PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23281046-7	2013	The ROK inhibitor Y-27632 abolished the stretch-induced increase and reduced the level of MYPT1-p[Thr853] to <50% of the basal values in normal Krebs buffer.	Y 27632	18-25	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	90-95	
21393429-9	2011	ET-1 induced phosphorylation of MYPT1 at Thr853, which was suppressed by the ROCK inhibitor Y-27632.	Y 27632	92-99	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	32-37	
22817114-8	2012	In intact synaptosomes, TMC increased, whereas Y27632 decreased the phosphorylation levels of MYPT1(Thr696) , myosin-II light chain(Ser19) , synapsin-I(Ser9) , and syntaxin-1(Ser14) , indicating that PP1M and ROK influence their phosphorylation status.	Y 27632	47-53	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	94-99	
22817114-8	2012	In intact synaptosomes, TMC increased, whereas Y27632 decreased the phosphorylation levels of MYPT1(Thr696) , myosin-II light chain(Ser19) , synapsin-I(Ser9) , and syntaxin-1(Ser14) , indicating that PP1M and ROK influence their phosphorylation status.	Y 27632	47-53	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	200-204	
18929559-4	2008	Pre-incubation with a selective mineralocorticoid receptor antagonist, eplerenone (10 micromol/L), or a specific Rho-kinase inhibitor, Y27632 (10 micromol/L), attenuated the aldosterone-induced increase in MYPT-1 phosphorylation.	Y 27632	135-141	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	206-212	
21787615-7	2010	Both H1152 and Y27632, inhibitors of Rho kinase, but not Ro31-8220, an inhibitor of PKC, attenuated NaF-induced contraction and phosphorylation level of MLC(20), MYPT1(Thr855) and CPI17(Thr38).	Y 27632	15-21	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	162-167	
15127884-4	2004	The phosphorylation level of myosin phosphatase target subunit 1 (MYPT1) at the inhibitory site was also significantly higher in SHRSP, and the phosphorylation levels in both VSMCs were strongly inhibited to a similar extent by treatment with Y-27632, a Rho-kinase inhibitor.	Y 27632	243-250	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	29-64	
18032393-13	2008	The effects of SU6656 and Y27632, on both contraction and MYPT-1 and MLC20 phosphorylation, were not additive.	Y 27632	26-32	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	58-64	
17382904-6	2007	The increased MYPT1(Thr855) phosphorylation was inhibited by Y27632 (1.0 microM) in parallel with inhibition of MLC(20) phosphorylation and vascular contraction.	Y 27632	61-67	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	14-19	
16953424-4	2006	Phenylephrine and U46619 significantly increased MYPT1(Thr855) phosphorylation that was eliminated by Y27632 pretreatment, whereas MYPT1(Thr697) phosphorylation was not stimulated.	Y 27632	102-108	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	49-54	
15371261-7	2004	Phosphorylation of the myosin light chain phosphatase target subunit (MYPT1) was increased by ROS, and preincubation with Y-27632 blocked this increased phosphorylation.	Y 27632	122-129	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	70-75	
15127884-4	2004	The phosphorylation level of myosin phosphatase target subunit 1 (MYPT1) at the inhibitory site was also significantly higher in SHRSP, and the phosphorylation levels in both VSMCs were strongly inhibited to a similar extent by treatment with Y-27632, a Rho-kinase inhibitor.	Y 27632	243-250	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	66-71	
29795210-9	2018	Intergroup differences in contractile responses and phospho-MYPT1-Thr855 were eliminated by Y27632.	Y 27632	92-98	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	60-65	
12600888-4	2003	The angiotensin II-induced phosphorylation of MYPT1 was completely blocked by 8-bromo-cGMP or Y-27632 (a Rho-kinase inhibitor), but not by GF109203X (a PKC inhibitor).	Y 27632	94-101	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	46-51	
34634287-0	2021	The ROCK inhibitor Y-27632 ameliorates blood-spinal cord barrier disruption by reducing tight junction protein degradation via the MYPT1-MLC2 pathway after spinal cord injury in rats.	Y 27632	19-26	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	131-136	
31997879-9	2019	Results: Except for RhoA protein expression, compared with the SCI model group, EA, blocking agent Y27632 and EA+blocking agent Y27632 treatment groups had significantly reduced mRNA and protein expression of Nogo-A, NgR, LINGO-1, RhoA and ROCK II in spinal cord tissues, increased mRNA and protein expression of MLCP, decreased p-MYPT1 protein expression and p-MYPT1/MYPT1 ratio, and caspase3 expression, and improved lower limb movement function after treatment for 14 days (P<0.01 or <0.05).	Y 27632	128-134	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	331-336	
31997879-9	2019	Results: Except for RhoA protein expression, compared with the SCI model group, EA, blocking agent Y27632 and EA+blocking agent Y27632 treatment groups had significantly reduced mRNA and protein expression of Nogo-A, NgR, LINGO-1, RhoA and ROCK II in spinal cord tissues, increased mRNA and protein expression of MLCP, decreased p-MYPT1 protein expression and p-MYPT1/MYPT1 ratio, and caspase3 expression, and improved lower limb movement function after treatment for 14 days (P<0.01 or <0.05).	Y 27632	128-134	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	362-367	
31997879-9	2019	Results: Except for RhoA protein expression, compared with the SCI model group, EA, blocking agent Y27632 and EA+blocking agent Y27632 treatment groups had significantly reduced mRNA and protein expression of Nogo-A, NgR, LINGO-1, RhoA and ROCK II in spinal cord tissues, increased mRNA and protein expression of MLCP, decreased p-MYPT1 protein expression and p-MYPT1/MYPT1 ratio, and caspase3 expression, and improved lower limb movement function after treatment for 14 days (P<0.01 or <0.05).	Y 27632	128-134	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	362-367	
26610064-10	2016	Western blot analysis revealed that both atorvastatin (10(-4) m) and Y-27632 (10(-6) m) pretreatment inhibited the phosphorylation of myosin phosphatase target subunit-1 (MYPT-1) triggered by NA, indicating an inhibitory influence on myosin phosphatase.	Y 27632	69-76	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	134-169	
26610064-10	2016	Western blot analysis revealed that both atorvastatin (10(-4) m) and Y-27632 (10(-6) m) pretreatment inhibited the phosphorylation of myosin phosphatase target subunit-1 (MYPT-1) triggered by NA, indicating an inhibitory influence on myosin phosphatase.	Y 27632	69-76	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	171-177	
26603619-11	2016	Cystamine and the Rho kinase inhibitor Y27632 reduced basal MYPT1-Thr(855) phosphorylation, but only Y27632 reduced phenylephrine-induced increases in MYPT1-Thr(855) and myosin regulatory light chain phosphorylation.	Y 27632	39-45	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	60-65	
26603619-11	2016	Cystamine and the Rho kinase inhibitor Y27632 reduced basal MYPT1-Thr(855) phosphorylation, but only Y27632 reduced phenylephrine-induced increases in MYPT1-Thr(855) and myosin regulatory light chain phosphorylation.	Y 27632	101-107	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	151-156