PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22178413-7 2012 Further studies in TNF-alpha-stimulated endothelial cells revealed that nitrite dose-dependently reduced the expression of ICAM-1. Nitrites 72-79 tumor necrosis factor Rattus norvegicus 19-28 19628069-8 2009 In correlation with graft survival, mRNA levels for interferon-gamma in the spleen or tumor necrosis factor-alpha in the grafts were significantly less when animals were fed nitrite water compared with those without nitrite supplementation. Nitrites 174-181 tumor necrosis factor Rattus norvegicus 86-113 18054434-8 2008 Furthermore, exposure to exogenous NO donors inhibited SULT2B1a mRNA expression, and exposure to sodium nitroprusside, LPS/TNF-alpha and L-glutamic acid in combination with cyclothiazide increased the production of nitrite, a stable degradation product of NO. Nitrites 215-222 tumor necrosis factor Rattus norvegicus 123-132 16133968-10 2005 The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression. Nitrites 30-37 tumor necrosis factor Rattus norvegicus 72-81 15081246-2 2004 Upon LPS challenge, we observed a dramatic increase in the culture medium of the TNF-alpha protein, an effect thereafter followed by an increase of nitric oxide synthase type 2 (NOS2) mRNA and, at later times, of nitrite accumulation, an index of nitric oxide (NO) production. Nitrites 213-220 tumor necrosis factor Rattus norvegicus 81-90 14558624-8 2003 Under the optimum conditions, we monitored the changes in the concentration of the nitrite levels through synergistic stimulation of tumor necrosis factor alpha plus gamma-interferon in PC12 cells. Nitrites 83-90 tumor necrosis factor Rattus norvegicus 133-160 14559427-10 2003 Incubation of L2 cells with a mixture of interferon gamma (IFNgamma), lipopolysaccharide (LPS), and tumor necrosis factor (TNFalpha) resulted in high levels of nitrite formation resulting from iNOS induction. Nitrites 160-167 tumor necrosis factor Rattus norvegicus 123-131 12509805-6 2003 By contrast, the selective p38 kinase inhibitor SB203,580 amplified the effects of IL-1beta/TNF-alpha on nitrite accumulation. Nitrites 105-112 tumor necrosis factor Rattus norvegicus 92-101 12069938-6 2002 TNF-alpha caused significant inhibition of ACh- and bradykinin-induced vascular relaxation and nitrite/nitrate production that were more prominent in pregnant than virgin rats. Nitrites 95-102 tumor necrosis factor Rattus norvegicus 0-9 11863253-6 2002 RESULTS: A twofold increase in plasma TNF-alpha levels in pregnant rats resulted in a significant increase in arterial pressure (97 +/- 3.6 v 116 +/- 2.1 mm Hg, pregnant versus TNF-alpha pregnant, respectively, P < .05), but no significant change in urinary nitrite/nitrate excretion (22.0 +/- 1.9 v 20.8 +/- 2.5 micromol/24 h, pregnant versus TNF-alpha pregnant, respectively), a measure of whole body NO production. Nitrites 261-268 tumor necrosis factor Rattus norvegicus 38-47 11792648-8 2002 Basal and ACh-induced nitrite/nitrate production was less in TNF-alpha-infused than in control pregnant rats. Nitrites 22-29 tumor necrosis factor Rattus norvegicus 61-70 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. Nitrites 105-112 tumor necrosis factor Rattus norvegicus 18-27 11697130-2 2001 Combined treatment of lipopolysaccharide (LPS, 1 microgram/ml) and tumor necrosis factor-alpha (TNF-alpha, 50 ng/ml) synergistically enhanced (23-folds) nitrite production from KNRK cells. Nitrites 153-160 tumor necrosis factor Rattus norvegicus 67-94 11697130-2 2001 Combined treatment of lipopolysaccharide (LPS, 1 microgram/ml) and tumor necrosis factor-alpha (TNF-alpha, 50 ng/ml) synergistically enhanced (23-folds) nitrite production from KNRK cells. Nitrites 153-160 tumor necrosis factor Rattus norvegicus 96-105 11474215-6 2001 TNF-alpha increased nitrite release to the incubation medium. Nitrites 20-27 tumor necrosis factor Rattus norvegicus 0-9 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrites 0-7 tumor necrosis factor Rattus norvegicus 73-106 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. Nitrites 86-94 tumor necrosis factor Rattus norvegicus 32-65 10203355-4 1999 (1) Nitrite produced by rat mesangial cells in primary culture was measured in incubations with tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS), with or