PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19628069-8 2009 In correlation with graft survival, mRNA levels for interferon-gamma in the spleen or tumor necrosis factor-alpha in the grafts were significantly less when animals were fed nitrite water compared with those without nitrite supplementation. Nitrites 174-181 interferon gamma Rattus norvegicus 52-68 27973680-3 2017 IFN-gamma increased the release of nitrite, a metabolite of nitric oxide, which was augmented by PGE2 , although PGE2 by itself slightly affects nitrite release. Nitrites 35-42 interferon gamma Rattus norvegicus 0-9 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrites 107-114 interferon gamma Rattus norvegicus 30-40 27973680-6 2017 An EP2 agonist, ONO-AE1-259-01 also augmented IFN-gamma-induced nitrite release, while an EP1 agonist, ONO-DI-004, an EP3 agonist, ONO-AE-248, or an EP4 agonist, ONO-AE1-329, did not. Nitrites 64-71 interferon gamma Rattus norvegicus 46-55 27973680-9 2017 Furthermore, other prostanoid receptor agonists, PGD2 , PGF2alpha , iloprost, and U-46119, slightly affected IFN-gamma-induced nitrite release. Nitrites 127-134 interferon gamma Rattus norvegicus 109-118 20543082-4 2010 Concurrent stimulation of quiescent rat aortic SMCs with lipopolysaccharide (LPS) and interferon (IFN)-gamma increased COX-2, iNOS, and nitrite production. Nitrites 136-143 interferon gamma Rattus norvegicus 86-108 18558493-7 2008 Conversely, murine rIFN-gamma-activated mouse MPhi produced high levels of nitrite and killed intracellular M. leprae in vitro. Nitrites 75-82 interferon gamma Rattus norvegicus 19-29 17457174-10 2007 Interestingly, inhibition of IFN-gamma in CpG-treated animals reduced TNF-alpha (P < 0.05), IL-6 (P < 0.05), nitrite (P < 0.05), and intestinal permeability following hemorrhagic shock (P < 0.05) and down-regulated expression of TLR4. Nitrites 115-122 interferon gamma Rattus norvegicus 29-38 18078452-5 2008 Treatment with LPS/IFN-gamma for 24 hr elicited the induction of inducible (iNOS) activity as determined by nitrite and nitrate (NO(x)) accumulation in the culture medium. Nitrites 108-115 interferon gamma Rattus norvegicus 19-28 14559427-10 2003 Incubation of L2 cells with a mixture of interferon gamma (IFNgamma), lipopolysaccharide (LPS), and tumor necrosis factor (TNFalpha) resulted in high levels of nitrite formation resulting from iNOS induction. Nitrites 160-167 interferon gamma Rattus norvegicus 41-57 12911628-3 2003 Application of IFN-gamma followed by LPS caused dopaminergic cell death and accompanying increases in nitrite production and lactate dehydrogenase release. Nitrites 102-109 interferon gamma Rattus norvegicus 15-24 15857166-4 2006 Treatment with erythropoietin inhibited the expression of iNOS mRNA and nitrite production resulting from proinflammatory stimulation by IFN-gamma and LPS. Nitrites 72-79 interferon gamma Rattus norvegicus 137-146 14559427-10 2003 Incubation of L2 cells with a mixture of interferon gamma (IFNgamma), lipopolysaccharide (LPS), and tumor necrosis factor (TNFalpha) resulted in high levels of nitrite formation resulting from iNOS induction. Nitrites 160-167 interferon gamma Rattus norvegicus 59-67 12869138-4 2003 When stimulated with IFN-gamma, culture supernatants from young PMs contained higher amounts of nitrite and TNF-alpha. Nitrites 96-103 interferon gamma Rattus norvegicus 21-30 11927648-7 2002 Upon stimulation with antigen, IFN-gamma, or anti-CD8, nitrite production was increased significantly (8.4+/-0.6, 7.6+/-0.9, and 6.6+/-0.9 microM/2x10(5) cells/48 h NO2-, respectively; P<0.01), whereas unstimulated PMC released 2.1 +/- 0.3 microM/2 x 10(5) cells/48 h NO2-. Nitrites 55-62 interferon gamma Rattus norvegicus 31-40 12230105-3 2002 When OD (1 mg/ml) was used in combination with 10 U/ml of recombinant interferon-gamma (rIFN-gamma), there