PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24396568-4 2013 TNF-alpha increased the levels of superoxide, Nox (nitrate and nitrite), malondialdehyde, and nitrotyrosine production, accompanied by increased protein expression of p-PKC-beta2, gP91phox, and endothelial cell apoptosis, whereas all these changes were further enhanced by nitroglycerine. Nitrites 63-70 tumor necrosis factor Homo sapiens 0-9 24269637-6 2014 Whereas AdXBP1S can inhibit ER stress-mediated apoptosis and TNFalpha induced nitrite production in OA cartilage. Nitrites 78-85 tumor necrosis factor Homo sapiens 61-69 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 tumor necrosis factor Homo sapiens 43-52 21792375-6 2011 To aid characterize this process, a quantitative analysis of nitrite generation was undertaken on agents developed to lower TNF-alpha levels in cell culture. Nitrites 61-68 tumor necrosis factor Homo sapiens 124-133 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 tumor necrosis factor Homo sapiens 100-127 16328964-5 2006 This cytokine increased inosine concentration from 30 min to 6 h, with no effect at 24 h. Both TNF-alpha and inosine increased nitrite accumulation and nitric oxide synthase activity. Nitrites 127-134 tumor necrosis factor Homo sapiens 95-104 16033420-3 2005 Although Abeta 25-35 by itself had little effect on iNOS mRNA, protein, and nitrite production, it enhanced TNF-alpha-induced iNOS expression and nitrite generation in OLGs. Nitrites 146-153 tumor necrosis factor Homo sapiens 108-117 16033420-5 2005 Cell permeable C2-ceramide enhanced TNF-alpha-induced iNOS expression and nitrite generation. Nitrites 74-81 tumor necrosis factor Homo sapiens 36-45 16033420-6 2005 Moreover, the specific nSMase inhibitor, 3-O-methyl-sphingomyelin (3-OMS), inhibited iNOS expression and nitrite production induced by TNF-alpha or by the combination of TNF-alpha and Abeta. Nitrites 105-112 tumor necrosis factor Homo sapiens 135-144 15086905-8 2004 AGE-stimulated nitrite release was attenuated by pretreatment with anti-tumor necrosis factor-alpha (TNF-alpha) and anti-transforming growth factor-beta (TGF-beta) antibodies. Nitrites 15-22 tumor necrosis factor Homo sapiens 101-110 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 tumor necrosis factor Homo sapiens 129-138 12009845-5 2002 The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P < 0.001. Nitrites 71-78 tumor necrosis factor Homo sapiens 27-36 12594738-4 2003 LPS significantly increased iNOS mRNA expression, peaking at 6 h, while nitrite formation increased with time up to 72 h. Although TNFalpha alone induced neither iNOS mRNA expression nor nitrite formation, it significantly potentiated the effect of LPS on both. Nitrites 72-79 tumor necrosis factor Homo sapiens 131-139 12526099-2 2002 Adipocytes incubated with TNF induced dose- and time-dependent accumulation of nitrite in the culture medium through the iNOS induction as confirmed by Western blotting. Nitrites 79-86 tumor necrosis factor Homo sapiens 26-29 12526099-3 2002 Treatment of cells with TNF in the presence of all-trans-retinoic acid (RA) significantly decreased their ability to produce nitrite and iNOS induction. Nitrites 125-132 tumor necrosis factor Homo sapiens 24-27 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Nitrites 13-20 tumor necrosis factor Homo sapiens 69-77 12188499-5 2002 The expression levels of iNOS mRNA and the nitrite content in the membranes significantly correlated with those of TNF-alpha and cPLA2 mRNAs, respectively. Nitrites 43-50 tumor necrosis factor Homo sapiens 115-124 9176264-4 1997 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Nitrites 143-150 tumor necrosis factor Homo sapiens 25-34 11326829-10 2001 Spontaneous TNF-alpha production showed a stronger correlation with nitrite production than with IL-1 beta. Nitrites 68-75 tumor necrosis factor Homo sapiens 12-21 10802225-5 2000 Incubation with agonistic anti-Fas monoclonal antibody or tumor necrosis factor-alpha (TNF-alpha) enhanced neutrophil apoptosis at 6 h, although it decreased nitrite accumulation. Nitrites 158-165 tumor necrosis factor Homo sapiens 58-85 10802225-5 2000 Incubation with agonistic anti-Fas monoclonal antibody or tumor necrosis factor-alpha (TNF-alpha) enhanced neutrophil apoptosis at 6 h, although it decreased nitrite accumulation. Nitrites 158-165 tumor necrosis factor Homo sapiens 87-96 11112001-18 2000 In addition, CS nitrite levels correlated with CS TNF-alpha levels in patients with impaired CFVR (r = 0.44, P = 0.003). Nitrites 16-23 tumor necrosis factor Homo sapiens 50-59 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrites 222-229 tumor necrosis factor Homo sapiens 37-64 9691088-4 1998 The IL-1 receptor antagonist protein (IRAP) prevents TNF + LPS + IFN-gamma-induced iNOS expression and nitrite production, and attenuates the inhibitory effects