PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24757411-10	2014	Treatment with LY294002 further decreased the expression of survivin and Bcl-2 and increased caspase-3 levels.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	BCL2 apoptosis regulator	Homo sapiens	73-78	
24941119-8	2014	The PI3K inhibitor LY294002 reverses the AEG-1 dependent effects on Akt phosphorylation, Bcl-2 expression and anoikis resistance.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	BCL2 apoptosis regulator	Homo sapiens	89-94	
19709444-12	2009	When cells were treated with LY294002, a potent phosphoinositide 3-kinase inhibitor, Akt phosphorylation and Bcl-2 levels were reduced and Hsp70 downregulation no longer had a cytoprotective effect.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2 apoptosis regulator	Homo sapiens	109-114	
24476894-11	2014	The addition of LY294002 enabled to suppress Bcl-2 expression and cell proliferation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	BCL2 apoptosis regulator	Homo sapiens	45-50	
23910058-7	2014	Molecularly, LY294002 treatment down-regulated AEG-1 expression, AKT and GSK3beta phosphorylation, and expression of cyclinD1, CDK4, VEGF and Bcl2, but up-regulated Bax and c-Myc expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2 apoptosis regulator	Homo sapiens	142-146	
21749866-4	2012	In addition, PI-3Kinase Inhibitor (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY294002) could suppress the Chlorogenic acid-induced: (1) the cellular protective role, (2) the increase of the FOXO family genes expression, (3) increased expression of Bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	35-83	BCL2 apoptosis regulator	Homo sapiens	256-261	
21749866-4	2012	In addition, PI-3Kinase Inhibitor (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, LY294002) could suppress the Chlorogenic acid-induced: (1) the cellular protective role, (2) the increase of the FOXO family genes expression, (3) increased expression of Bcl-2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	85-93	BCL2 apoptosis regulator	Homo sapiens	256-261	
21765100-7	2011	Pretreatment with phosphatidylinositide 3-kinase/Akt inhibitor (LY-294002) prior to Ucn2 led to downregulation of CREB phosphorylation and hence reduced Bcl-2 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-73	BCL2 apoptosis regulator	Homo sapiens	153-158	
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 apoptosis regulator	Homo sapiens	104-109	
21130731-6	2011	Inhibition of AKT activation by phosphoinocitide 3-kinase (PI3K) inhibitor LY294002 resulted in reduced Bcl-2 expression and enhanced Bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of ERK1/2 activation by mitogen-activated protein kinase (MEK) inhibitor U0126 did not induce apoptosis without affecting the expression of Bcl-2 and Bax but decreased cell growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	75-83	BCL2 apoptosis regulator	Homo sapiens	359-364	
23743572-11	2013	Finally, LY294002 was able to decrease the expression of MDR1/P-gp, Bcl-2 and XIAP, and upregulate expression of Bax and caspase-3, thereby enhancing chemosensitivity to VCR by inhibiting a drug pump and inducing apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BCL2 apoptosis regulator	Homo sapiens	68-73	
23420486-4	2013	The combination mifepristone/LY294002, but not the individual drugs, killed ovarian cancer cells via apoptosis, as attested by genomic DNA fragmentation and cleavage of caspase-3, and the concomitant down-regulation of anti-apoptotic proteins Bcl-2 and XIAP.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	29-37	BCL2 apoptosis regulator	Homo sapiens	243-248	
22086271-9	2012	In addition, p-Akt and Bcl-2, which can promote TMZ resistance, were markedly decreased by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	91-99	BCL2 apoptosis regulator	Homo sapiens	23-28	
21468550-11	2011	Furthermore, the miR-21 induced BCL-2 up-regulation could be cancelled by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	93-101	BCL2 apoptosis regulator	Homo sapiens	32-37	