without IFN-gamma. Nitrites 4-11 tumor necrosis factor Rattus norvegicus 96-123 10203355-4 1999 (1) Nitrite produced by rat mesangial cells in primary culture was measured in incubations with tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS), with or without IFN-gamma. Nitrites 4-11 tumor necrosis factor Rattus norvegicus 125-134 9723949-13 1998 TNF-alpha production was proportional to the indomethacin dose (from 3-20 mg kg(-1)) and correlated with the surface area of ulcerations and nitrite production, 24 h after indomethacin administration. Nitrites 141-148 tumor necrosis factor Rattus norvegicus 0-9 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 tumor necrosis factor Rattus norvegicus 86-113 9683921-3 1998 RESULTS: Incubation of the cultures with interleukin-1 beta (IL-1 beta; 10 ng/ml) and tumor necrosis factor alpha (TNF alpha; 10 ng/ml) caused a marked increase in nitrite production. Nitrites 164-171 tumor necrosis factor Rattus norvegicus 115-124 9510167-4 1998 The IL-1R antagonist protein completely prevents TNF + LPS-induced nitrite production, iNOS expression and the inhibitory effects on glucose-stimulated insulin secretion by rat islets. Nitrites 67-74 tumor necrosis factor Rattus norvegicus 49-52 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 tumor necrosis factor Rattus norvegicus 54-57 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 tumor necrosis factor Rattus norvegicus 89-92 9510167-8 1998 IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS-induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS-induced nitrite production by rat islets. Nitrites 226-233 tumor necrosis factor Rattus norvegicus 89-92 9559891-12 1998 Incubation with tumour necrosis factor alpha (TNF alpha, 1 ng ml(-1)) resulted in significant nitrite accumulation in the incubation media and suppression of the smooth muscle contractile response to phenylephrine, similar to IL-1beta. Nitrites 94-101 tumor necrosis factor Rattus norvegicus 46-58 9478960-9 1998 Indeed, 1) elevated TNFalpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and 2) incubation of macrophages with a neutralizing anti-TNFalpha antibody impaired both NF-kappaB activation and nitrite accumulation in response to acid challenge. Nitrites 217-224 tumor necrosis factor Rattus norvegicus 20-28 9478960-9 1998 Indeed, 1) elevated TNFalpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and 2) incubation of macrophages with a neutralizing anti-TNFalpha antibody impaired both NF-kappaB activation and nitrite accumulation in response to acid challenge. Nitrites 217-224 tumor necrosis factor Rattus norvegicus 160-168 9475399-4 1998 Nitrite production in Sertoli cells and peritubular cells required both IFNgamma and TNF alpha and was potentiated by LPS, whereas IL-1alpha was ineffective. Nitrites 0-7 tumor necrosis factor Rattus norvegicus 85-94 9475399-5 1998 The induction of nitrite production and iNOS mRNA by IFNgamma+TNF alpha+LPS could be further enhanced by basic fibroblast growth factor in Sertoli cells but not in peritubular cells. Nitrites 17-24 tumor necrosis factor Rattus norvegicus 62-71 9585124-3 1998 In these cells, simultaneous addition of endothelin (ET) markedly inhibited TNF-alpha/IL-1beta-induced and LPS-induced nitrite production and iNOS expression, although ET by itself had no effect. Nitrites 119-126 tumor necrosis factor Rattus norvegicus 76-85 9281616-3 1997 Consistent with nitrite production, the amount of inducible nitric oxide synthase (iNOS) mRNA and protein is initially detected at 4 hr after treatment with TNF-alpha/LPS/ethanol. Nitrites 16-23 tumor necrosis factor Rattus norvegicus 157-166 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 tumor necrosis factor Rattus norvegicus 85-112 9231726-1 1997 In primary cultured rat glial cells, a combination of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) stimulates production of nitrite via expression of the inducible form of nitric oxide synthase (iNOS). Nitrites 183-190 tumor necrosis factor Rattus norvegicus 114-123 9231726-2 1997 In these cells, simultaneous addition of endothelin (ET) decreased iNOS expression and nitrite accumulation induced by TNF-alpha/IL-1beta. Nitrites 87-94 tumor necrosis factor Rattus norvegicus 119-128 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 