was a marked cooperative induction of NO production (36.13+/-7.12 microM) by the Griess method (nitrite). Nitrites 203-210 interferon gamma Rattus norvegicus 88-98 11520904-2 2001 After 24 h of lipopolysaccharide (LPS) (1 microg/mL) and interferon-gamma (IFN-gamma) (300 U/mL) stimulation, a significant increase in NO production, evaluated as nitrite, was observed in the culture medium. Nitrites 164-171 interferon gamma Rattus norvegicus 75-84 11744809-8 2002 RESULTS: High 30 mM glucose concentration led to significant increases in nitrite production of rat mesangial cells upon stimulation with lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) compared with control 5.6 mM glucose concentration. Nitrites 74-81 interferon gamma Rattus norvegicus 168-184 11744809-8 2002 RESULTS: High 30 mM glucose concentration led to significant increases in nitrite production of rat mesangial cells upon stimulation with lipopolysaccharide (LPS) plus interferon-gamma (IFN-gamma) compared with control 5.6 mM glucose concentration. Nitrites 74-81 interferon gamma Rattus norvegicus 186-195 11454939-2 2001 Maximal induced activity, measured by the accumulation of nitrite in culture medium, occurred following treatment with lipopolysaccharide and interferon-gamma. Nitrites 58-65 interferon gamma Rattus norvegicus 142-158 11742807-1 2002 In rat aortic smooth muscle cells (RASMC), interferon (IFN)-gamma enhanced nitrite accumulation and type II nitric oxide synthase (iNOS) protein expression induced by interleukin (IL)-1 beta. Nitrites 75-82 interferon gamma Rattus norvegicus 43-65 11104730-0 2000 Surfactant protein A differentially regulates IFN-gamma- and LPS-induced nitrite production by rat alveolar macrophages. Nitrites 73-80 interferon gamma Rattus norvegicus 46-55 11294465-4 2001 Incubation with local anesthetics alone did not induce nitrite accumulation; however, the nitrite production induced by stimulation with bacterial endotoxin lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) was increased in a dose-dependent manner by bupivacaine (maximal 3-fold at 360 microM), tetracaine (maximal 7-fold at 360 microM), and lidocaine at higher doses (5-fold increase at 3.3 mM). Nitrites 90-97 interferon gamma Rattus norvegicus 186-202 11294465-4 2001 Incubation with local anesthetics alone did not induce nitrite accumulation; however, the nitrite production induced by stimulation with bacterial endotoxin lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) was increased in a dose-dependent manner by bupivacaine (maximal 3-fold at 360 microM), tetracaine (maximal 7-fold at 360 microM), and lidocaine at higher doses (5-fold increase at 3.3 mM). Nitrites 90-97 interferon gamma Rattus norvegicus 204-213 10212230-8 1999 Treatment of macrophage-depleted rat islets for 40 h with poly(IC) + IFN-gamma results in the expression of iNOS, production of nitrite, and inhibition of insulin secretion. Nitrites 128-135 interferon gamma Rattus norvegicus 69-78 11093766-2 2000 Lipopolysaccharides (LPSs) and interferon-gamma stimulated in the same concentration- and time-dependent manner NO synthesis (measured by nitrite accumulation) and L-[(3)H]arginine uptake. Nitrites 138-145 interferon gamma Rattus norvegicus 31-47 11093766-5 2000 The NF-kappaB inhibitors pyrrolidine dithiocarbamate and N(alpha)-p-tosyl-L-lysine chloromethyl ketone abrogated LPS- and interferon-gamma-induced increase of nitrite accumulation and L-[(3)H]arginine uptake as well as up-regulation of iNOS and CAT-2B mRNA. Nitrites 159-166 interferon gamma Rattus norvegicus 122-138 10996037-6 2000 The response of IFN-gamma (50 U/ml)-activated macrophages (1.68 nmol nitrite/well) was potentiated (3.52, 4.96, and 4.44 nmol nitrite/well) by fumonisin B(1) (1, 10, and 100 microg/ml, respectively). Nitrites 69-76 interferon gamma Rattus norvegicus 16-25 10996037-6 