PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25239655-2 2014 NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival. Nitrites 39-46 nitric oxide synthase 3 Homo sapiens 0-4 29104725-1 2017 The purpose of this study was to verify the influence of the genotype or haplotype (interaction) of the NOS3 polymorphisms [-786T>C, 894G>T (Glu298Asp), and intron 4b/a] on the response to multicomponent training (various capacities and motor skills) on blood pressure (BP), nitrite concentration, redox status, and physical fitness in older adult women. Nitrites 281-288 nitric oxide synthase 3 Homo sapiens 104-108 24943287-0 2015 The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents. Nitrites 60-67 nitric oxide synthase 3 Homo sapiens 15-48 24943287-1 2015 Obesity and the nitric oxide synthase 3 (NOS3) gene polymorphisms are associated with nitrite levels and hypertension. Nitrites 86-93 nitric oxide synthase 3 Homo sapiens 16-39 24943287-1 2015 Obesity and the nitric oxide synthase 3 (NOS3) gene polymorphisms are associated with nitrite levels and hypertension. Nitrites 86-93 nitric oxide synthase 3 Homo sapiens 41-45 24943287-2 2015 However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity. Nitrites 111-118 nitric oxide synthase 3 Homo sapiens 49-53 25878398-4 2015 Interestingly, the NOS3 -786TT genotype was associated with increased nitrite/nitrate levels only in IEI patients. Nitrites 70-77 nitric oxide synthase 3 Homo sapiens 19-23 25878398-8 2015 Here, we first demonstrate that NOS3 -786T>C variant affects nitrite/nitrate levels in IEI patients and that screening for NOS2A -2.5 kb (CCTTT) n polymorphism may be useful for differential diagnosis of various IEI. Nitrites 64-71 nitric oxide synthase 3 Homo sapiens 32-36 33790801-0 2021 NOS3 Polymorphisms Can Influence the Effect of Multicomponent Training on Blood Pressure, Nitrite Concentration and Physical Fitness in Prehypertensive and Hypertensive Older Adult Women. Nitrites 90-97 nitric oxide synthase 3 Homo sapiens 0-4 33790801-3 2021 It analyzed the influence of NOS3 polymorphisms [-786T > C, 894G > T (Glu298Asp), and intron 4b/a] on the response of blood pressure (BP), nitrite concentration, and physical fitness in older adult women. Nitrites 139-146 nitric oxide synthase 3 Homo sapiens 29-33 32228174-8 2021 Interestingly, we found that the changes mentioned were linked with reduced levels of nitrites both at 24 h (< 171 pmol/mug protein; P < 0.001), and 48 h (< 250 pmol/mug protein; P < 0.05), which was associated with a reduced expression of mRNA of eNOS in endothelial cells incubated with TPP and high glucose. Nitrites 86-94 nitric oxide synthase 3 Homo sapiens 248-252 30335864-0 2018 Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults. Nitrites 115-122 nitric oxide synthase 3 Homo sapiens 15-48 30335864-5 2018 Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. Nitrites 108-115 nitric oxide synthase 3 Homo sapiens 57-61 27927230-7 2016 RESULTS: NO production as measured by nitrite was significantly increased in eNOS and CAV-1F92A transduced eASCs +(5.59 +- 0.22 muM) compared to eNOS alone (4.81 +- 0.59 muM) and un-transduced control cells (0.91 +- 0.23 muM) (p < 0.05). Nitrites 38-45 nitric oxide synthase 3 Homo sapiens 77-81 27613099-8 2016 eNOS gene haplotypes GCB, TCB (G-allele of 894G/T, C-allele -786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p < 0.01). Nitrites 134-141 nitric oxide synthase 3 Homo sapiens 0-4 25163536-10 2014 The absence of eNOS leads to enhanced plasma nitrite levels following nitrate administration in vivo, which negatively impacts on platelet function. Nitrites 45-52 nitric oxide synthase 3 Homo sapiens 15-19 24748593-2 2014 The present study was designed to evaluate the relationship between exercise training and NOS3 polymorphisms at -786T>C, 894G>T, and intron 4b/a on blood pressure (BP) using 24-h ambulatory BP monitoring (ABPM), nitrate/nitrite levels (NOx), and redox state. Nitrites 226-233 nitric oxide synthase 3 Homo sapiens 90-94 24447953-5 2014 Nitrite levels were enhanced by pretreatment with deltaV1-1 30 minutes before ACA possibly attributable to enhanced endothelial NOS protein levels. Nitrites 0-7 nitric oxide synthase 3 Homo sapiens 116-131 23876348-4 2013 Moreover, we verified whether obese women carrying the C variant of T(-786)C polymorphism located in eNOS may have increased levels of nitrite after treatment compared to TT genotype. Nitrites 135-142 nitric oxide synthase 3 Homo sapiens 101-105 23876348-0 2013 Simvastatin treatment increases nitrite levels in obese women: modulation by T(-786)C polymorphism of eNOS. Nitrites 32-39 nitric oxide synthase 3 Homo sapiens 102-106 23069892-0 2013 Effects of endothelial nitric oxide synthase tagSNPs haplotypes on nitrite levels in black subjects. Nitrites 67-74 nitric oxide synthase 3 Homo sapiens 11-44 23463757-10 2013 ATbG-NOS3 haplotype homozygosity was associated with up to 64% higher nitrite/nitrate levels (P=0.003). Nitrites 70-77 nitric oxide synthase 3 Homo sapiens 5-9 20531373-0 2011 Endothelial nitric oxide synthase gene haplotypes affect nitrite levels in black subjects. Nitrites 57-64 nitric oxide synthase 3 Homo sapiens 0-33 21986532-5 2011 eNOS activity was determined by nitrite/nitrate accumulation, either via a fluorometric assay or by(15)N-nitrite or estimated (15)N(3)-citrulline concentrations when (15)N(4)-ARG was used to challenge the