PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34779255-6 2022 CCK increased body temperature by ~0.4 C from 10 min post-infusion, which was attenuated by metamizol. Dipyrone 92-101 cholecystokinin Rattus norvegicus 0-3 15494191-0 2004 Involvement of cholecystokinin in the opioid tolerance induced by dipyrone (metamizol) microinjections into the periaqueductal gray matter of rats. Dipyrone 66-74 cholecystokinin Rattus norvegicus 15-30 15494191-0 2004 Involvement of cholecystokinin in the opioid tolerance induced by dipyrone (metamizol) microinjections into the periaqueductal gray matter of rats. Dipyrone 76-85 cholecystokinin Rattus norvegicus 15-30 15494191-5 2004 Microinjection of cholecystokinin (1 ng/0.5 microl) into PAG blocked the antinociceptive effect of a subsequent microinjection of dipyrone (150 microg/0.5 microl) into the same site, as evaluated by the tail flick and hot plate tests. Dipyrone 130-138 cholecystokinin Rattus norvegicus 18-33 15494191-8 2004 These results suggest that PAG-microinjected dipyrone triggers and/or potentiates local opioidergic circuits leading to descending inhibition of nociception, on the one hand, and to a local antiopioid action by cholecystokinin, on the other. Dipyrone 45-53 cholecystokinin Rattus norvegicus 211-226 15494191-9 2004 Reiteration of these events would then result in an enhancement of cholecystokinin"s antiopioid action and thus tolerance to opioids and dipyrone in the PAG. Dipyrone 137-145 cholecystokinin Rattus norvegicus 67-82 34779255-7 2022 CCK reduced the number of c-Fos-positive cells in the median preoptic area (by ~70%) but increased it in the dorsal hypothalamic area and in the rostral raphe pallidus (by ~50% in both); all these changes were all completely blocked with metamizol. Dipyrone 238-247 cholecystokinin Rattus norvegicus 0-3