2000 The response of IFN-gamma (50 U/ml)-activated macrophages (1.68 nmol nitrite/well) was potentiated (3.52, 4.96, and 4.44 nmol nitrite/well) by fumonisin B(1) (1, 10, and 100 microg/ml, respectively). Nitrites 126-133 interferon gamma Rattus norvegicus 16-25 10684988-7 2000 The number of intracellular parasites in PE was markedly decreased in young born to IFN-gamma-treated mothers, this not being accompanied by higher nitrite levels in culture supernatants. Nitrites 148-155 interferon gamma Rattus norvegicus 84-93 10510444-3 1999 2 Treatment with LPS/IFN-gamma and mixed cytokines for 24 h elicited the induction of iNOS activity as determined by nitrite accumulation in the culture medium and assay of enzyme activity. Nitrites 117-124 interferon gamma Rattus norvegicus 21-30 10212230-3 1999 Treatment of rat islets with poly(IC) + interferon-gamma (IFN-gamma) stimulates the time- and concentration-dependent expression of iNOS and production of nitrite by rat islets. Nitrites 155-162 interferon gamma Rattus norvegicus 40-56 10212230-3 1999 Treatment of rat islets with poly(IC) + interferon-gamma (IFN-gamma) stimulates the time- and concentration-dependent expression of iNOS and production of nitrite by rat islets. Nitrites 155-162 interferon gamma Rattus norvegicus 58-67 10212230-4 1999 iNOS expression and nitrite production by rat islets in response to poly(IC) + IFN-gamma correlate with an inhibition of insulin secretion and islet degeneration, effects that are prevented by the iNOS inhibitor aminoguanidine (AG). Nitrites 20-27 interferon gamma Rattus norvegicus 79-88 10874128-9 2000 Finally, clonidine (1.0 x 10(-4) M to 1.0 x 10(-3) M) dose dependently increased the levels of LPS/IFN-gamma-induced nitrites, the breakdown product of NO, in supernatants of rat C6 glioma cells. Nitrites 117-125 interferon gamma Rattus norvegicus 95-108 10532951-4 1999 Similarly, incubation of NRVMs with IL-1beta and IFNgamma for 48 hours resulted in an increase in iNOS expression, nitrite production, and programmed cell death. Nitrites 115-122 interferon gamma Rattus norvegicus 49-57 10506184-4 1999 However, a 30-60-min pulse of rat islets with IFN-gamma, followed by washing to remove the cytokine and continued culture with 0.1 unit/ml IL-1 for 40 h, results in iNOS expression and nitrite production to levels similar in magnitude to the individual effects of 1.0 unit/ml IL-1. Nitrites 185-192 interferon gamma Rattus norvegicus 46-55 10506184-7 1999 The priming actions of IFN-gamma appear to be selective for beta-cells, as IFN-gamma primes for IL-1-induced nitrite formation by primary beta-cells and RINm5F insulinoma cells, but not primary alpha-cells. Nitrites 109-116 interferon gamma Rattus norvegicus 23-32 10506184-7 1999 The priming actions of IFN-gamma appear to be selective for beta-cells, as IFN-gamma primes for IL-1-induced nitrite formation by primary beta-cells and RINm5F insulinoma cells, but not primary alpha-cells. Nitrites 109-116 interferon gamma Rattus norvegicus 75-84 10523329-7 1999 Nitrite accumulation was higher by the cells treated with interleukin-1beta combined with either interferon-gamma or tumor necrosis factor-alpha compared with those treated with interleukin-1beta alone. Nitrites 0-7 interferon gamma Rattus norvegicus 97-144 9585299-4 1998 Incubation of cells with LPS (1 microg/mL) and IFN-gamma (100 u/mL) for 24 h resulted in significant increases in nitrite production and L-arginine transport. Nitrites 114-121 interferon gamma Rattus norvegicus 47-56 9878697-2 1999 CsA applied simultaneously with iNOS activator IFN-gamma caused dose-dependent reduction of NO synthesis in confluent C6 cells, as determined by measuring accumulation of nitrite, an indicator of NO production, in 48 h culture supernatants. Nitrites 171-178 interferon gamma Rattus norvegicus 47-56 9767607-2 1998 