PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17270255-1 2007 INTRODUCTION: Dermatan sulfate (DS) is well-known for its anticoagulant activity through binding to heparin cofactor II to enhance antithrombin action. Dermatan Sulfate 14-30 serpin family C member 1 Homo sapiens 131-143 17270255-1 2007 INTRODUCTION: Dermatan sulfate (DS) is well-known for its anticoagulant activity through binding to heparin cofactor II to enhance antithrombin action. Dermatan Sulfate 32-34 serpin family C member 1 Homo sapiens 131-143 16442510-0 2006 Thrombin inhibition by antithrombin in the presence of oversulfated dermatan sulfates. Dermatan Sulfate 68-85 serpin family C member 1 Homo sapiens 23-35 15749837-1 2005 Dermatan sulfate mediates the blood coagulation cascade by binding to heparin cofactor II and potentiating the antithrombin activity. Dermatan Sulfate 0-16 serpin family C member 1 Homo sapiens 111-123 15078125-1 2004 Heparin and other iduronic acid-containing glycosaminoglycans (GAG) such as dermatan sulfate exert their anticoagulant properties primarily by accelerating the rate of inhibition of the natural protease inhibitors antithrombin III (AT, which inhibits both factor Xa and thrombin) and heparin cofactor II (HCII, which selectively inhibits thrombin). Dermatan Sulfate 76-92 serpin family C member 1 Homo sapiens 214-230 12886459-5 2003 On the other hand, heparin, heparan sulfate, and bovine and tuna dermatan sulfate improved (1.2 to 3.4 times) kallikrein inhibition by antithrombin (1.4 microM), while chondroitin 4- and 6-sulfates reduced it (1.3 times). Dermatan Sulfate 65-81 serpin family C member 1 Homo sapiens 135-147 13679662-1 2002 Dermatan sulphate (DS) is a glycosaminoglycan which selectively catalyzes the inactivation of thrombin by Heparin Cofactor II without interacting with Antithrombin III. Dermatan Sulfate 0-17 serpin family C member 1 Homo sapiens 151-167 13679662-1 2002 Dermatan sulphate (DS) is a glycosaminoglycan which selectively catalyzes the inactivation of thrombin by Heparin Cofactor II without interacting with Antithrombin III. Dermatan Sulfate 19-21 serpin family C member 1 Homo sapiens 151-167 11776053-16 2000 GAG was similar to dermatan sulfate both in the efficiency and in the mechanism of antithrombin. Dermatan Sulfate 19-35 serpin family C member 1 Homo sapiens 83-95 10914239-1 1999 Danaparoid sodium is an antithrombin composed of 3 glycosaminoglycans: heparan sulfate, dermatan sulfate and chondroitin sulfate. Dermatan Sulfate 88-104 serpin family C member 1 Homo sapiens 24-36 15622771-4 1997 CONCLUSION: Sjamp was similar to dermatan sulfate both in the efficiency and in the mechanism of antithrombin. Dermatan Sulfate 33-49 serpin family C member 1 Homo sapiens 97-109 8994426-0 1997 Effect of nonspecific binding to plasma proteins on the antithrombin activities of unfractionated heparin, low-molecular-weight heparin, and dermatan sulfate. Dermatan Sulfate 141-157 serpin family C member 1 Homo sapiens 56-68 8885144-3 1996 Unlike heparin, DS does not act through Antithrombin III (ATIII) but primarily through thrombin on Heparin Cofactor II (HCII). Dermatan Sulfate 16-18 serpin family C member 1 Homo sapiens 58-63 7833476-0 1995 Fibrinogen inhibits the heparin cofactor II-mediated antithrombin activity of dermatan sulfate. Dermatan Sulfate 78-94 serpin family C member 1 Homo sapiens 53-65 7833476-2 1995 The antithrombin activity of several dermatan sulfate preparations has been measured in whole human plasma and found to be -55% of that in purified systems. Dermatan Sulfate 37-53 serpin family C member 1 Homo sapiens 4-16 7833476-3 1995 Kinetic studies under pseudo-first-order conditions indicated that the reduction in antithrombin activity of dermatan sulfate in plasma compared with that in buffer was due to noncompetitive inhibition with respect to dermatan sulfate. Dermatan Sulfate 109-125 serpin family C member 1 Homo sapiens 84-96 7833476-3 1995 Kinetic studies under pseudo-first-order conditions indicated that the reduction in antithrombin activity of dermatan sulfate in plasma compared with that in buffer was due to noncompetitive inhibition with respect to dermatan sulfate. Dermatan Sulfate 218-234 serpin family C member 1 Homo sapiens 84-96 7833476-5 1995 Addition of these proteins to the purified system showed that only fibrinogen inhibited the antithrombin activity of dermatan sulfate and that it did so in a concentration-dependent manner over the physiologic range of plasma fibrinogen levels. Dermatan Sulfate 117-133 serpin