PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26955761-9 2016 In addition, in cultured BASMCs, Ang II induced phosphorylation of myosin phosphatase-targeting subunit 1, and myosin light chains were significantly enhanced by TMEM16A overexpression, which were reversed by Rho-associated protein kinase (ROCK) inhibitor, Y-27632, while TMEM16A silencing demonstrated an opposing result. Y 27632 257-264 angiotensinogen Rattus norvegicus 33-39 30108507-7 2018 In the presence of a Rho-kinase inhibitor (Y27632), constrictor responses to NE, Ang II, and PE were significantly reduced in young and old SFA. Y 27632 43-49 angiotensinogen Rattus norvegicus 81-87 28438902-11 2017 Pretreatment of neonate rat cardiomyocytes with ROCK inhibitor Y27632 reduced Ang-II-induced FHOD3 activation and upregulation, suggesting the involvement of ROCK activities. Y 27632 63-69 angiotensinogen Rattus norvegicus 78-84 26652313-13 2016 Addition of Y-27632 to podocytes treated with Ang II could ameliorate F-actin cytoskeleton remodeling and the increment in p-MLC expression. Y 27632 12-19 angiotensinogen Rattus norvegicus 46-52 16916946-10 2006 Y27632 also abolished the cortical F-actin ring induced by Ang II. Y 27632 0-6 angiotensinogen Rattus norvegicus 59-65 22227335-9 2012 Y-27632 reduced the angiotensin II-induced contraction in endothelium-intact or -denuded diabetic rat carotid. Y 27632 0-7 angiotensinogen Rattus norvegicus 20-34 21033356-1 2010 It has been shown that Y-27632, an inhibitor of Rho-associated kinase, delays sarcomere assembly in rat neonatal cardiomyocytes pretreated with angiotensin II. Y 27632 23-30 angiotensinogen Rattus norvegicus 144-158 17666953-11 2008 These effects of Ang-II on vascular reactivity were abolished by Y-27632, the specific Rho kinase inhibitor. Y 27632 65-72 angiotensinogen Rattus norvegicus 17-23 17256744-14 2007 Inhibition of angiotensin II-induced aortic contraction by the Rho-kinase inhibitor Y-27632 was pronounced in BDL rats. Y 27632 84-91 angiotensinogen Rattus norvegicus 14-28 21385178-8 2011 The Rho-kinase inhibitor, Y27632 inhibited sustained constrictions to angiotensin II in ZDF arteries and in +/Fa arteries exposed to HG. Y 27632 26-32 angiotensinogen Rattus norvegicus 70-84 21385178-10 2011 In VSMCs exposed to HG and treated with Y27632, angiotensin II decreased surface AT(1) receptors. Y 27632 40-46 angiotensinogen Rattus norvegicus 48-62 21409351-8 2011 Y27632 (3 x 10(-7)M), a specific inhibitor of Rho kinase, inhibited the Ang II-induced contraction in SHR, but not in WKY. Y 27632 0-6 angiotensinogen Rattus norvegicus 72-78 19716825-3 2009 The anti-hypertrophic effects of inhibition of FPP synthase with alendronate in Ang II-cultured neonatal cardiomyocytes were partially reversed by geranylgeranyol (GGOH) and were mimicked by GGTI-286, a geranylgeranyl transferase-I inhibitor, C3 exoenzyme, an inhibitor of Rho, or Y-27632, an inhibitor of ROCK. Y 27632 281-288 angiotensinogen Rattus norvegicus 80-86 19129253-10 2009 Angiotensin II responses were blunted by Y-27632. Y 27632 41-48 angiotensinogen Rattus norvegicus 0-14 19129253-11 2009 Angiotensin II (1.0 nM) reduced afferent diameter by 17 +/- 1% in untreated arterioles and by 6 +/- 2% during exposure to Y-27632. Y 27632 122-129 angiotensinogen Rattus norvegicus 0-14 18583240-6 2008 Irbesartan or Y27632 treatment significantly lowered MLC phosphorylation level in AngII-induced cells (P<0.01). Y 27632 14-20 angiotensinogen Rattus norvegicus 82-87 18250367-5 2008 Intrarenal Tempol (superoxide dismutase mimetic) or Y27632 (Rho kinase inhibitor) abolished the interaction between UK14,304 and angiotensin II both in vivo and in vitro. Y 27632 52-58 angiotensinogen Rattus norvegicus 129-143 17211247-10 2007 Y-27632 reduced the expression levels of p-ERM in angiotensin