akt phosphorylation, LY294002, suggesting that CCC inhibited adipocyte differentiation through the down-regulation of Akt signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 214-222 thymoma viral proto-oncogene 1 Mus musculus 193-196 25181477-4 2014 Interestingly, the CCC treatment of the 3T3-L1 adipocytes suppressed the insulin-stimulated Akt and GSK3beta phosphorylation, and these effects were stronger in the presence of an inhibitor of Akt phosphorylation, LY294002, suggesting that CCC inhibited adipocyte differentiation through the down-regulation of Akt signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 214-222 thymoma viral proto-oncogene 1 Mus musculus 193-196 24748323-7 2014 The observed promoting effect was significantly inhibited by the administration of the PI3K/AKT inhibitor, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 107-115 thymoma viral proto-oncogene 1 Mus musculus 92-95 25212816-7 2014 When LY294002 was applied along with RA, collinear expression induced by RA was delayed, suggesting that the PI3K/Akt signaling pathway somehow regulates RA-induced collinear expression of Hox genes in F9 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 5-13 thymoma viral proto-oncogene 1 Mus musculus 114-117 24953974-4 2014 Pharmacological inhibition of AMPK by Compound C suppressed the glabridin-induced glucose uptake, whereas phosphoinositide 3-kinase and Akt inhibition by LY294002 and Akt1/2 inhibitor, respectively, did not. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 154-162 thymoma viral proto-oncogene 1 Mus musculus 136-139 24946212-6 2014 TGF-beta induced AKT activation in mouse PSCs, while the PI3K/AKT inhibitor (LY294002) and the AKT specific inhibitors (perifosine and MK-2206) largely suppressed TGF-beta-induced collagen II, Sox 9, and aggrecan mRNA expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 77-85 thymoma viral proto-oncogene 1 Mus musculus 62-65 24946212-6 2014 TGF-beta induced AKT activation in mouse PSCs, while the PI3K/AKT inhibitor (LY294002) and the AKT specific inhibitors (perifosine and MK-2206) largely suppressed TGF-beta-induced collagen II, Sox 9, and aggrecan mRNA expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 77-85 thymoma viral proto-oncogene 1 Mus musculus 62-65 24667703-9 2014 The MSC-CM-mediated induction of beta cell proliferation was completely blocked by the PI3K/Akt inhibitor LY294002 but not by the MEK/Erk inhibitor PD98059. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 92-95 24632067-5 2014 Role of MEK/ERK and PI3K/Akt signaling pathway in the melanogenesis was confirmed by using specific inhibitors, PD98059 (for MEK/ERK) and LY294002 (for PI3K/Akt), respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 138-146 thymoma viral proto-oncogene 1 Mus musculus 25-28 24896346-6 2014 Administration of VEGF neutralizing antibody or PI3K/Akt pharmacological inhibitor LY294002 blocked the vasculogenesis in CREG over-expressing EB, while supplement of VEGF rescued vasculogenesis deficiency in CREG knocked down EB. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 thymoma viral proto-oncogene 1 Mus musculus 53-56 24375569-5 2014 Inhibition of PI3K/Akt with LY294002 or ERK1/2 with PD98059 significantly attenuated IL-6 upregulation, and IL-6 expression was abolished by inhibiting both pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 thymoma viral proto-oncogene 1 Mus musculus 19-22 24296130-5 2014 Phosphatidylinositol-3-kinase/Akt and MAPKs were also significantly activated by genipin, and Akt and MAPKs inhibitors (PD98059, SB20358, SP600125, and LY294002) inhibited genipin-induced COX-2 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 152-160 thymoma viral proto-oncogene 1 Mus musculus 30-33 24594219-6 2014 Pre-treatment with PI3K inhibitors, wortmannin or LY294002 prevented the activation of Akt brought on by plantar incision in a dose-dependent manner. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 50-58 thymoma viral proto-oncogene 1 Mus musculus 87-90 24580070-5 2014 PI3 inhibitors LY294002 and Wortmannin abolished the effect of IGF-1 on FoxO3a phosphorylation indicating that FoxO3a phosphorylation is mediated by PI3/Akt-1 pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 thymoma viral proto-oncogene 1 Mus musculus 153-158 24569077-6 2014 The phosphorylation of Akt induced by clusterin was blocked by pretreatment with gallein or LY294002 but not with U73122, indicating that Gbetagamma released from the PTX-sensitive Gi protein complex activated PLC and PI3K/Akt signaling pathways separately. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 92-100 thymoma viral proto-oncogene 1 Mus musculus 23-26 24361597-6 2014 TNF-alpha-stimulated Akt phosphorylation was inhibited by genistein, PP1, AG1296, LY294002, or SH5. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 82-90 thymoma viral proto-oncogene 1 Mus musculus 21-24 24638941-5 2014 The expression levels of the above genes in the pseudopregnant group and in the group injected with the PI3K/Akt inhibitor, LY294002, were markedly lower than those in the pregnant group. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 124-132 thymoma viral proto-oncogene 1 Mus musculus 109-112 24449419-4 2014 LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), blocked Cd2+-evoked Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 92-95 24296130-5 2014 Phosphatidylinositol-3-kinase/Akt and MAPKs were also significantly activated by genipin, and Akt and MAPKs inhibitors (PD98059, SB20358, SP600125, and LY294002) inhibited genipin-induced COX-2 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 152-160 thymoma viral proto-oncogene 1 Mus musculus 94-97 24486459-3 2014 Further, the PI3K/Akt inhibitor, LY294002 diminished the expression of LPS-stimulated iNOS and COX-2 genes by suppressing NF-kappaB activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 thymoma viral proto-oncogene 1 Mus musculus 18-21 24005670-6 2013 Of clinical significance, systemic administration of the AKT inhibitor LY294002 blocked the formation of tumor tissues in the bone marrow cavity and essentially abolished the MM-induced osteoclast formation and osteolysis in SCID mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 71-79 thymoma viral proto-oncogene 1 Mus musculus 57-60 24291391-5 2014 In addition, we demonstrated that a specific NF-kappaB inhibitor PDTC and a selective PI3K/Akt inhibitor, LY294002 effectively attenuated the expression of LPS-stimulated iNOS and COX-2 mRNA, while LY294002 suppressed LPS-induced NF-kappaB activity, suggesting that TIA attenuates the expression of these proinflammatory genes by suppressing PI3K/Akt-mediated NF-kappaB activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 91-94 24291391-5 2014 In addition, we demonstrated that a specific NF-kappaB inhibitor PDTC and a selective PI3K/Akt inhibitor, LY294002 effectively attenuated the expression of LPS-stimulated iNOS and COX-2 mRNA, while LY294002 suppressed LPS-induced NF-kappaB activity, suggesting that TIA attenuates the expression of these proinflammatory genes by suppressing PI3K/Akt-mediated NF-kappaB activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 347-350 24142192-8 2013 A further increase in LC3-II levels was observed in cells treated with both palmitate and 50 microM PI3K/Akt inhibitor LY294002 compared with cells treated with palmitate alone. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 119-127 thymoma viral proto-oncogene 1 Mus musculus 105-108 24129178-6 2013 Using inhibitors against PI3K/Akt (LY294002) or MEK/ERK-specific (PD98059), the hypopigmentation effect was suppressed, and the gallic acid-initiated activation of MEK/ERK and PI3K/Akt was also revoked. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 35-43 thymoma viral proto-oncogene 1 Mus musculus 30-33 24332015-3 2014 Elastase-treated Raw cells produced increased p308 and significant amounts of matrix metalloproteinase 9 (MMP-9), and these effects were suppressed by LY294002 treatment, a known AKT inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-159 thymoma viral proto-oncogene 1 Mus musculus 179-182 23735482-9 2013 Moreover, quercetin arrested Src, PI3K, PDK1 and Akt activation in a time- and dose-dependent manner, which was comparable to PP2 and LY294002 inhibition of Src, PI3K/Akt and iNOS expressions. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 134-142 thymoma viral proto-oncogene 1 Mus musculus 167-170 23867319-7 2013 Pretreatment of liver donors with PI3K inhibitor (LY294002) disrupted Akt/HIF-1A signaling and recreated hepatocellular damage in otherwise IR-resistant Keap1 HKO transplants. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 50-58 thymoma viral proto-oncogene 1 Mus musculus 70-73 23707761-9 2013 LY294002, an inhibitor of PI3K/Akt signaling, significantly decreased Akt phosphorylation in the hippocampus of DA/UA mice, which weakened UA actions. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 31-34 23859404-4 2013 LY294002 was seen to abolish phosphorylation of both ERK1/2 and Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 64-67 23686005-10 2013 LY294002, a specific Akt inhibitor, attenuated LPS-induced pro-inflammatory gene expression via suppression of NF-kappaB activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 21-24 24098402-7 2013 Furthermore, we confirmed that miR-21 plays a protective role in myocardial apoptosis through PTEN/Akt signaling pathway, which was abrogated by the PI3K inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 164-172 thymoma viral proto-oncogene 1 Mus musculus 99-102 23640537-6 2013 This effect was blocked by phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and Akt inhibitor triciribine, thus indicating the neuroprotective effects of MLB are most likely mediated by the PI3K/Akt/GSK-3beta pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 70-78 thymoma viral proto-oncogene 1 Mus musculus 198-201 23617625-9 2013 Following AKT2 knockdown and treatment with the PI3K/AKT pathway inhibitor LY294002, the expression of OCN in MC3T3-E1 cells was decreased (p<0.05), as was the calcification area (p<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 thymoma viral proto-oncogene 1 Mus musculus 10-13 23707761-9 2013 LY294002, an inhibitor of PI3K/Akt signaling, significantly decreased Akt phosphorylation in the hippocampus of DA/UA mice, which weakened UA actions. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 70-73 24187831-5 2013 The expression of ERK1/2 and NSE was detected when the ERK1/2 and PI3K/AKT/ mTOR signal pathway was blocked by PD98059 and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-131 thymoma viral proto-oncogene 1 Mus musculus 71-74 23246160-12 2013 Furthermore, a PI3-kinase inhibitor (LY294002) and a p38 MAPK inhibitor (SB203580) both significantly diminished PKC activation and p38 MAPK and Akt phosphorylation; in contrast, a PKC inhibitor (RO318220) did not diminish p38 MAPK or Akt phosphorylation stimulated by collagen. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 thymoma viral proto-oncogene 1 Mus musculus 145-148 23246160-12 2013 Furthermore, a PI3-kinase inhibitor (LY294002) and a p38 MAPK inhibitor (SB203580) both significantly diminished PKC activation and p38 MAPK and Akt phosphorylation; in contrast, a PKC inhibitor (RO318220) did not diminish p38 MAPK or Akt phosphorylation stimulated by collagen. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 thymoma viral proto-oncogene 1 Mus musculus 235-238 23099361-10 2013 Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 131-139 thymoma viral proto-oncogene 1 Mus musculus 220-223 23435959-5 2013 LY294002 (PI3-kinase inhibitor) and L-NAME (NOS inhibitor) significantly inhibited reverse D-4F mediated improvement of EPCs biological functions, and LY294002 significantly decreased reverse D-4F stimulated activation of phospho-AKT (473) and phospho-eNOS (1177). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 230-233 23435959-5 2013 LY294002 (PI3-kinase inhibitor) and L-NAME (NOS inhibitor) significantly inhibited reverse D-4F mediated improvement of EPCs biological functions, and LY294002 significantly decreased reverse D-4F stimulated activation of phospho-AKT (473) and phospho-eNOS (1177). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 151-159 thymoma viral proto-oncogene 1 Mus musculus 230-233 22941963-8 2013 Osteoblast proliferation, as well as the level of p-Akt, was significantly inhibited by LY294002 in all three Ti surfaces. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 88-96 thymoma viral proto-oncogene 1 Mus musculus 52-55 23099361-10 2013 Decreased FoxO3A in COPD cells was associated with increased phosphorylation of EGFR, Akt and FoxO3A and treatment with quercetin, LY294002 or erlotinib increased nuclear FoxO3A and decreased IL-8 and phosphorylation of Akt, EGFR and FoxO3A, Compared with control, elastase/LPS-exposed mice showed decreased nuclear FoxO3A, increased chemokines and phosphorylation of EGFR and Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 131-139 thymoma viral proto-oncogene 1 Mus musculus 220-223 24335166-12 2013 AZA"s effects were significantly reduced by Akt inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 58-66 thymoma viral proto-oncogene 1 Mus musculus 44-47 23472139-6 2013 The AGEs-stimulated Akt activation was blocked by a PI3-kinase inhibitor LY 294002, Src inhibitor PP2, an antioxidant NAC, superoxide scavenger Tiron, or nicotinamide adenine dinucleotide phosphate (NAD(P)H) oxidase inhibitor DPI, suggesting the involvement of Src and NAD(P)H oxidase in the activation of PI3-kinase-Akt pathway by AGEs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 73-82 thymoma viral proto-oncogene 1 Mus musculus 20-23 22694815-10 2012 LY294002 could abolish the AKT1 activation and attenuate the protective effect of H 2S on hepatocytes A/R and hepatic I/R injuries. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 27-31 23208416-8 2012 Inhibition of GIP expression by the PI3/AKT inhibitor, LY294002, was abrogated in STC-1 cells with reduced menin levels, whereas the MAPK inhibitor, UO126, inhibited the expression of GIP independent of menin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 thymoma viral proto-oncogene 1 Mus musculus 40-43 22819846-7 2012 Consistently, the HDGF-overexpressing NIH/3T3 transfectants exhibited significantly increased motility and elevated PI3K/Akt activities, which were repressed by LY294002 or adenovirus-mediated overexpression of endogenous PI3K antagonist, PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 161-169 thymoma viral proto-oncogene 1 Mus musculus 121-124 22469516-3 2012 BBR (0.1-10 nM) led to increasing insulin receptor expression, Akt phosphorylation and enhanced oxidant-sensitive Nrf2/HO-1 induction, which were blocked by a PI3K inhibitor, LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 175-183 thymoma viral proto-oncogene 1 Mus musculus 63-66 23129756-8 2012 The PI3K/AKT inhibitor Ly294002 inhibited S1P-directed migration by Th1 cells, whereas the ERK inhibitor U0126 inhibited Th2 cell S1P-directed migration. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 thymoma viral proto-oncogene 1 Mus musculus 9-12 22956516-8 2012 However, western blot analyses coupled with pretreatment of cells with the PI3K inhibitor LY294002 indicated that the synergistic effect of cAMP and IGF1 on transcript levels was due in part to cooperative increases in Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 thymoma viral proto-oncogene 1 Mus musculus 219-222 22249904-6 2012 The IGF-1-induced osteoblast proliferation was mediated via both MAPK and Akt pathways because the IGF-1-mediated cell proliferation was blocked by U0126, an MEK/MAPK inhibitor, or LY294002, a PI3-kinase inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 181-189 thymoma viral proto-oncogene 1 Mus musculus 74-77 22465692-9 2012 Changes in the Ca transient amplitude and tau were prevented by the PI3K inhibitors Wortmannin (100nmol/L) and LY294002 (10mumol/L) and the Akt inhibitor V (20mumol/L) indicating regulation through PI3K signal transduction and Akt activation which was confirmed by western blotting. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 111-119 thymoma viral proto-oncogene 1 Mus musculus 227-230 22145570-5 2012 Cocaine effects on morphology and ERK/Akt phosphorylation were inhibited by pre-incubation with the phosphatidylinositol 3-kinase inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 140-148 thymoma viral proto-oncogene 1 Mus musculus 38-41 22218715-8 2012 While the inactivation of Akt by LY294002 suppressed TLR2-mediated MCP-1 induction, the inactivation of GSK3beta by LiCl potentiated TLR2-mediated MCP-1 induction. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 thymoma viral proto-oncogene 1 Mus musculus 26-29 22159760-9 2012 LY294002, a PI3K-Akt inhibitor, blocked the CpG ODN effect of TRAIL expression and the sub-G1 population in serum starved cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 17-20 22405892-4 2012 Furthermore, we found that testosterone significantly increased the phosphorylation level of V-akt murine thymoma viral oncogene (Akt), a key effector of the phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway, while a specific PI3-K inhibitor LY294002 obviously prevented the activation of Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 248-256 thymoma viral proto-oncogene 1 Mus musculus 95-98 22405892-4 2012 Furthermore, we found that testosterone significantly increased the phosphorylation level of V-akt murine thymoma viral oncogene (Akt), a key effector of the phosphoinositide 3-kinase (PI3-K)/Akt signaling pathway, while a specific PI3-K inhibitor LY294002 obviously prevented the activation of Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 248-256 thymoma viral proto-oncogene 1 Mus musculus 130-133 21946431-6 2012 The effect of 8-OH-DPAT was accompanied by an increase in the active phosphorylation of Akt, and was blocked by LY294002, an inhibitor of phosphoinositide 3-kinases (PI3K). