PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16297873-4 2006 When provided in combination, IL-4 and dynamic compression could further abrogate the IL-1beta induced nitrite and PGE2 release. Nitrites 103-110 interleukin 1 beta Homo sapiens 86-94 18348730-11 2008 IL-1beta induced a transient increase in iNOS expression and stimulated the production of nitrite release. Nitrites 90-97 interleukin 1 beta Homo sapiens 0-8 18348730-12 2008 Stimulation by either dynamic compression or SB203580 in isolation reduced the IL-1beta induced iNOS expression and nitrite production. Nitrites 116-123 interleukin 1 beta Homo sapiens 79-87 17605605-6 2007 RESULTS: IL-1-GLN-CS and GLN-CS treatments decreased nitrite release, compared with IL-1 treatment; IL-1-GLN-CS treatment decreased IL-1-induced PGE(2) release. Nitrites 53-60 interleukin 1 beta Homo sapiens 9-13 17407761-5 2007 Here, we report for the first time on the use of lentiviral vector-based shRNA delivery to efficiently suppress the IL-1beta-mediated induction of iNOS expression, the accumulation of nitrite and provide significant protection against the cytotoxic effects of IL-1beta exposure. Nitrites 184-191 interleukin 1 beta Homo sapiens 116-124 20092674-7 2010 Furthermore, plasma interleukin-1beta also positively correlated with plasma nitrite/nitrate (p=0.003). Nitrites 77-84 interleukin 1 beta Homo sapiens 20-37 15725942-4 2005 Cultured human aortic vascular smooth muscle cells (HASMC) were stimulated for 18 hours with 10 ng/mL interleukin-1beta (IL-1beta), resulting in a marked increase of iNOS levels and NO production, as determined by Western blotting and nitrite measurement, respectively. Nitrites 235-242 interleukin 1 beta Homo sapiens 102-119 16912414-4 2006 The current data demonstrate that IL-1beta induced nitrite and PGE2 release and inhibited [3H]-thymidine and 35SO4 incorporation. Nitrites 51-58 interleukin 1 beta Homo sapiens 34-42 16912414-5 2006 Inhibitor experiments indicate that 1400W and NS-398 either partially reversed or abolished IL-1beta induced nitrite and PGE2 release. Nitrites 109-116 interleukin 1 beta Homo sapiens 92-100 15725942-4 2005 Cultured human aortic vascular smooth muscle cells (HASMC) were stimulated for 18 hours with 10 ng/mL interleukin-1beta (IL-1beta), resulting in a marked increase of iNOS levels and NO production, as determined by Western blotting and nitrite measurement, respectively. Nitrites 235-242 interleukin 1 beta Homo sapiens 121-129 15294346-4 2004 IL-1beta mRNA transcription was reduced by 35% following nitrite inhalant exposure, consistent with inhibition of activation-induced phosphorylation of macrophage mitogen-activated protein kinase p38. Nitrites 57-64 interleukin 1 beta Homo sapiens 0-8 15294346-7 2004 Nitrite inhalant exposure blocked activation-induced increases in caspase-1 activity, consistent with a 50% reduction in 17 kDa IL-1beta shown in Western blots. Nitrites 0-7 interleukin 1 beta Homo sapiens 128-136 15294346-8 2004 Thus, exposure to nitrite inhalants reduced macrophage production of IL-1beta by reducing transcription, as well as post-translational processing mediated by caspase-1. Nitrites 18-25 interleukin 1 beta Homo sapiens 69-77 15673165-5 2004 Nitrite production induced by inflammatory IL-1beta on cultured chondrocytes was inhibited by the N-benzo[d]isothiazol-3-yl-amidines tested, in particular by N-benzo[d]isothiazol-3-yl-benzamidine, which was the most active. Nitrites 0-7 interleukin 1 beta Homo sapiens 43-51 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 75-82 interleukin 1 beta Homo sapiens 49-57 15115662-6 2004 Overexpression of c-Jun in hepatocytes inhibited IL-1beta+IFNgamma-induced nitrite accumulation and iNOS promoter activity while dominant negative c-Jun partially reversed the inhibitory effects of cAMP on nitrite accumulation. Nitrites 206-213 interleukin 1 beta Homo sapiens 49-57 12782181-3 2003 Exposure of A498 cells to a cytokine mixture consisting of interferon gamma, interleukin-1 beta and tumor necrosis factor-alpha (TNF-alpha) increased nitrite production, iNOS mRNA and protein expression. Nitrites 150-157 interleukin 1 beta