PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33237472-4 2021 Rats at postnatal day 7 (PND7) were injected intraperitoneally with RhoA pathway inhibitor Y27632 or saline 20 min before exposed to 2.8% sevoflurane for 4 h. The apoptosis-related proteins and RhoA/CRMP2 pathway proteins in the hippocampus were measured 6 h after sevoflurane exposure. Y 27632 91-97 ras homolog family member A Rattus norvegicus 68-72 32788474-8 2021 Intervention with a Nogo-66 antibody, a LINGO1 blocker, or Y27632, an inhibitor in the Nogo-66-NgR/p75/LINGO-1-RhoA-ROCK pathway, did not affect the death of oligodendrocytes. Y 27632 59-65 ras homolog family member A Rattus norvegicus 111-115 35077573-2 2022 The aim of the present study was to enhance neural tissue regeneration and axon regrowth using Rho-A-kinase inhibitor (Y-27632) in a rat SCI model (Th9 compression) and to bridge the lesion with a chitosan/collagen porous scaffold (ChC-PS) applied two weeks after SCI. Y 27632 119-126 ras homolog family member A Rattus norvegicus 95-100 31596180-9 2021 Results: Compared with injured rats in SCI group, EA, blocking agent Y27632 and EA + blocking agent Y27632 treatment had significantly reduced mRNA and protein expression levels of RhoA and ROCKII, decreased p-MLC protein expression and p-MLC/MLC ratio, suppressed cPLA2 activity and PGE2 level, improved spinal cord tissue morphology and BBB score of lower limb movement function at 7 days and at 14 days (P < 0.01 or <0.05). Y 27632 69-75 ras homolog family member A Rattus norvegicus 181-185 31596180-9 2021 Results: Compared with injured rats in SCI group, EA, blocking agent Y27632 and EA + blocking agent Y27632 treatment had significantly reduced mRNA and protein expression levels of RhoA and ROCKII, decreased p-MLC protein expression and p-MLC/MLC ratio, suppressed cPLA2 activity and PGE2 level, improved spinal cord tissue morphology and BBB score of lower limb movement function at 7 days and at 14 days (P < 0.01 or <0.05). Y 27632 100-106 ras homolog family member A Rattus norvegicus 181-185 33052255-11 2020 It was also substantially prevented by co-incubation with antagonists of RhoA/Rho kinase-mediated signaling (Y27632) or Gq11/phospholipase C/inositol triphosphate receptor-coupled signaling. Y 27632 109-115 ras homolog family member A Rattus norvegicus 73-77 30784777-6 2019 In animal study, we found that activated RhoA-ROCK signaling was responsible for the imbalance in RAS vasoconstrictors both in vitro and in vivo, and further evidence indicated that ROCK inhibitors (Y27632 or HA1077) and an ACE2 activator (Resorcinol naphthalein) restored the dysregulated RAS vasoconstrictors significantly and had a protective role in an APE rat model. Y 27632 199-205 ras homolog family member A Rattus norvegicus 41-45 31963385-3 2020 Herein, CT04 and Y27632 were used to inactivate RhoA and its downstream effector Rho-associated coiled coil-forming kinase (ROCK), while the RhoAQ63L lentiviral vector was utilized to overexpress the constitutively activated RhoA in dorsal root ganglion (DRG) neurons or neuronal differentiated PC12 cells. Y 27632 17-23 ras homolog family member A Rattus norvegicus 48-52 31497201-8 2019 Meanwhile, Y-27632 intervention group also showed lower serum amylase or ascites, plus lower RhoA or ROCK I (P<0.05). Y 27632 11-18 ras homolog family member A Rattus norvegicus 93-97 31369604-7 2019 Inhibiting RhoA/rho kinase (ROCK) with Y27632 (10 muM) suppressed contractions to U46619 and phenylephrine by ~80% and prevented their inhibition by simvastatin. Y 27632 39-45 ras homolog family member A Rattus norvegicus 11-15 29200912-10 2017 Although DeltaTPlum was consistently observed under pretreatment with