tumor necrosis factor Rattus norvegicus 186-195 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 tumor necrosis factor Rattus norvegicus 229-238 9252565-8 1997 The nitrite generation from rat pulmonary artery endothelial cells was intermediate between RAEC and RLMVEC responses when stimulated with IFN-gamma + LPS or TNF-alpha. Nitrites 4-11 tumor necrosis factor Rattus norvegicus 158-167 9227507-6 1997 In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma. Nitrites 91-98 tumor necrosis factor Rattus norvegicus 130-157 9210623-9 1997 The concentration of nitrites in the hepatocyte supernatant rose from 14.70+/-3.55 micromol x l(-1) to 150.50+/-45.55 micromol x l(-1) in the presence of a combination of interleukin-1beta, TNF alpha and interferon gamma. Nitrites 21-29 tumor necrosis factor Rattus norvegicus 190-199 9235225-7 1997 Indeed, [1] elevated TNF-alpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and [2] incubation of macrophages with a neutralizing anti-TNF-alpha antibody impaired both NF-kappa B activation and nitrite accumulation in response to acid challenge. Nitrites 222-229 tumor necrosis factor Rattus norvegicus 21-30 9235225-7 1997 Indeed, [1] elevated TNF-alpha bioactivity was observed in the medium of macrophages exposed to pH 7.0, and [2] incubation of macrophages with a neutralizing anti-TNF-alpha antibody impaired both NF-kappa B activation and nitrite accumulation in response to acid challenge. Nitrites 222-229 tumor necrosis factor Rattus norvegicus 163-172 9010260-3 1997 MC isolated from rat glomeruli generated substantial amounts of nitrite, the stable NO end-product, when cells were stimulated with IL-1beta and tumour necrosis factor-alpha (TNF-alpha). Nitrites 64-71 tumor necrosis factor Rattus norvegicus 175-184 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 tumor necrosis factor Rattus norvegicus 98-125 8549863-7 1996 Use of arginine-free medium, without or with NG-monomethyl-L-arginine, resulted in inhibition of nitrite formation by 5-1,000 U/ml IFN+TNF and partial restoration of the insulin secretory response to glucose. Nitrites 97-104 tumor necrosis factor Rattus norvegicus 131-138 8548421-9 1996 Simultaneous treatment with IFN-gamma and TNF-alpha or IL-1 beta induced elaboration of nitrite, an end product of nitric oxide, in rat but not human SMCs. Nitrites 88-95 tumor necrosis factor Rattus norvegicus 42-51 7588294-7 1995 IL-1 beta, TNF-alpha, and bacterial lipopolysaccharide were found to have weak stimulatory effects on nitrite production on their own. Nitrites 102-109 tumor necrosis factor Rattus norvegicus 11-20 7540573-4 1995 Addition of IL-1 beta alone or in combination with tumor necrosis factor-alpha induced a concentration- and time-dependent expression of the iNOS gene and associated NO production (measured as nitrite) from both islets and RIN cells. Nitrites 193-200 tumor necrosis factor Rattus norvegicus 51-78 7536714-2 1995 A combination of interleukin-1 alpha (100 U/mL) and tumor necrosis factor--alpha (5000 U/mL) induced accumulation of nitrite/nitrate, the stable end products of nitric oxide, in culture media within 48 hours. Nitrites 117-124 tumor necrosis factor Rattus norvegicus 17-80 7536714-6 1995 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrites 13-20 tumor necrosis factor Rattus norvegicus 62-89 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 tumor necrosis factor Rattus norvegicus 66-93 7535004-4 1995 Treatment of vascular SMC with interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) resulted in parallel increases in L-arginine transport and nitric oxide (NO) synthesis, as measured by nitrite production. Nitrites 209-216 tumor necrosis factor Rattus norvegicus 95-104 7535004-5 1995 Increasing the concentration of IL-1 beta and TNF-alpha caused a progressive elevation in nitrite production but did not further stimulate L-arginine uptake. Nitrites 90-97 tumor necrosis factor Rattus norvegicus 46-55 7535004-6 1995 Treatment of SMC with the combination of TNF-alpha and interferon-gamma (IFN-gamma) synergistically enhanced nitrite release without having any additional effect on L-arginine transport. Nitrites 109-116 tumor necrosis factor Rattus norvegicus 41-50 7533786-9 1995 Transforming growth factor-beta 1 decreased IFN-gamma/TNF-alpha--stimulated iNOS mRNA