PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18292505-0 2008 Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis. Heparitin Sulfate 0-15 mitogen-activated protein kinase 1 Homo sapiens 36-39 28209511-0 2017 Heparanase-1-induced shedding of heparan sulfate from syndecan-1 in hepatocarcinoma cell facilitates lymphatic endothelial cell proliferation via VEGF-C/ERK pathway. Heparitin Sulfate 33-48 mitogen-activated protein kinase 1 Homo sapiens 153-156 18240216-0 2008 Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts. Heparitin Sulfate 0-15 mitogen-activated protein kinase 1 Homo sapiens 26-29 18240216-6 2008 Antagonizing heparan sulfate side chain formation with beta-xyloside or the addition of soluble heparin prevented ERK activation, in addition to reducing the expression of these proadhesive/contractile proteins. Heparitin Sulfate 13-28 mitogen-activated protein kinase 1 Homo sapiens 114-117 18240216-9 2008 CONCLUSION: The results of this study suggest that heparan sulfate-dependent ERK activation contributes to the enhanced contractile ability demonstrated by dermal fibroblasts from lesional skin of patients with scleroderma. Heparitin Sulfate 51-66 mitogen-activated protein kinase 1 Homo sapiens 77-80 18240216-11 2008 Additionally, the results suggest that antagonizing the MEK/ERK pathway is likely to modulate heparan sulfate proteoglycan activity, which in turn may have a profound effect on the fibrotic response in SSc. Heparitin Sulfate 94-109 mitogen-activated protein kinase 1 Homo sapiens 60-63