II-treated WKY and SHR. Y 27632 0-7 angiotensinogen Rattus norvegicus 50-64 11997258-5 2002 The distinct Rho-associated kinase (ROK) inhibitors HA-1077 and Y-27632, as well as the Rho inhibitor Clostridium botulinum C3 exoenzyme, also significantly attenuated ANG II- and LPA-stimulated Pyk2 tyrosine phosphorylation. Y 27632 64-71 angiotensinogen Rattus norvegicus 168-174 16336575-8 2005 RESULTS: Rats infused with AngII for three days present renal inflammatory cell infiltration and slight tubular damage, which were diminished by treatment with the Rho-kinase inhibitor Y-27632. Y 27632 185-192 angiotensinogen Rattus norvegicus 27-32 16336575-10 2005 Treatment of AngII-infused rats with Y-27632 decreases the upregulation of these proinflammatory and profibrotic mediators. Y 27632 37-44 angiotensinogen Rattus norvegicus 13-18 16712874-8 2006 Specific Rho kinase inhibitor, Y-27632 inhibited angiotensin II-induced cardiomyocyte hypertrophy and increased cyclin D1. Y 27632 31-38 angiotensinogen Rattus norvegicus 49-63 16569756-5 2006 The Rho-kinase inhibitor (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide (Y-27632) (0.1-10 microM) concentration dependently inhibited spontaneous tone in aortic rings from angiotensin II-treated rats. Y 27632 25-92 angiotensinogen Rattus norvegicus 193-207 15550522-5 2005 ANG II-induced vasoconstriction was enhanced in the aortic rings of OZ rats compared with LZ rats, and this enhanced vasoconstriction was partially normalized by fluvastatin and was abolished when the aorta of OZ rats was preincubated with the Rho kinase inhibitor Y-27632. Y 27632 265-272 angiotensinogen Rattus norvegicus 0-6 14512087-7 2003 Both Rho inhibitor, C3 exoenzyme, and Rho kinase inhibitor, Y-27632, mimicked the inhibitory effects of simvastatin against TF and PAI-1 induced by Ang II. Y 27632 60-67 angiotensinogen Rattus norvegicus 148-154 12600888-4 2003 The angiotensin II-induced phosphorylation of MYPT1 was completely blocked by 8-bromo-cGMP or Y-27632 (a Rho-kinase inhibitor), but not by GF109203X (a PKC inhibitor). Y 27632 94-101 angiotensinogen Rattus norvegicus 4-18 11961044-5 2002 Ang II-induced PAI-1 mRNA up-regulation in the left ventricle was inhibited by Y-27632 and candesartan. Y 27632 79-86 angiotensinogen Rattus norvegicus 0-6 11841996-4 2002 ANG II-induced contraction of rat IAS smooth muscle and SMC was attenuated by tyrosine kinase inhibitors genistein and tyrphostin, protein kinase C (PKC) inhibitor H-7, Ca(2+) channel blocker nicardipine, Rho kinase inhibitor Y-27632 or p(44/42) mitogen-activating protein kinase (MAPK(44/42)) inhibitor PD-98059. Y 27632 226-233 angiotensinogen Rattus norvegicus 0-6 11841996-5 2002 Combinations of nicardipine and H-7, Y-27632, and PD-98059 caused further attenuation of the ANG II effects. Y 27632 37-44 angiotensinogen Rattus norvegicus 93-99 11463768-9 2001 Both AdDNRhoK and Y-27632 strongly inhibited Ang II-induced MCP-1 expression. Y 27632 18-25 angiotensinogen Rattus norvegicus 45-51 11498455-7 2001 Selective inhibition of Rho-kinase by Y-27632 (10 micromol/L) and selective disruption of the actin filament network by cytochalasin B (10 micromol/L) both decreased the Ang II-induced contraction by 78+/-1.2% and 87+/-1.9%, respectively, and significantly diminished ERK1/2 activity. Y 27632 38-45 angiotensinogen Rattus norvegicus 170-176 10642317-8 2000 The specific Rho-kinase inhibitor, Y-27632, dose-dependently abolished Ang II-induced protein synthesis and also suppressed Ang II-induced c-fos mRNA expression. Y 27632 35-42 angiotensinogen Rattus norvegicus 71-77 10642317-8 2000 The specific Rho-kinase inhibitor, Y-27632, dose-dependently abolished Ang II-induced protein synthesis and also suppressed Ang II-induced c-fos mRNA expression. Y 27632 35-42 angiotensinogen Rattus norvegicus 124-130