Under these conditions, we were able to detect nitrite in the incubation medium when the eosinophils were stimulated with IFN-gamma or IL-8 in the presence of LPS. Nitrites 47-54 interferon gamma Rattus norvegicus 122-131 9767607-4 1998 Significant levels of nitrite in the medium were already present after 12 h of stimulation and increased steadily within the next 48 h. Regarding NO synthase, its highest activity was achieved at 12 h after IFN-gamma/LPS stimulation. Nitrites 22-29 interferon gamma Rattus norvegicus 207-216 9767607-9 1998 It was observed that these cells were able to produce nitrite and to kill the parasite after activation with LPS/IFN-gamma. Nitrites 54-61 interferon gamma Rattus norvegicus 113-122 10203355-9 1999 TNF-alpha or LPS alone did not induce nitrite production, but with IFN-gamma these compounds did induce nitrite production. Nitrites 104-111 interferon gamma Rattus norvegicus 67-76 9794915-6 1998 In cocultured hepatocytes incubated with LPS and IFN-gamma, DNIC and nitrite levels decreased compared with those observed in hepatocytes cultured without macrophages in the same conditions. Nitrites 69-76 interferon gamma Rattus norvegicus 49-58 9689011-3 1998 ATP (10(-3) M) inhibited 24-h nitrite production induced by lipopolysaccharide (LPS, 10 microg/ml)/interferon-gamma (IFN-gamma, 100 U/ml) by 48.2 +/- 6. Nitrites 30-37 interferon gamma Rattus norvegicus 99-115 9689011-3 1998 ATP (10(-3) M) inhibited 24-h nitrite production induced by lipopolysaccharide (LPS, 10 microg/ml)/interferon-gamma (IFN-gamma, 100 U/ml) by 48.2 +/- 6. Nitrites 30-37 interferon gamma Rattus norvegicus 117-126 9689011-5 1998 Also, coincubation with either 10(-4) M of UTP, ATP, or ATPgammaS inhibited LPS/IFN-gamma-induced nitrite production by 29.9 +/- 5.8, 36.4 +/- 4.3, and 50.3 +/- 6.5%, respectively, indicating involvement of purinergic P2Y2 receptors. Nitrites 98-105 interferon gamma Rattus norvegicus 76-89 8822811-4 1996 Incubation of cells from Janvier and Charles River rats with lipopolysaccharide and/or interferon-gamma increased nitrite production to a similar extent. Nitrites 114-121 interferon gamma Rattus norvegicus 87-103 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 interferon gamma Rattus norvegicus 198-207 9252565-6 1997 Nitrite production by rat aortic macrovascular endothelial cells (RAEC) was significantly greater than that by the rat lung microvascular endothelial cells (RLMVEC) when stimulated with TNF-alpha + IFN-gamma, LPS + IFN-gamma, or TNF-alpha + LPS. Nitrites 0-7 interferon gamma Rattus norvegicus 215-224 9252565-8 1997 The nitrite generation from rat pulmonary artery endothelial cells was intermediate between RAEC and RLMVEC responses when stimulated with IFN-gamma + LPS or TNF-alpha. Nitrites 4-11 interferon gamma Rattus norvegicus 139-148 9153221-6 1997 iNOS expression and nitrite production by rat islets in response to 150 units/ml rat IFN-gamma and 0.1 unit/ml IL-1beta are correlated with an inhibition of insulin secretion and islet degeneration that are prevented by the iNOS inhibitor aminoguanidine. Nitrites 20-27 interferon gamma Rattus norvegicus 85-94 9145305-2 1997 We have demonstrated here that retinal Muller glial (RMG) cells obtained from RCS dystrophic rats and stimulated in vitro with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) accumulated higher levels of tumor necrosis factor (TNF) and inducible nitric oxide synthase (NOS II) mRNA and released in culture supernatants significantly higher amounts of TNF and nitrite compared to cells derived from nondystrophic controls. Nitrites 369-376 interferon gamma Rattus norvegicus 156-172 9145305-2 1997 We have demonstrated here that retinal Muller glial (RMG) cells obtained from RCS dystrophic rats and stimulated in vitro with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) accumulated