PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25461271-7 2015 Dietary nitrite dose-dependently reduced the size of the hypertrophic adipocytes and TNF-alpha transcription in the adipose tissue of KKA(y) diabetic mice, which also restored the insulin-mediated signal transduction, including p85 and Akt phosphorylation, and subsequently restored the GLUT4 expression in the skeletal muscles. Nitrites 8-15 tumor necrosis factor Mus musculus 85-94 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrites 107-114 tumor necrosis factor Mus musculus 58-79 29253818-8 2018 The infected groups treated with Asp49-PLA2-liposomes showed significant production in TNF-alpha measured in lymph nodes and paw (43.73pg/mL+-2.25 and 81.03pg/mL+-5.52, respectively) and nitrite levels (31.28muM+-0.58 and 35.64muM+-5.08) also measured in lymph nodes and paw tissues, respectively, compared to untreated groups. Nitrites 187-194 tumor necrosis factor Mus musculus 87-96 22721505-7 2012 All these effects of TNF- alpha/CHX were partially prevented by pretreatment with a carbon monoxide-releasing agent (CORM-A1) and nitrite. Nitrites 130-137 tumor necrosis factor Mus musculus 21-31 15778348-9 2005 TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production. Nitrites 219-226 tumor necrosis factor Mus musculus 0-9 22036766-8 2012 TNF-alpha-toxicity led to significant increase in myeloperoxidase (MPO, an index of neutrophils infiltration), nitrites (stable nitric oxide metabolites) and malondialdehyde (MDA, a marker of lipid peroxides) levels and cell apoptosis in liver and colon. Nitrites 111-119 tumor necrosis factor Mus musculus 0-9 15778348-9 2005 TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production. Nitrites 219-226 tumor necrosis factor Mus musculus 143-152 20399279-8 2010 Oral nitrite supplementation to colitis mice reversed colonic nitrite levels and TNF-alpha expression to that of normal control mice at day 3, resulting in the reduction of MPO activity as well as iNOS and HO-1 expressions in colonic tissues with clinical and histological improvements at day 7. Nitrites 5-12 tumor necrosis factor Mus musculus 81-90 19934018-0 2009 Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner. Nitrites 0-7 tumor necrosis factor Mus musculus 65-68 17548042-4 2007 As compared with wild-type mice, the increases in the plasma NO level measured as nitrite and nitrate and hepatic iNOS were significantly reduced in IL-1alpha/beta(-/-) and TNFalpha(-/-) mice 8 and 12h after the LPS challenge. Nitrites 82-89 tumor necrosis factor Mus musculus 173-181 16955242-6 2006 RESULTS: In cultured synoviocytes, SP, TNF-alpha and IL-1beta induced significantly increased nitrite concentrations. Nitrites 94-101 tumor necrosis factor Mus musculus 39-48 16436205-5 2006 Nonetheless astrocytes cultured from G93A-SOD1 (but not wild-type human SOD1-expressing) transgenic mouse pups demonstrated a significant elevation in either the basal or the tumor necrosis alpha (TNFalpha)-stimulated levels of proinflammatory eicosanoids prostaglandin E2 (PGE2) and leukotriene B4 (LTB4); inducible nitric oxide synthase (iNOS) and *NO (indexed by nitrite release into the culture medium); and protein carbonyl products. Nitrites 366-373 tumor necrosis factor Mus musculus 197-205 12839867-6 2003 In differentiated 3T3-F442A, treatment with TNFalpha (20 ng ml(-1)) induced the expression of a functional iNOS as demonstrated by nitrite assay, Western blot, reverse transcription-polymerase chain reaction and Northern blot analysis. Nitrites 131-138 tumor necrosis factor Mus musculus 44-52 15353992-14 2004 A cytokine cocktail of IL-1beta, TNFalpha, and IFNgamma synergistically enhanced nitrite production. Nitrites 81-88 tumor necrosis factor Mus musculus 33-41 15353992-19 2004 The pro-inflammatory cytokines, IL-1beta, TNFalpha, and IFNgamma, synergistically induce nitrite production, which was abrogated by treatment with the nitric oxide synthase inhibitor, AG. Nitrites 89-96 tumor necrosis factor Mus musculus 42-50 14679069-4 2003 Incubation of MIN6 cells with IL-1beta, IFN-gamma, and TNF-alpha (cytomix) increased production of nitrites, with increased expression of iNOS mRNA. Nitrites 99-107 tumor necrosis factor Mus musculus 55-64 12839867-9 2003 ET-1, but not ET-3, inhibited the TNFalpha-induced expression of iNOS protein and mRNA as well as nitrite production. Nitrites 98-105 tumor necrosis factor Mus musculus 34-42 12820230-5 2003 Nitrite accumulation in culture medium and