PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11230326-8 2001 Ang II increased SBP (from 133+/-10 to 158+/-8 mm Hg), plasma Ang II (179+/-77 pg/mL), and isoprostanes (156+/-19 pg/mL) without altering ET levels (38+/-5 pg/mL) or urinary nitrites (1.8+/-0.5 microgram/d). Nitrites 174-182 angiotensinogen Rattus norvegicus 0-6 11230326-9 2001 Losartan prevented Ang II-induced increases in SBP and isoprostanes (SBP went from 137+/-5 to 120+/-4 mm Hg; isoprostanes were 115+/-15 pg/mL) while increasing urinary nitrite levels (5.2+/-1.1 microgram/d). Nitrites 168-175 angiotensinogen Rattus norvegicus 19-25 10646512-5 2000 The inhibitory effects of Ang II on lipopolysaccharide-induced expression of iNOS mRNA and protein and nitrite accumulation were mimicked by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate. Nitrites 103-110 angiotensinogen Rattus norvegicus 26-32 11097628-3 2000 LPS/IFN-induced nitrite production, the inducible form of nitric oxide synthase (NOS-2) mRNA, and protein expression were dose dependently inhibited by ANG II on coincubation, which was abolished on ANG II type 2 (AT(2)) receptor blockade by PD-123319. Nitrites 16-23 angiotensinogen Rattus norvegicus 152-158 10646512-6 2000 Down-regulation of PKC produced by long-term treatment of astroglia with phorbol 12-myristate 13-acetate abolished the inhibitory effect of Ang II on lipopolysaccharide-stimulated expression of iNOS mRNA and nitrite accumulation. Nitrites 208-215 angiotensinogen Rattus norvegicus 140-146 10646512-7 2000 Finally, the reduction of lipopolysaccharide-induced nitrite accumulation by Ang II was attenuated by the selective PKC inhibitor chelerythrine. Nitrites 53-60 angiotensinogen Rattus norvegicus 77-83 8621213-3 1996 Therefore, we designed these studies to test the hypothesis that Ang II exerts time-dependent effects on renal NO generation as assessed from renal excretion of nitrate and nitrite, percent increases in renal vascular resistance during inhibition of NO synthase with intravenous NG -nitro-L-arginine methyl ester (L-NAME), or decreases in renal vascular resistance during stimulation of endothelial NO synthase with intravenous acetylcholine. Nitrites 173-180 angiotensinogen Rattus norvegicus 65-71 10200991-7 1999 RESULTS: Angiotensin II and TGF-beta significantly decreased IL-1 beta-stimulated nitrite accumulation. Nitrites 82-89 angiotensinogen Rattus norvegicus 9-23 9458730-4 1998 NO production, measured by the accumulation of nitrite and nitrate, was enhanced by 10(-7) M ANG II. Nitrites 47-54 angiotensinogen Rattus norvegicus 93-99 9453315-8 1998 Tissue slices of the renal cortex and medulla were studied to determine the effects of Ang II and L-NAME on the nitrite/nitrate production. Nitrites 112-119 angiotensinogen Rattus norvegicus 87-93 9453315-9 1998 Ang II stimulated the nitrite/nitrate production predominately in the renal medulla, which was significantly attenuated by L-NAME. Nitrites 22-29 angiotensinogen Rattus norvegicus 0-6 8626679-6 1996 Ang II in the presence of cytokines up-regulated L-arginine transport while inhibiting nitrite accumulation. Nitrites 87-94 angiotensinogen Rattus norvegicus 0-6 8621213-6 1996 The renal excretion of nitrate and nitrite was increased during short-term Ang II infusions (from 205 +/- 22 to 331 +/- 58 pmol.min-1, P < .05) but was unchanged during prolonged Ang II infusion (control group, 197 +/- 33 versus Ang II, 245 +/- 42 pmol.min-1, P=NS). Nitrites 35-42 angiotensinogen Rattus norvegicus 75-81 28438687-7 2017 However, dietary nitrite supplementation inhibited TGF-beta1-mediated cardiac remodeling by suppressing AT II and AT1R. Nitrites 17-24 angiotensinogen Rattus norvegicus 104-109 29657937-10 2018 In RDN model, the serum nitrite levels were decreased in male and increased in female by Ang II infusion when compared with vehicle infusion. Nitrites 24-31 angiotensinogen Rattus norvegicus 89-95 29531923-9 2018 Results: In female rats, the serum and kidney nitrite levels increased significantly by Ang II (P < 0.05) and decreased significantly (P < 0.05) when PD123319 was accompanied with Ang II. Nitrites 46-53 angiotensinogen Rattus norvegicus 88-94 29531923-9 2018 Results: In female rats, the serum and kidney nitrite levels increased significantly by Ang II (P < 0.05) and decreased significantly (P < 0.05) when PD123319 was accompanied with Ang