higher levels of tumor necrosis factor (TNF) and inducible nitric oxide synthase (NOS II) mRNA and released in culture supernatants significantly higher amounts of TNF and nitrite compared to cells derived from nondystrophic controls. Nitrites 369-376 interferon gamma Rattus norvegicus 174-183 9145305-3 1997 The TNF and NOS II mRNA expression and TNF and nitrite synthesis induced in RMG cells from both strains by LPS + IFN-gamma was significantly prevented by including transforming growth factor-beta (TGF-beta) in the culture medium. Nitrites 47-54 interferon gamma Rattus norvegicus 113-122 9038808-3 1997 In L6 cells, the combination of interleukin-1 beta and interferon-gamma induced a marked accumulation of nitrite, a stable metabolite of nitric oxide. Nitrites 105-112 interferon gamma Rattus norvegicus 55-71 9010260-7 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma), but not IL-1beta and TNF-alpha, induced rat peritoneal macrophages to produce large amounts of nitrite. Nitrites 154-161 interferon gamma Rattus norvegicus 29-45 9010260-7 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma), but not IL-1beta and TNF-alpha, induced rat peritoneal macrophages to produce large amounts of nitrite. Nitrites 154-161 interferon gamma Rattus norvegicus 47-56 9669207-9 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) stimulated release of nitrite, lactate dehydrogenase (LDH), TNF alpha, IL-1 beta and IL-8 from rat peritoneal macrophages, all of which were significantly reduced by ITU. Nitrites 80-87 interferon gamma Rattus norvegicus 29-45 9669207-9 1997 Lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) stimulated release of nitrite, lactate dehydrogenase (LDH), TNF alpha, IL-1 beta and IL-8 from rat peritoneal macrophages, all of which were significantly reduced by ITU. Nitrites 80-87 interferon gamma Rattus norvegicus 47-56 9400741-9 1997 Rat AM, stimulated with either LPS or IFN-gamma, produced nitrite in a time- and dose-dependent manner. Nitrites 58-65 interferon gamma Rattus norvegicus 38-47 9400741-10 1997 Combination of LPS and IFN-gamma resulted in a significantly enhanced nitrite formation. Nitrites 70-77 interferon gamma Rattus norvegicus 23-32 9227507-6 1997 In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma. Nitrites 91-98 interferon gamma Rattus norvegicus 183-199 9234372-6 1997 Incubation of RMG cells and microglia with the stereoselective inhibitor of NOS, NG-monomethyl-L-arginine (L-NMMA), inhibited nitrite release in LPS + IFN-gamma-stimulated RMG cells and microglia. Nitrites 126-133 interferon gamma Rattus norvegicus 151-160 9153221-10 1997 These studies show that the T-lymphocyte cytokine, IFN-gamma, increases the sensitivity of rat islets to the effects of IL-1beta on iNOS expression and nitrite production by 10-fold, in part, through the stabilization of iNOS mRNA. Nitrites 152-159 interferon gamma Rattus norvegicus 51-60 8548421-9 1996 Simultaneous treatment with IFN-gamma and TNF-alpha or IL-1 beta induced elaboration of nitrite, an end product of nitric oxide, in rat but not human SMCs. Nitrites 88-95 interferon gamma Rattus norvegicus 28-37 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 interferon gamma Rattus norvegicus 139-155 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrites 253-260 interferon gamma Rattus norvegicus 157-166 8780024-5 1996 We also found that interferon-gamma potentiated the effect of lipopolysaccharide on nitrite accumulation as previously described by others and depressed the lipopolysaccharide-evoked production of prostaglandin E2, prostaglandin D2, and thromboxane. Nitrites 84-91 interferon gamma Rattus norvegicus 19-35 7588294-6 1995 Nitrite accumulation in culture medium was induced by IFN-gamma in a time- and dose-dependent manner and inhibited by cotreatment with inhibitors of NOS activity and by