Homo sapiens 77-95 14657615-5 2004 Nitrites accumulated in supernatants of SMC cultures were measured as an index of NO released following treatment with IL-1beta. Nitrites 0-8 interleukin 1 beta Homo sapiens 119-127 11996950-5 2002 Incubation of cell cultures with interleukin-1beta (IL-1beta) for 24 h caused a significant increase in nitrite accumulation. Nitrites 104-111 interleukin 1 beta Homo sapiens 33-50 12627879-4 2003 Pretreatment with ONO-RS-082, the secretory PLA2 (sPLA2) inhibitor, at 1 to 10 micromol/l reduced IL-1beta-stimulated nitrite production and iNOS expression. Nitrites 118-125 interleukin 1 beta Homo sapiens 98-106 12627879-5 2003 Nordihydroguaiaretic acid (NDGA, 1 to 10 micromol/l), the LOX inhibitor, also reduced IL-1beta (10 ng/ml)-stimulated nitrite production and iNOS expression in a dose-dependent manner. Nitrites 117-124 interleukin 1 beta Homo sapiens 86-94 12627879-6 2003 Exogenous 12(S)-hydroxyeicosatetraenoic acids (HETE) enhanced the IL-1beta-stimulated nitrite production and iNOS expression. Nitrites 86-93 interleukin 1 beta Homo sapiens 66-74 12351936-11 2002 Induction of nitrite production by a cytomix [IFNgamma (100 ng/ml) + TNFalpha (30 ng/ml) + IL-1beta (5 ng/ml)] was differentially enhanced by exposure to supplemental factors including LPS, L-arginine, and BH4. Nitrites 13-20 interleukin 1 beta Homo sapiens 91-99 11996950-9 2002 Use of specific tyrosine kinase inhibitor herbimycin A, genistein, or PP2 (Src family kinase inhibitor) indicated that tyrosine kinases are required for IL-1beta-stimulated and beta-VLDL-enhanced nitrite accumulation, while specific inhibition of ERK1/2 or p38-MAP kinase had no effects. Nitrites 196-203 interleukin 1 beta Homo sapiens 153-161 11996950-10 2002 Our results suggest that beta-VLDL enhances iNOS expression and nitrite accumulation in IL-1beta-stimulated VSMC through tyrosine kinase(s)-dependent mechanisms. Nitrites 64-71 interleukin 1 beta Homo sapiens 88-96 11996950-5 2002 Incubation of cell cultures with interleukin-1beta (IL-1beta) for 24 h caused a significant increase in nitrite accumulation. Nitrites 104-111 interleukin 1 beta Homo sapiens 52-60 11996950-6 2002 Although beta-VLDL alone did not increase nitrite accumulation in unstimulated VSMC, beta-VLDL significantly enhanced nitrite accumulation in IL-1beta-stimulated VSMC in a time- and dose-dependent manner. Nitrites 118-125 interleukin 1 beta Homo sapiens 142-150 11996950-7 2002 beta-VLDL-induced nitrite accumulation in IL-1beta-stimulated VSMC was accompanied by an increase in iNOS protein and mRNA expression. Nitrites 18-25 interleukin 1 beta Homo sapiens 42-50 12009845-5 2002 The addition of IL-1 beta, TNF-alpha, and IFN-gamma together increased nitrite production: 257.5 +/- 35.8 % and S-nitrosothiol production : 413 +/- 29%, P < 0.001. Nitrites 71-78 interleukin 1 beta Homo sapiens 16-25 11751214-3 2002 Human bronchial epithelial cells stimulated with 50 ng/ml interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma express iNOS mRNA, protein and increased nitrite in the cell culture media, which was inhibited by the selective iNOS inhibitor 1400W. Nitrites 168-175 interleukin 1 beta Homo sapiens 58-104 12062366-5 2002 RESULTS: Nitrite accumulation in the myoblast culture supernatant or iNOS protein in the cell pellet was significantly increased after incubation with IL-1beta in combination with gamma-IFN. Nitrites 9-16 interleukin 1 beta Homo sapiens 151-159 11178941-8 2001 After IL-1beta stimulation, NO degrees production was highly increased in the supernatants (45-fold increase in nitrite, 60-fold increase in nitrosothiols) as well as in cell lysates (35-fold increase in nitrosothiols). Nitrites 112-119 interleukin 1 beta Homo sapiens 6-14 10913230-3 2000 The incubation of HPASMC with various concentrations of LPS, IL-1(beta)or TNF(alpha)for 24 h caused a significant increase in nitrite release and PGI(2)production. Nitrites 126-133 interleukin 1 beta Homo sapiens 61-71 10913230-7 2000 Addition of L-NMMA to a medium containing LPS or IL-1(beta)reduced nitrite release and attenuated the stimulatory effect of those agents on