PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7739201-7	1994	IL-1 alpha increased nitrite release in a dose-dependent fashion and a significant enhancement (p < 0.01) was attained at 10 U/ml.	Nitrites	21-28	interleukin 1 alpha	Homo sapiens	0-10	
10919016-5	2000	Stimulation with IL-1 alpha + TNF-alpha + IFN-alpha induced a significant (P < 0.001) increase of nitrite generation by both human colonic biopsies and HT-29 cells.	Nitrites	101-108	interleukin 1 alpha	Homo sapiens	17-27	
8680718-7	1995	The combination of IL-1 alpha/IFN-gamma produced a highly significant (P < 0.001) 4 fold increase in nitrite production at 48 h, compared to basal values, while no other pair of cytokines was effective.	Nitrites	104-111	interleukin 1 alpha	Homo sapiens	19-29	
8680718-8	1995	5 Time course studies with IL-1 alpha/IFN-gamma combination revealed significant (P < 0.001) increases in nitrite at 24 h (153 +/- 7), 48 h (306 +/- 24), and 72 h (384 +/- 15) compared to basal values of 50 +/- 4, 75 +/- 8, and 103 +/- 8 nM per 10(6) cells respectively.	Nitrites	109-116	interleukin 1 alpha	Homo sapiens	27-37	
8680718-9	1995	6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values.	Nitrites	393-400	interleukin 1 alpha	Homo sapiens	15-25	
8680718-10	1995	These data suggest that the IL-1 alpha/IFN-gamma-induced nitrite production by HT-29 cells is dependent on de novo protein synthesis, probably the iNOS enzyme.	Nitrites	57-64	interleukin 1 alpha	Homo sapiens	28-38	
8680718-11	1995	8 The addition of TNF-alpha produced a significant (P < 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation.	Nitrites	114-121	interleukin 1 alpha	Homo sapiens	85-95	
8680718-13	1995	These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level.	Nitrites	91-98	interleukin 1 alpha	Homo sapiens	62-72	
7739201-8	1994	OBs released 14.2 nmol/4.0 x 10(4) cells of nitrite after 72 hrs stimulation by 100 U/ml IL-1 alpha.	Nitrites	44-51	interleukin 1 alpha	Homo sapiens	89-99	
34078001-6	2021	RESULTS: We found that FA activated SIRT1/AMPK/PGC-1alpha signaling pathway and attenuated IL-1beta-induced osteoarthritis chondrocyte degeneration by suppressing the production of IL-6, PGE2 , nitrite, Collagen I, Runx-2, MMP-1, MMP-3, and MMP-13, enhancing Collagen II and Aggrecan expression and inhibiting oxidative stress.	Nitrites	194-201	interleukin 1 alpha	Homo sapiens	91-99	
1658153-5	1991	A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation.	Nitrites	120-127	interleukin 1 alpha	Homo sapiens	17-21	
2109093-5	1990	Interferon gamma, in combination with tumor necrosis factor, interleukin-1 (IL-1), or endotoxin, induced murine brain endothelial cells to secrete nitrites (20-45 microM within 48 hr), which are breakdown products of nitric oxide.	Nitrites	147-155	interleukin 1 alpha	Homo sapiens	61-74