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 thymoma viral proto-oncogene 1 Mus musculus 88-91 21964322-7 2012 Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 101-109 thymoma viral proto-oncogene 1 Mus musculus 161-164 22138155-8 2012 Using LY294002 to block phosphoinositide 3-kinases (PI3K)/Akt signaling pathway prevented the phosphorylation of mTOR and attenuated the neuroprotection of FLZ in MN9D cells challenged by MPP(+). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6-14 thymoma viral proto-oncogene 1 Mus musculus 58-61 22081609-7 2012 Inhibition of Akt signaling by treatment with dominant-negative Akt or LY294002 blocked the stimulatory effects of omentin on differentiation and survival of HUVECs and reversed omentin-stimulated eNOS phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 71-79 thymoma viral proto-oncogene 1 Mus musculus 14-17 22508044-4 2012 Moreover, LY294002, an Akt phosphorylation inhibitor, was used to determine whether the suppression of metastatic behavior of colon carcinoma cells was mediated by Akt phosphorylation that was confirmed by EMSA. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 10-18 thymoma viral proto-oncogene 1 Mus musculus 23-26 22508044-8 2012 However, no additional changes were noted following inhibition of PI3K/Akt pathway by LY294002 in the PARG-shRNA cells; these cells displayed reduced number of liver metastases when characterized in the murine in vivo model. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 thymoma viral proto-oncogene 1 Mus musculus 71-74 21770712-5 2011 Furthermore, we demonstrated for the first time that the brain-specific blockade of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, by intranasal administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway, significantly blocked acupuncture-induced dopaminergic neuron protection and motor function improvement. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 176-184 thymoma viral proto-oncogene 1 Mus musculus 121-124 23049865-5 2012 Using LY294002 (a PI3K inhibitor) and Akt inhibitor IV, we showed that the regulation of enzyme activities and protein expressions of the RCs was dependent on PI3K/Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6-14 thymoma viral proto-oncogene 1 Mus musculus 164-167 22438954-9 2012 Finally, our data indicated that CAR treatment increased the level of phosphorylated Akt and the neuroprotection of CAR was reversed by a PI3K inhibitor LY-294002, demonstrating the involvement of the PI3K/Akt pathway in the anti-apoptotic mechanisms of CAR. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 153-162 thymoma viral proto-oncogene 1 Mus musculus 206-209 21803945-12 2011 Supplementation with the phosphoinositide 3-kinase/Akt inhibitor LY-294002 during the late stage of differentiation was found to partially restore myofibrillogenesis while suppressing the increase in size of individual mature cardiomyocytes derived from the SHP2-Q510E mutants. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 65-74 thymoma viral proto-oncogene 1 Mus musculus 51-54 22438954-9 2012 Finally, our data indicated that CAR treatment increased the level of phosphorylated Akt and the neuroprotection of CAR was reversed by a PI3K inhibitor LY-294002, demonstrating the involvement of the PI3K/Akt pathway in the anti-apoptotic mechanisms of CAR. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 153-162 thymoma viral proto-oncogene 1 Mus musculus 85-88 21782929-4 2011 Luteolin significantly increased the viability of MC3T3-E1 cells in the presence of AMA and the effect of luteolin in increasing cell viability was completely prevented by the presence of LY294002, Akt inhibitor, or auranofin, suggesting that the effect of luteolin might be partly mediated from PI3K, Akt, and thioredoxin reductase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 188-196 thymoma viral proto-oncogene 1 Mus musculus 302-305 21816215-8 2011 The specific MEK/ERK inhibitor PD98059 and PI3K/Akt inhibitor LY294002, block the PPNC-induced hypopigmentation effect, and abrogate the PPNC-suppressed expression of melanogenic proteins such as MITF, tyrosinase, TRP-1, and Dct. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 62-70 thymoma viral proto-oncogene 1 Mus musculus 48-51 21872252-7 2011 Blocking assays using the neutralizing antibody for vascular endothelial growth factor (VEGF) and the specific inhibitor of phosphoinositide 3-kinase (PI3K), such as LY294002 or wortmannin, demonstrated that the protective effect of CREG on ECs apoptosis was mainly mediated by activation of the VEGF/PI3K/AKT signaling pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 166-174 thymoma viral proto-oncogene 1 Mus musculus 306-309 21770712-5 2011 Furthermore, we demonstrated for the first time that the brain-specific blockade of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, by intranasal administration of LY294002, a specific inhibitor of PI3K/Akt signaling pathway, significantly blocked acupuncture-induced dopaminergic neuron protection and motor function improvement. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 176-184 thymoma viral proto-oncogene 1 Mus musculus 215-218 21449895-7 2011 When the PI3K-Akt pathway was inhibited by LY294002, the adhesion and migration of BM-MSCs from ICR mice were suppressed as well. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 thymoma viral proto-oncogene 1 Mus musculus 14-17 21512969-6 2011 In BV-2 cells, OGD induced ROS and nitric oxide production by upregulating NOX2 and iNOS via the phosphatidylinositol-3-kinase (PI3K)/AKT-dependent NF- kappaB and HIF-1 alpha pathways, and these changes were suppressed by andrographolide and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 242-250 thymoma viral proto-oncogene 1 Mus musculus 134-137 21321983-9 2011 Treatment with LY294002 at the same dose reduced the viability of C4-2AT6 more effectively than that of C4-2, reflecting the dependency of cancer cells on PI3K/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 thymoma viral proto-oncogene 1 Mus musculus 160-163 21138475-5 2011 Treatment with Akt inhibitors (LY 294002, wortmannin) plus melatonin reduced p-Akt expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31-40 thymoma viral proto-oncogene 1 Mus musculus 15-18 21838918-10 2011 Furthermore, we found that the Akt inhibitor LY294002 restored SPC-mediated downregulation of LC3 II and inhibited the activation of mTOR by SPC. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 thymoma viral proto-oncogene 1 Mus musculus 31-34 21561530-8 2011 In a mouse tumor model, we found the phosphorylation of Akt obviously increased following anti-angiogenic therapy using plasmids encoding soluble vascular endothelial growth factor receptor-2, but significantly reduced after treatment with LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 240-248 thymoma viral proto-oncogene 1 Mus musculus 56-59 21730021-7 2011 The PI3K-Akt inhibitor, LY294002, completely blocked adipocyte differentiation of MSCs, unveiling that the reduced adipogenic potential of Ncam(-/-) MSCs is due to insulin resistance as a result of loss of NCAM function. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 24-32 thymoma viral proto-oncogene 1 Mus musculus 9-12 21511697-5 2011 Conversely, the phosphoinositide 3-kinase (PI3K) inhibitor LY 294002 diminished phosphorylation of Akt (S473) and AS160. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-68 thymoma viral proto-oncogene 1 Mus musculus 99-102 21538894-5 2011 Furthermore, phosphorylation of Akt and antioxidant response element-mediated reporter gene expression were enhanced by glyceollins but suppressed by LY294002, an inhibitor of phosphoinositide 3-kinases (PI3K). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 150-158 thymoma viral proto-oncogene 1 Mus musculus 32-35 21255641-3 2011 LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, inhibited Akt activation and induced apoptotic cell death in cells expressing JAK2 V617F mutant and EpoR. