PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22337336-8	2012	In both cases, the antinociceptive effect of metamizol was reduced by a microinjection of AM251, an antagonist at the CB1 cannabinoid receptor, either into the LVL-PAG or into the rostral ventromedial medulla (RVM).	Dipyrone	45-54	cannabinoid receptor 1	Rattus norvegicus	118-121	
22337336-10	2012	These results show that endocannabinoids and their CB1 receptor (1) contribute at the LVL-PAG to the antinociceptive effects of metamizol, and possibly other non-opioid analgesics; and (2) participate in the PAG-derived activation of RVM descending antinociceptive influences.	Dipyrone	128-137	cannabinoid receptor 1	Rattus norvegicus	51-54	
25058903-3	2014	The aim of this study was to investigate the participation of peripheral CB1 and CB2 cannabinoid receptors activation in the anti-hyperalgesic effect of dipyrone, 4-MAA or 4-AA.	Dipyrone	153-161	cannabinoid receptor 1	Rattus norvegicus	73-76	
25058903-9	2014	AM251 or ODN anti-sense against neuronal CB1 receptor, but not AM630, reversed the anti-hyperalgesic effect mediated by 4-AA, but not by dipyrone or 4-MAA.	Dipyrone	137-145	cannabinoid receptor 1	Rattus norvegicus	41-44