on glucose-stimulated insulin secretion by human islets. Nitrites 103-110 tumor necrosis factor Homo sapiens 53-56 10806781-3 1998 The results were as follows: The content of nitrite and TNF-alpha in patients with malignant bone tumors was significantly higher than that in normal control; the content of nitrite and TNF-alpha in the malignant bone tumor group presented the positive correlation (r = 0.8909, P < 0.01). Nitrites 44-51 tumor necrosis factor Homo sapiens 186-195 9473147-6 1997 The upregulation of CAT-2 expression by TNF-alpha was associated with enhanced nitrite accumulation in the culture medium (70% increase compared with vehicle-treated cells at 24 h). Nitrites 79-86 tumor necrosis factor Homo sapiens 40-49 9405166-6 1997 Only in high concentration - the specific proinflammatory action being documented by an enhanced release of interleukin-6 from cardiomyocytes - TNF alpha (1000 U/mol; 6, 24 h) weakly induces the mRNA for iNOS, with a consecutive moderate rise in cellular nitrite production. Nitrites 255-262 tumor necrosis factor Homo sapiens 144-153 9369379-5 1997 Increasing concentrations of TNF-alpha (0.5-50 ng/ml) for 24 h resulted in a concentration-dependent decrease in lipoprotein lipase activity with reciprocal increase in nitrite production in the medium. Nitrites 169-176 tumor necrosis factor Homo sapiens 29-38 9191464-9 1997 Cell cultures treated with TNF alpha/IFN gamma/LPS in combination expressed iNOS mRNA, and this was associated with increases in supernatant nitrite concentrations over 24 h; however, this response diminished with successive passage of cells. Nitrites 141-148 tumor necrosis factor Homo sapiens 27-36 10921509-6 2000 To determine the role of TNF-alpha on mesangial cell nitrite production, we examined the effect of anti-TNF-alpha antibody on morphine-induced nitrite production. Nitrites 143-150 tumor necrosis factor Homo sapiens 104-113 10921509-12 2000 Anti-TNF-alpha antibody attenuated morphine induced nitrite generation. Nitrites 52-59 tumor necrosis factor Homo sapiens 5-14 10913230-3 2000 The incubation of HPASMC with various concentrations of LPS, IL-1(beta)or TNF(alpha)for 24 h caused a significant increase in nitrite release and PGI(2)production. Nitrites 126-133 tumor necrosis factor Homo sapiens 74-84 10919016-5 2000 Stimulation with IL-1 alpha + TNF-alpha + IFN-alpha induced a significant (P < 0.001) increase of nitrite generation by both human colonic biopsies and HT-29 cells. Nitrites 101-108 tumor necrosis factor Homo sapiens 30-39 9690866-4 1998 Incubation of T 67 astroglial cell line with IL-beta (10 ng ml(-1)) and TNF-alpha (500 u ml(-1)) produced a significant (P<0.05) increase of both nitrite (the breakdown product of NO), cyclic GMP and PGE2 levels in cell supernatants. Nitrites 149-156 tumor necrosis factor Homo sapiens 72-81 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitrites 266-273 tumor necrosis factor Homo sapiens 47-50 9573098-5 1998 When RAW264.7 cells were pretreated with human TNF or TNF(70-80) in the presence of IFN-gamma, there was a dose-dependent reduction in the replication of BCG as measured by the uptake of 3H-labeled uracil and a concomitant release of nitric oxide as measured by the nitrite in the culture supernatants. Nitrites 266-273 tumor necrosis factor Homo sapiens 54-57 9176264-4 1997 PAEM were incubated with TNF-alpha (100 U/ml) for 4 h. Incubation of PAEM with TNF-alpha resulted in increases in 1) the .NO oxidation product nitrite (NO2-), 2) nitrotyrosine immunofluorescence, 3) the oxidation of p42 (tentatively identified as actin), and 4) permeability to Evans blue dye-albumin. Nitrites 143-150 tumor necrosis factor Homo sapiens 79-88 9237228-10 1996 In the presence of TNF alpha, nitrite accumulation was significantly reduced in normozoospermic samples. Nitrites 30-37 tumor necrosis factor Homo sapiens 19-28 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrites 46-53 tumor necrosis factor Homo sapiens 135-168 8599841-2 1996 Schwann cells treated with IFN-gamma and TNF-alpha upregulated iNOS-specific mRNA within 12 hr and released nitrite in a time- and dose-dependent manner, reaching a plateau of secretion after 3 days. Nitrites 108-115 tumor necrosis factor Homo sapiens 41-50 8655981-5 1996 CSF levels of NO/nitrite correlated with those of TNF-alpha (r = .55; P = .001) and glucose (r = -.43; P = .02). Nitrites 17-24 tumor necrosis factor Homo sapiens 50-59 8783331-10 1996 TNF alpha significantly stimulated islet nitrite production and cGMP accumulation, both effects being of a similar magnitude in cryopreserved and noncryopreserved islets. Nitrites 41-48 tumor necrosis factor Homo sapiens 0-9 8614565-2 1995 In fact, stimulation with Escherichia coli lipopolysaccharide (LPS) (1 microgram ml-1) or tumor necrosis factor alpha (TNF alpha) (500 U ml-1) enhances nitrite release in cell supernatants, as