II. Nitrites 46-53 angiotensinogen Rattus norvegicus 186-192 7534984-2 1995 Addition of the peptide angiotensin II (ANG II) with LPS decreased subsequent formation of nitrite in a concentration-dependent manner (concentration inhibiting 50% of maximal response approximately 1 nM). Nitrites 91-98 angiotensinogen Rattus norvegicus 24-38 7534984-2 1995 Addition of the peptide angiotensin II (ANG II) with LPS decreased subsequent formation of nitrite in a concentration-dependent manner (concentration inhibiting 50% of maximal response approximately 1 nM). Nitrites 91-98 angiotensinogen Rattus norvegicus 40-46 34064664-7 2021 Exposure to Ang II increased cell surface area, intracellular superoxide anion level, NADPH oxidase and inducible nitric oxide synthase activities, and reduced cellular superoxide dismutase activity and nitrite level, which were similarly reversed by both rutin and quercetin. Nitrites 203-210 angiotensinogen Rattus norvegicus 12-18 28438687-8 2017 These results suggest that dietary nitrite levels achievable via a daily high-vegetable diet could improve hypertensive heart disease by inhibiting AT II-AT1R-mediated cardiac remodeling. Nitrites 35-42 angiotensinogen Rattus norvegicus 148-153 24627754-7 2014 RESULTS: At the presence of AT2R, the serum level of nitrite in response to AngII administration in OVE groups increased significantly (P < 0.05). Nitrites 53-60 angiotensinogen Rattus norvegicus 76-81 27376045-16 2016 CONCLUSION: Our findings suggest that central effect of Ang II on blood pressure is accompanied with increased levels of MDA and nitrite in the circulation. Nitrites 129-136 angiotensinogen Rattus norvegicus 56-62 27474450-9 2016 Our results show that boosting the nitrate-nitrite-NO pathway can partly compensate for age-related disturbances in endogenous NO generation via inhibition of NADPH oxidase and modulation of ANG II receptor expression. Nitrites 43-50 angiotensinogen Rattus norvegicus 191-197 24627754-9 2014 It seems that AT2R involves nitrite production response to AngII in OVE. Nitrites 28-35 angiotensinogen Rattus norvegicus 59-64 23626887-6 2013 However, administration of Ang II in male and female rats caused a gender difference in the nitrite level, which resulted in the serum level of the nitrite significantly increasing in males (P < 0.05) when compared with the females. Nitrites 148-155 angiotensinogen Rattus norvegicus 27-33 23626887-7 2013 In addition, masR blockade or co-blockade of masR and AT2R in male rats abolished the gender difference related to the effect of Ang II on nitrite production. Nitrites 139-146 angiotensinogen Rattus norvegicus 129-135 23626887-8 2013 In the presence of masR and AT2R, or when masR alone was blocked, the level of nitrite in the kidney, in response to the Ang II infusion was not significantly different between the two sexes. Nitrites 79-86 angiotensinogen Rattus norvegicus 121-127 23626887-9 2013 On the contrary, masR and AT2R co-blockades significantly decreased the kidney nitrite concentration response to Ang II administration in both male and female rats (P < 0.05), but no sex difference was detected. Nitrites 79-86 angiotensinogen Rattus norvegicus 113-119 12198324-6 2002 Angiotensin II (1 microg) released renal nitrites by 485 +/- 178, 470 +/- 150, 185 +/- 45, and 515 +/- 100 nmol/ml/30 s in the kidneys from normotensive, losartan-treated normotensive rats, hypertensive, and losartan-treated hypertensive rats, respectively. Nitrites 41-49 angiotensinogen Rattus norvegicus 0-14 23626887-6 2013 However, administration of Ang II in male and female rats caused a gender difference in the nitrite level, which resulted in the serum level of the nitrite significantly increasing in males (P < 0.05) when compared with the females. Nitrites 92-99 angiotensinogen Rattus norvegicus 27-33 18190523-8 2008 ANG II application enhanced the LPS-induced increases in IL-1 and nitrite concentrations, as well as the LPS-induced morphological changes and AP-1 activation, and these enhancements were inhibited by losartan (10(-5) M). Nitrites 66-73 angiotensinogen Rattus norvegicus 0-6 11566950-10 2001 In addition, Ang II increased the systemic and renal venous levels of isoprostanes, TBARS, and ET and caused a transient decrease in urinary nitrites (that returned to control levels by day 9). Nitrites 141-149 angiotensinogen Rattus norvegicus 13-19