PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29940912-8 2018 Regarding the biosynthesis of heparan sulfate chains, differential alterations in transcription depending on the presence or not of metastasis affected genes involved in the modification of uronic acid (epimerization and 2-O sulfation), and some isoforms responsible for sulfation of glucosamine (NDST1, HS6ST1). Heparitin Sulfate 30-45 N-deacetylase and N-sulfotransferase 1 Homo sapiens 297-302 23696150-6 2013 In contrast, both NDST1 and HS6ST1 showed lower activities at the NRE of heparan sulfate (HS) chains than at the interior of the chain. Heparitin Sulfate 73-88 N-deacetylase and N-sulfotransferase 1 Homo sapiens 18-23 25156775-6 2014 The increased NDST1 then activated a heparan sulfate-related pathway involving activation of heparanase. Heparitin Sulfate 37-52 N-deacetylase and N-sulfotransferase 1 Homo sapiens 14-19 28211985-1 2017 NDST1 encodes an enzyme involved in the first steps in the synthesis of heparan sulfate chains, proteoglycans that are regulators found on the cell surface and in the extracellular matrix. Heparitin Sulfate 72-87 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-5 24412195-8 2014 Differences in transcript expression of NDST1, HS6ST2 and HS6ST3, three heparan sulfate biosynthetic enzymes, within splanchnic mesoderm cells compared to H9 cells correlate to changes in glycosaminoglycan structure. Heparitin Sulfate 72-87 N-deacetylase and N-sulfotransferase 1 Homo sapiens 40-45 23696150-7 2013 Contrary to the traditional view of HS biosynthesis processes, NDST1 also showed activity on O-sulfated GlcNAc residues. Heparitin Sulfate 36-38 N-deacetylase and N-sulfotransferase 1 Homo sapiens 63-68 19657062-10 2009 Epac-induced heparan sulfate production was attributable to the increased expression of N-deacetylase/N-sulfotransferase-1 (NDST-1) accompanied by an increased NDST-1 translation rate. Heparitin Sulfate 13-28 N-deacetylase and N-sulfotransferase 1 Homo sapiens 88-122 21586278-8 2011 When considered together with previous studies of Ndst1-deficient glands, the data presented here raise the possibility of partially-independent regulation by heparan sulfate-dependent pathways of primary ductal branching, terminal end bud bifurcation, secondary branching, ductal side-branching and lobuloalveolar formation. Heparitin Sulfate 159-174 N-deacetylase and N-sulfotransferase 1 Homo sapiens 50-55 20463901-5 2010 Inflammatory cell invasion and neointimal hyperplasia were significantly reduced in N-deacetylase-N-sulfotransferase-1 (Ndst1(f/f)TekCre(+)) heparan sulfate (GAG)-deficient (Ndst1(-/-), p<0.044) and CCR2-deficient (Ccr2(-/-), p<0.04) donor transplants. Heparitin Sulfate 141-156 N-deacetylase and N-sulfotransferase 1 Homo sapiens 84-118 21454625-0 2011 The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfate. Heparitin Sulfate 90-105 N-deacetylase and N-sulfotransferase 1 Homo sapiens 23-57 19657062-10 2009 Epac-induced heparan sulfate production was attributable to the increased expression of N-deacetylase/N-sulfotransferase-1 (NDST-1) accompanied by an increased NDST-1 translation rate. Heparitin Sulfate 13-28 N-deacetylase and N-sulfotransferase 1 Homo sapiens 124-130 19657062-10 2009 Epac-induced heparan sulfate production was attributable to the increased expression of N-deacetylase/N-sulfotransferase-1 (NDST-1) accompanied by an increased NDST-1 translation rate. Heparitin Sulfate 13-28 N-deacetylase and N-sulfotransferase 1 Homo sapiens 160-166 12634318-5 2003 Both NDST-1 and -2 N-deacetylate heparan sulfate from human aorta ( approximately 0.6 sulfate groups/disaccharide) with comparable high efficiency, apparent Km values of 0.35 and 0.76 microM (calculation based on [HexA]) being lower (representing a higher affinity) than those for K5 polysaccharide (13.3 and 4.7 microM, respectively). Heparitin Sulfate 33-48 N-deacetylase and N-sulfotransferase 1 Homo sapiens 5-18 19259985-5 2009 Runx2 increases expression of the glycosyltransferase Exostosin-1 (Ext1) and heparanase, as well as alters the relative expression of N-linked sulfotransferases (Ndst1 = Ndst2 > Ndst3) and enzymes mediating O-linked sulfation of heparan sulfate (Hs2st > Hs6st) or chondroitin sulfate (Cs4st > Cs6st). Heparitin Sulfate 232-247 N-deacetylase and N-sulfotransferase 1 Homo sapiens 162-167 18337501-0 2008 Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. Heparitin Sulfate 0-15 N-deacetylase and N-sulfotransferase 1 Homo sapiens 58-63 17107998-0 2006 Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Heparitin Sulfate 0-15 N-deacetylase and N-sulfotransferase 1 Homo sapiens 34-39 17107998-4 2006 In this study, we demonstrate that inactivation of the heparan sulfate biosynthetic gene Ndst1 resulted in invagination defects of the early lens and in the disruption of lens-determination gene expression, leading to severe lens hypoplasia or anophthalmia. Heparitin Sulfate 55-70 N-deacetylase and N-sulfotransferase 1 Homo sapiens 89-94 17107998-5 2006 Ndst1 mutants exhibited reduced sulfation of heparan sulfate, but both BMP- and Wnt-signaling remained unchanged. Heparitin Sulfate 45-60 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-5 12590599-0 2003 Distinct effects on heparan sulfate structure by different active site mutations in NDST-1. Heparitin Sulfate 20-35 N-deacetylase and N-sulfotransferase 1 Homo