PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32871684-7	2020	RESULT: Our results showed that the decreasing effects of CUMS and CSDS on the mTORC1 signaling cascade in the hippocampus and mPFC were restored by venlafaxine, and the use of rapamycin, LY294002, U0126 and mTORC1-shRNA fully abolished the anti-stress actions of venlafaxine in mice.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	188-196	CREB regulated transcription coactivator 1	Mus musculus	79-85	
31120172-5	2019	In addition, AKT, which is an upstream protein kinase of mTORC1 and is downstream of mTORC2, is inhibited by LY294002 (a phosphatidylinositol 3-kinase inhibitor), but not by rapamycin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	109-117	CREB regulated transcription coactivator 1	Mus musculus	57-63	
28365917-12	2017	HBSP activated the PI3K/Akt/mTORC1 pathway, which was confirmed by the PI3K inhibitor LY294002 both in vivo and in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	86-94	CREB regulated transcription coactivator 1	Mus musculus	28-34	
27167250-7	2016	This carbachol-stimulated S6K1 activation was abrogated by LY294002 or the mTORC1 inhibitor rapamycin, supporting the notion that mAChRs mediate S6K1 activation via the PI3K-Akt-mTORC1 pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	59-67	CREB regulated transcription coactivator 1	Mus musculus	178-184	
27421985-10	2016	Besides, we found evidence that LY294002 directly inhibits mTORC1.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	CREB regulated transcription coactivator 1	Mus musculus	59-65	
22820188-5	2012	Suppression Akt/mTOR complex 1(mTORC1) activation by LY 294002 and rapamycin inhibited TNF-alpha-mediated MMP-9 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	53-62	CREB regulated transcription coactivator 1	Mus musculus	31-37	
23272152-9	2012	mTORC1 activity was sensitive to LY294002 and rapamycin or transfection of cells with GRP78 dsRNA.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	33-41	CREB regulated transcription coactivator 1	Mus musculus	0-6	
19120326-11	2009	CONCLUSIONS: mTORC1 inhibition with rapamycin and with LY294002 can lead to AKT phosphorylation in melanoma cells via mTORC2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	55-63	CREB regulated transcription coactivator 1	Mus musculus	13-19	
29792861-7	2018	Conversely, Akt-mTORC1 inhibitors (RAD001 and LY294002) reduced NLGN3-induced HO1, NOQ1 and GCLC mRNA expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	46-54	CREB regulated transcription coactivator 1	Mus musculus	16-22	
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	CREB regulated transcription coactivator 1	Mus musculus	149-155	
35582997-11	2022	In addition, LY294002 treatment reversed the increased Th17 cell percentage, as well as the increased expression of Notch1, NICD1, Hes1, AKT, p-AKT, mTORC1, p-mTORC1, S6K1, S6K2 and IL-17A, and the decreased expression of PTEN.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	CREB regulated transcription coactivator 1	Mus musculus	159-165