apoptosis of MC3T3-E1 cells were induced by the addition of 10(-10) M TNF-alpha, and inhibited by the simultaneous addition of soy extract (0.05g/L). Nitrites 0-7 tumor necrosis factor Mus musculus 113-122 10835296-4 2000 Our results demonstrate that PBN cotreatment prevents the generation of nitrite by RIN-5F cells induced by treatment with tumor necrosis factor-alpha, interleukin 1beta, and interferon-gamma in a dose-dependent fashion. Nitrites 72-79 tumor necrosis factor Mus musculus 122-149 11642005-3 2001 TNF alpha was measured by cytotoxicity on L-929 cells and nitrite by the Griess reaction, after reduction of all nitrates to nitrites by nitrate reductase, 1 h after LPS injection (0.5 mg/kg i.p.) Nitrites 58-65 tumor necrosis factor Mus musculus 0-9 11642005-3 2001 TNF alpha was measured by cytotoxicity on L-929 cells and nitrite by the Griess reaction, after reduction of all nitrates to nitrites by nitrate reductase, 1 h after LPS injection (0.5 mg/kg i.p.) Nitrites 125-133 tumor necrosis factor Mus musculus 0-9 11113053-7 2000 However, simultaneous addition of IL-1beta, interferon-gamma, and TNF-alpha or the chemokines to cultures resulted in the induction of iNOS, high levels of nitrite, and a marked trypanocidal activity. Nitrites 156-163 tumor necrosis factor Mus musculus 66-75 10939618-13 2000 Nitrite prevented HOCl-mediated bacterial killing, inhibition of MPO activity, cellular cytotoxicity and inhibition of TNF-alpha production. Nitrites 0-7 tumor necrosis factor Mus musculus 119-128 11899430-8 2001 Furthermore, we demonstrated that exogenous TNF-alpha, at a dose range of 1.9-50 ng per ml, also restored the nitrite response to LPS in the presence of adrenaline. Nitrites 110-117 tumor necrosis factor Mus musculus 44-53 10571667-4 1999 Similarly, significant increases in myeloperoxidase activity, a marker for neutrophil and macrophage content, were observed in the peritoneal lavage cells after intraperitoneal injection of mastoparan M. However, induction of nitrite by mastoparan M was completely inhibited by simultaneous addition of antimouse TNF-alpha antibody to the macrophage cultures. Nitrites 226-233 tumor necrosis factor Mus musculus 313-322 10705297-3 2000 IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite. Nitrites 149-156 tumor necrosis factor Mus musculus 11-20 10728381-11 2000 TNF alpha induced a concentration-dependent increase in iNOS mRNA expression and nitrite production as well as significant apoptosis of cardiomyocytes in the wild type mice (n = 4, P < 0.01). Nitrites 81-88 tumor necrosis factor Mus musculus 0-9 10515827-4 1999 In contrast, higher levels of IL-6, IL-10, and MCP-1 in plasma and higher levels of IL-12, interferon (IFN)-gamma, and nitrite/nitrate were found in all compartments of TNF/Lt-alpha-deficient mice. Nitrites 119-126 tumor necrosis factor Mus musculus 169-172 10515827-5 1999 These data confirm that TNF or Lt-alpha is a key cytokine for the anticryptococcal response and demonstrate its major role for the induction of IL-1beta, IL-6, and KC in the brain; however, its presence is not a prerequisite for IL-12, IFN-gamma, and nitrite/nitrate production. Nitrites 251-258 tumor necrosis factor Mus musculus 24-27 9659467-8 1998 Addition of tumor necrosis factor-alpha (TNF-alpha) also enhanced IL-1 beta-induced nitrite production by VSMCs, but TNF-alpha showed no effect in the presence of monocytes. Nitrites 84-91 tumor necrosis factor Mus musculus 12-39 10410269-10 1999 Stimulation with CM increased nitrite production in 3T3 fibroblasts, which was significantly inhibited by antibodies against interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and iNOS inhibitor, L-NMMA. Nitrites 30-37 tumor necrosis factor Mus musculus 186-195 9659467-8 1998 Addition of tumor necrosis factor-alpha (TNF-alpha) also enhanced IL-1 beta-induced nitrite production by VSMCs, but TNF-alpha showed no effect in the presence of monocytes. Nitrites 84-91 tumor necrosis factor Mus musculus 41-50 9659467-10 1998 The production of nitrite by coculture was markedly inhibited by an anti-TNF-alpha antibody. Nitrites 18-25 tumor necrosis factor Mus musculus 73-82 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 85-92 tumor necrosis factor Mus musculus 16-19 9281616-1 1997 This study demonstrates that exposure of primary rat hepatocytes or mouse BNL Cl.2 liver cell line to ethanol causes potentiation of tumor necrosis factor-alpha (TNF-alpha)- and lipopolysaccharide (LPS)-stimulated nitrite