and nitrite. Nitrites 90-97 tumor necrosis factor Rattus norvegicus 54-63 7578879-6 1995 The combination IFN-gamma + TNF-alpha caused a 5-fold increase in the medium nitrite accumulation, indicating induction of nitric oxide formation. Nitrites 77-84 tumor necrosis factor Rattus norvegicus 28-37 7945814-9 1994 In the presence of anti-TNF antibody, the amounts of superoxide and hydrogen peroxide release were moderately reduced but nitrite release was dramatically inhibited. Nitrites 122-129 tumor necrosis factor Rattus norvegicus 24-27 7518300-15 1994 Combination of Bt2 cyclic AMP and IL-1 beta or TNF alpha revealed a strong synergy in terms of nitrite formation. Nitrites 95-102 tumor necrosis factor Rattus norvegicus 47-56 7514363-4 1994 IL-1 beta, TNF-alpha, and LPS each induced NO synthase activity, assessed by release of nitrite, conversion of L-arginine to L-citrulline, and increased levels of guanosine 3",5"-cyclic monophosphate, whereas IL-2, IL-6, and interferon-gamma were ineffective. Nitrites 88-95 tumor necrosis factor Rattus norvegicus 11-20 7516691-4 1994 Besides employing TPA directly, the synergistic effect of TNF could be traced back to protein kinase C activation since protein kinase C inhibitors (IC50 value for staurosporine: 4 nM) potently suppressed nitrite production in the case of IL-1/TNF administration. Nitrites 205-212 tumor necrosis factor Rattus norvegicus 58-61 7516691-5 1994 Further experiments using anti-TNF antibodies aimed to an autocrine loop following IL-1 addition to RINm5F cells, possibly involved in nitrite generation. Nitrites 135-142 tumor necrosis factor Rattus norvegicus 31-34 7505207-4 1994 IGF-I inhibited, in a concentration-dependent manner, the production of nitrite and L-citrulline evoked by IL-1 beta or TNF-alpha. Nitrites 72-79 tumor necrosis factor Rattus norvegicus 120-129 7509009-2 1993 The combination of interferon-gamma (100 U/ml) and tumor necrosis factor-alpha (5000 U/ml) evoked a time-dependent increase in nitric oxide synthase mRNA and nitrite/nitrate production, both of which were inhibited by dexamethasone. Nitrites 158-165 tumor necrosis factor Rattus norvegicus 19-78 7690801-9 1993 Conversely, addition of high concentrations of TNF-alpha (> or = 500 U/ml) led to near maximal levels of nitrite formation even at lowest IL-1 beta concentrations (40 U/ml). Nitrites 108-115 tumor necrosis factor Rattus norvegicus 47-56 7684333-7 1993 Pretreatment with 5 and 50 mM nitrite markedly depressed tumor necrosis factor (TNF)-alpha-dependent natural cytotoxicity of PMC for the tumor target WEHI-164. Nitrites 30-37 tumor necrosis factor Rattus norvegicus 57-90 7684333-8 1993 Thus, high concentrations of nitrite enhanced mast cell histamine release, but depressed TNF-alpha-dependent cytotoxicity. Nitrites 29-36 tumor necrosis factor Rattus norvegicus 89-98 1384580-3 1992 Exposure to tumor necrosis factor-alpha caused a modest (2x) increase in nitrite production. Nitrites 73-80 tumor necrosis factor Rattus norvegicus 12-39 2265709-3 1990 Tissue culture medium nitrite levels were raised in islets treated with IL-1 beta or TNF-alpha (48 h). Nitrites 22-29 tumor necrosis factor Rattus norvegicus 85-94 35215227-5 2022 It exhibited scavenging activity of 50-85% at 1-10 mg/mL, it inhibited nitrite production and ICAM-1 expression in TNF-alpha-stimulated endothelial cell cultures dose-dependently, at a maximum of 58.7% at the maximum dose administered and exerted an obvious anti-inflammatory effect in vivo, settling early and decreasing at 180 min; a new herbal bioactive product was presented with promising therapeutic potential that can be an adjunct to conventional therapies for diseases based on oxidative stress and inflammation. Nitrites 71-78 tumor necrosis factor Rattus norvegicus 115-124 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrites 107-114 tumor necrosis factor Rattus norvegicus 81-85 31590920-4 2019 Co-treatment of cells with a cocktail of pro-inflammatory cytokines (IL-1beta, IFNgamma and TNFalpha) caused a marked increase in caspase activation and a reduction in cell viability, effects attenuated by inclusion of each EET; this was also associated with a reduction in cytokine-induced NFkappaB activation and nitrite accumulation. Nitrites 315-322 tumor necrosis factor Rattus norvegicus 92-100