PGI(2)production. Nitrites 67-74 interleukin 1 beta Homo sapiens 49-59 10489101-10 1999 rHuEPO inhibited not only IL-1beta induced nitrite production, but also the expression of iNOS mRNA and protein. Nitrites 43-50 interleukin 1 beta Homo sapiens 26-34 10642306-5 2000 For this, we measured IL-1beta-stimulated nitrite (NOx) production with use of the Griess reagent, prostaglandin E(2) (PGE(2)) production with use of an enzyme immunoassay, and arachidonic acid release in the presence and absence of BEL. Nitrites 42-49 interleukin 1 beta Homo sapiens 22-30 10779013-3 2000 The NOS-2 activity, assessed by nitrite accumulation, was absent from untreated cultures but was induced by interleukin-1beta and interferon-gamma acting synergistically. Nitrites 32-39 interleukin 1 beta Homo sapiens 108-125 10489101-13 1999 The inhibitory effect of rHuEPO on IL-1beta induced nitrite production was also eliminated in PKC depleted cells or in the existence of anti-EpoR antibody. Nitrites 52-59 interleukin 1 beta Homo sapiens 35-43 10076187-3 1999 Treatment with IL-1beta enhanced media accumulation of nitrites (4.8-fold), prostaglandin E2 (PGE2, 3. Nitrites 55-63 interleukin 1 beta Homo sapiens 15-23 10076187-7 1999 However, the addition of TGFbeta1 inhibited IL-1beta-stimulated nitrite (100%), PGE2 (44%) and lactate (78%) accumulation and inhibited IL-1beta-stimulated glucose consumption (74%) in a dose-dependent manner. Nitrites 64-71 interleukin 1 beta Homo sapiens 44-52 10352496-5 1998 LPC by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose-dependently inhibited IL-1 beta-stimulated nitrite production. Nitrites 138-145 interleukin 1 beta Homo sapiens 117-126 10437301-7 1999 After interleukin-1 beta stimulation chondrocytes produced great quantities of nitrosothiols and nitrite. Nitrites 97-104 interleukin 1 beta Homo sapiens 6-24 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrites 222-229 interleukin 1 beta Homo sapiens 81-98 9252519-4 1997 Dose-dependent inhibition of interleukin-1 beta- and interferon-gamma-stimulated nitrite/nitrate production was observed when cells were preincubated for 6 h with UDCA (0-800 microM), and a substantial inhibition (81 +/- 3.2%) was seen at 500 microM. Nitrites 81-88 interleukin 1 beta Homo sapiens 29-69 9402285-3 1997 Both follicular nitrite (r = 0.42, P < 0.01) and nitrate (r = 0.49, P < 0.001) were found to be significantly correlated with follicular IL-1beta concentrations. Nitrites 16-23 interleukin 1 beta Homo sapiens 143-151 9299361-7 1997 Simultaneous incubation with IL-1beta in the presence of the NOS inhibitor NG-monomethyl-l-arginine or the RNA synthesis inhibitor actinomycin D for 24 h completely inhibited ANP- and BNP- as well as IL-1beta-induced nitrite production. Nitrites 217-224 interleukin 1 beta Homo sapiens 29-37 9436821-7 1997 The IL-1beta-stimulated increase in nitrite formation, iNOS protein, and mRNA abundance in VSMCs was significantly augmented in the presence of thiopental (100 microM), whereas methohexital, hexobarbital, pentobarbital, and phenobarbital were without effect. Nitrites 36-43 interleukin 1 beta Homo sapiens 4-12 8598489-9 1996 These results demonstrate that, unlike TNF, IL-1 does not cause neutrophil degranulation in man, despite its ability to cause neutrophilia and the rapid release of IL-6, IL-8, and nitrite/nitrate. Nitrites 180-187 interleukin 1 beta Homo sapiens 44-48 8982730-5 1996 Induction of inducible NO synthase in mesangial cells by interleukin-1 beta leads to excessive formation of NO by the cells as measured by nitrite production. Nitrites 139-146 interleukin 1 beta Homo sapiens 57-75 8904645-8 1996 The IL-1 beta (60 u ml-1 for 24 h)-stimulated accumulation of nitrite, which was taken as an index of NO production, was concentration-dependently increased by preferential inhibitors of cyclic AMP-dependent phosphodiesterases (rolipram and trequinsin). Nitrites 62-69 interleukin 1 beta Homo sapiens 4-13 24178685-8 1996 Ang II also inhibited the IL-1beta induced nitrite accumulation by SMCs. Nitrites 43-50 interleukin 1 beta Homo sapiens 26-34 8598489-0 1996 IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer. Nitrites 