PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32552933-7 2020 After K562/ADR cells were treated with PI3K/AKT pathway inhibitor LY294002, the protein expressions of NF-kappaB and P-gp were analyzed to determine the regulation of AKT on the expression of NF-kappaB and P-gp. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 66-74 nuclear factor kappa B subunit 1 Homo sapiens 192-201 32602017-8 2020 The NF-kappaB-specific small molecule inhibitor BAY 11-7082, prostaglandin E2, and LY294002 prevented hypoxia-induced EndMT. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 nuclear factor kappa B subunit 1 Homo sapiens 4-13 32552933-15 2020 The protein expressions of p-AKT, P-gp and the activity of NF-kappaB were inhibited significantly by using PI3K/AKT inhibitor LY294002 (P<0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 126-134 nuclear factor kappa B subunit 1 Homo sapiens 59-68 32318240-7 2020 Following the addition of LY294002, the levels of p-AKT, p-ERK1/2, and p-NF-kappaB decreased significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 26-34 nuclear factor kappa B subunit 1 Homo sapiens 73-82 31026389-11 2019 Cotreatment of HeLa cells with TPA plus Pra-B or LY294002 reduced NF-kappaB nuclear translocation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 49-57 nuclear factor kappa B subunit 1 Homo sapiens 66-75 30260006-10 2019 Treatment with Pingchuanning decoction activated PI3K/Akt/mTOR pathway and inhibited HMGB1/TLR4/NF-kappaB pathway, which could be overturned by LY294002, a PI3K antagonist, or rapamycin (Rapa), an autophagy inducer. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 144-152 nuclear factor kappa B subunit 1 Homo sapiens 96-105 32174780-6 2020 S100A8 and S100A9 also induce the phosphorylation of AKT, ERK, p38 MAPK and JNK, and activation of NF-kappaB, which were blocked after exposure to TLR4i, LY294002, AKTi, PD98059, SB202190 or SP600125. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 154-162 nuclear factor kappa B subunit 1 Homo sapiens 99-108 31756335-11 2020 Moreover, triptolide cotreatment with the phosphatidylinositol 3 kinase (PI3k) inhibitor, 2-(4-morpholinyl)-8-phenylchromone (LY294002), could further suppress the proliferation, NF-kappaB activation and cyclinD1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 126-134 nuclear factor kappa B subunit 1 Homo sapiens 179-188 29427163-6 2018 The role of NF-kappaB, MAPKs, and Akt signaling pathways was confirmed by using specific inhibitors (BAY 11-7082, U0126, SB202190, SP600125, and LY294002) mediated suppression of TNF-alpha and COX-2 production. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 145-153 nuclear factor kappa B subunit 1 Homo sapiens 12-21 31068539-7 2019 Treatment of PDL cells with both the MEK1/2 inhibitor U0126 and the PI3K inhibitor LY294002 strongly attenuated TiO2-NPs-induced activation of NF-kappaB, and also the expression of COX-2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 83-91 nuclear factor kappa B subunit 1 Homo sapiens 143-152 29512729-14 2018 Furthermore, the levels of p-Akt and p-NF-kappaB caused by SOD could be offset by treatment with curcumin and LY 294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 110-119 nuclear factor kappa B subunit 1 Homo sapiens 39-48 23229346-10 2013 Additionally, treatment with the PI3K inhibitor LY294002 dramatically inhibited activation of NF-kappaB in HER2-overexpressing breast cancer cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 60-68 nuclear factor kappa B subunit 1 Homo sapiens 106-115 27125675-10 2016 Furthermore, JNK inhibitor SP600125 and Akt (Ser473) inhibitor LY294002 enhanced the inhibition of curcumol on NF-kappaB p65 nuclear translocation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 63-71 nuclear factor kappa B subunit 1 Homo sapiens 111-120 26522351-8 2015 The expressions of p-ACL and p-NF-kappaB protein in MCF-7 cells treated with 10 mumol/L LY294002 were also reduced significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 88-96 nuclear factor kappa B subunit 1 Homo sapiens 31-40 23564227-7 2013 Treatment with the PI3K inhibitor LY294002 abolished Der f 2-induced activation of Akt and NF-kappaB and the expression of IL-13. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 34-42 nuclear factor kappa B subunit 1 Homo sapiens 91-100 29330470-6 2018 Subsequently, Akt-dependent NF-kappaB activation is required for Bcl-2 upregulation, but not Bax downregulation, in response to beta-Ecd, which was validated by the use of LY294002 and Bay11-7082. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 172-180 nuclear factor kappa B subunit 1 Homo sapiens 28-37 29577981-9 2018 In addition, pretreatment with AKT inhibitor LY294002 could obviously attenuate PFOS-induced NF-kappaB activation and IL-1beta secretion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 45-53 nuclear factor kappa B subunit 1 Homo sapiens 93-102 28385482-6 2017 Moreover, we demonstrated that the specific PI3K inhibitor LY294002 could reverse nicotine-induced cell migration and invasion, NF-kappaB activation and up-regulation of Vimentin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 59-67 nuclear factor kappa B subunit 1 Homo sapiens 128-137 28288190-6 2017 Moreover, co-treatment with LY294002 (PI3K inhibitor) could further enhance the Tet-inhibited migration and invasion, and the NF-kappaB and MMP-9 protein levels were further decreased. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 nuclear factor kappa B subunit 1 Homo sapiens 126-135 28057758-6 2017 The reporter activity of claudin-2 was decreased by AZA and LY-294002, which was blocked by the mutation in a putative NF-kappaB-binding site. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 60-69 nuclear factor kappa B subunit 1 Homo sapiens 119-128 28057758-7 2017 NF-kappaB bound to the promoter region of claudin-2, which was inhibited by AZA and LY-294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 84-93 nuclear factor kappa B subunit 1 Homo sapiens 0-9 26453509-6 2015 Interestingly, PI3K inhibitor LY294002 completely blocked the TNF-alpha-induced activation of p85, Akt and the whole cascade of the NF-kappaB signaling components and suppressed inflammatory cytokines production in mRNA and protein levels similarly as CuE. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 30-38 nuclear factor kappa B subunit 1 Homo sapiens 132-141 24939823-5 2014 Jaceosidin-induced proliferation and migration of human umbilical vascular endothelial cells were strongly inhibited by the phosphatidylinositol 3-kinase inhibitor LY294002 and NF-kappaB inhibitor BAY11-7082, indicating that the PI3K/AKT/NF-kappaB signaling pathway is involved in jaceosidin-induced angiogenesis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 164-172 nuclear factor kappa B subunit 1 Homo sapiens 238-247 25085593-7 2014 Moreover, both ZJW and a PI3K specific inhibitor (LY294002) suppressed phosphorylation of Akt (Ser473) and NF-kappaB, which is necessary in the activation of the PI3K/Akt/NF-kappaB pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 50-58 nuclear factor kappa B subunit 1 Homo sapiens 107-116 25085593-7 2014 Moreover, both ZJW and a PI3K specific inhibitor (LY294002) suppressed phosphorylation of Akt (Ser473) and NF-kappaB, which is necessary in the activation of the PI3K/Akt/NF-kappaB pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 50-58 nuclear factor kappa B subunit 1 Homo sapiens 171-180 24506791-7 2014 In addition, thrombin also enhanced Akt and NF-kappaB translocation from the cytosol to the nucleus, which was reduced by PP1, AG1296 or LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 137-145 nuclear factor kappa B subunit 1 Homo sapiens 44-53 24506791-8 2014 Thrombin induced NF-kappaB promoter activity and the formation of the p65-Akt-p300 complex, which were inhibited by AG1296, LY294002 or PP1. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 124-132 nuclear factor kappa B subunit 1 Homo sapiens 17-26 24760275-17 2014 The phosphorylation levels of p65 were significantly decreased in Huh-7 and Hep3B cells after treatment with the Akt signaling inhibitor LY294002 and EP4R agonist for 24 h. Treatment with the NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC) at 10 muM for 24 h blocked EP4R-agonist-induced Snail upregulation in Huh-7 and Hep3B cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 137-145 nuclear factor kappa B subunit 1 Homo sapiens 192-201 24206109-8 2014 Furthermore, blocking ERK, PI3K and NFkappaB signaling pathways with U0126, LY294002 and pyrrolidine dithiocarbamate, respectively, significantly inhibited the mGluR2/3-mediated restorative effects. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 nuclear factor kappa B subunit 1 Homo sapiens 36-44 24244375-8 2013 Pre-treatment with SC514 (NF-kappaB inhibitor), LY294002 (PI3K inhibitor), AG490 (JAK2 inhibitor) and Janex-1 (JAK3 inhibitor) showed partial reduction of the Tat-mediated induction of CCL5 suggesting involvement of JAK, PI3K/Akt and NF-kappaB in CCL5 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 nuclear factor kappa B subunit 1 Homo sapiens 234-243 23791833-9 2013 An AKT inhibitor LY294002 effectively suppressed IKK/IkappaB/NF-kappaB signaling and PON1 gene expression induced by IL-6. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17-25 nuclear factor kappa B subunit 1 Homo sapiens 61-70 23449446-6 2013 In this study, we investigated beta-catenin and NF-kappaB signaling through regulation of glycogen synthase kinase 3beta activity (GSK-3beta, which modulates beta-catenin and NF-kappaB signaling) using a specific inhibitor LiCl and a phosphatidylinositol 3-kinase (PI3K) inhibitor LY 294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 281-290 nuclear factor kappa B subunit 1 Homo sapiens 48-57 22459175-6 2012 Moreover, NF-kappaB phosphorylation and nuclear translocation was especially noted at the leading edge, which was attenuated by treatment with SP600125 or LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 155-163 nuclear factor kappa B subunit 1 Homo sapiens 10-19 23603894-4 2013 We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-kappaB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt"s lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 188-196 nuclear factor kappa B subunit 1 Homo sapiens 127-136 23255946-13 2013 The Akt inhibitor LY294002 caused a significant decrease in TNF-alpha-induced NF-kappaB activity and MMP-9 gene expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 18-26 nuclear factor kappa B subunit 1 Homo sapiens 78-87 23992306-5 2013 In addition, the levels of phospho-Akt and phospho- NF-kappaB in BxPC-3 and Panc-1 cells were reduced by both resveratrol and LY294002 (a PI3-K inhibitor). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 126-134 nuclear factor kappa B subunit 1 Homo sapiens 52-61 23383347-6 2013 The involvement of Akt and NF-kappaB signaling pathways in the EGF-induced IL-1beta gene expression was confirmed by knockdown of RelA and Akt in cells or treating cells with Akt and NF-kappaB inhibitors, LY294002 and parthenolide, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 205-213 nuclear factor kappa B subunit 1 Homo sapiens 27-36 23383347-8 2013 Using immunofluorescence staining assay, the EGF-stimulated nuclear translocation of NF-kappaB (p65) was inhibited by pre-treating cells with LY294002 and parthenolide. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 142-150 nuclear factor kappa B subunit 1 Homo sapiens 85-94 22193240-6 2012 A pharmacological inhibitor of the phosphoinositide 3-kinase (PI3K)-Akt pathway, LY294002, abrogated IKK/IkappaB/NF-kappaB-mediated iNOS gene expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 81-89 nuclear factor kappa B subunit 1 Homo sapiens 113-122 22455747-19 2012 LY294002 reversed the effects of FSH on increasing the expression of p-Akt and the ratio of NF-kappaB p65 in the nucleus versus cytoplasm, there were significant differences among LY294002 group, FSH + LY294002 group and FSH group (P < 0.05). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 nuclear factor kappa B subunit 1 Homo sapiens 92-101 22005520-0 2012 The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappaB inhibition, in a PI3K-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 51-59 nuclear factor kappa B subunit 1 Homo sapiens 109-112 22005520-0 2012 The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappaB inhibition, in a PI3K-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 51-59 nuclear factor kappa B subunit 1 Homo sapiens 113-134 22005520-1 2012 The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 nuclear factor kappa B subunit 1 Homo sapiens 108-129 22005520-1 2012 The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-60 nuclear factor kappa B subunit 1 Homo sapiens 131-139 22005520-1 2012 The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-55 nuclear factor kappa B subunit 1 Homo sapiens 108-129 22005520-1 2012 The Phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002 (LY2), has been previously reported to inhibit