PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30070769-1 2018 INTRODUCTION: Administration of cholic acid, or its synthetic derivative, 6-alpha-ethyl-23(S)-methylcholic acid (INT-777), activates the membrane GPCR, TGR5, influences whole body metabolism, reduces atherosclerosis, and benefits the cardiovascular physiology in mice. Cholic Acid 32-43 G protein-coupled bile acid receptor 1 Mus musculus 152-156 23686672-9 2013 After bile duct ligation or upon a cholic acid-enriched diet, TGR5 KO mice exhibited more severe liver injury than WT as well as impaired BA elimination in urine. Cholic Acid 35-46 G protein-coupled bile acid receptor 1 Mus musculus 62-66 35257795-3 2022 INT-777, a 6alpha-ethyl-23(S)-methyl derivative of cholic acid (S-EMCA), acts as an agonist for Takeda G protein-coupled receptor-5 (TGR5) and has neuroprotective properties. Cholic Acid 51-62 G protein-coupled bile acid receptor 1 Mus musculus 133-137