21320517-5	2011	And inhibition of phosphatidylinositol-3-kinase (PI3K)/Akt cascade by LY294002 and wortmannin significantly blocked the protective effects of PQQ, and alleviated the increase in Bcl-2/Bax ratio.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	BCL2 apoptosis regulator	Homo sapiens	178-183	
17234779-6	2007	In turn, leukemic cells growing in direct contact with bone marrow stromal elements induce activation of Akt, ERK1/2, and STAT3 signaling in MSC, accompanied by significant increase in Hes1 and Bcl-2 proteins, which were all suppressed by QLT0267 and LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	251-259	BCL2 apoptosis regulator	Homo sapiens	194-199	
19051078-7	2008	Both LY294002 and API-2, an Akt inhibitor, decreased the Bcl-2/Bax ratio in menadione-exposed myotubes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2 apoptosis regulator	Homo sapiens	57-62	
18356276-10	2008	The progrowth signaling via AKT-mammalian target rapamycin-p70(S6K) and cyclin D1/cyclin-dependent kinase were inhibited, and proapoptotic activity of Bcl-2-associated death promoter was increased by LY294002 treatment.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	200-208	BCL2 apoptosis regulator	Homo sapiens	151-156	
16162974-6	2005	Finally, the analysis of the molecular markers that might be implicated in the synergism between LY294002 and gemcitabine suggests that PI3K inhibition might aid chemotherapeutic treatment, leading to changes in the balance between anti- and pro-apoptotic molecules of the Bcl-2 family, Bcl-XL and Bax.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	97-105	BCL2 apoptosis regulator	Homo sapiens	273-278	
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	BCL2 apoptosis regulator	Homo sapiens	305-310	
16546963-8	2006	Treatment of cells with cerulenin and LY294002 down-regulated the protein levels of X chromosome-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis 1 (cIAP-1), and Akt, whereas the levels of mitogen-activated protein/extracellular signal-regulated kinase kinase and other antiapoptotic Bcl-2 family proteins (Bcl-2 and Bcl-xl) did not change.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	BCL2 apoptosis regulator	Homo sapiens	328-333	
14605879-7	2004	Decreased phosphorylated-Akt by LY294002 treatment led to a down-regulation of Mcl-2 and phosphorylated Bad proteins, which are anti-apoptotic factors and belong to the Bcl-2 family.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	BCL2 apoptosis regulator	Homo sapiens	169-174	
15292252-9	2004	Bcl-2 expression was markedly elevated in VEGF-treated HDMECs, and it was significantly inhibited by the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	120-128	BCL2 apoptosis regulator	Homo sapiens	0-5	
12879014-7	2003	In contrast, treatment of cells with LY294002, to inhibit phosphoinositide 3-kinase (PI3K), caused downregulation of Bcl-2 and Mcl-1 and allowed deltaMEKK1:ER* to elicit a robust apoptotic response characterized by activation of Bax and caspases.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	BCL2 apoptosis regulator	Homo sapiens	117-122	
34558536-7	2022	These effects on Bax, Bcl-2, and Caspase-3 were blocked by pretreatment with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	96-104	BCL2 apoptosis regulator	Homo sapiens	22-27	
12731064-7	2003	All TGF-beta 1-mediated effects, but Bcl2 up-regulation, can be reproduced by the LY294002 phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor but not by inhibitors of the MAPK/ERK (MEK) and Janus kinase (Jak)/STAT pathways, which promote cell death.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	82-90	BCL2 apoptosis regulator	Homo sapiens	37-41	
11767000-4	2001	LY294002 (LY)-mediated inhibition of P13-K activity down-regulated Bcl-2 but not Mcl-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-8	BCL2 apoptosis regulator	Homo sapiens	67-72	
11767000-4	2001	LY294002 (LY)-mediated inhibition of P13-K activity down-regulated Bcl-2 but not Mcl-1 expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	0-2	BCL2 apoptosis regulator	Homo sapiens	67-72	
12663669-6	2003	In contrast, overexpression of Bcl-2 protects EC treated with cytokine plus LY294002 but not EC treated with cytokine plus cycloheximide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	BCL2 apoptosis regulator	Homo sapiens	31-36	