83-90 interleukin 1 beta Homo sapiens 0-9 9059850-6 1997 Only interleukin-1 beta treatment resulted in significant nitrite production, immunohistochemical staining for inducible nitric oxide synthase and detection of inducible NO synthase messenger RNA by reverse transcriptase-polymerase chain reaction (RT-PCR). Nitrites 58-65 interleukin 1 beta Homo sapiens 5-23 8986132-8 1996 Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines (IL-1 beta, tumor necrosis factor-alpha and interferon-gamma). Nitrites 34-41 interleukin 1 beta Homo sapiens 118-156 8921801-5 1996 Incubation of the cultures with interleukin-1 beta (10 ng/mL) for 24 hours caused a significant increase in nitrite accumulation. Nitrites 108-115 interleukin 1 beta Homo sapiens 32-50 8921801-6 1996 Adrenomedullin significantly augmented nitrite production by interleukin-1 beta-stimulated but not by unstimulated cardiac myocytes in a dose-dependent manner (10(-10) to 10(-6) mol/L). Nitrites 39-46 interleukin 1 beta Homo sapiens 61-79 8921801-7 1996 The adrenomedullin-induced nitrite production by interleukin-1 beta-stimulated cells was accompanied by increased inducible NO synthase mRNA and protein expression. Nitrites 27-34 interleukin 1 beta Homo sapiens 49-67 8921801-8 1996 In the presence of dibutyryl cAMP, the interleukin-1 beta-induced nitrite accumulation was increased further, but the stimulatory effect of adrenomedullin on nitrite production was abolished. Nitrites 66-73 interleukin 1 beta Homo sapiens 39-57 8784069-4 1996 The cytokine combination of interleukin-1 beta (50 U/mL), tumor necrosis factor-alpha (10(3) U/mL), and interferon-gamma (10(3) U/mL) induced significant increases in MDA and nitrite and significant decreases in insulin and DNA in islets after 60-h incubation. Nitrites 175-182 interleukin 1 beta Homo sapiens 28-46 7965120-13 1994 In contrast, Hb markedly augmented nitrite accumulation induced by IL-1 beta. Nitrites 35-42 interleukin 1 beta Homo sapiens 67-76 7500055-10 1995 Exposure of OA-affected cartilage to interleukin 1 beta, tumor necrosis factor-alpha, and lipopolysaccharide resulted in approximately 20-50% augmentation of nitrite accumulation, which was also sensitive to cycloheximide and pyrrolidine dithiocarbamate. Nitrites 158-165 interleukin 1 beta Homo sapiens 37-84 7621072-5 1995 The functional significance of this ligand pairing was demonstrated by triggering CD11b and CD11c on monocytes with either recombinant CD23 or anti-CD11b and anti-CD11c MAbs to cause a marked increase in nitrite-oxidative products and pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF alpha). Nitrites 204-211 interleukin 1 beta Homo sapiens 263-272 7875768-4 1995 Treatment of cardiocytes with 3.4 nmol/L IL-1 beta for 24 hours stimulated NO (nitrite) production by threefold, which resulted from an increase in the inducible isoform of NO synthase mRNA. Nitrites 79-86 interleukin 1 beta Homo sapiens 41-50 7875768-5 1995 Dexamethasone inhibited IL-1 beta induction of nitrite production, whereas the protein kinase C inhibitor staurosporine had no effect. Nitrites 47-54 interleukin 1 beta Homo sapiens 24-33 7539260-2 1995 PDTC decreased by 90% both IL-1 beta-induced increase in medium nitrite accumulation (an indicator of NO production) and induction of iNOS mRNA expression. Nitrites 64-71 interleukin 1 beta Homo sapiens 27-36 7531790-1 1994 Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production. Nitrites 224-231 interleukin 1 beta Homo sapiens 52-70 7531790-1 1994 Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) triggers the expression of a macrophage-type of nitric oxide (NO) synthase and the subsequent increase of cellular concentration of cGMP and nitrite production. Nitrites 224-231 interleukin 1 beta Homo sapiens 72-81 7534178-3 1994 AII by itself did not stimulate the production of nitrite, a stable metabolite of NO, but dose-dependently inhibited IL1 beta-induced nitrite production. Nitrites 134-141 interleukin 1 beta Homo sapiens 117-125 7514190-6 1994 Combinations of cytokines, notably IL-1 beta plus IFN-gamma plus TNF-alpha, induced increased expression of inducible NO