dexamethasone. Nitrites 0-7 interferon gamma Rattus norvegicus 54-63 7499860-7 1995 Concurrent stimulation of rIFN-gamma with either viable or killed BCG resulted in a strong nitrite production by macrophages. Nitrites 91-98 interferon gamma Rattus norvegicus 26-36 7499860-8 1995 Neutralization of IFN-gamma and TNF-alpha caused a complete inhibition of nitrite production. Nitrites 74-81 interferon gamma Rattus norvegicus 18-27 8719803-9 1995 Furthermore, activation of cells with LPS and IFN-gamma had no effect on uptake of the neutral amino acid L-citrulline but selectively increased the Vmax for L-arginine transport 2.8 fold and nitrite levels from 24 +/- 7 to 188 +/- 14 pmol micrograms-1 protein 24 h-1. Nitrites 192-199 interferon gamma Rattus norvegicus 46-55 8719803-13 1995 Cycloheximide (1 microM) abolished induction of L-arginine transport and nitrite accumulation in response to LPS and IFN-gamma. Nitrites 73-80 interferon gamma Rattus norvegicus 117-126 7588294-8 1995 However, IL-1 beta and TNF-alpha showed strong synergy with IFN-gamma, but, surprisingly, lipopolysaccharide was found to exert potent inhibitory effects on IFN-gamma-induced nitrite synthesis. Nitrites 175-182 interferon gamma Rattus norvegicus 157-166 7501421-4 1995 Significantly higher levels of nitrite (NO2) were detected in supernatants from macrophage cultures treated with rIFN-gamma (10 u/ml or 100 u/ml) which induced microbistatic macrophage activity as well as from macrophage cultures treated with LPS + rIFN- when compared with levels of nitrite detected in supernatants of infected macrophages treated with medium only. Nitrites 31-38 interferon gamma Rattus norvegicus 113-123 7585804-5 1995 RESULTS: Stimulation by LPS or in combination with interferon-gamma increased the accumulation of nitrite in the supernatant of J774 macrophages or cardiac myocytes. Nitrites 98-105 interferon gamma Rattus norvegicus 51-67 7582541-6 1995 NAS (0.01-5 mM) caused a concentration-dependent inhibition of the accumulation of nitrite in the conditioned medium of LPS/interferon-gamma (IFN gamma)-stimulated RAW 264.7 macrophages and interleukin-1 beta (IL-1 beta)-activated vascular smooth muscle cells (VSMC). Nitrites 83-90 interferon gamma Rattus norvegicus 120-140 7582541-6 1995 NAS (0.01-5 mM) caused a concentration-dependent inhibition of the accumulation of nitrite in the conditioned medium of LPS/interferon-gamma (IFN gamma)-stimulated RAW 264.7 macrophages and interleukin-1 beta (IL-1 beta)-activated vascular smooth muscle cells (VSMC). Nitrites 83-90 interferon gamma Rattus norvegicus 142-151 7501421-4 1995 Significantly higher levels of nitrite (NO2) were detected in supernatants from macrophage cultures treated with rIFN-gamma (10 u/ml or 100 u/ml) which induced microbistatic macrophage activity as well as from macrophage cultures treated with LPS + rIFN- when compared with levels of nitrite detected in supernatants of infected macrophages treated with medium only. Nitrites 284-291 interferon gamma Rattus norvegicus 113-123 7541386-5 1995 Hepatocytes isolated from endotoxemic rats released increased amounts of nitric oxide, measured by nitrite production, in response to interferon gamma (gamma-IFN) alone or in combination with LPS, tumor necrosis factor alpha, macrophage-colony stimulating factor, granulocyte/macrophage-colony stimulating factor, or hepatocyte growth factor. Nitrites 99-106 interferon gamma Rattus norvegicus 134-161 7535004-6 1995 Treatment of SMC with the combination of TNF-alpha and interferon-gamma (IFN-gamma) synergistically enhanced nitrite release without having any additional effect on L-arginine transport. Nitrites 109-116 interferon gamma Rattus norvegicus 55-71 7536714-6 1995 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrites 13-20 interferon gamma Rattus norvegicus 158-185 7535004-6 1995 