12056831-8	2002	In contrast, LY294002-treated astrocytes expressed a higher level of Bcl-2 than controls as shown by Western blots.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-21	BCL2 apoptosis regulator	Homo sapiens	69-74	
34339756-11	2021	Gene and protein detection showed that DG-8d or DG-8d combined with LY294002 could down-regulate signaling molecules of Bcl-2, PI3k, p-Akt, p-FoxO3a and up-regulate signaling molecules of Bax snd Bim.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	68-76	BCL2 apoptosis regulator	Homo sapiens	120-125	
34697781-11	2021	Western blotting results showed that JB and LY294002 treatment significantly inhibited the levels of Bcl-2, p-PI3K, and p-Akt while the levels of Bax, cleaved caspase-3, and PTEN protein significantly increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	44-52	BCL2 apoptosis regulator	Homo sapiens	101-106	
33846811-4	2021	At the molecular level, LY294002 and ABT199 combination treatment significantly downregulated Skp2, Bcl2, procaspase-3 and procaspase-9 expression levels, but markedly upregulated p27, Bax, cleaved caspase-3 and caspase-9 expression levels in K562, HL-60 and KG1a cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	24-32	BCL2 apoptosis regulator	Homo sapiens	100-104	
32463592-7	2020	Cystic fibrosis transmembrane conductance regulator activates Akt/Bcl2 pathway, and suppression of PI3K/Akt pathway abolishes CFTR overexpression-induced up-regulation of Bcl2 (MK-2206 and LY294002) and cell viability (MK-2206).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	189-197	BCL2 apoptosis regulator	Homo sapiens	171-175	
32922037-12	2020	However, LY294002 reversed CPA4 overexpression-stimulated cell proliferation and drug resistance in vitro in Bcl2/Bax and caspase3-dependent apoptosis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	9-17	BCL2 apoptosis regulator	Homo sapiens	109-113	
32722075-8	2020	In addition, LY and TAM combination induced the apoptotic genes Caspase-3, Caspase-7, and p53, as well as p21 as cell cycle promotor, and significantly downregulated the anti-apoptotic genes Bcl-2 and survivin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	13-15	BCL2 apoptosis regulator	Homo sapiens	191-196	
32722075-11	2020	The results suggested that the synergistic cytotoxic effect of LY and TAM is achieved by the induction of apoptosis and cell cycle arrest through cyclin D1, pAKT, caspases, and Bcl-2 signaling pathways.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	63-65	BCL2 apoptosis regulator	Homo sapiens	177-182	
32691555-4	2020	With LY294002 pretreatment, the mitochondrial transmembrane potential level and the expressions of p-PI3K, p-AKt and Bcl-2 were decreased, the expression of Bax and the apoptosis rate were increased.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	5-13	BCL2 apoptosis regulator	Homo sapiens	117-122	
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	BCL2 apoptosis regulator	Homo sapiens	433-450	
31786865-3	2019	The experimental methods are as follows: (1) The proliferation of HGC-27 cells inhibited by Apatinib and LY294002 was observed by 3-(4,5)-dimethylthiahiazo-(z-y1)-3,5-diphenytetrazoli- umromide (MTT) assay; (2) flow cytometry was adopted to detect the apoptosis of cells after they were treated with drugs and the positive control; (3) different effects of varying concentrations of Apatinib on apoptosis-related genes and proteins, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax) and cysteine-aspartic acid protease (Caspase) 9, were detected via fluorescence quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB), and the effects of different concentrations of Apatinib on the protein expressions of PI3K, phosphorylated (p)-PI3K, Akt and p-Akt were detected by Western blotting.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	105-113	BCL2 apoptosis regulator	Homo sapiens	452-457	