synthase mRNA after 6 h and resulted in a fivefold increase in medium nitrite accumulation after 48 h. These cytokines did not impair glucose metabolism or insulin release in response to 16.7 mM glucose, but there was an 80% decrease in islet insulin content. Nitrites 191-198 interleukin 1 beta Homo sapiens 35-44 8142651-3 1994 Treatment of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite in the culture media and in marked elevation of intracellular cyclic guanosine monophosphate (GMP) levels. Nitrites 97-104 interleukin 1 beta Homo sapiens 47-56 8142651-4 1994 The releasate from collagen-aggregated platelets blocked the IL-1 beta-mediated production of nitrite and the accumulation of cyclic GMP in smooth muscle cells in a platelet number-dependent manner. Nitrites 94-101 interleukin 1 beta Homo sapiens 61-70 7846335-9 1994 No correlation was found between TNF-alpha and NO/nitrite, whereas a weak but significant correlation was found between NO/nitrite and concentrations of another cytokine, interleukin-1 beta (IL-1 beta). Nitrites 123-130 interleukin 1 beta Homo sapiens 171-189 7846335-9 1994 No correlation was found between TNF-alpha and NO/nitrite, whereas a weak but significant correlation was found between NO/nitrite and concentrations of another cytokine, interleukin-1 beta (IL-1 beta). Nitrites 123-130 interleukin 1 beta Homo sapiens 191-200 7512570-7 1994 A protein kinase C-activating phorbol ester, phorbol 12-myristate 13-acetate, and a membrane-permeable diacylglycerol, 1,2-dioctanoyl-glycerol, similarly inhibited the IL-1 beta-induced nitrite production and iNOS mRNA and protein expression, although repetitive additions were needed in the case of diacylglycerol. Nitrites 186-193 interleukin 1 beta Homo sapiens 168-177 7578850-3 1994 IL-1 beta, but not TNF-alpha, induced an increase in nitrite production, which was significantly reduced by the competitive inhibitor of nitric oxide synthase L-NG-monomethyl-arginine (L-NMMA) (0.1 mmol/L and 0.5 mmol/L). Nitrites 53-60 interleukin 1 beta Homo sapiens 0-9 7534178-5 1994 In parallel with the decrease in nitrite production, AII suppressed IL1 beta-induced increases in iNOS mRNA and protein levels, as measured by Northern blotting using an iNOS cDNA probe and by immunoblotting using an anti-iNOS antibody, respectively. Nitrites 33-40 interleukin 1 beta Homo sapiens 68-76 7689587-4 1993 In this report, we present evidence for the production of NO, as measured by the production of nitrite, in highly enriched human fetal astrocyte cultures stimulated with IL-1 beta. Nitrites 95-102 interleukin 1 beta Homo sapiens 170-179 7506668-1 1993 Treatment of mesangial cells with recombinant human interleukin 1 beta dose dependently increased nitrite formation due to the induction of a macrophage-type of nitric oxide (NO) synthase. Nitrites 98-105 interleukin 1 beta Homo sapiens 52-70 7506668-2 1993 Addition of cyclosporin A, cyclosporin G or cyclosporin H dose dependently inhibited interleukin 1 beta-induced nitrite generation. Nitrites 112-119 interleukin 1 beta Homo sapiens 85-103 7506700-2 1994 Interferon gamma, tumor necrosis factor-alpha, and interleukin-1 beta each markedly increased mRNA and protein levels of this enzyme in parallel with the production of nitrite, a stable oxidative metabolite of nitric oxide. Nitrites 168-175 interleukin 1 beta Homo sapiens 51-69 7689587-6 1993 The IL-1 beta-induced nitrite production by astrocytes was markedly enhanced when cells were co-stimulated with IFN-gamma or TNF-alpha (IFN-gamma > TNF-alpha); LPS had no effect used as a single agent or in combination with other cytokines. Nitrites 22-29 interleukin 1 beta Homo sapiens 4-13 8357951-2 1993 Incubation of cultured rat or human aortic smooth muscle cells with interleukin-1 beta evoked a time- and concentration-dependent release of nitrite, an oxidation product of nitric oxide. Nitrites 141-148 interleukin 1 beta Homo sapiens 68-86 8357951-3 1993 The exposure of cells to interleukin-1 beta in combination with eicosapentaenoic acid caused a significantly larger production of nitrite than that evoked by the cytokine alone. Nitrites 130-137 interleukin 