PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33212150-9	2021	Compared to T2D + nitrite, co-administration of nitrite and NaSH resulted in significant increases in mRNA expression of PI3K, Akt, and eNOS and significant decreases in mRNA expression of G6Pase and FBPase but had no effect on PEPCK expression.	Nitrites	48-55	nitric oxide synthase 3	Rattus norvegicus	136-140	
35504499-10	2022	Co-administration of nitrite and NaSH further increased cystathionine gamma-lyase (CSE, 2.8-fold) and endothelial NOS (eNOS, 2.0-fold) expression and further decreased iNOS (0.4-fold) expression.	Nitrites	21-28	nitric oxide synthase 3	Rattus norvegicus	102-117	
33212150-11	2021	This inhibitory effect of nitrite and NaSH co-administration on gluconeogenesis were associated with increased gene expression of PI3K, Akt, and eNOS in the liver.	Nitrites	26-33	nitric oxide synthase 3	Rattus norvegicus	145-149	
20551918-3	2010	Rats receiving co-treatment with dietary BH(4) and eNOS gene transfer (the [eNOS, +BH(4)] group) had greater eNOS expression, phospho-eNOS expression (Ser(1177)), Ca(2+)-dependent NOS activity, and nitrite + nitrate concentrations in the ischemic gastrocnemius than did rats receiving AdeNOS alone.	Nitrites	198-205	nitric oxide synthase 3	Rattus norvegicus	51-55	
29396380-7	2018	We demonstrated an increased expression of eNOs in myocardial tissue the heightening of nitrite concentration, accompanied with upregulation of proangiogenic growth factors and myocardium related mRNA.	Nitrites	88-95	nitric oxide synthase 3	Rattus norvegicus	43-47	
26044183-6	2015	Inhibition of endothelial nitric oxide synthase (eNOS) and the absence of endothelium decreased nitrite-induced relaxations in both WKY and SHR aortae, indicating the role of endothelium-derived nitric oxide (NO) in the response.	Nitrites	96-103	nitric oxide synthase 3	Rattus norvegicus	14-47	
26044183-10	2015	The endothelium-dependent component of the relaxation to nitrite involves activation of eNOS with production of endothelium-derived NO, while the endothelium-independent component is due to stimulation of sGC.	Nitrites	57-64	nitric oxide synthase 3	Rattus norvegicus	88-92	
19673940-13	2009	In contrast with Ad-PGK-infected cells, in cardiomyocytes infected with Ad-eNOS, there was increased calcium-dependent NOS activity and nitrite production.	Nitrites	136-143	nitric oxide synthase 3	Rattus norvegicus	75-79	
12171788-3	2002	METHODS AND RESULTS: After gene transfer, expression of eNOS in cultured cells was detected by increased intracellular cGMP and nitrate/nitrite levels and NO synthase activity.	Nitrites	136-143	nitric oxide synthase 3	Rattus norvegicus	56-60	
17109653-8	2006	prevented hypertension-induced attenuation of acetylcholine-induced endothelium-dependent relaxation, impairment of vascular endothelial lining, decrease in expression of mRNA for endothelial nitric oxide synthase (eNOS), serum nitrite/nitrate concentration and increase in expression of mRNA for p22phox, superoxide anion and serum TBARS.	Nitrites	228-235	nitric oxide synthase 3	Rattus norvegicus	215-219	
14665447-12	2004	Expressions of endothelial NOS protein and NOx, the stable end product of NO, i.e., nitrite/nitrate, concentration in the kidney were significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas those in the TA-0201-treated exercise group were significantly higher than those in the vehicle-treated exercise group.	Nitrites	84-91	nitric oxide synthase 3	Rattus norvegicus	15-30	
14568906-3	2003	In addition, tissue concentrations of nitrite and nitrate were significantly increased in rats transfected with the eNOS gene up to 2 weeks after transfection.	Nitrites	38-45	nitric oxide synthase 3	Rattus norvegicus	116-120	
12686872-10	2003	This change in erectile function was a result of eNOS over expression with an increase in eNOS protein expression and constitutive NOS activity as well as an increase in nitric oxide biosynthesis, as reflected by an increase in cavernous nitrate plus nitrite formation.	Nitrites	251-258	nitric oxide synthase 3	Rattus norvegicus	49-53	
19008412-5	2009	In support of the beneficial effects of pcDNA3.1-eNOS treatment being because of enhanced eNOS expression and activity, increased eNOS protein levels were documented in aorta, liver, kidney, and heart of fructose-treated rats injected with pcDNA3.1-eNOS, and corresponding elevations in nitrite/nitrate and cGMP concentrations were observed in urine.	Nitrites	287-294	nitric oxide synthase 3	Rattus norvegicus	49-53	
14700515-6	2004	RESULTS: Infection of neuronal cells with Ad-eNOS increased the nitrite production but decreased the level of superoxide anion (O(2)(-)), indicating that eNOS gene delivery increased NO availability.	Nitrites	64-71	nitric oxide synthase 3	Rattus norvegicus	45-49	
14700515-6	2004	RESULTS: Infection of neuronal cells with Ad-eNOS increased the nitrite production but decreased the level of superoxide anion (O(2)(-)), indicating that eNOS gene delivery increased NO availability.	Nitrites	64-71	nitric oxide synthase 3	Rattus norvegicus	154-158	
10690352-6	1999	RESULTS: Cultured endothelial cells showed almost 100% transduction with both viruses and a dose response of eNOS expression showed a five-fold increase in nitrite production for AdCMVeNOS with no change for beta-galactosidase-containing virus.	Nitrites	156-163	nitric oxide synthase 3	Rattus norvegicus	109-113	
11116119-4	2000	In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis.	Nitrites	192-199	nitric oxide synthase 3	Rattus norvegicus	9-13	
11116119-4	2000	In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis.	Nitrites	192-199	nitric oxide synthase 3	Rattus norvegicus	52-56	
10964667-0	2000	Nitrite inhalation in rats elevates tissue NOS III expression and alters tyrosine nitration and phosphorylation.	Nitrites	0-7	nitric oxide synthase 3	Rattus norvegicus	43-50	
10529453-4	1999	The expression of the potentially therapeutic ecNOS gene was evidenced by confirmation of ecNOS mRNA generation, indirect detection of active ecNOS protein and by measurement of nitrite ion accumulation in the medium from the transfected cell cultures.	Nitrites	178-185	nitric oxide synthase 3	Rattus norvegicus	46-51	
10485617-5	1999	The expression of both bNOS and ecNOS was increased in SHR with concomitant changes of tissue nitrite/nitrate contents.	Nitrites	94-101	nitric oxide synthase 3	Rattus norvegicus	32-37	
8575064-2	1996	Since the activity of NOS3 is known to be regulated in part by the intracellular Ca2+ activity ([Ca2+]i) in endothelial cells, we determined whether increasing myocyte [Ca2+]i by uniform electric field pacing was accompanied by an increase in NOS3 activity, detected as nitrite accumulation in the medium.	Nitrites	270-277	nitric oxide synthase 3	Rattus norvegicus	22-26	
8841982-7	1996	The rapidity of the effect of endotoxin on Ca2+ channel activity suggested that constitutive NOS (cNOS) was involved, in accordance with our finding that endotoxin-induced transcriptional induction of NOS, as measured by nitrite production, required > 6 hr.	Nitrites	221-228	nitric oxide synthase 3	Rattus norvegicus	80-96