PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18157167-1 2008 BACKGROUND AND PURPOSE: The analgesics, paracetamol and dipyrone are weak inhibitors of the cyclooxygenase isoforms 1 or 2 (COX-1, COX-2) but more potent on COX-3. Dipyrone 56-64 cytochrome c oxidase III, mitochondrial Rattus norvegicus 157-162 28416926-5 2017 Inhibition of COX enzymes (COX-3, COX-3 + COX-1, COX-1+ COX-2 + COX-3 by dipyrone 10-4, 7 x 10-4, 2 x 10-3 M, respectively) augmented the relaxant effects of losartan or lisinopril. Dipyrone 73-81 cytochrome c oxidase III, mitochondrial Rattus norvegicus 27-32 28416926-5 2017 Inhibition of COX enzymes (COX-3, COX-3 + COX-1, COX-1+ COX-2 + COX-3 by dipyrone 10-4, 7 x 10-4, 2 x 10-3 M, respectively) augmented the relaxant effects of losartan or lisinopril. Dipyrone 73-81 cytochrome c oxidase III, mitochondrial Rattus norvegicus 34-39 28416926-5 2017 Inhibition of COX enzymes (COX-3, COX-3 + COX-1, COX-1+ COX-2 + COX-3 by dipyrone 10-4, 7 x 10-4, 2 x 10-3 M, respectively) augmented the relaxant effects of losartan or lisinopril. Dipyrone 73-81 cytochrome c oxidase III, mitochondrial Rattus norvegicus 34-39 17627114-2 2007 An explanation for this difference in pharmacologic activity was provided by the recent discovery of a new cyclooxygenase isoform, cyclooxygenase (COX)-3, that is reported to be inhibited by phenacetin, acetaminophen and dipyrone. Dipyrone 221-229 cytochrome c oxidase III, mitochondrial Rattus norvegicus 131-153 21537904-12 2012 The vasodilatory activities of bradykinin and des-Arg9-bradykinin were significantly increased upon the inhibition of COX-3 (dipyrone at 100 muM). Dipyrone 125-133 cytochrome c oxidase III, mitochondrial Rattus norvegicus 118-123