30061946-10	2018	PI3K/AKT inhibitor LY294002 restored DTX-induced caspase-3 activation and Bcl-2 phosphorylation, reversed the effect of CCL2 on the viability of A549 cells and enhanced DTX-induced cytotoxicity.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	BCL2 apoptosis regulator	Homo sapiens	74-79	
29263137-8	2018	Using the signaling pathway inhibitor LY294002, we found that Bcl-2 expression and eNOS phosphorylation after Ninj1 blockade were regulated via PI3K/Akt signaling pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	38-46	BCL2 apoptosis regulator	Homo sapiens	62-67	
29545835-5	2018	Western blotting demonstrated that the expression of p-FOXO1 and B-cell lymphoma 2 (Bcl2) were significantly reduced, whereas the expression of Bcl-2-associated X protein was significantly increased following treatment with LY294002 and/or UO126 (all P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	BCL2 apoptosis regulator	Homo sapiens	65-82	
29545835-5	2018	Western blotting demonstrated that the expression of p-FOXO1 and B-cell lymphoma 2 (Bcl2) were significantly reduced, whereas the expression of Bcl-2-associated X protein was significantly increased following treatment with LY294002 and/or UO126 (all P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	BCL2 apoptosis regulator	Homo sapiens	84-88	
29545835-5	2018	Western blotting demonstrated that the expression of p-FOXO1 and B-cell lymphoma 2 (Bcl2) were significantly reduced, whereas the expression of Bcl-2-associated X protein was significantly increased following treatment with LY294002 and/or UO126 (all P<0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	224-232	BCL2 apoptosis regulator	Homo sapiens	144-149	
29071206-8	2017	The expression of p-p65, p-AKT and Bcl-2 was significantly reduced by LY294002, but increased by ERbeta siRNA (p < 0.05).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	70-78	BCL2 apoptosis regulator	Homo sapiens	35-40	
28789432-6	2017	In addition, luteolin combined with LY294002 markedly increased the Bax/Bcl-2 ratio, while when combined with U0126, luteolin had less effects on the Bax/Bcl-2 ratio compared with luteolin treatment alone, suggesting that both the MAPK and PI3K signaling pathways are involved in the apoptosis induced by luteolin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	36-44	BCL2 apoptosis regulator	Homo sapiens	72-77	
26796279-9	2016	The combination of LY294002, PI3K inhibitor, and curcumin induced cell cycle arrest by decreasing CDK4, CDK2 and cyclin E2 in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	19-27	BCL2 apoptosis regulator	Homo sapiens	126-131	
28775672-11	2017	Subsequently, a significantly decreased expression of p-AKT and Bcl-2, increased expression of Caspase-3 were observed in the LY294002 plus radiation group compared with radiation alone group, while these influences caused by LY294002 or X-ray radiation were reversed after COL1A1 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	126-134	BCL2 apoptosis regulator	Homo sapiens	64-69	
26796279-10	2016	Moreover, LY294002 further inhibited the phosphorylation of Akt in Bcl-2+ MCF-7 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	10-18	BCL2 apoptosis regulator	Homo sapiens	67-72	
25960232-6	2015	Pre-treatment of PI3K inhibitor LY294002 enhanced curcumin-induced cell death, apoptosis, and autophagy via modulating the expression of Bcl-2 family members and autophagosome formation in MCF-7 breast cancer cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	BCL2 apoptosis regulator	Homo sapiens	137-142	
26256949-8	2015	Inhibition of endogenous Akt by LY294002 resulted in decreased expression of Sox2, ALDH1, and CD133, leading to enhancement of cobalt chloride-mediated apoptotic events due to altered ratio of bcl-2 to bax expression.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	BCL2 apoptosis regulator	Homo sapiens	193-198	
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	BCL2 apoptosis regulator	Homo sapiens	50-54	
25510413-6	2015	In parallel, the interaction between the level of BCL2, BAX and PTEN with the specific PI3K/AKT inhibitor-LY294002 was highly significant for BCL2 and nearly significant for PTEN and BAX.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	106-114	BCL2 apoptosis regulator	Homo sapiens	142-146