Treatment of SMC with the combination of TNF-alpha and interferon-gamma (IFN-gamma) synergistically enhanced nitrite release without having any additional effect on L-arginine transport. Nitrites 109-116 interferon gamma Rattus norvegicus 73-82 7535004-8 1995 Finally, treatment of SMC with interferon-gamma and N6,2"-O-dibutyryl adenosine 3",5"-cyclic monophosphate selectively stimulated the formation of nitrite by SMC but had no effect on L-arginine transport. Nitrites 147-154 interferon gamma Rattus norvegicus 31-47 7578879-6 1995 The combination IFN-gamma + TNF-alpha caused a 5-fold increase in the medium nitrite accumulation, indicating induction of nitric oxide formation. Nitrites 77-84 interferon gamma Rattus norvegicus 16-25 7533786-9 1995 Transforming growth factor-beta 1 decreased IFN-gamma/TNF-alpha--stimulated iNOS mRNA and nitrite. Nitrites 90-97 interferon gamma Rattus norvegicus 44-53 7475930-7 1995 Verapamil markedly increased the formation of nitrite in cardiac myocytes in response to LPS and IFN gamma, but not in vascular smooth muscle or mesangial cells. Nitrites 46-53 interferon gamma Rattus norvegicus 97-106 7527832-5 1994 Interestingly, although nitrite accumulation in the culture medium of IMs isolated 48 h after induction of acute endotoxemia and stimulated with low concentrations of IFN-gamma and LPS was reduced, when compared with cells from control animals, these cells, as well as AMs, continued to express high levels of iNOS protein and mRNA. Nitrites 24-31 interferon gamma Rattus norvegicus 167-176 7478126-6 1995 RESULTS: The addition of IFN to dialysis fluid or saline resulted in a significant (P < 0.01) increase in the number of peritoneal macrophages at the time of infection; this was accompanied by a significant increase in both the number of Ia-positive peritoneal macrophages (P < 0.01) and the production of nitrite by macrophages (P < 0.05) at the time. Nitrites 312-319 interferon gamma Rattus norvegicus 25-28 7527442-8 1994 4) Only the addition of rIFN-gamma, and not IL-2 or IL-4, to cultures of purified GdKCs resulted in the release of nitrite. Nitrites 115-122 interferon gamma Rattus norvegicus 24-34 7684804-2 1993 The LPS-induced cyclic GMP and nitrite increase was enhanced by interferon-gamma and was prevented by L-NG-nitroarginine, dexamethasone and cycloheximide. Nitrites 31-38 interferon gamma Rattus norvegicus 64-80 8027551-5 1994 rIFN-gamma-induced antimicrobial effects in AM correlated with amount of nitrites produced, but nitric oxide played only a minimal role in antibacterial effects induced in AM, because NG-MMLA (specific inhibitor of L-arginine-dependent nitric oxide production) failed to block antimicrobial activity of IFN-gamma-stimulated AM. Nitrites 73-81 interferon gamma Rattus norvegicus 0-10 8027551-5 1994 rIFN-gamma-induced antimicrobial effects in AM correlated with amount of nitrites produced, but nitric oxide played only a minimal role in antibacterial effects induced in AM, because NG-MMLA (specific inhibitor of L-arginine-dependent nitric oxide production) failed to block antimicrobial activity of IFN-gamma-stimulated AM. Nitrites 73-81 interferon gamma Rattus norvegicus 1-10 7515948-2 1994 Treatment of retinal Muller glial (RMG) cells with lipopolysaccharide (LPS), interferon-gamma, and tumor necrosis factor-alpha induced NO synthesis as determined by nitrite release in media. Nitrites 165-172 interferon gamma Rattus norvegicus 77-126 8163651-4 1994 In this study we show that primary rat osteoblast-like cells as well as the clonal rat osteoblast-like cell line UMR-106, stimulated with IFN-gamma together with TNF-alpha and LPS, produce NO, measured as nitrite production. Nitrites 205-212 interferon gamma Rattus norvegicus 138-147 8135804-2 1994 Stimulation of the cells with lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) after