1 beta Homo sapiens 25-43 8357951-5 1993 The production of nitrite evoked by equieffective concentrations of interleukin-1 beta in the presence and absence of eicosapentaenoic acid were inhibited to a similar extent by nitro L-arginine (an inhibitor of nitric oxide synthase), transforming growth factor beta 1, platelet-derived growth factorAB and thrombin. Nitrites 18-25 interleukin 1 beta Homo sapiens 68-86 1327576-4 1992 Elevation of nitrite levels in the conditioned medium of cultures exposed to interleukin-1 beta correlated with the inhibition of thymidine incorporation. Nitrites 13-20 interleukin 1 beta Homo sapiens 77-95 8447474-2 1993 Incubation of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite and nitrate in the culture media. Nitrites 98-105 interleukin 1 beta Homo sapiens 48-57 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrites 159-166 interleukin 1 beta Homo sapiens 129-138 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrites 277-284 interleukin 1 beta Homo sapiens 129-138 1327576-5 1992 Platelet-derived growth factor-AB and -BB inhibited the production of nitric oxide (measured as nitrite levels in conditioned medium) by cells treated simultaneously with interleukin-1 beta and growth factor. Nitrites 96-103 interleukin 1 beta Homo sapiens 171-207 1621837-9 1992 In cells cultured in multiwell plates, interleukin-1 beta evoked a time- and concentration-dependent accumulation of nitrite in the extracellular medium that was inhibited dose dependently by transforming growth factor-beta 1. Nitrites 117-124 interleukin 1 beta Homo sapiens 39-57 1282159-11 1992 Interleukin-1 beta induced a time- and concentration-dependent production of nitrite. Nitrites 77-84 interleukin 1 beta Homo sapiens 0-18 1282159-12 1992 Cycloheximide and nitro-L-arginine inhibited the relaxations and the production of nitrite evoked by interleukin-1 beta-treated cells. Nitrites 83-90 interleukin 1 beta Homo sapiens 101-119 1282159-14 1992 Transforming growth factor-beta 1 reduced the interleukin-1 beta-dependent generation of nitrite by cultured smooth muscle cells and relaxation of contracted bioassay tissues. Nitrites 89-96 interleukin 1 beta Homo sapiens 46-64 1385162-2 1992 TGF-beta 1, PDGFAB and PDGFBB but not PDGFAA inhibited in a concentration-dependent manner the production of nitrite, an oxidation product of nitric oxide, evoked by interleukin-1 beta. Nitrites 109-116 interleukin 1 beta Homo sapiens 166-184 1384465-5 1992 cGMP formation and nitrite production induced by IL-1 beta pretreatment of islets are also blocked by the protein synthesis inhibitor, cycloheximide. Nitrites 19-26 interleukin 1 beta Homo sapiens 49-58 28131792-10 2017 Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue. Nitrites 215-222 interleukin 1 beta Homo sapiens 12-16 21954917-4 2012 Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1beta on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor) beta2, TGFbeta3 and osteocalcin. Nitrites 122-129 interleukin 1 beta Homo sapiens 104-112 26500455-8 2015 Treatment with a combination of IL-6, LPS, TNF-alpha, IFN- gamma and IL-1beta induced the highest nitrite secretion (2.91 fold, P < 0.01) as compared to cells incubated in medium alone. Nitrites 98-105 interleukin 1 beta Homo sapiens 69-77 24613657-7 2014 The EC50 for inhibition of induced IL-1beta production by the cells was estimated to be 10-12microg/ml (about 36microM) and corresponded to the production of around 30microM nitrites in the culture medium. Nitrites 174-182 interleukin 1 beta Homo sapiens 35-43 22533969-9 2012 IL-1beta strongly increased the expression of inducible nitric oxide synthase (iNOS) mRNA and the nitrite concentration in both healthy and DIGO cells (p < 0.05). Nitrites 98-105 interleukin 1 beta Homo sapiens 0-8 22533969-10 2012 However, co-administration of IL-1beta and nifedipine largely abrogated the expression of iNOS mRNA and the nitrite concentration with the same treatment. Nitrites 108-115 interleukin 1 beta Homo sapiens 30-38 23850530-6 2013 Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at <1% O2. Nitrites 32-39 interleukin 1 beta Homo sapiens 13-21