Rho A-kinase inhibitor (Y27632, 1 microM), a PKC inhibitor (GF 109203X, 10 microM) largely suppressed DeltaTPlum. Y 27632 94-100 ras homolog family member A Rattus norvegicus 70-75 25807302-7 2015 Moreover, inhibition of the RhoA/ROCK pathway by a ROCK inhibitor, Y27632, also attenuated annexin V-induced proliferation and cell cycle progression. Y 27632 67-73 ras homolog family member A Rattus norvegicus 28-32 27216618-5 2016 Treatments that reduced RhoA/LIMK/cofilin pathway activity, including simvastatin, the Rho kinase inhibitor Y-27632, and the synthetic peptide Tat-S3, attenuated actin filament disruption in the dorsal root ganglion and CCI-induced neuropathic pain. Y 27632 108-115 ras homolog family member A Rattus norvegicus 24-28 23424995-14 2013 Addition of Y27632 (a RhoA inhibitor) and DNRhoA counteracted the anti-migratory effects, confirming RhoA involvement. Y 27632 12-18 ras homolog family member A Rattus norvegicus 22-26 23985719-2 2013 Administration of mutated class I major histocompatibility complex molecules or selective targeting of the RhoA pathway, which controls T-cell cytoskeletal activity, using Y27632 (a selective Rock1 inhibitor) resulted in reduced T-cell infiltration and abrogation of CR as judged from the neointimal index (13.9+-19.7 vs. 45+-37.5; P<0.001) and the number of affected vessels (30% vs. 60%; P<0.01). Y 27632 172-178 ras homolog family member A Rattus norvegicus 107-111 23567108-7 2013 Moreover, we found that microinfusion of Y-27632, a specific inhibitor of the ROCK that is a downstream effector of RhoA, into dorsal striatum of young rats also impaired their working memory tested in delayed alternation in T Maze task. Y 27632 41-48 ras homolog family member A Rattus norvegicus 116-120 23564082-3 2013 METHODS: The RhoA-ROCK pathway inhibitor Y27632 (8.56 mug/1 muL per side) or the Rac1 inhibitor NSC23766 (25 mug/1 muL per side) was microinjected into the dorsal hippocampus of rats. Y 27632 41-47 ras homolog family member A Rattus norvegicus 13-17 20629317-6 2010 Simultaneously, inhibited expression of RhoA induced by simvastatin and Y-27632 was also observed. Y 27632 72-79 ras homolog family member A Rattus norvegicus 40-44 23365678-4 2013 The neuroprotective effects of the intravitreal injection of RhoA kinase inhibitor Y27632 were examined in vivo. Y 27632 83-89 ras homolog family member A Rattus norvegicus 61-65 23365678-13 2013 Inhibiting RhoA kinase with Y27632 significantly reduced diabetes- and proNGF-induced activation of proapoptotic p38MAPK/JNK, expression of cleaved-PARP and caspase-3 and prevented retinal neurodegeneration in vivo and in vitro. Y 27632 28-34 ras homolog family member A Rattus norvegicus 11-15 22615126-7 2012 Blockage of RhoA activity in rTDSCs by C3 toxin or ROCK activity, a downstream target of RhoA, by Y-27632 inhibited UMT-induced osteogenesis in rTDSCs. Y 27632 98-105 ras homolog family member A Rattus norvegicus 12-16 22615126-7 2012 Blockage of RhoA activity in rTDSCs by C3 toxin or ROCK activity, a downstream target of RhoA, by Y-27632 inhibited UMT-induced osteogenesis in rTDSCs. Y 27632 98-105 ras homolog family member A Rattus norvegicus 89-93 23376009-3 2013 In cultured glomerular mesangial cells (GMCs), the high glucose-activated NF-kappaB nuclear translocation and DNA binding activity were attenuated by ROCK inhibitor Y27632 or dominant-negative RhoA mutant, indicating that RhoA/ROCK signaling regulates high glucose-activated NF-kappaB pathway. Y 27632 165-171 ras homolog family member A Rattus norvegicus 222-226 22750411-3 2012 Expression of active-RhoA was decreased after EPO or Y-27632 per pull down assay and affinity precipitation. Y 27632 53-60 ras homolog