PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11477102-8	2001	IL-18-induced adhesion molecule expression appears to be mediated through nuclear factor kappa B (NF kappa B) and phosphatidyl-inositol 3 kinase (PI 3-kinase) since addition of inhibitors to either NF kappa B (pyrrolidine dithiocarbamate and N-acetyl-l-cysteine) or PI 3-kinase (LY294002) inhibited RA synovial fibroblast VCAM-1 expression by 50 to 60%.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	279-287	interleukin 18	Homo sapiens	0-5	
18520705-5	2008	However, pretreatment with the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 increased apoptosis more effectively in IL-18- than in LPS-stimulated cells, whereas the ERK inhibitor PD98059 had the same effect in both.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	78-86	interleukin 18	Homo sapiens	127-132	
15574430-7	2005	Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-199	interleukin 18	Homo sapiens	67-72	
15574430-7	2005	Investigation into possible signal transduction pathways mediating IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect that was blocked by wortmannin and LY-294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	190-199	interleukin 18	Homo sapiens	95-100	
12105209-3	2002	Using phosphoinositide 3-kinase (PI3-kinase) inhibitor LY294002 and Src inhibitor PP2, we show that interleukin (IL)-18-induced ERK1/2 activation is Src kinase-dependent.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	interleukin 18	Homo sapiens	100-119	
29218606-6	2018	Then we found that PI3K inhibitor LY294002 reduced L-selectin- and PSGL-1-induced mRNA upregulation of IL-18 in Jurkat cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	34-42	interleukin 18	Homo sapiens	103-108	
18064631-7	2008	Investigation of signaling intermediates revealed that IL-18 stimulated PI3 kinase activity (blocked by wortmannin, LY294002, or Ad.dnPI3Kp85), and Akt phosphorylation and kinase activity (blocked by SH-5 or Ad.dnAkt).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	116-124	interleukin 18	Homo sapiens	55-60	
14872485-10	2004	NF-kappaB inhibitors N-acetyl-L-cysteine and Bay 11-7085 and PI 3-kinase inhibitor LY294002 inhibited the enhancing effects of IL-18, but MAPK p38 inhibitor SB203580, ERK inhibitor PD98059, and JNK inhibitor SP600125 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	83-91	interleukin 18	Homo sapiens	127-132