accumulation. Nitrites 214-221 tumor necrosis factor Mus musculus 133-160 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 tumor necrosis factor Mus musculus 244-271 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 tumor necrosis factor Mus musculus 273-282 9453609-2 1998 Substantial amounts of nitrite (a degradation product of NO) were produced and the initial rickettsial infection was suppressed in cultures of L929 cells treated with crude lymphokine preparations (LK) or with gamma interferon (IFN-gamma) plus tumor necrosis factor alpha (TNF-alpha) but not in L929 cell cultures treated with IFN-gamma alone or TNF-alpha alone. Nitrites 23-30 tumor necrosis factor Mus musculus 346-355 9234375-6 1997 The addition of TNF in the culture medium containing LPS/IFN-gamma further increases nitrite production in C3H/HeN RMG cells and allows the synthesis of low levels of nitrite in C3H/HeJ RMG cells. Nitrites 167-174 tumor necrosis factor Mus musculus 16-19 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 67-74 tumor necrosis factor Mus musculus 14-17 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 56-63 tumor necrosis factor Mus musculus 14-17 8647201-3 1996 Incubation of macrophages with both LPS and TNF-alpha resulted in the expression of both IL-1 beta and inducible nitric oxide synthase (iNOS) mRNA transcripts and increased the release of IL-1 beta protein and nitrite production in culture supernatants. Nitrites 210-217 tumor necrosis factor Mus musculus 44-53 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrites 67-74 tumor necrosis factor Mus musculus 14-17 8864129-0 1996 Elevated TNF-alpha and inducible nitric oxide production by alveolar macrophages after exposure to a nitrite inhalant. Nitrites 101-108 tumor necrosis factor Mus musculus 9-18 8809546-7 1996 In mouse peritoneal macrophages treated with IFN-gamma, both L-NMMA and anti-TNF-alpha antibody inhibited nitrite production and restored CT replication. Nitrites 106-113 tumor necrosis factor Mus musculus 77-86 7524369-4 1994 However, combinations of IFN with either TNF or IL-1 resulted in significant nitrite production; simultaneous stimulation of cells with all three cytokines resulted in significantly increased nitrite production compared with any combination of two cytokines. Nitrites 77-84 tumor necrosis factor Mus musculus 41-44 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 42-49 tumor necrosis factor Mus musculus 119-146 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 234-241 tumor necrosis factor Mus musculus 119-146 7537467-2 1995 Under basal conditions, the production of nitrite, a stable metabolite of NO, was negligible; however, incubation with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IF-gamma) for 24 h resulted in a 12-fold increase in nitrite synthesis and the appearance of abundant iNOS mRNA and protein. Nitrites 234-241 tumor necrosis factor Mus musculus 148-157 7822799-0 1995 Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. Nitrites 123-130 tumor necrosis factor Mus musculus 25-28 7475946-5 1995 Tumor necrosis factor-alpha caused some enhancement of interferon-gamma-induced nitrite release only at high doses of 100 and 10,000 unit/ml. Nitrites 80-87 tumor necrosis factor Mus musculus 0-27 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 0-7 tumor necrosis factor Mus musculus 101-110 7927208-6 1994 Polyclonal rabbit anti-mouse anti-tumor necrosis factor-alpha reduced in vivo tumor necrosis factor-alpha levels (1 hr, 7,332 +/- 1,492 U tumor necrosis factor-alpha per milliliter) and reduced nitric oxide synthesis as measured by plasma nitrite and nitrate (352 +/- 69 mumol/L). Nitrites 239-246 tumor necrosis factor Mus musculus 34-61 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 0-7 tumor necrosis factor Mus musculus 221-230 7518807-12 1994 Nitrite production was induced in X-irradiated, strain EVir-infected L929 cell cultures treated with TNF-alpha alone or IFN-gamma alone; however, more nitrite was produced in infected cultures treated with IFN-gamma plus TNF-alpha. Nitrites 151-158 tumor necrosis factor Mus musculus 221-230 8003032-2 1994 TNF alpha, IL-1 beta, and LPS caused a dose- and time-dependent increase of nitrite (NO2-), the stable metabolite of nitric oxide (NO), in conditioned media over 48 hours, while IFN gamma had a minimal effect. Nitrites 76-83 tumor necrosis factor Mus musculus 0-9 8505145-7 1993 Out of the different combinations tested, only IFN-gamma plus TNF-treated