cells. Nitrites 32-39 nitric oxide synthase 3 Homo sapiens 0-4 20448437-8 2010 In contrast, endothelial nitric oxide synthase (eNOS) was expressed in both types of EPCs, and both cell types could produce nitric oxide (NO), as judged by measuring the total amounts of nitrites and nitrates in culture media. Nitrites 188-196 nitric oxide synthase 3 Homo sapiens 13-46 20213743-7 2010 Most interestingly, the nitrite production was significantly reduced in eNOS and Cdk5/p35 co-transfected SH-SY5Y cells when compared with co-transfection of Cdk5/p35 and S113A. Nitrites 24-31 nitric oxide synthase 3 Homo sapiens 72-76 21899406-3 2011 The aim of this study was to determine the role of the T-786C and Glu298Asp polymorphisms of the eNOS gene on nitrite concentrations following Hg exposure in humans. Nitrites 110-117 nitric oxide synthase 3 Homo sapiens 97-101 17697943-2 2007 However, the effects of endothelial nitric oxide synthase (eNOS) gene polymorphisms or haplotypes on the circulating concentrations of nitrite (a sensitive marker of NO formation) and cGMP are unknown. Nitrites 135-142 nitric oxide synthase 3 Homo sapiens 59-63 19727605-3 2009 Thus, the conversion of nitrite into NO during cellular stress may be an evolutionarily conserved and redundant means for NO generation at a time when endothelial nitric oxide synthase is non-functional. Nitrites 24-31 nitric oxide synthase 3 Homo sapiens 151-184 18818408-6 2008 Thus, XOR and eNOS are ideally situated on the membranes of RBCs and blood vessels to generate intravascular vasodilator NO from nitrite during ischemic episodes. Nitrites 129-136 nitric oxide synthase 3 Homo sapiens 14-18 17658478-2 2007 We investigated the association of -786T/C, -922A/G, 4B/4A, and 894G/T polymorphisms of eNOS with the disease and its impact on nitrite and malonaldehyde levels in 190 COPD patients and 134 healthy controls, all smokers. Nitrites 128-135 nitric oxide synthase 3 Homo sapiens 88-92 14583343-1 2003 Changes in plasma nitrite concentration in the human forearm circulation have recently been shown to reflect acute changes in endothelial nitric oxide synthase (eNOS)-activity. Nitrites 18-25 nitric oxide synthase 3 Homo sapiens 126-159 16609365-0 2006 A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine. Nitrites 86-93 nitric oxide synthase 3 Homo sapiens 33-66 16413411-2 2006 Recently, we have shown that plasma nitrite mirrors acute changes in endothelial nitric oxide synthase activity in various mammals, including humans. Nitrites 36-43 nitric oxide synthase 3 Homo sapiens 69-102 15810551-6 2005 Using microelectrodes, NA and nitrite were simultaneously measured in pure recombinant eNOS giving similar enzyme activity. Nitrites 30-37 nitric oxide synthase 3 Homo sapiens 87-91 15490108-6 2004 The expression and activity of eNOS were measured using quantitative PCR and nitrite measurements respectively. Nitrites 77-84 nitric oxide synthase 3 Homo sapiens 31-35 17306574-2 2007 We evaluated the association of eNOS genotypes/haplotypes with the plasma concentrations of nitrite/nitrate (NO(x)), which are products of nitric oxide in HT, T2DM, and T2DM+HT patients. Nitrites 92-99 nitric oxide synthase 3 Homo sapiens 32-36 16962929-0 2006 eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite. Nitrites 79-86 nitric oxide synthase 3 Homo sapiens 0-4 16442076-1 2006 In this work, we demonstrate that endothelial nitric oxide synthase is capable of anoxic reduction of nitrite anions to nitric oxide at physiological pH by absorption and EPR spectroscopy and electrochemical measurements. Nitrites 102-109 nitric oxide synthase 3 Homo sapiens 34-67 16007000-1 2005 OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations. Nitrites 126-134 nitric oxide synthase 3 Homo sapiens 77-110 16007000-1 2005 OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations. Nitrites 126-134 nitric oxide synthase 3 Homo sapiens 112-116 15224139-11 2004 The results suggested that eNOS gene promoter activity was enhanced to 148.2+/-33.7% (P<0.05) of the control after PAECs were incubated with 10 micromol/L histamine for 24 h. The nitrite and nitrate content in culture media measured by colorimetric method after incubation with 10 micromol/L histamine for 24 h indicated that the NO production in PAECs was increased. Nitrites 182-189 nitric oxide synthase 3 Homo sapiens 27-31 10600037-6 1999 VSMC transfected with another plasmid, containing endothelial constitutive NO synthase (ecNOS) cDNA generated micromolar quantities of nitrite. Nitrites 135-142 nitric oxide synthase 3 Homo sapiens 88-93 11063722-6 2000 The functional importance of the diminished eNOS expression was revealed by the finding that serum nitrite/nitrate levels among individuals carrying the -786T-->C mutation were significantly lower than among those without the mutation. Nitrites 99-106 nitric oxide synthase 3 Homo sapiens 44-48 9314409-8 1997 Human eNOS gene delivery induces significant increases in urinary and aortic cGMP levels and urinary and serum nitrite/nitrate content (P<.05), while no significant differences in body weight, heart rate, water intake, food consumption, or urine excretion were observed. Nitrites 111-118 nitric oxide synthase 3 Homo sapiens 6-10 8704216-4 1996 Constitutive NOS expression was detected by Western blotting of cell lysates and by the accumulation of nitrite in the culture media. Nitrites 104-111 nitric oxide synthase 3 Homo sapiens 0-16