determined by the Griess reaction. Nitrites 152-159 tumor necrosis factor Homo sapiens 119-128 8680718-11 1995 8 The addition of TNF-alpha produced a significant (P < 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation. Nitrites 114-121 tumor necrosis factor Homo sapiens 18-27 8680718-13 1995 These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level. Nitrites 91-98 tumor necrosis factor Homo sapiens 49-58 7514190-6 1994 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Nitrites 191-198 tumor necrosis factor Homo sapiens 65-74 7592903-7 1995 Furthermore, SNP is capable of inhibiting LPS/TNF alpha-inducible nitrite release, as determined by Griess reaction. Nitrites 66-73 tumor necrosis factor Homo sapiens 46-55 7622526-3 1995 The induction of M-CSF mRNA expression by either oxidized low density lipoprotein (ox-LDL) or tumor necrosis factor-alpha (TNF alpha) was attenuated by NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP), and 3-morpholinosydnonimine, but not by cGMP analogues, glutathione, or nitrite. Nitrites 292-299 tumor necrosis factor Homo sapiens 94-121 7622526-3 1995 The induction of M-CSF mRNA expression by either oxidized low density lipoprotein (ox-LDL) or tumor necrosis factor-alpha (TNF alpha) was attenuated by NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP), and 3-morpholinosydnonimine, but not by cGMP analogues, glutathione, or nitrite. Nitrites 292-299 tumor necrosis factor Homo sapiens 123-132 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 tumor necrosis factor Homo sapiens 284-293 7506700-5 1994 Transforming growth factor-beta 1, which inhibited the interferon gamma-, interleukin-1 beta-, and tumor necrosis factor-alpha-induced nitrite production, did not affect the increases in mRNA levels caused by these cytokines. Nitrites 135-142 tumor necrosis factor Homo sapiens 55-126 7683959-1 1993 Inflammatory cytokines (interleukin 1 alpha, 1 beta and tumor necrosis factor-alpha) induce the formation of nitrite by C6 astrocytoma cells in a manner that was blocked by inhibitors of NO synthase such as NG-monomethylarginine. Nitrites 109-116 tumor necrosis factor Homo sapiens 24-83 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 tumor necrosis factor Homo sapiens 125-134 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 tumor necrosis factor Homo sapiens 151-160 8499487-4 1993 TNF also increased nitrite production in TNF-resistant U937A/R cells. Nitrites 19-26 tumor necrosis factor Homo sapiens 0-3 8499487-4 1993 TNF also increased nitrite production in TNF-resistant U937A/R cells. Nitrites 19-26 tumor necrosis factor Homo sapiens 41-44 8499487-3 1993 TNF stimulated U937A nitrite production through a process that was abolished by the competitive inhibitors of nitric-oxide synthase N-omega-nitro-L-arginine methyl ester (NAME) and N-G-monomethyl-L-arginine (NMMA) without inhibition of TNF-induced cytotoxicity. Nitrites 21-28 tumor necrosis factor Homo sapiens 0-3 8499487-3 1993 TNF stimulated U937A nitrite production through a process that was abolished by the competitive inhibitors of nitric-oxide synthase N-omega-nitro-L-arginine methyl ester (NAME) and N-G-monomethyl-L-arginine (NMMA) without inhibition of TNF-induced cytotoxicity. Nitrites 21-28 tumor necrosis factor Homo sapiens 236-239 1658153-5 1991 A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation. Nitrites 120-127 tumor necrosis factor Homo sapiens 32-41 8383325-5 1993 IL-1 beta and IFN-gamma are sufficient to induce nitric oxide formation by human islets, whereas TNF-alpha potentiates nitrite production. Nitrites 119-126 tumor necrosis factor Homo sapiens 97-106 7680009-4 1993 Actinomycin D abolished the IFN gamma- and TNF alpha-induced increases in iNOS mRNA and nitrite production. Nitrites 88-95 tumor necrosis factor Homo sapiens 43-52 7680009-5 1993 Cycloheximide, which abolished both the IFN gamma- and TNF alpha-induced increases in nitrite production, had no effect on the IFN gamma-induced increase in iNOS mRNA but markedly inhibited the TNF alpha-induced one. Nitrites 86-93 tumor necrosis factor Homo sapiens 55-64 8447456-6 1993 After 24 h of incubation, TNF and LPS impaired the contractions to 5-hydroxytryptamine and increased the accumulation of nitrite, a stable degradation product of NO. Nitrites 121-128 tumor necrosis factor Homo sapiens 26-29 2109093-5 1990 Interferon gamma, in combination with tumor necrosis factor, interleukin-1 (IL-1), or endotoxin, induced murine brain endothelial cells to secrete nitrites (20-45 microM within 48 hr), which are breakdown products of nitric oxide. Nitrites 147-155 tumor necrosis factor Homo sapiens 38-59 35217293-10 2022 In human proximal tubule epithelial cells (HK-2), inorganic nitrite treatment prevented transforming growth factor beta-induced pro-fibrotic changes. Nitrites 60-67 tumor necrosis factor Homo sapiens 88-119