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 66-69 21496122-5 2011 LY294002, an inhibitor of phosphatidylinositol 3-kinase that initiates Akt-catalysed phosphorylation of eNOS on Ser1179, was administered 1 h before the induction of SCI; 24 h after SCI sections were taken for histological examination and for biochemical studies. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 71-74 21496122-6 2011 In this study we clearly demonstrated that pre-treatment with LY294002 reversed the increased activation of eNOS and Akt observed following SCI, and developed a severe trauma characterized by oedema, tissue damage and apoptosis (measured by TUNEL staining, Bax, Bcl-2 and Fas-L expression). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 62-70 thymoma viral proto-oncogene 1 Mus musculus 117-120 21138475-5 2011 Treatment with Akt inhibitors (LY 294002, wortmannin) plus melatonin reduced p-Akt expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31-40 thymoma viral proto-oncogene 1 Mus musculus 79-82 20153001-5 2011 In addition, phosphatidylinositol-3 kinase and Akt protein expressions were increased when C2C12 myotubes were exposed to IH-901 for up to 3 hours; and these effects including glucose uptake were attenuated by pretreatment with LY294002, a selective phosphatidylinositol-3 kinase inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 228-236 thymoma viral proto-oncogene 1 Mus musculus 47-50 21159855-8 2011 Furthermore, pretreatment of ISEMF cells with the phosphatidylinositol 3 kinase (PI3K) inhibitors, LY294002 and wortmannin, abrogated the IGF-I mRNA response to GLP-2, as did overexpression of kinase-dead Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99-107 thymoma viral proto-oncogene 1 Mus musculus 205-208 22028792-7 2011 Indeed, inhibition of Rho by C3 toxin and Akt by LY294002 blocked Sema4D-mediated endothelial cell migration and tubulogenesis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 49-57 thymoma viral proto-oncogene 1 Mus musculus 42-45 20876581-7 2010 We show that TGF-beta1 induced autophagy through TAK1 and Akt activation, and inhibition of PI3K-Akt pathway by LY294002 or dominant-negative Akt suppressed LC3 levels and enhanced caspase 3 activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 thymoma viral proto-oncogene 1 Mus musculus 97-100 21068409-5 2010 We also found that expression of miR-101 is induced by multiple TLR ligands, including LPS, peptidoglycan, or polyinosinic-polycytidylic acid, and that inhibition of PI3K/Akt by LY294002 or Akt RNA interference blocks the induction of miR-101 by LPS in RAW264.7 macrophage cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 178-186 thymoma viral proto-oncogene 1 Mus musculus 171-174 20876581-7 2010 We show that TGF-beta1 induced autophagy through TAK1 and Akt activation, and inhibition of PI3K-Akt pathway by LY294002 or dominant-negative Akt suppressed LC3 levels and enhanced caspase 3 activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 thymoma viral proto-oncogene 1 Mus musculus 97-100 20561929-7 2010 As well, JP05 blocked the inhibition of PI3K/Akt and ERK activities by LY294002 (PI3K/Akt inhibitor) and PD98059 (mitogen-activated protein kinase inhibitor), respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 71-79 thymoma viral proto-oncogene 1 Mus musculus 45-48 20229527-8 2010 LY294002, a specific inhibitor of phosphoinositide-3-kinase, suppressed Akt and IFN-gamma mRNA expression up-regulated by LPS, whereas PEITC exhibited a similar inhibition profile. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 72-75 20561929-7 2010 As well, JP05 blocked the inhibition of PI3K/Akt and ERK activities by LY294002 (PI3K/Akt inhibitor) and PD98059 (mitogen-activated protein kinase inhibitor), respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 71-79 thymoma viral proto-oncogene 1 Mus musculus 86-89 20380832-4 2010 While the ER antagonist ICI182780 was able to abolish these effects, AKT phosphorylation induced by E2 was also inhibited by the PI3K inhibitor LY294002 and the SRC family inhibitor PP2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 thymoma viral proto-oncogene 1 Mus musculus 69-72 20228268-5 2010 ERK1/2 or Akt phosphorylation is blocked upstream by PD98059 or Wortmannin or LY294002, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 78-86 thymoma viral proto-oncogene 1 Mus musculus 10-13 20108254-2 2010 Physcion-Glu-induced BMP-2 expression and mineralization were attenuated by LY294002, an inhibitor of PI3K that lies upstream of Akt and MAP kinases, suggesting that physcion-Glu induces osteoblast differentiation via PI3K-Akt/MAP kinase signaling pathways, which play important roles in inducing BMP-2 gene expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 129-132 20395448-6 2010 Addition of the phosphatidylinositol 3-kinase inhibitor LY294002 completely inhibits bromodeoxyuridine incorporation and cyclinD1 expression, confirming that in vitro growth of endometrial glands depends on phosphatidylinositol 3-kinase/Akt signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 56-64 thymoma viral proto-oncogene 1 Mus musculus 237-240 20520761-10 2010 PRINCIPAL FINDINGS: LY294002, a PI3K/AKT pathway inhibitor, decreased both tumor growth in vivo and cell survival in Matrigel in MPA-independent tumors with higher AKT activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 thymoma viral proto-oncogene 1 Mus musculus 37-40 20520761-10 2010 PRINCIPAL FINDINGS: LY294002, a PI3K/AKT pathway inhibitor, decreased both tumor growth in vivo and cell survival in Matrigel in MPA-independent tumors with higher AKT activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 thymoma viral proto-oncogene 1 Mus musculus 164-167 20170671-5 2010 Pre-treatment with PI3K inhibitor wortmannin or LY294002 prevented activation of peripheral AKT by ephrinB1-Fc. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 thymoma viral proto-oncogene 1 Mus musculus 92-95 20108254-2 2010 Physcion-Glu-induced BMP-2 expression and mineralization were attenuated by LY294002, an inhibitor of PI3K that lies upstream of Akt and MAP kinases, suggesting that physcion-Glu induces osteoblast differentiation via PI3K-Akt/MAP kinase signaling pathways, which play important roles in inducing BMP-2 gene expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 thymoma viral proto-oncogene 1 Mus musculus 223-226 19585524-10 2009 On the other hand, the PI3K/Akt inhibitor LY 294002 potentiated apoptosis induced by PFAs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 42-51 thymoma viral proto-oncogene 1 Mus musculus 28-31 20487197-7 2010 Moreover, the specific Akt pathway inhibitor LY294002 blocked the hypopigmenting effect of sphingosylphosphorylcholine and abrogated the sphingosylphosphorylcholine-mediated down-regulation of microphthalmia-associated transcription factor (MITF), showing that the Akt pathway is involved in sphingosylphosphorylcholine-mediated melanin inhibition. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 thymoma viral proto-oncogene 1 Mus musculus 23-26 20487197-7 2010 Moreover, the specific Akt pathway inhibitor LY294002 blocked the hypopigmenting effect of sphingosylphosphorylcholine and abrogated the sphingosylphosphorylcholine-mediated down-regulation of microphthalmia-associated transcription factor (MITF), showing that the Akt pathway is involved in sphingosylphosphorylcholine-mediated melanin inhibition. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 thymoma viral proto-oncogene 1 Mus musculus 265-268 19700402-7 2009 In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 124-132 thymoma viral proto-oncogene 1 Mus musculus 26-29 20179211-6 2010 Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 54-62 thymoma viral proto-oncogene 1 Mus musculus 35-38 20798517-7 2010 LY294002, an inhibitor PI3K abolished TNF induced IL-4 release and phosphorylation of Akt in P815 cells, indicating Akt cell signalling pathway is involved in the event. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 86-89 20798517-7 2010 LY294002, an inhibitor PI3K abolished TNF induced IL-4 release and phosphorylation of Akt in P815 cells, indicating Akt cell signalling pathway is involved in the event. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 116-119 19724285-8 2010 TO901317 also significantly increased neurite outgrowth, and inhibition of the PI3K/Akt pathway by LY294002 decreased neurite outgrowth in both controls and TO901317-treated groups in cultured hypoxic PCN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99-107 thymoma viral proto-oncogene 1 Mus musculus 84-87 20019838-7 2009 Involvement of the PI3K/Akt pathway was assessed using LY294002, a selective PI3K inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 thymoma viral proto-oncogene 1 Mus musculus 24-27 19855934-4 2009 Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 40-48 thymoma viral proto-oncogene 1 Mus musculus 23-26 19535511-7 2009 Forskolin and 8-Br-cGMP not only increased the activity of PI3K but also induced the phosphorylation of Akt, a signaling molecule downstream of PI3K, which were again inhibited by wortmannin and LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 195-203 thymoma viral proto-oncogene 1 Mus musculus 104-107 19648963-8 2009 Treatment of lung tumor-bearing mice with the phosphoinositol-3 kinase inhibitor LY294002 induced a rapid decrease in phosphorylated Akt and phosphorylated p27, concomitant with an increase in nuclear p27. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 81-89 thymoma viral proto-oncogene 1 Mus musculus 133-136 19307451-5 2009 Cotreatment with the phosphatidylinositol 3 (PI3)-kinase inhibitor, LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], or treatment of cardiomyocytes infected with a dominant negative adenovirus targeted to Akt1 (ADV-dnAkt1) blocked the effects of EPO on nNOS expression, suggesting that EPO regulates nNOS expression via PI3-kinase and Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 68-76 thymoma viral proto-oncogene 1 Mus musculus 232-235 19676073-7 2009 The latter was blocked by PP2, rapamycin or LY294002, but not by Wortmannin, whereas phosphorylation of Akt was blocked by LY294002 or Wortmannin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-131 thymoma viral proto-oncogene 1 Mus musculus 104-107 19362548-5 2009 Further studies with Wortmannin and LY294002 revealed that phophoinositol-3-kinase (PI3K) plays a central role in opioid-induced Akt activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-44 thymoma viral proto-oncogene 1 Mus musculus 129-132 19258518-10 2009 The PI3K inhibitor LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride] abolished the H(2)S-mediated activation of AKT and increases tumor necrosis factor alpha and interleukin 1beta levels in caerulein-treated acinar cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 137-140 19162061-2 2009 Our in vitro findings, using cerebellar granule neurons, demonstrate that lithium (1-10mM) exerts neuroprotective effects in young cultures (7-8 days) against LY294002-induced Akt inhibition. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 159-167 thymoma viral proto-oncogene 1 Mus musculus 176-179 19336408-8 2009 Insulin-induced changes in mtDNA, mitochondrial mass, intracellular ATP content, and transcripts of mitochondrion-associated genes were prevented by blockade of Akt activation with the phosphatidylinositol 3-kinase inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 225-233 thymoma viral proto-oncogene 1 Mus musculus 161-164 19363269-5 2009 Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 78-94 18640717-3 2009 PI3K/Akt activity, analyzed by phosphatidylinositol trisphosphate production and phosphorylated Akt (p-Akt) expression, was higher in the resistant cell lines than in the sensitive one and inhibition with wortmannin or LY294002 improved apoptosis in the resistant cell lines. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 219-227 thymoma viral proto-oncogene 1 Mus musculus 5-8 19363269-5 2009 Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 96-99 19363269-5 2009 Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 101-104 19363269-5 2009 Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 140-143 19363269-5 2009 Furthermore, lovastatin-mediated neuroprotection was shown to be dependent on protein kinase B (PKB)/Akt signaling since treatment with the PKB/Akt inhibitor LY294002 blocked the lovastatin-induced neuroprotective effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 thymoma viral proto-oncogene 1 Mus musculus 144-147 18295594-8 2008 However, pretreatment with PD98059 and LY294002 (ERK1/2 and Akt inhibitors) inhibited MT-III-induced stimulation of HIF-1alpha protein expression and VEGF production. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 39-47 thymoma viral proto-oncogene 1 Mus musculus 60-63 18840672-7 2009 Blocking the pathway of phosphatidylinositol 3-kinase (PI3K)/Akt with the specific inhibitor LY294002 decreased the proliferation and elevated RHOB protein level, indicating that PI3K/Akt signal plays its role of proliferation modulation upstream of RHOB protein. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 93-101 thymoma viral proto-oncogene 1 Mus musculus 61-64 18840672-7 2009 Blocking the pathway of phosphatidylinositol 3-kinase (PI3K)/Akt with the specific inhibitor LY294002 decreased the proliferation and elevated RHOB protein level, indicating that PI3K/Akt signal plays its role of proliferation modulation upstream of RHOB protein. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 93-101 thymoma viral proto-oncogene 1 Mus musculus 184-187 19032736-9 2008 In the in vivo study, blocking the PI3K/Akt cascade with LY294002 increased the efficacy of cisplatin-induced inhibition of tumor growth in nude mice, suppressing half the tumor growth with cisplatin alone. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 57-65 thymoma viral proto-oncogene 1 Mus musculus 40-43 18340006-4 2008 This effect and the activation of the EphB4 promoter were mediated by the phosphatidylinositol-3-kinase (P13-K)/Akt pathway and sensitive to the P13-K inhibitor LY 294002 as well as to simultaneous transfection with dominant-negative Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 161-170 thymoma viral proto-oncogene 1 Mus musculus 234-237 18641171-13 2008 Administration of IGF-I, a PI3K/Akt activator, in ASB15+ was able to partially override the previously observed phenotype of delayed differentiation, whereas administration of the PI3K/ Akt inhibitor, LY294002, decreased phosphorylation of Akt and differentiation of all cell lines similar to the untreated ASB15+ myoblasts. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 201-209 thymoma viral proto-oncogene 1 Mus musculus 186-189 18641171-13 2008 Administration of IGF-I, a PI3K/Akt activator, in ASB15+ was able to partially override the previously observed phenotype of delayed differentiation, whereas administration of the PI3K/ Akt inhibitor, LY294002, decreased phosphorylation of Akt and differentiation of all cell lines similar to the untreated ASB15+ myoblasts. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 201-209 thymoma viral proto-oncogene 1 Mus musculus 186-189 18356276-10 2008 The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 200-208 thymoma viral proto-oncogene 1 Mus musculus 28-31 18206295-5 2008 Akt/PKB activation by GnRH and IGF-1 was completely eliminated in the presence of the PI3-kinase inhibitor, LY 294002, but not in the presence of an Akt/PKB inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 108-117 thymoma viral proto-oncogene 1 Mus musculus 4-7 18245559-10 2008 Pharmacological blockade of PI3-kinase-Akt pathway with LY-294002 inhibited FMD. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 56-65 thymoma viral proto-oncogene 1 Mus musculus 39-42 17924084-5 2008 In addition, LPA increased the phosphorylation of AKT-1 with no effects on IRS-1, and LPA-induced glucose uptake was abrogated by pretreatment with the PI 3-kinase inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 174-182 thymoma viral proto-oncogene 1 Mus musculus 50-55 17631873-7 2007 NaHS increased Akt phosphorylation and this effect was also blocked by either LY 294002 or wortmannin (25 nmol/l). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 78-87 thymoma viral proto-oncogene 1 Mus musculus 15-18 17980966-6 2007 This effect could be blocked by the phosphatidylinositol 3-kinase (PI3K)/Akt pathway inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 95-103 thymoma viral proto-oncogene 1 Mus musculus 73-76 17562163-6 2007 The ERK activation was inhibited by U0126, a specific inhibitor of MEK, but not by LY294002, a specific inhibitor of PI3K, whereas the Akt activation was blocked by LY294002, but not by U0126. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 165-173 thymoma viral proto-oncogene 1 Mus musculus 135-138 17901071-8 2008 PD98059 and LY294002 also inhibited (P < 0.05) FGF2- and VEGF-induced phosphorylation of MAPK3/1 and AKT1, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 12-20 thymoma viral proto-oncogene 1 Mus musculus 104-108 17592496-8 2007 PD98059, U0126 and LY294002 not only abolished IL-12-induced IL-4 release but also inhibited IL-12-induced phosphorylation of extracellular signal-regulated kinase and Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 168-171 17322282-3 2007 Pretreatment with 50 microM of the PI3K inhibitor, LY-294002, or 20 microM PP2, a Src kinase inhibitor, significantly attenuated the increase in K(f), whereas 10 microM Akt inhibitor IV significantly augmented the increased K(f). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 51-60 thymoma viral proto-oncogene 1 Mus musculus 169-172 17540722-8 2007 Inhibition of PI3K/Akt activity with PI3K inhibitor LY294002 or by expressing the dominant negative p85 or Akt prevented the HG-enhanced PPAR gamma-dependent adipogenic induction of lipid accumulation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 19-22 17467686-6 2007 LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 149-152 17467686-6 2007 LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 275-278 17467686-6 2007 LY294002 (a specific inhibitor of PI3K) abolished KL-dependent PGC migration or the chemoattractant activity of the conditioned medium and inhibited AKT phosphorylation; Src kinase inhibitors PP2 and SU6656, caused significant reduction of the KL-dependent PGC migration and AKT phosphorylation, while U0126, a selective inhibitor of the MEK/ERK protein kinase cascade, reduced PGC migration and AKT phosphorylation at lesser extent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 275-278 17450173-6 2007 KEY RESULTS: Either LY-294002 or geldanamycin reversed the increased activation of eNOS and Akt observed following SAO shock. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-29 thymoma viral proto-oncogene 1 Mus musculus 92-95 17321472-8 2007 Moreover, the LPS-induced NO production and NF-kappaB activation was inhibited by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase/Akt pathway, in RAW 264.7 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 82-90 thymoma viral proto-oncogene 1 Mus musculus 146-149 17382199-2 2007 Using the PI3K inhibitor LY294002 and PTEN knockout mouse embryonic fibroblasts, we show that phosphorylation of Akt by superoxide requires the production of PIP3 and that the target for the induction of Akt phosphorylation by O2.- is the phosphatase PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 113-116 17382199-2 2007 Using the PI3K inhibitor LY294002 and PTEN knockout mouse embryonic fibroblasts, we show that phosphorylation of Akt by superoxide requires the production of PIP3 and that the target for the induction of Akt phosphorylation by O2.- is the phosphatase PTEN. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 204-207 17714594-6 2007 Both the large tidal volume ventilation of Akt mutant mice and the pharmacological inhibition of Akt with LY294002 attenuated neutrophil sequestration, MIP-2 protein production, and Akt and eNOS activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 97-100 17011750-6 2007 The Wnt3a-induced Akt activation was abolished by pre-treatment with PI3K inhibitor, LY294002 and Wortmanin, but not by MEK inhibitor, U0126, indicating that Wnt3a activates Akt via PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 85-93 thymoma viral proto-oncogene 1 Mus musculus 18-21 17011750-6 2007 The Wnt3a-induced Akt activation was abolished by pre-treatment with PI3K inhibitor, LY294002 and Wortmanin, but not by MEK inhibitor, U0126, indicating that Wnt3a activates Akt via PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 85-93 thymoma viral proto-oncogene 1 Mus musculus 174-177 17215071-5 2007 The phosphorylation of Akt induced by FGF-2 was markedly attenuated by wortmannin and LY294002, inhibitors of phosphatidylinositol 3-kinase (PI3-kinase) in osteoblast-like MC3T3-E1 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 86-94 thymoma viral proto-oncogene 1 Mus musculus 23-26 17714594-6 2007 Both the large tidal volume ventilation of Akt mutant mice and the pharmacological inhibition of Akt with LY294002 attenuated neutrophil sequestration, MIP-2 protein production, and Akt and eNOS activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 97-100 16987252-6 2006 In our hands, activated PI-3-K reduced the stability of c-Myc, because (i) the PI-3-K inhibitor, LY294002, prevented the reduction in c-Myc levels induced by MPEP; and (ii) over-expression of AKT promoted c-Myc ubiquitination. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 97-105 thymoma viral proto-oncogene 1 Mus musculus 192-195 17145871-5 2006 On the other hand, Akt, the pathway of which can up-regulate HIF-1alpha expression, was activated in the mouse lesions, whereas HIF-1alpha was markedly down-regulated in the mouse hepatocellular carcinoma (HCC) cell lines after treatment with a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002, indicating that HIF-1alpha expression is dependent on PI3K/Akt signaling. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 293-301 thymoma viral proto-oncogene 1 Mus musculus 19-22 17093064-10 2006 In addition, Smad3 activation was stimulated by IGF-I and blocked by LY294002, suggesting cross-talk between Smad and the phosphatidylinositol-3 kinase/AKT pathways. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 69-77 thymoma viral proto-oncogene 1 Mus musculus 152-155 18523362-5 2007 RESULTS: PI3K inhibitors LY294002 and LY303511 were shown to suppress TNF-alpha expression that is stimulated by GM3 in B16 cells, suggesting that the GM3 signal is located upstream of the PI3K-Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 194-197 16960136-8 2007 Inhibition of the phosphoinositide-3-kinase (PI3-K)/Akt pathway by LY294002 significantly reduced the number of newly formed neurospheres, which indicates that this is an essential pathway for neural stem cell self-renewal. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 67-75 thymoma viral proto-oncogene 1 Mus musculus 52-55 16817229-7 2006 Wortmannin and LY294002 suppressed the PDGF-BB-induced phosphorylation of Akt and GSK-3beta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 thymoma viral proto-oncogene 1 Mus musculus 74-77 16905201-5 2006 The modulation of PI3K/Akt activation by treatment of LY294002 or expression of Akt mutants such as Akt-DN or Myr-Akt exerted a significant effect on the activation of ERK1/2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 54-62 thymoma viral proto-oncogene 1 Mus musculus 23-26 16966610-6 2006 The activation of Akt and eNOS by T3 was abolished by the PI3-kinase inhibitors, LY294002 and wortmannin, but not by the transcriptional inhibitor, actinomycin D. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 81-89 thymoma viral proto-oncogene 1 Mus musculus 18-21 16787946-8 2006 Inhibition of PI 3-kinase by LY294002 produced strong and moderate reductions in IGF-I-stimulated P-Akt(Ser473) and P-Akt(Thr308), respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 thymoma viral proto-oncogene 1 Mus musculus 100-103 16981137-5 2006 The phosphorylation of Akt induced by TNF-alpha was markedly attenuated by LY294002 and wortmannin, inhibitors of PI3-kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 thymoma viral proto-oncogene 1 Mus musculus 23-26 16310342-7 2006 (4) LY294002 and the Akt-specific siRNA inhibited the TGF-beta1-induced SM22alpha gene expression and promoter activity, suggesting that the TGF-beta1-induced gene expression was mediated by PI3K/Akt at the transcriptional level. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 4-12 thymoma viral proto-oncogene 1 Mus musculus 196-199 16741926-7 2006 Pretreatment of diaphragm with PI3K inhibitor LY294002 blocked the activation of Akt in normal and mdx mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 46-54 thymoma viral proto-oncogene 1 Mus musculus 81-84 16787946-8 2006 Inhibition of PI 3-kinase by LY294002 produced strong and moderate reductions in IGF-I-stimulated P-Akt(Ser473) and P-Akt(Thr308), respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 thymoma viral proto-oncogene 1 Mus musculus 118-121 15590928-5 2004 Insulin treatment also led to phosphatidylinositol-3 (PI3) kinase activation evidenced by Akt phosphorylation, which was blocked by PI3 kinase inhibitors, wortmannin and LY 294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 170-179 thymoma viral proto-oncogene 1 Mus musculus 90-93 15842198-10 2006 LY-294002, an inhibitor of phosphoinositide 3-kinase-PKB signalling, suppressed activation of PKB and CDK1 as well as resumption of meiosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-9 thymoma viral proto-oncogene 1 Mus musculus 53-56 15842198-10 2006 LY-294002, an inhibitor of phosphoinositide 3-kinase-PKB signalling, suppressed activation of PKB and CDK1 as well as resumption of meiosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-9 thymoma viral proto-oncogene 1 Mus musculus 94-97 16014032-10 2005 We also found that LY294002 and rapamycin blocked Gas6-induced activation of the Akt/mTOR pathway and mesangial hypertrophy. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 81-84 15971148-6 2005 The phosphorylation of Akt induced by IGF-I was markedly reduced by LY294002 and wortmannin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 68-76 thymoma viral proto-oncogene 1 Mus musculus 23-26 15683846-7 2005 Western blot analysis of whole lung lysates shows that LY294002 markedly attenuated OVA-induced serine phosphorylation of Akt, a direct downstream substrate of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 55-63 thymoma viral proto-oncogene 1 Mus musculus 122-125 15678124-6 2005 Indeed, the protective effect of OPN was reduced by inhibiting the activation of Akt and p42/p44 MAPK using LY294002 and U0126, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 108-116 thymoma viral proto-oncogene 1 Mus musculus 81-84 16282323-6 2006 The PI3K inhibitor, LY294002, blocked IL-3-stimulated Akt activity and partially blocked Bim(EL) phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20-28 thymoma viral proto-oncogene 1 Mus musculus 54-57 16166744-10 2006 Incubation of cells with LY294002, PD098059, or U0126 abolished HIMF-induced Akt and ERK1/2 phosphorylation and suppressed HIMF-induced SP-B and SP-C production, whereas SB203580 had no effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 77-80 16086373-11 2005 In addition, inhibition of PI3K/Akt with LY294002 reversed many of the cell cycle related changes observed in untreated transgenic animals. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 thymoma viral proto-oncogene 1 Mus musculus 32-35 15792956-7 2005 However, pretreatment of cells with the DNA-protein kinase (PK) inhibitor LY294002 strongly reversed silibinin-enhanced Akt-Ser(473) and p53-Ser(15) as well as ERK1/2 phosphorylation together with a dose-dependent decrease in cleaved caspase 3 and apoptosis (p < 0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 74-82 thymoma viral proto-oncogene 1 Mus musculus 120-123 15572521-6 2005 Inhibition of phosphatidylinositol 3-kinase (responsible for Akt activation) either by wortmanin or LY-294002 prevented Li(+)- or BIO-induced Akt phosphorylation and reduces cell survival without altering the phosphorylation state of GSK3beta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 100-109 thymoma viral proto-oncogene 1 Mus musculus 61-64 15572521-6 2005 Inhibition of phosphatidylinositol 3-kinase (responsible for Akt activation) either by wortmanin or LY-294002 prevented Li(+)- or BIO-induced Akt phosphorylation and reduces cell survival without altering the phosphorylation state of GSK3beta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 100-109 thymoma viral proto-oncogene 1 Mus musculus 142-145 15472100-8 2004 Moreover, the ILK/Akt complex was prevented by LY294002, but promoted by SOD1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 47-55 thymoma viral proto-oncogene 1 Mus musculus 18-21 15555922-7 2004 Preventing Akt activation with the phosphatidylinositol-3 (PI-3) kinase inhibitor LY294002 blocked the HGF survival response, and inhibition of ERK activation with the MEK inhibitors PD98059 or U0126 reduced the HGF survival response and the neurite growth-promoting effects of HGF. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 82-90 thymoma viral proto-oncogene 1 Mus musculus 11-14 15020298-7 2004 In contrast to its extensively documented antiapoptotic effect, the elevated activity of Akt appears to be important in sensitizing caveolin-1-expressing cells to TNF-alpha, since pretreatment of cells with the phosphatidylinositide 3-kinase (PI3K) inhibitor LY-294002 or wortmannin completely blocked PI3K activation and markedly improved the survival of TNF-alpha-treated L929 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 259-268 thymoma viral proto-oncogene 1 Mus musculus 89-92 15319270-4 2004 METHODS AND RESULTS: Wortmannin and LY294002 were used to inhibit the PI3K-Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 36-44 thymoma viral proto-oncogene 1 Mus musculus 75-78 15286700-10 2004 Overexpression of a constitutively activated Akt (myristoylated Akt) in W53 cells overcame the inhibitory effect of LY294002 on c-Myc expression, as well as cell death upon PRL deprivation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 thymoma viral proto-oncogene 1 Mus musculus 45-48 15286700-10 2004 Overexpression of a constitutively activated Akt (myristoylated Akt) in W53 cells overcame the inhibitory effect of LY294002 on c-Myc expression, as well as cell death upon PRL deprivation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 thymoma viral proto-oncogene 1 Mus musculus 64-67 15278907-10 2004 LY294002 decreased the amount of Thr(308) phosphorylated Akt to very low to undetectable levels in MI and MII oocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 thymoma viral proto-oncogene 1 Mus musculus 57-60 15278907-11 2004 Ser(473) phosphorylated Akt showed aberrant distribution and very low to undetectable levels of expression in LY294002-treated MI and MII oocytes, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 110-118 thymoma viral proto-oncogene 1 Mus musculus 24-27 15161854-11 2004 CONCLUSIONS: The Ly294002-sensitive PI3K/Akt pathway regulates MCP-1, but not IL-8 expression in hRPE cells independent of MAPK and IkappaB. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 thymoma viral proto-oncogene 1 Mus musculus 41-44 15147956-5 2004 Phosphorylation of AKT and FoxO3 was blocked by the PI-3 kinase inhibitor LY294002 but not by the MAP kinase inhibitor PD98059. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 74-82 thymoma viral proto-oncogene 1 Mus musculus 19-22 15194403-8 2004 Meanwhile, the protective effect of insulin was partially blocked with an inhibitor of PI3-kinase, LY294002, suggesting the utilization of PI3-kinase/Akt signaling pathway for the observed cytoprotective effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 99-107 thymoma viral proto-oncogene 1 Mus musculus 150-153 15344880-3 2004 In these R- cells, PI3K inhibition by LY294002 enhanced insulin stimulation of ERK phosphorylation whereas LY294002 inhibited insulin stimulation of Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 107-115 thymoma viral proto-oncogene 1 Mus musculus 149-152 14595115-7 2004 An adenovirus encoding active Akt could partially restore terminal differentiation of MyoD-expressing and LY294002-treated myoblasts, but the resultant myofibers contained fewer nuclei and were smaller and thinner than normal, indicating that another PI3-kinase-stimulated pathway in addition to Akt is required for full myocyte maturation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 thymoma viral proto-oncogene 1 Mus musculus 30-33 14654170-6 2003 After the inhibition of protein kinase B (Akt) by LY294002 or p38 mitogen-activated protein kinase (p38MAPK) by SB203580, the addition of TNF-alpha did not cause apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 50-58 thymoma viral proto-oncogene 1 Mus musculus 42-45 14612947-6 2003 Similarly, inhibition of PI3K activation by its specific inhibitor LY294002 suppressed Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 67-75 thymoma viral proto-oncogene 1 Mus musculus 87-90 14522959-8 2003 Moreover, Akt activation can be normally stimulated by treatment with insulin growth factor-1 and blocked by treatment with the phosphatidylinositol 3-kinase inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 168-176 thymoma viral proto-oncogene 1 Mus musculus 10-13 12851395-5 2003 Treatment of bone marrow with LY294002, an inhibitor of the Akt effector protein phosphatidylinositol 3-kinase, led to a reversible loss of the SP fraction. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 30-38 thymoma viral proto-oncogene 1 Mus musculus 60-63 14583467-14 2003 PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-67 thymoma viral proto-oncogene 1 Mus musculus 231-234 12873705-8 2003 Furthermore, the specific inhibition of the ERK and Akt pathways by PD98059 and LY294002, respectively, restored the cytoprotective effect induced by sphingosine-1-phosphate. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 80-88 thymoma viral proto-oncogene 1 Mus musculus 52-55 12498789-6 2002 The protective effects of lithium in vitro were blocked by LY294002, an inhibitor of the phosphatidylinositol 3-kinase/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-67 thymoma viral proto-oncogene 1 Mus musculus 119-122 12589802-4 2003 Furthermore, cross-linking of alpha4beta1 induced activation of the Rho family small GTPase Rac, which was enhanced by induced overexpression of CrkL and was inhibited by the phosphatidylinositol 3(")-kinase (PI3K) inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 225-233 thymoma viral proto-oncogene 1 Mus musculus 92-95 12574380-5 2003 Pretreatment with LY294002, a PI3K inhibitor, strongly suppressed group IIA PLA(2)-induced iNOS expression and PI3K/Akt activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 18-26 thymoma viral proto-oncogene 1 Mus musculus 116-119 12464678-6 2002 In a ligand-dependent manner, GR activated PI3K and Akt in vitro and in vivo caused NO-dependent vasodilation, which was blocked by cotreatment with RU486 or the PI3K inhibitor LY294002 but not by transcriptional inhibitors. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 177-185 thymoma viral proto-oncogene 1 Mus musculus 52-55 11740206-9 2001 Phosphorylation of Akt was prevented after focal cerebral ischemia by LY294002, a phosphatidylinositol 3-kinase inhibitor, which facilitated subsequent DNA fragmentation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 70-78 thymoma viral proto-oncogene 1 Mus musculus 19-22 11918738-8 2002 Blocking PI3-kinase with LY294002 reduced Akt activation and abrogated the anti-apoptotic effect of insulin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 42-45 11705740-3 2001 The PI3K inhibitor LY-294002 blocks TNF-alpha- and Fas-mediated Akt phosphorylation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-28 thymoma viral proto-oncogene 1 Mus musculus 64-67 12225969-6 2002 Preincubation with wortmannin or LY-294002 completely blocked TSH activation of p70 S6K and PKB/Akt, implicating phosphoinositide 3-kinase (PI3K) in their regulation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-42 thymoma viral proto-oncogene 1 Mus musculus 92-95 12225969-6 2002 Preincubation with wortmannin or LY-294002 completely blocked TSH activation of p70 S6K and PKB/Akt, implicating phosphoinositide 3-kinase (PI3K) in their regulation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-42 thymoma viral proto-oncogene 1 Mus musculus 96-99 11904450-5 2002 Phosphorylation is diminished by wortmannin and LY294002, inhibitors of PI3-kinase, the upstream activator of Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 thymoma viral proto-oncogene 1 Mus musculus 110-113 11850823-6 2002 Suppression of PI3-K and Akt by specific inhibitors LY294002 and Wortmannin reversed TC21-induced transformation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 thymoma viral proto-oncogene 1 Mus musculus 25-28 11903815-14 2002 The PI3-kinase inhibitor LY294002 also inhibited the activation of Akt by oestrogen. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 thymoma viral proto-oncogene 1 Mus musculus 67-70 11698260-7 2001 Wortmannin and LY-294002 abolished phosphorylation of Akt, further supporting activation of PI 3-kinase/Akt as a signaling pathway, which mediates hepatocyte protection by LPA. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-24 thymoma viral proto-oncogene 1 Mus musculus 54-57 11698260-7 2001 Wortmannin and LY-294002 abolished phosphorylation of Akt, further supporting activation of PI 3-kinase/Akt as a signaling pathway, which mediates hepatocyte protection by LPA. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-24 thymoma viral proto-oncogene 1 Mus musculus 104-107 11500504-8 2001 The differentiation-promoting effects of IGF-I were mimicked by a modified membrane-targeted inducible Akt-1 (iAkt), and iAkt was able to stimulate differentiation of C2 myoblasts and primary mouse myoblasts incubated with otherwise inhibitory concentrations of LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 262-270 thymoma viral proto-oncogene 1 Mus musculus 103-108 11418622-6 2001 Expression of constitutively active Akt in BaF3/Mpl cells restored the ability of thrombopoietin to promote cell cycling in the presence of LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 140-148 thymoma viral proto-oncogene 1 Mus musculus 36-39 11241354-10 2001 Insulin rescued serum-deprived cells from apoptosis in an AKT-dependent manner, as demonstrated by the inhibition of AKT-activity by the use of LY294002 and ML-9, meanwhile neither inhibition of p70S6-kinase, nor MAPK affected insulin-induced survival. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 thymoma viral proto-oncogene 1 Mus musculus 58-61 11444439-6 2001 However, inhibition of either MAPK/ERK kinase with PD98059 or PI-3 kinase with LY294002 successfully inhibited progesterone"s actions on ERK and Akt, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 79-87 thymoma viral proto-oncogene 1 Mus musculus 145-148 11453646-3 2001 The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 75-78 11453646-3 2001 The PI3K inhibitor LY294002 significantly inhibited TNFalpha activation of Rac as well as Erk and abolished that of the PI3K target Akt, without showing any inhibitory effects on JNK and p38 activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 thymoma viral proto-oncogene 1 Mus musculus 132-135 11241354-10 2001 Insulin rescued serum-deprived cells from apoptosis in an AKT-dependent manner, as demonstrated by the inhibition of AKT-activity by the use of LY294002 and ML-9, meanwhile neither inhibition of p70S6-kinase, nor MAPK affected insulin-induced survival. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 thymoma viral proto-oncogene 1 Mus musculus 117-120 11162460-5 2000 Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 61-69 thymoma viral proto-oncogene 1 Mus musculus 152-155 11162460-5 2000 Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 61-69 thymoma viral proto-oncogene 1 Mus musculus 109-112 11162460-5 2000 Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 61-69 thymoma viral proto-oncogene 1 Mus musculus 113-116 11162460-5 2000 Pretreatment of cells with the specific PI3 kinase inhibitor LY294002 abolished insulin- or PE-activation of PKB/Akt, suggesting that activation of PKB/Akt is mediated by a PI3 kinase-dependent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 61-69 thymoma viral proto-oncogene 1 Mus musculus 148-151 10969078-6 2000 Consistent with these data, TGFbeta-induced p3TP-Lux and p(CAGA)(12)-Lux reporter activities were inhibited by LY294002 and transiently expressed dominant-negative p85 and Akt mutants in NMuMG and 4T1 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 111-119 thymoma viral proto-oncogene 1 Mus musculus 172-175 10969078-8 2000 Finally, LY294002 and neutralizing TGFbeta1 antibodies inhibited ligand-independent constitutively active Akt as well as basal and TGFbeta-stimulated migration in 4T1 and EMT6 breast tumor cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 thymoma viral proto-oncogene 1 Mus musculus 106-109 9927197-5 1999 The involvement of phosphatidylinositol 3-kinase downstream of Rac was demonstrated by the inhibition of Rac-induced cell survival by wortmannin and LY294002 and the presence of phosphatidylinositol kinase activity in the Rac immunoprecipitate. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 149-157 thymoma viral proto-oncogene 1 Mus musculus 63-66 10339482-4 1999 PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 thymoma viral proto-oncogene 1 Mus musculus 49-52 10339482-4 1999 PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 thymoma viral proto-oncogene 1 Mus musculus 53-56 10339482-4 1999 PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 thymoma viral proto-oncogene 1 Mus musculus 125-128 10339482-4 1999 PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 thymoma viral proto-oncogene 1 Mus musculus 129-132 10339482-4 1999 PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 thymoma viral proto-oncogene 1 Mus musculus 125-128 10339482-4 1999 PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 90-98 thymoma viral proto-oncogene 1 Mus musculus 129-132 10791951-5 2000 We also obtained results suggesting that the kinase inhibitors LY294002 and Wortmannin arrest cell growth and induce a senescence-like phenotype, at least partially, through inhibition of PI3K and protein kinase B/Akt, activation of the forkhead protein AFX, and up-regulation of p27(Kip1)expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 63-71 thymoma viral proto-oncogene 1 Mus musculus 214-217 9927197-5 1999 The involvement of phosphatidylinositol 3-kinase downstream of Rac was demonstrated by the inhibition of Rac-induced cell survival by wortmannin and LY294002 and the presence of phosphatidylinositol kinase activity in the Rac immunoprecipitate. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 149-157 thymoma viral proto-oncogene 1 Mus musculus 105-108 9927197-5 1999 The involvement of phosphatidylinositol 3-kinase downstream of Rac was demonstrated by the inhibition of Rac-induced cell survival by wortmannin and LY294002 and the presence of phosphatidylinositol kinase activity in the Rac immunoprecipitate. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 149-157 thymoma viral proto-oncogene 1 Mus musculus 105-108