the treatment of recombinant interferon-gamma (rIFN-gamma) resulted in the increased accumulation of nitrite in the medium. Nitrites 203-210 interferon gamma Rattus norvegicus 149-159 8480530-1 1993 Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. Nitrites 149-156 interferon gamma Rattus norvegicus 56-72 8480530-1 1993 Rat alveolar macrophages incubated with recombinant rat interferon-gamma produce L-arginine-dependent nitric oxide, which is rapidly decomposed into nitrite: this production by interferon-gamma was markedly enhanced by granulocyte-macrophage colony-stimulating factor and muramyldipeptide, but not by other cytokines. Nitrites 149-156 interferon gamma Rattus norvegicus 177-193 8480530-3 1993 It was based on a simple synergism between interferon-gamma and muramyldipeptide and a priming effect of granulocyte-macrophage colony-stimulating factor for interferon-gamma-induced nitrite production. Nitrites 183-190 interferon gamma Rattus norvegicus 158-174 1555245-2 1992 Upon incubation with bacterial lipopolysaccharide (LPS) or rat interferon-gamma (IFN-gamma), cells from the microglia-enriched fraction released measurable amounts of nitrite into the supernatant within 24-48 hr. Nitrites 167-174 interferon gamma Rattus norvegicus 63-79 1280597-2 1992 In cultured rat lung fibroblasts the presence of L-arginine was necessary for the production of nitrite to be induced by rat recombinant interferon-gamma and synergistically enhanced by lipopolysaccharide and interleukin-1 beta. Nitrites 96-103 interferon gamma Rattus norvegicus 137-153 1555245-2 1992 Upon incubation with bacterial lipopolysaccharide (LPS) or rat interferon-gamma (IFN-gamma), cells from the microglia-enriched fraction released measurable amounts of nitrite into the supernatant within 24-48 hr. Nitrites 167-174 interferon gamma Rattus norvegicus 81-90 1555245-3 1992 The production of nitrite was dependent on the cell number and the dose of IFN-gamma and LPS. Nitrites 18-25 interferon gamma Rattus norvegicus 75-84 1314486-3 1992 A combination of lipopolysaccharide (LPS), interferon-gamma, tumor necrosis factor, and interleukin-1 stimulates the biosynthesis of large quantities of nitrite and nitrate (NO2- + NO3-). Nitrites 153-160 interferon gamma Rattus norvegicus 43-59 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 79-86 interferon gamma Rattus norvegicus 37-47 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 79-86 interferon gamma Rattus norvegicus 214-224 1804302-13 1991 In case of macrophages cultured with rIFN-gamma or rIL-4, the concentration of nitrite was related with cytotoxicity of macrophages against T. vaginalis, but the cytotoxicity of macrophages cultured with rIL-2 and rIFN-gamma was decreased in spite of its high production of nitrite. Nitrites 274-281 interferon gamma Rattus norvegicus 37-47 1804302-14 1991 From the results obtained, it is assumed that rIL-2 and rIFN-gamma enhance the cytotoxicity of macrophages while rIL-4 inhibits the cytotoxicity against T. vaginalis, and that the production of nitrite does not relate with the cytotoxicity of macrophages, but nitric oxide may play a role as an inhibitory factor on the proliferation of T. vaginalis. Nitrites 194-201 interferon gamma Rattus norvegicus 56-66 1782986-1 1991 Rat alveolar and pleural macrophages incubated with lipopolysaccharide, opsonized zymosan or recombinant interferon-gamma, but not with recombinant tumor necrosis factor-alpha, produced nitrite dose and time dependently. Nitrites 186-193 interferon gamma Rattus norvegicus 105-121 1915557-1 1991 Previously, we reported that exposure of bone marrow-derived macrophages (M phi) to a phagocytic stimulus in the simultaneous presence of interferon-gamma (IFN-gamma) induced these cells to generate nitrite (NO2-). Nitrites 199-206 interferon gamma Rattus norvegicus 156-165