nuclear factor kappaB (NFkappaB) activity, in a PI3K-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 52-55 nuclear factor kappa B subunit 1 Homo sapiens 131-139 22975513-6 2012 This induction was completely inhibited by treatment with phosphatidylinositol (PI) 3-kinase inhibitors such as LY294002 or wortmannin, and by the nuclear factor-kappa B (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 112-120 nuclear factor kappa B subunit 1 Homo sapiens 171-180 22419429-8 2012 Pharmacological inhibition of AKT by LY294002 effectively suppressed NF-kappaB activation and PON1 gene expression, suggesting that AKT was an upstream regulator of GP50E-mediated biological events. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 nuclear factor kappa B subunit 1 Homo sapiens 69-78 22005520-8 2012 The effects of LY2 and LY3 on p50 translocation and on cytokine production in LPS-stimulated macrophages are thus consistent with specific PI3K-independent inhibition of p50 NFkappaB homodimer activity by LY2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-18 nuclear factor kappa B subunit 1 Homo sapiens 30-33 22005520-8 2012 The effects of LY2 and LY3 on p50 translocation and on cytokine production in LPS-stimulated macrophages are thus consistent with specific PI3K-independent inhibition of p50 NFkappaB homodimer activity by LY2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-18 nuclear factor kappa B subunit 1 Homo sapiens 170-173 22005520-8 2012 The effects of LY2 and LY3 on p50 translocation and on cytokine production in LPS-stimulated macrophages are thus consistent with specific PI3K-independent inhibition of p50 NFkappaB homodimer activity by LY2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-18 nuclear factor kappa B subunit 1 Homo sapiens 174-182 21276823-10 2011 We demonstrate that CsA and LY294002 reduced MMP transcription partly via modulation of IkappaB phosphorylation and NFkappaB transcriptional activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 nuclear factor kappa B subunit 1 Homo sapiens 116-124 21422731-6 2011 Inhibition studies using LY294002 (20 microM) revealed the requirement of the PI3K/Akt pathway for LPS-stimulated IL-6 production and NF-kappaB activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 25-33 nuclear factor kappa B subunit 1 Homo sapiens 134-143 21245990-8 2011 In MKN45 and AGS cells, oxaliplatin treatment promoted both protein kinase B (Akt) and NFkappaB activation, while pretreatment with LY294002 significantly attenuated oxaliplatin-induced Akt activity and NFkappaB binding. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 132-140 nuclear factor kappa B subunit 1 Homo sapiens 87-95 21245990-8 2011 In MKN45 and AGS cells, oxaliplatin treatment promoted both protein kinase B (Akt) and NFkappaB activation, while pretreatment with LY294002 significantly attenuated oxaliplatin-induced Akt activity and NFkappaB binding. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 132-140 nuclear factor kappa B subunit 1 Homo sapiens 203-211 21245990-10 2011 In vivo, LY294002 inhibited oxaliplatin-induced activation of Akt and NFkappaB, and increased oxaliplatin-induced expression of FasL, inhibition of c-FLIP(S), and activation of caspase-8, Bid, and caspase-3. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9-17 nuclear factor kappa B subunit 1 Homo sapiens 70-78 18358890-4 2008 LPS-stimulated translocation of nuclear factor kappa B (NF-kappaB) into the nucleus, which was blocked by inhibitors of amino kinase terminal (AKT, LY294002), extracellular signal regulated kinase 1/2 (ERK 1/2, PD98059), p38 (SB203580), and c-jun NH2-terminal kinase (JNK, SP600125) or terrein. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 148-156 nuclear factor kappa B subunit 1 Homo sapiens 32-54 18700866-4 2008 RESULTS: Inhibition of NF-kappaB transcriptional activity by transient transfection with mutant plasmids encoding Akt1 and glycogen synthase kinase-3beta (GSK-3beta), or by treatment with chemical inhibitors, wortmannin and LY294002, showed little effect on the survival of Chang/HBx cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 224-232 nuclear factor kappa B subunit 1 Homo sapiens 23-32 18389481-6 2008 The results obtained by mutating specific tyrosine residues within the CD28 cytoplasmic tail as well as by using LY294002 inhibitory drug evidenced that the recruitment and activation of the phosphatidylinositol 3-kinase/Akt signalling pathway is crucial in mediating CD28-induced HIV transcription through RelA/NF-kappaB. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 113-121 nuclear factor kappa B subunit 1 Homo sapiens 312-321 20947290-4 2010 Our work demonstrates that blocking PI3K/Akt by LY294002 inhibits the NF-kappaB activity with significantly increased apoptosis in gastric cancer cell. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 48-56 nuclear factor kappa B subunit 1 Homo sapiens 70-79 20649564-11 2010 IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 169-177 nuclear factor kappa B subunit 1 Homo sapiens 60-69 20649564-11 2010 IL-1beta-stimulated activation and translocation of Akt and NF-kappaB (p65); the recruitment of activated NF-kappaB (p65) to the MMP-9 promoter region was attenuated by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 169-177 nuclear factor kappa B subunit 1 Homo sapiens 106-115 20120770-7 2009 The inhibition of phosphorylated Akt by LY294002 led to the inhibition of NF-kappaB in a dose-dependent manner. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 40-48 nuclear factor kappa B subunit 1 Homo sapiens 74-83 19717552-6 2009 Furthermore, CSE-stimulated NF-kappaB p65 phosphorylation and translocation were also attenuated by pretreatment with Go6976, PP1, AG1478, AG1296, or LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 150-158 nuclear factor kappa B subunit 1 Homo sapiens 28-37 19301309-11 2009 LY294002 mimicked RES effects on NF kappaB activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 nuclear factor kappa B subunit 1 Homo sapiens 33-42 19428548-7 2009 Treatment with LY294002 (PI3K inhibitor) and SP600125 (JNK inhibitor) suppressed NF-kappaB inhibitor induced MIF mRNA expression and MIF secretion. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 nuclear factor kappa B subunit 1 Homo sapiens 81-90 18628489-8 2008 Inhibition of AKT by LY294002 (a PI3K inhibitor) blocked BCL10 nuclear translocation, NF-kappaB transactivity, and BAFF expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 21-29 nuclear factor kappa B subunit 1 Homo sapiens 86-95 18358890-4 2008 LPS-stimulated translocation of nuclear factor kappa B (NF-kappaB) into the nucleus, which was blocked by inhibitors of amino kinase terminal (AKT, LY294002), extracellular signal regulated kinase 1/2 (ERK 1/2, PD98059), p38 (SB203580), and c-jun NH2-terminal kinase (JNK, SP600125) or terrein. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 148-156 nuclear factor kappa B subunit 1 Homo sapiens 56-65 17849421-7 2008 Using a stable IkappaBalpha mutant LN-18 cell line and pharmacological inhibitors to PI3K/Akt (LY294002) and Akt (Akt2), we provide evidence that Akt and NF-kappaB are activated independently on stimulation with TNF-alpha and both the pathways contribute towards resistance to TNF-alpha mediated cell death. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 95-103 nuclear factor kappa B subunit 1 Homo sapiens 154-163 16563718-7 2006 Furthermore, inhibition of ERK activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly reduced the LA-induced activation of nuclear factor kappa B (NF-kappaB). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 nuclear factor kappa B subunit 1 Homo sapiens 150-172 17638919-4 2007 Transient transfection of Id-1 into HEK293 cells confirmed activation of PI3K/Akt/NFkappaB signaling and the effects were counteracted by the PI3K inhibitor LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 157-165 nuclear factor kappa B subunit 1 Homo sapiens 82-90 17638919-7 2007 In addition, inhibition of PI3K or NFkappaB signaling using the PI3K inhibitor LY294002 or the NFkappaB inhibitor Bay11-7082 increased the sensitivity of Id-1-over-expressing esophageal cancer cells to TNF-alpha-induced apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 79-87 nuclear factor kappa B subunit 1 Homo sapiens 35-43 17464346-10 2007 The increased secretion of TNF-alpha and sICAM-1 and the increased activity of NF-kappaB by ADMA were altered by SB203580 (5 micromol/L) or PD98059 (20 micromol/L), but not by LY294002 (20 micromol/L). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 176-184 nuclear factor kappa B subunit 1 Homo sapiens 79-88 16563718-7 2006 Furthermore, inhibition of ERK activity by PD98059 and PI3K/Akt activity by LY294002 or wortmannin significantly reduced the LA-induced activation of nuclear factor kappa B (NF-kappaB). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 76-84 nuclear factor kappa B subunit 1 Homo sapiens 174-183 15894170-6 2005 Both NO donor and LPS/IFN-gamma markedly activated the PI3K activity and the phosphorylation of Akt and nuclear factor (NF)-kappaB DNA binding activity in mesangial cells, which could be inhibited by LY294002 and transfection of dominant-negative vectors of PI3K/p85 and Akt. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 200-208 nuclear factor kappa B subunit 1 Homo sapiens 104-130 16282450-8 2005 The effect of Akt on CXCL10 mRNA expression occurred via NFkappaB-dependent transcriptional activation, since AktAAA overexpression and Ly294002 both inhibited CXCL10 and NFkappaB promoter activation in luciferase reporter experiments. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 136-144 nuclear factor kappa B subunit 1 Homo sapiens 171-179 16644476-6 2006 Gel shift assays showed that LY294002 (LY29) potently increased interleukin (IL)-1-induced NF-kappaB DNA binding in human monocytic THP-1 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-37 nuclear factor kappa B subunit 1 Homo sapiens 91-100 16644476-6 2006 Gel shift assays showed that LY294002 (LY29) potently increased interleukin (IL)-1-induced NF-kappaB DNA binding in human monocytic THP-1 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 29-33 nuclear factor kappa B subunit 1 Homo sapiens 91-100 16644476-9 2006 LY29 treatment also augmented tumor necrosis factor (TNF)-mediated NF-kappaB DNA binding. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-4 nuclear factor kappa B subunit 1 Homo sapiens 67-76 15678501-8 2005 Furthermore, the IL-4-induced NF-kappaB activation and nuclear translocation can be blocked by LY294002, a PI3K/Akt specific inhibitor, suggesting that IL-4-induced NF-(kappa)B activation is mediated by activation of PI3K/Akt pathway. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 95-103 nuclear factor kappa B subunit 1 Homo sapiens 165-176 15688415-8 2005 The patterns for NF-kappaB and calpain activities followed that of PI3K and were inhibited by LY294002. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 94-102 nuclear factor kappa B subunit 1 Homo sapiens 17-26 15889536-7 2005 Because LY294002, an inhibitor of cellular phosphatidylinositol 3-kinase (PI3-K), also prohibited HCMV-mediated activation of Akt and NFkappaB and synthesis of the MIE proteins, PI3-K signalling was necessary for expressing the MIE genes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 8-16 nuclear factor kappa B subunit 1 Homo sapiens 134-142 15558015-10 2005 Two different PI-3K inhibitors, wortmannin and LY294002, showed Akt-independent activation of NF-kappaB. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 47-55 nuclear factor kappa B subunit 1 Homo sapiens 94-103 15184909-7 2004 Functional correlation between Akt activation and the activation of NFkappaB was confirmed in U251MG GBM cells in which inhibition of Akt activation either by stable expression of PTEN or by the PI3-kinase inhibitors, wortmannin and LY294002, led to a concomitant decrease in NFkappaB-binding activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 233-241 nuclear factor kappa B subunit 1 Homo sapiens 68-76 15240151-8 2004 Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 92-100 nuclear factor kappa B subunit 1 Homo sapiens 56-65 15240151-8 2004 Specifically, IL-1beta-induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K-dependent nuclear translocation of NF-kappaB in response to IL-1beta. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 92-100 nuclear factor kappa B subunit 1 Homo sapiens 199-208 12493764-4 2003 In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 176-184 nuclear factor kappa B subunit 1 Homo sapiens 73-82 14960322-5 2004 LY29 and LY30 inhibited activation of nuclear factor-kappaB (NF-kappaB). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-4 nuclear factor kappa B subunit 1 Homo sapiens 38-59 14960322-5 2004 LY29 and LY30 inhibited activation of nuclear factor-kappaB (NF-kappaB). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-4 nuclear factor kappa B subunit 1 Homo sapiens 61-70 14960322-6 2004 These results suggest that LY29 inhibits MCP-1 expression at least in part via suppression of NF-kappaB, independent of PI3K, and the structure of LY29 and LY30 may be a novel template for development of new anti-inflammatory drugs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 27-31 nuclear factor kappa B subunit 1 Homo sapiens 94-103 12771144-9 2003 However, both pharmacological (wortmannin and LY294002) and genetic (Deltap85) inhibitors of PI 3"-kinase inhibited OPN-induced Akt phosphorylation, IKK activity, and NFkappaB activation through phosphorylation and degradation of IkappaBalpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 46-54 nuclear factor kappa B subunit 1 Homo sapiens 167-175 15073105-6 2004 The activation of Akt and NF-kappa B was prevented by LY294002, whereas the activity of MAPK(Erk), but not NF-kappa B, was inhibited by U0126. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 54-62 nuclear factor kappa B subunit 1 Homo sapiens 26-36 15016316-13 2004 Inhibition of PI 3-K with Wortmannin and LY294002 blocked IkappaB phosphorylation, reduced NF-kappaB nuclear activity, reduced COX-2 expression and induced apoptosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 41-49 nuclear factor kappa B subunit 1 Homo sapiens 91-100 14578214-6 2004 The phosphoinositide 3-OH kinase inhibitor Ly294002 prevented nuclear translocation of NF-kappaB and the subsequent release of interleukin-6 and macrophage inflammatory protein-2alpha in overventilated but not in endotoxic lungs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 43-51 nuclear factor kappa B subunit 1 Homo sapiens 87-96 14578214-7 2004 Similar results were obtained in rats in vivo, where Ly294002 prevented NF-kappaB activation by overventilation but not by endotoxin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 53-61 nuclear factor kappa B subunit 1 Homo sapiens 72-81 12865424-6 2003 LY294002, dominant-negative (DN) phosphatidylinositol 3-kinase (PI3K), or AKT(DN) inhibited NFkappaB activation, p65 transactivation, and cyclooxygenase-2 (COX-2) expression induced by lauric acid or constitutively active (CA) TLR4. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 nuclear factor kappa B subunit 1 Homo sapiens 92-100 12767057-5 2003 Constitutive NF-kappaB/Rel activity and the transactivation potential of RelA(p65) can be inhibited by dominant negative mutant Ras, the PI3 kinase inhibitor LY294002, or dominant negative mutant Akt kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 158-166 nuclear factor kappa B subunit 1 Homo sapiens 13-22 12767057-6 2003 Transfection of a dominant negative mutant epidermal growth factor receptor (EGF-R), EGF-R kinase inhibitor Tyrphostin and LY 294002 blocked IKK activity and NF-kappaB-dependent transcription. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 123-132 nuclear factor kappa B subunit 1 Homo sapiens 158-167 12493764-4 2003 In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 176-184 nuclear factor kappa B subunit 1 Homo sapiens 102-111 12493764-4 2003 In electrophoretic mobility shift assays, thrombin-mediated induction of NF-kappaB p65 binding to two NF-kappaB motifs in the upstream promoter region of VCAM-1 was blocked by LY294002 and rottlerin, whereas the inducible binding of GATA-2 to a tandem GATA motif was inhibited by LY294002 and the PKC-zeta peptide inhibitor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 280-288 nuclear factor kappa B subunit 1 Homo sapiens 73-82 12423306-7 2002 The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 107-115 nuclear factor kappa B subunit 1 Homo sapiens 292-301 12588890-9 2003 Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 174-182 nuclear factor kappa B subunit 1 Homo sapiens 32-41 12423306-7 2002 The effects of IL-3 on apoptosis and CD69 surface expression of human basophils were completely blocked by LY294002 (LY), a potent inhibitor of phosphatidylinositol 3-kinase (PI3-K), but only partially inhibited by lactacystin, a proteasome inhibitor that prevents degradation of IkappaB and NF-kappaB translocation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 107-109 nuclear factor kappa B subunit 1 Homo sapiens 292-301 12097303-7 2002 We confirm involvement of PI3k/Akt/NFkappaB signaling because the PI3k inhibitors wortmannin and LY294002 or the inhibitor of NFkappaB (IkappaB) kinase inhibitor PS-1145 block constitutive and cytokine-induced up-regulation of telomerase activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 97-105 nuclear factor kappa B subunit 1 Homo sapiens 35-43 12379708-7 2002 IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 280-289 nuclear factor kappa B subunit 1 Homo sapiens 85-91 12379708-7 2002 IL-8 expression by TNF-alpha was inhibited when two survival signals, nuclear factor kappaB (NF-kappaB) and phosphatidylinositol 3-kinase (PI3K)/Akt, were inhibited by a mutant form of inhibitor of NF-kappaB (IkappaB); by dominant negative (kinase-dead) Akt; or by treatment with LY 294002, an inhibitor of PI3K. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 280-289 nuclear factor kappa B subunit 1 Homo sapiens 93-102 11282033-5 2001 We found that integrins activated both NF-kappaB and MAPK in a PI 3-K-dependent manner, as wortmannin and LY294002 blocked these responses. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 106-114 nuclear factor kappa B subunit 1 Homo sapiens 39-48 12086898-9 2001 PI3K inhibition significantly enhanced the antiproliferative and proapoptotic effects of TNF-alpha in both cell lines, Ly294002 also blocked TNF-alpha-induced Akt activation but failed to alter cytoplasmic IkappaBalpha degradation or subsequent NF-kappaB nuclear translocation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 119-127 nuclear factor kappa B subunit 1 Homo sapiens 245-254 12086898-10 2001 NF-kappaB-dependent gene expression, however, was ultimately suppressed by Ly294002, suggesting that PI3k-dependent activation of NF-kappaB is IkappaBalpha independent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 nuclear factor kappa B subunit 1 Homo sapiens 0-9 12086898-10 2001 NF-kappaB-dependent gene expression, however, was ultimately suppressed by Ly294002, suggesting that PI3k-dependent activation of NF-kappaB is IkappaBalpha independent. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 nuclear factor kappa B subunit 1 Homo sapiens 130-139 11435419-7 2001 Placing PYK2 upstream of both PI3K and Akt activation, PYK2 activated Akt through a PI3K-dependent pathway, and either a dominant negative form of Akt or the PI3K inhibitor LY294002 blocked PYK2-stimulated NF-kappa B-dependent transcription. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 173-181 nuclear factor kappa B subunit 1 Homo sapiens 206-216 11931654-11 2002 In addition, inhibition of PI-3K with wortmannin and LY294002 blocked beta1 integrin-mediated NF-kappaB activation, but did not affect that mediated by beta2 integrin. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 53-61 nuclear factor kappa B subunit 1 Homo sapiens 94-103 11728454-3 2001 The formation of tubular morphogenesis was inhibited by using the PI3-kinase and NF-kappaB antagonists LY294002 and SN50 respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 103-111 nuclear factor kappa B subunit 1 Homo sapiens 81-90 11590203-4 2001 Activation of both ERK and NF-kappaB was blocked by wortmannin and LY294002, specific inhibitors of PI 3-K. Wortmannin also inhibited the Fc receptor-mediated increase in the cytosolic calcium concentration, but it did not block immunoglobulin G (IgG)-mediated phagocytosis. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 67-75 nuclear factor kappa B subunit 1 Homo sapiens 27-36 11367542-6 2001 In this context, pretreatment of LY294002, but not SB203580, inhibited IL-1-induced NF-kappa B activation significantly. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 33-41 nuclear factor kappa B subunit 1 Homo sapiens 84-94 11367542-9 2001 Namely, LY294002 inhibited TRAF6-mediated IL-1-induced NF-kappa B and AP-1 activation markedly, while SB203580 inhibited TRAF6-induced AP-1 activation but not NF-kappa B activation. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 8-16 nuclear factor kappa B subunit 1 Homo sapiens 55-65 34419144-17 2021 LY294002, a PI3K inhibitor, attenuated the phosphorylation of PI3K, AKT, and NF-kappaB p65, and the nuclear translocation of NF-kappaB p65. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 nuclear factor kappa B subunit 1 Homo sapiens 77-86 35500642-11 2022 NAC, LY294002 and PDTC treatment resulted in reduced nuclear translocation of NF-kappaB and decreased expression of inflammatory markers in HG treated ARPE-19 cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 5-13 nuclear factor kappa B subunit 1 Homo sapiens 78-87