PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19331140-9	2009	RESULTS: Y-27632 reduced phosphorylation of ERK1/2 at 0.5 and 2 h. U0126 in combination with Y-27632 led to a more pronounced repression of platelet-derived growth factor (PDGF)- or fibronectin (FN)-induced ERK1/2 activation than U0126 treatment alone.	Y 27632	9-16	fibronectin 1	Homo sapiens	182-193	
19331140-9	2009	RESULTS: Y-27632 reduced phosphorylation of ERK1/2 at 0.5 and 2 h. U0126 in combination with Y-27632 led to a more pronounced repression of platelet-derived growth factor (PDGF)- or fibronectin (FN)-induced ERK1/2 activation than U0126 treatment alone.	Y 27632	9-16	fibronectin 1	Homo sapiens	195-197	
19331140-9	2009	RESULTS: Y-27632 reduced phosphorylation of ERK1/2 at 0.5 and 2 h. U0126 in combination with Y-27632 led to a more pronounced repression of platelet-derived growth factor (PDGF)- or fibronectin (FN)-induced ERK1/2 activation than U0126 treatment alone.	Y 27632	93-100	fibronectin 1	Homo sapiens	182-193	
19331140-9	2009	RESULTS: Y-27632 reduced phosphorylation of ERK1/2 at 0.5 and 2 h. U0126 in combination with Y-27632 led to a more pronounced repression of platelet-derived growth factor (PDGF)- or fibronectin (FN)-induced ERK1/2 activation than U0126 treatment alone.	Y 27632	93-100	fibronectin 1	Homo sapiens	195-197	
19331140-11	2009	Furthermore, PDGF and FN-induced cell proliferation was suppressed by pre-treatment with Y-27632 or U0126, with the greatest reduction achieved by a combination of the two inhibitors.	Y 27632	89-96	fibronectin 1	Homo sapiens	22-24	
16125171-5	2006	The cell adhesion assay showed that Y-27632 promoted the cell adhesiveness to both fibronectin and collagen type I in a dose-dependent manner.	Y 27632	36-43	fibronectin 1	Homo sapiens	83-94	
12208777-10	2002	In smooth muscle cells, Y-27632 induced disassembly of both actin cytoskeleton and extracellular fibronectin matrix.	Y 27632	24-31	fibronectin 1	Homo sapiens	97-108	
14991713-15	2004	In addition, an in vitro caspase-3 activity assay was used to determine that caspase-3 activity was higher in epithelia treated with 10 microM Y-27632 than in those isolated without the basal lamina or epithelia stimulated with fibronectin, COL, or LPA.	Y 27632	143-150	fibronectin 1	Homo sapiens	228-239	
28370928-9	2017	Y-27632 significantly inhibited ALP at the mRNA and protein activity levels in the late stage of differentiation; concomitantly, the actin filament content and the extracellular levels of collagen-I and fibronectin were markedly decreased by Y-27632.	Y 27632	0-7	fibronectin 1	Homo sapiens	203-214	
27590529-5	2016	FIB significantly enhanced cell elongation even in presence of actin polymerization blockers cytochalasin D (CytoD) and ROCK inhibitor Y-27632, which generally caused more rounded cells.	Y 27632	135-142	fibronectin 1	Homo sapiens	0-3	
27590529-8	2016	CytoD enabled osteogenic differentiation independently from the ECM, while it was rather blocked via Y-27632 treatment; on FIB the general highest extent of differentiation occurred.	Y 27632	101-108	fibronectin 1	Homo sapiens	123-126	
25627685-5	2015	The augmented rate of FN matrix formation by myofibroblasts was dependent on intact Rho/Rho kinase (ROCK) and myosin signals inasmuch as treatment with Y27632 or blebbistatin attenuated 488-FN assembly.	Y 27632	152-158	fibronectin 1	Homo sapiens	22-24	
25627685-5	2015	The augmented rate of FN matrix formation by myofibroblasts was dependent on intact Rho/Rho kinase (ROCK) and myosin signals inasmuch as treatment with Y27632 or blebbistatin attenuated 488-FN assembly.	Y 27632	152-158	fibronectin 1	Homo sapiens	190-192	
23550216-1	2013	AIM: To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor (CTGF) or transforming growth factor-beta (TGF-beta) in a human retinal pigment epithelial cell line, ARPE-19.	Y 27632	80-86	fibronectin 1	Homo sapiens	167-178	
23550216-11	2013	Y27632, a ROCK inhibitor, inhibited the transcription of fibronectin, MMP-2 and type I collagen, but not laminin.	Y 27632	0-6	fibronectin 1	Homo sapiens	57-68	
22969074-9	2012	In TM cells, the mRNA expressions of COL4A1 and fibronectin were increased significantly by DEX treatment, but combined treatment with Y-27632 and DEX significantly inhibited the increase in COL4A1 and fibronectin expression.	Y 27632	135-142	fibronectin 1	Homo sapiens	48-59	
22969074-9	2012	In TM cells, the mRNA expressions of COL4A1 and fibronectin were increased significantly by DEX treatment, but combined treatment with Y-27632 and DEX significantly inhibited the increase in COL4A1 and fibronectin expression.	Y 27632	135-142	fibronectin 1	Homo sapiens	202-213	
22232246-7	2012	Furthermore, ROCK inhibitor Y27632 reversed the increase in fibronectin induced by ET-1/ET(A)R.	Y 27632	28-34	fibronectin 1	Homo sapiens	60-71	
25561973-6	2015	Inhibition of stress fiber formation with the Rho kinase inhibitor Y-27632, in turn, reduced fibronectin matrix assembly and colony formation in fibrin suggesting that spreading is a critical mechanism for the outgrowth of metastatic kidney tumor cells.	Y 27632	67-74	fibronectin 1	Homo sapiens	93-104