PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7739201-7 1994 IL-1 alpha increased nitrite release in a dose-dependent fashion and a significant enhancement (p < 0.01) was attained at 10 U/ml. Nitrites 21-28 interleukin 1 alpha Homo sapiens 0-10 10919016-5 2000 Stimulation with IL-1 alpha + TNF-alpha + IFN-alpha induced a significant (P < 0.001) increase of nitrite generation by both human colonic biopsies and HT-29 cells. Nitrites 101-108 interleukin 1 alpha Homo sapiens 17-27 8680718-7 1995 The combination of IL-1 alpha/IFN-gamma produced a highly significant (P < 0.001) 4 fold increase in nitrite production at 48 h, compared to basal values, while no other pair of cytokines was effective. Nitrites 104-111 interleukin 1 alpha Homo sapiens 19-29 8680718-8 1995 5 Time course studies with IL-1 alpha/IFN-gamma combination revealed significant (P < 0.001) increases in nitrite at 24 h (153 +/- 7), 48 h (306 +/- 24), and 72 h (384 +/- 15) compared to basal values of 50 +/- 4, 75 +/- 8, and 103 +/- 8 nM per 10(6) cells respectively. Nitrites 109-116 interleukin 1 alpha Homo sapiens 27-37 8680718-9 1995 6 Studies with IL-1 alpha/IFN-gamma combination demonstrated a time dependent expression of iNOS mRNA, first observed at 6 h, peaked at 24 h and was undetectable by 72 h. IL-1 alpha (0.3-10 ng ml-1) and IFN-gamma (10-300 u ml-1) in combination induced a concentration-dependent expression of iNOS mRNA at 24 h. 7 Pretreatment with cycloheximide before IL-1 alpha/IFN-gamma stimulation reduced nitrite levels to basal values. Nitrites 393-400 interleukin 1 alpha Homo sapiens 15-25 8680718-10 1995 These data suggest that the IL-1 alpha/IFN-gamma-induced nitrite production by HT-29 cells is dependent on de novo protein synthesis, probably the iNOS enzyme. Nitrites 57-64 interleukin 1 alpha Homo sapiens 28-38 8680718-11 1995 8 The addition of TNF-alpha produced a significant (P < 0.001) 3 fold increase of IL-1 alpha/IFN-gamma-induced nitrite generation. Nitrites 114-121 interleukin 1 alpha Homo sapiens 85-95 8680718-13 1995 These findings suggest that the up-regulation by TNF-alpha of IL-1 alpha/IFN-gamma-induced nitrite generation is at the post-transcriptional level. Nitrites 91-98 interleukin 1 alpha Homo sapiens 62-72 7739201-8 1994 OBs released 14.2 nmol/4.0 x 10(4) cells of nitrite after 72 hrs stimulation by 100 U/ml IL-1 alpha. Nitrites 44-51 interleukin 1 alpha Homo sapiens 89-99 34078001-6 2021 RESULTS: We found that FA activated SIRT1/AMPK/PGC-1alpha signaling pathway and attenuated IL-1beta-induced osteoarthritis chondrocyte degeneration by suppressing the production of IL-6, PGE2 , nitrite, Collagen I, Runx-2, MMP-1, MMP-3, and MMP-13, enhancing Collagen II and Aggrecan expression and inhibiting oxidative stress. Nitrites 194-201 interleukin 1 alpha Homo sapiens 91-99 1658153-5 1991 A combination of IL-1, LPS, and TNF-alpha was shown to induce maximal production of 355 +/- 51 nmol/10(6) cells/72 h of nitrite (NO2-), which was measured as a stable end-product of .N = O generation. Nitrites 120-127 interleukin 1 alpha Homo sapiens 17-21 2109093-5 1990 Interferon gamma, in combination with tumor necrosis factor, interleukin-1 (IL-1), or endotoxin, induced murine brain endothelial cells to secrete nitrites (20-45 microM within 48 hr), which are breakdown products of nitric oxide. Nitrites 147-155 interleukin 1 alpha Homo sapiens 61-74