sapiens 84-90 12590599-4 2003 NDST-1 and -2 have a wide and largely overlapping tissue distribution, but it is not known if they can act on the same heparan sulfate chain. Heparitin Sulfate 119-134 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-13 12590599-12 2003 Structural analyses of heparan sulfate synthesized by these cells and by cells overexpressing wild-type NDST-1 demonstrate that the N-deacetylation step is not only prerequisite but also rate-limiting, determining the degree of N-sulfation. Heparitin Sulfate 23-38 N-deacetylase and N-sulfotransferase 1 Homo sapiens 104-110 12590599-15 2003 In addition, we show that oversulfation of heparan sulfate produced by cells tranfected with wild-type NDST-1 or the mutant lacking N-sulfotranferase activity results in decreased sulfation of chondroitin sulfate. Heparitin Sulfate 43-58 N-deacetylase and N-sulfotransferase 1 Homo sapiens 103-109 12634318-6 2003 Comparison of various HS preparations and the unsulfated K5 polysaccharide as substrates indicate that both NDST-1 and -2 can differentially N-sulfate polysaccharides already modified to some extent by various other enzymes involved in HS/heparin synthesis. Heparitin Sulfate 22-24 N-deacetylase and N-sulfotransferase 1 Homo sapiens 108-121 12634318-6 2003 Comparison of various HS preparations and the unsulfated K5 polysaccharide as substrates indicate that both NDST-1 and -2 can differentially N-sulfate polysaccharides already modified to some extent by various other enzymes involved in HS/heparin synthesis. Heparitin Sulfate 236-238 N-deacetylase and N-sulfotransferase 1 Homo sapiens 108-121 8838814-1 1996 Heparan sulfate-N-deacetylase/N-sulfotransferase (HSST) catalyzes both the N-deacetylation and the N-sulfation of heparan sulfate. Heparitin Sulfate 114-129 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-48 11106599-1 2000 Heparan sulfate N-deacetylase/N-sulfotransferase (NDST) catalyzes the deacetylation and sulfation of N-acetyl-D-glucosamine residues of heparan sulfate, a key step in its biosynthesis. Heparitin Sulfate 136-151 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-48 10196134-1 1999 Heparan sulfate N-deacetylase/N-sulfotransferase (HSNST) catalyzes the first and obligatory step in the biosynthesis of heparan sulfates and heparin. Heparitin Sulfate 120-136 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-48 8838814-1 1996 Heparan sulfate-N-deacetylase/N-sulfotransferase (HSST) catalyzes both the N-deacetylation and the N-sulfation of heparan sulfate. Heparitin Sulfate 114-129 N-deacetylase and N-sulfotransferase 1 Homo sapiens 50-54 34715561-2 2021 We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in heparan sulfate biosynthesis) targeted to antigen presenting cells (APCs) may augment acquired anti-tumor T cell immune mechanisms. Heparitin Sulfate 141-156 N-deacetylase and N-sulfotransferase 1 Homo sapiens 86-120 34715561-2 2021 We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in heparan sulfate biosynthesis) targeted to antigen presenting cells (APCs) may augment acquired anti-tumor T cell immune mechanisms. Heparitin Sulfate 141-156 N-deacetylase and N-sulfotransferase 1 Homo sapiens 122-127 35137078-0 2022 A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation. Heparitin Sulfate 42-57 N-deacetylase and N-sulfotransferase 1 Homo sapiens 78-83 35137078-0 2022 A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation. Heparitin Sulfate 92-107 N-deacetylase and N-sulfotransferase 1 Homo sapiens 78-83 35137078-1 2022 NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis where it is responsible for HS N-deacetylation and N-sulfation. Heparitin Sulfate 73-88 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-5 35137078-1 2022 NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis where it is responsible for HS N-deacetylation and N-sulfation. Heparitin Sulfate 90-92 N-deacetylase and N-sulfotransferase 1 Homo sapiens 0-5 35631109-8 2022 Antisense to N-deacetylase N-sulfotransferase1 (ASONdst1) that modifies heparan sulfate, was less effective with immediate pre-treatment, but reduced scarring and C4d staining with donor pre-treatment for 7 days before transplantation. Heparitin Sulfate 72-87 N-deacetylase and N-sulfotransferase 1 Homo sapiens 13-46 35106474-4 2022 Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme N-deacetylase-N-sulfotransferase-1, reduces heparan sulfate in the glycocalyx and suppresses SN12L1 motility in response to interstitial flow. Heparitin Sulfate 204-219 N-deacetylase and N-sulfotransferase 1 Homo sapiens 237-271 35106474-4 2022 Using a highly metastatic renal carcinoma cell line (SN12L1) and its low metastatic counterpart (SN12C) we demonstrate in vitro that the small molecule Suberoylanilide Hydroxamic Acid (SAHA) inhibits the heparan sulfate synthesis enzyme N-deacetylase-N-sulfotransferase-1, reduces heparan sulfate in the glycocalyx and suppresses SN12L1 motility in response to interstitial flow. Heparitin Sulfate 281-296 N-deacetylase and N-sulfotransferase 1 Homo sapiens 237-271 32515730-2 2020 Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Heparitin Sulfate 131-147 N-deacetylase and N-sulfotransferase 1 Homo sapiens 107-112 32515730-2 2020 Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) synthesis. Heparitin Sulfate 149-151 N-deacetylase and N-sulfotransferase 1 Homo sapiens 107-112