family C member 1 Homo sapiens 92-104 8241508-6 1993 This was confirmed in a heparin cofactor II-dependent antithrombin assay for DS that showed anticoagulant equivalent to 2.2 +/- 0.3 micrograms/mL (mean +/- SD) of porcine mucosal DS. Dermatan Sulfate 77-79 serpin family C member 1 Homo sapiens 54-66 8259546-7 1993 Compared to plasma containing DS alone, the formation of ATIII-IIa complexes also is increased when the combination of DS and LMWH is added. Dermatan Sulfate 119-121 serpin family C member 1 Homo sapiens 57-62 8335699-1 1993 Three sulphated polysaccharides, dermatan sulphate, fucan and heparin, were fractionated according to their affinity towards antithrombin III (ATIII) and heparin cofactor II (HCII), the two main physiological thrombin (IIa) inhibitors. Dermatan Sulfate 33-50 serpin family C member 1 Homo sapiens 125-141 8335699-1 1993 Three sulphated polysaccharides, dermatan sulphate, fucan and heparin, were fractionated according to their affinity towards antithrombin III (ATIII) and heparin cofactor II (HCII), the two main physiological thrombin (IIa) inhibitors. Dermatan Sulfate 33-50 serpin family C member 1 Homo sapiens 143-148 1333106-4 1992 High affinity dermatan sulfate (DS) increased the antithrombin inhibition activity of HC II about 1000-fold in contrast to about 100-fold in the case of low affinity DS. Dermatan Sulfate 14-30 serpin family C member 1 Homo sapiens 50-62 1333106-4 1992 High affinity dermatan sulfate (DS) increased the antithrombin inhibition activity of HC II about 1000-fold in contrast to about 100-fold in the case of low affinity DS. Dermatan Sulfate 32-34 serpin family C member 1 Homo sapiens 50-62 2735662-8 1989 Drugs which act primarily on factor Xa (oligosaccharides) or thrombin by non-ATIII pathways (dermatan sulfate) are less efficient than UFH as antithrombotic drugs. Dermatan Sulfate 93-109 serpin family C member 1 Homo sapiens 77-82 2902851-0 1988 Effect of oversulphated chondroitin and dermatan sulphate upon thrombin and factor Xa inactivation by antithrombin III or heparin cofactor II. Dermatan Sulfate 40-57 serpin family C member 1 Homo sapiens 102-118 3348170-6 1988 After NaNO2/acetic acid treatment of DS (to inactivate heparin), there was enough residual heparin to cause AT-III interference. Dermatan Sulfate 37-39 serpin family C member 1 Homo sapiens 108-114 3619144-6 1987 II is likely that its antithrombin activity in vivo is restricted to the areas rich in dermatan sulfate. Dermatan Sulfate 87-103 serpin family C member 1 Homo sapiens 22-34 2432917-4 1986 The anticoagulant activities of heparin and dermatan sulphate were primarily attributable to their ability to enhance thrombin inhibition by AT III and HC II respectively. Dermatan Sulfate 44-61 serpin family C member 1 Homo sapiens 141-147 3838602-0 1985 Histidine-rich glycoprotein inhibits the antithrombin activity of heparin cofactor II in the presence of heparin or dermatan sulfate. Dermatan Sulfate 116-132 serpin family C member 1 Homo sapiens 41-53 6084876-8 1984 When mixed with thrombin in the presence of dermatan sulfate, normal human plasma showed antithrombin activity which was not due to AT III but to HC II only. Dermatan Sulfate 44-60 serpin family C member 1 Homo sapiens 89-101 6395434-3 1984 HCII activity was then determined by measuring the rate of human thrombin inhibition by 3 ways: a) activation with heparin in AT-free plasma, b) activation with dermatan sulfate in normal plasma and c) activation with dermatan sulfate in AT-free plasma. Dermatan Sulfate 218-234 serpin family C member 1 Homo sapiens 238-240 6209821-1 1984 In antithrombin III depleted plasma only a slight reduction was observed in thrombin inhibitory activity due to potentiation by dermatan sulphate or by pentosan polysulphate (SP54). Dermatan Sulfate 128-145 serpin family C member 1 Homo sapiens 3-19 6235872-5 1984 In contrast, dermatan sulfate inhibited thrombin generation in both normal and antithrombin III-depleted plasma. Dermatan Sulfate 13-29 serpin family C member 1 Homo sapiens 79-95 6206589-0 1984 Inhibition of thrombin-induced platelet aggregation and serotonin release by antithrombin III and heparin cofactor II in the presence of standard heparin, dermatan sulfate and pentosan polysulfate. Dermatan Sulfate 155-171 serpin family C member 1 Homo sapiens 77-93 7225714-2 1981 2 Only dermatan sulphate preparations of considerable heparin content potentiate AT III inhibition of thrombin, factor Xa and plasmin. Dermatan Sulfate 7-24 serpin family C member 1 Homo sapiens 81-87