family member A Rattus norvegicus 21-25 22750411-4 2012 Administration of EPO and Y-27632 cocktail resulted in even more RhoA inactivation, decreased expression of ROCK-1 and ROCK-2, and increased expression of growth associated protein-43 (GAP-43) protein per immunohistochemistry and western blot analysis. Y 27632 26-33 ras homolog family member A Rattus norvegicus 65-69 22392066-8 2012 Moreover, simvastatin, the RhoA inhibitor C3, and the RhoA-kinase inhibitor Y27632 all attenuated the proliferation rate induced by ET-1 in basilar artery smooth muscle cells via the Rho/Rho-kinase signaling pathway. Y 27632 76-82 ras homolog family member A Rattus norvegicus 54-58 22544632-3 2012 Treatment with bFGF activated the RhoA/Rho-associated kinase (ROCK)/c-jun N-terminal kinase (JNK) pathway, and bFGF-induced NT-3 expression was blocked by a dominant-negative RhoA as well as by a specific Rho-kinase inhibitor (Y27632) and a SAPK/JNK inhibitor (SP600125). Y 27632 227-233 ras homolog family member A Rattus norvegicus 34-38 22544632-3 2012 Treatment with bFGF activated the RhoA/Rho-associated kinase (ROCK)/c-jun N-terminal kinase (JNK) pathway, and bFGF-induced NT-3 expression was blocked by a dominant-negative RhoA as well as by a specific Rho-kinase inhibitor (Y27632) and a SAPK/JNK inhibitor (SP600125). Y 27632 227-233 ras homolog family member A Rattus norvegicus 175-179 21862940-7 2011 In contrast, pretreatment with Y27632, a specific inhibitor of Rho-A, resulted in an increase of the phosphorylation of PKB. Y 27632 31-37 ras homolog family member A Rattus norvegicus 63-68 17562852-7 2007 RhoA/ROCK and PI3K/Akt activation was associated with a significant increase in RPV wet weight (11 +/- 1%), protein synthesis (45 +/- 7%), SRF expression (136 +/- 11%), and polymerization of actin, as reflected by an increase in the F-/G-actin ratio, effects that were significantly attenuated by a leptin receptor (leptin obese receptor) antibody, the ROCK inhibitor (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) (Y-27632) as well as the PI3K inhibitor LY294002. Y 27632 414-421 ras homolog family member A Rattus norvegicus 0-4 18539332-7 2008 Inhibiting RhoA downstream effector p160 ROCK/Rho kinase using Y-27632, or activating p75 neurotrophin receptor (p75 NTR) using non-peptide mimetic LM11A-31, were able to reverse the degeneration caused by cisplatin and methotrexate. Y 27632 63-70 ras homolog family member A Rattus norvegicus 11-15 19039310-8 2009 Activated RhoA and myosin light chain phosphorylation and RhoA, ROCK expression was inhibited by pitavastatin or a specific ROCK inhibitor, Y-27632, and downregulated eNOS expression and Akt phosphorylation was ameliorated by Y-27632. Y 27632 140-147 ras homolog family member A Rattus norvegicus 10-14 19039310-8 2009 Activated RhoA and myosin light chain phosphorylation and RhoA, ROCK expression was inhibited by pitavastatin or a specific ROCK inhibitor, Y-27632, and downregulated eNOS expression and Akt phosphorylation was ameliorated by Y-27632. Y 27632 140-147 ras homolog family member A Rattus norvegicus 58-62 19039310-8 2009 Activated RhoA and myosin light chain phosphorylation and RhoA, ROCK expression was inhibited by pitavastatin or a specific ROCK inhibitor, Y-27632, and downregulated eNOS expression and Akt phosphorylation was ameliorated by Y-27632. Y 27632 226-233 ras homolog family member A Rattus norvegicus 10-14 19039310-8 2009 Activated RhoA and myosin light chain phosphorylation and RhoA, ROCK expression was inhibited by pitavastatin or a specific ROCK inhibitor, Y-27632, and downregulated eNOS expression and Akt phosphorylation was ameliorated by Y-27632. Y 27632 226-233 ras homolog family member