PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11746825-6	2001	Furthermore, application of the phosphatidylinositol-3"-OH kinase inhibitor LY294002 specifically induced apoptosis in Cx43-transfected cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	gap junction protein alpha 1	Homo sapiens	119-123	
10792610-11	2000	Using two structurally unrelated PI3K inhibitors, wortmanin and LY294002, both tyrosine phosphorylation of Cx43 and activation of ERK stimulated by PDGF were largely blocked.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	gap junction protein alpha 1	Homo sapiens	107-111	
24002703-5	2013	Doxycycline (10 mug/mL), an inhibitor of MMP, markedly attenuated the hypoxia-induced downregulation of Cx43 protein expression at 6 h. The hypoxia-induced decrease in Cx43 protein expression was significantly reversed by U0126 (10 muM), a MEK/ERK1/2 inhibitor, at 6 and 12 h; LY294002 (30 muM), a PI3K inhibitor, downregulated Cx43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	gap junction protein alpha 1	Homo sapiens	104-108	
26138882-7	2015	Our data also showed that the mineralcorticoid receptor (MR) antagonist spironolactone, ERK1/2 inhibitor PD98059 and PKC inhibitor GF109203X could attenuate the down-regulation of Cx43 expression in Aldo-induced MC proliferation; however, the PI3K inhibitor LY294002 could block MC proliferation without affecting Cx43 expression at either the mRNA or protein level.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	258-266	gap junction protein alpha 1	Homo sapiens	180-184	
24002703-5	2013	Doxycycline (10 mug/mL), an inhibitor of MMP, markedly attenuated the hypoxia-induced downregulation of Cx43 protein expression at 6 h. The hypoxia-induced decrease in Cx43 protein expression was significantly reversed by U0126 (10 muM), a MEK/ERK1/2 inhibitor, at 6 and 12 h; LY294002 (30 muM), a PI3K inhibitor, downregulated Cx43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	gap junction protein alpha 1	Homo sapiens	168-172	
24002703-5	2013	Doxycycline (10 mug/mL), an inhibitor of MMP, markedly attenuated the hypoxia-induced downregulation of Cx43 protein expression at 6 h. The hypoxia-induced decrease in Cx43 protein expression was significantly reversed by U0126 (10 muM), a MEK/ERK1/2 inhibitor, at 6 and 12 h; LY294002 (30 muM), a PI3K inhibitor, downregulated Cx43 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	277-285	gap junction protein alpha 1	Homo sapiens	168-172	
22611165-14	2012	Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	gap junction protein alpha 1	Homo sapiens	222-226	
22611165-14	2012	Furthermore, while the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway did not alter GJA1 phosphorylation, treatment with PI3K/AKT inhibitor LY294002 significantly (P=0.024) inhibited the EGF-stimulated increase in GJA1 total protein levels at 24 h. Immunolocalization indicated that loss of PI3K/AKT signaling was associated with increased cytosolic localization of Cx43 in this cell line.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	148-156	gap junction protein alpha 1	Homo sapiens	374-378	
15881420-8	2005	Addition of the PI3K inhibitor LY294002 decreased GJIC and Cx43 expression in astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	gap junction protein alpha 1	Homo sapiens	59-63