macrophages showed enhancement in nitrite production as compared to that of IFN-gamma alone. Nitrites 108-115 tumor necrosis factor Mus musculus 62-65 8163651-7 1994 The competitive inhibitor of NO production, NG-monomethyl-arginine (L-NMMA), and cycloheximide abolished the increase in nitrite production induced by TNF-alpha + IFN-gamma + LPS, while hydrocortisone had no effect, as previously reported for chondrocytes. Nitrites 121-128 tumor necrosis factor Mus musculus 151-160 7691748-7 1993 Nitrite production was induced in mock-infected or R. prowazekii-infected L929 cell cultures treated with IFN-gamma plus TNF-alpha, but not in mock-infected cultures that were untreated or treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 tumor necrosis factor Mus musculus 121-130 7691748-7 1993 Nitrite production was induced in mock-infected or R. prowazekii-infected L929 cell cultures treated with IFN-gamma plus TNF-alpha, but not in mock-infected cultures that were untreated or treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 tumor necrosis factor Mus musculus 215-224 7691748-8 1993 Nitrite production was also not induced in untreated, R. prowazekii-infected cultures; however, in some instances, it was induced in infected cultures treated with IFN-gamma or TNF-alpha alone. Nitrites 0-7 tumor necrosis factor Mus musculus 177-186 7691748-9 1993 Nitrite production was blocked by NGMA or aminoguanidine, and these compounds markedly relieved the synergistic inhibitory effect of IFN-gamma plus TNF-alpha on the growth of strain 83-2P in L929 cells. Nitrites 0-7 tumor necrosis factor Mus musculus 148-157 1500182-0 1992 In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria. Nitrites 21-28 tumor necrosis factor Mus musculus 44-65 1632773-2 1992 It has been demonstrated that activation of mouse brain endothelium by TNF-alpha and IFN-gamma led to accumulation of nitrite which is presumably formed by oxidation of nitric oxide. Nitrites 118-125 tumor necrosis factor Mus musculus 71-80 1522385-3 1992 We found that a cell line that was sensitive to TNF-mediated cytotoxicity produced NO in response to TNF as measured by the accumulation of nitrite in the supernatants of TNF-stimulated cells. Nitrites 140-147 tumor necrosis factor Mus musculus 48-51 1522385-3 1992 We found that a cell line that was sensitive to TNF-mediated cytotoxicity produced NO in response to TNF as measured by the accumulation of nitrite in the supernatants of TNF-stimulated cells. Nitrites 140-147 tumor necrosis factor Mus musculus 101-104 1522385-3 1992 We found that a cell line that was sensitive to TNF-mediated cytotoxicity produced NO in response to TNF as measured by the accumulation of nitrite in the supernatants of TNF-stimulated cells. Nitrites 140-147 tumor necrosis factor Mus musculus 101-104 1522385-6 1992 TNF-resistant cell lines produced less NO than a TNF-sensitive cell line, and the amount of nitrite produced correlated with the relative sensitivity of each cell line to TNF-mediated cytotoxicity. Nitrites 92-99 tumor necrosis factor Mus musculus 0-3 2117605-1 1990 The murine adenocarcinoma cell line TA 3 synthesized nitrite from L-arginine upon stimulation with gamma-interferon (IFN-gamma) associated with tumor necrosis factor (TNF), and/or bacterial lipopolysaccharide (LPS), but not with IFN-gamma, TNF, or LPS added separately. Nitrites 53-60 tumor necrosis factor Mus musculus 144-165 1902865-5 1991 The LPS inhibitor polymyxin B and TNF alpha antibody produced a modest decrease in nitrite production, while IFN gamma antibody markedly inhibited both nitrite production and cytostasis. Nitrites 83-90 tumor necrosis factor Mus musculus 34-43 1902865-6 1991 Simultaneous treatment with polymyxin B, TNF alpha antibody, and IFN gamma antibody reduced EMT-6 cell nitrite production by 81%, and cytostasis by 74%. Nitrites 103-110 tumor necrosis factor Mus musculus 41-50 2115549-3 1990 These inhibitors partially blocked induction of nitrite release in macrophages activated with the combination of IFN-gamma plus TNF-alpha, but were incapable of inhibiting when macrophages were activated by the combination of IFN-gamma plus LPS. Nitrites 48-55 tumor necrosis factor Mus musculus 128-137 35074739-6 2022 Meanwhile, high nitrite induced skin lesions in mice, accompanied with increased serum ALT, colon IL-6, TNF-alpha, and MDA levels, together with decreased serum Cr, colon sIgA, and T-AOC levels. Nitrites 16-23 tumor necrosis factor Mus musculus 104-113