A Rattus norvegicus 58-62 17615156-4 2007 Inhibition of RhoA signaling using either the RhoA kinase inhibitor Y-27632 or a dominant negative mutant of RhoA (RhoA-DN) dramatically extended the duration of p65-DNA binding, IkappaBalpha phosphorylation, and IKKbeta activity following LPS treatment. Y 27632 68-75 ras homolog family member A Rattus norvegicus 14-18 17615156-4 2007 Inhibition of RhoA signaling using either the RhoA kinase inhibitor Y-27632 or a dominant negative mutant of RhoA (RhoA-DN) dramatically extended the duration of p65-DNA binding, IkappaBalpha phosphorylation, and IKKbeta activity following LPS treatment. Y 27632 68-75 ras homolog family member A Rattus norvegicus 46-50 17615156-4 2007 Inhibition of RhoA signaling using either the RhoA kinase inhibitor Y-27632 or a dominant negative mutant of RhoA (RhoA-DN) dramatically extended the duration of p65-DNA binding, IkappaBalpha phosphorylation, and IKKbeta activity following LPS treatment. Y 27632 68-75 ras homolog family member A Rattus norvegicus 46-50 16267829-10 2005 Inhibition of neurite outgrowth by chimeric IL2R-alpha(3) can be rescued by treatment of transfected cells with the pharmacological inhibitor Y27632, which inhibits the RhoA downstream effector Rho kinase alpha. Y 27632 142-148 ras homolog family member A Rattus norvegicus 169-173 16555582-5 2005 Increased expression of RhoA and Rho-kinase and myosin light chain phosphorylation were decreased by spironolactone or Y-27632. Y 27632 119-126 ras homolog family member A Rattus norvegicus 24-28 14634067-7 2004 The effect of RhoA was found to be mediated by its down-stream effector Rho kinase (ROCK), as pretreatment with the selective ROCK inhibitor Y-27632 prevented this enhanced adhesion and migration. Y 27632 141-148 ras homolog family member A Rattus norvegicus 14-18 14961052-1 2004 Studies from this laboratory have demonstrated that RhoA/Rho-kinase signaling mediates vasoconstriction in the penile circulation of the rat and that erection results from inhibition of this activity with Y-27632. Y 27632 205-212 ras homolog family member A Rattus norvegicus 52-56 16231160-7 2005 Pretreatment with 1 microM Y-27632, a RhoA/Rho-kinase inhibitor, significantly inhibited the phenylephrine-induced contraction itself as well as the C2-ceramide-induced vasodilation. Y 27632 27-34 ras homolog family member A Rattus norvegicus 38-42 15951198-6 2005 Finally, the effect of geranylgeraniol on neurite outgrowth is prevented by Y-27632, an inhibitor of RhoA kinase. Y 27632 76-83 ras homolog family member A Rattus norvegicus 101-105 15655498-11 2005 Inactivating RhoA by exoenzyme C3 (2 mug ml(-1)) or inhibiting Rho-kinase with (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydrochloride monohydrate (Y-27632; 10(-5) M) had no effect on the decrease of both tension and [Ca(2+)](cyt) generated by exogenous NO. Y 27632 176-183 ras homolog family member A Rattus norvegicus 13-17 11553366-8 2001 These findings suggest that Y-27632 dilates acetylcholine-mediated contraction of rat bronchial smooth muscle by inhibiting RhoA/ROCK-mediated Ca(2+) sensitization. Y 27632 28-35 ras homolog family member A Rattus norvegicus 124-128 11925438-6 2002 Disassembly of actin stress fibers could also be observed using the Rho kinase-specific inhibitor Y-27632, indicating that the decrease in RhoA activity on its own is responsible for actin reorganization. Y 27632 98-105 ras homolog family member A Rattus norvegicus 139-143 11279039-5 2001 Moreover, Y-27632, an inhibitor of Rho-associated kinase, completely abolished the RhoA-induced down-regulation of the NGF-induced Rac1 activation. Y 27632 10-17 ras homolog family member A Rattus norvegicus 83-87