PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19278999-4 2009 ROCK inhibitors, including Y-27632 were reported to decrease aggregation of htt and androgen receptor (AR) through ROCK1 and protein kinase C-related protein kinase-2 (PRK-2). Y 27632 27-34 huntingtin Homo sapiens 76-79 19278999-8 2009 In this study, we show that Y-27632 not only reduced the mutant htt aggregation by enhancing its degradation, but surprisingly was able to activate the main cellular degradation pathways, proteasome, and macroautophagy. Y 27632 28-35 huntingtin Homo sapiens 64-67