PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9641612-14 1998 In conclusion, our present data demonstrate that the ACTH- and cortisol-releasing effect of HEX is abolished by either dexamethasone or alprazolam, a benzodiazepine, which is even able to blunt the GH-releasing activity of the hexapeptide. Alprazolam 136-146 proopiomelanocortin Homo sapiens 53-57 12700707-12 2003 Moreover, compared to placebo the CCK-4-induced ACTH and cortisol release were significantly attenuated during the CCK-4 challenge after alprazolam treatment. Alprazolam 137-147 proopiomelanocortin Homo sapiens 48-52 9663654-4 1998 Alprazolam (APZ) attenuates the ACTH release in response to Nal in normal individuals, probably by inhibiting CRH release. Alprazolam 0-10 proopiomelanocortin Homo sapiens 32-36 9663654-4 1998 Alprazolam (APZ) attenuates the ACTH release in response to Nal in normal individuals, probably by inhibiting CRH release. Alprazolam 12-15 proopiomelanocortin Homo sapiens 32-36 9663654-6 1998 The ACTH response to Nal in DM subjects was significantly reduced by APZ. Alprazolam 69-72 proopiomelanocortin Homo sapiens 4-8 9663654-7 1998 Despite this DM patients have a relative resistance to APZ inhibition of Nal-induced ACTH/cortisol release. Alprazolam 55-58 proopiomelanocortin Homo sapiens 85-89 9663654-8 1998 APZ caused a smaller percentage reduction in AUC for ACTH in DM compared with controls. Alprazolam 0-3 proopiomelanocortin Homo sapiens 53-57 10997633-10 2000 The GABAergic activation by alprazolam abolishes the ACTH response to hexarelin in normal subjects, while it only blunts that in obese subjects. Alprazolam 28-38 proopiomelanocortin Homo sapiens 53-57 8988798-0 1997 Adrenocorticotropic hormone and cortisol responses to corticotropin-releasing hormone: changes in panic disorder and effects of alprazolam treatment. Alprazolam 128-138 proopiomelanocortin Homo sapiens 0-27 8582096-3 1995 In humans, the opioid antagonist, naloxone, stimulates the release of CRH, and so of ACTH and cortisol, while alprazolam, an indirect GABAA agonist, blocks naloxone-induced ACTH and cortisol secretion. Alprazolam 110-120 proopiomelanocortin Homo sapiens 173-177 8027217-13 1994 This study also suggests that CRH/AVP synergy is an important physiological mechanism for ACTH release in humans, as indicated by the blunted ACTH response to AVP after APZ-mediated acute CRH deprivation. Alprazolam 169-172 proopiomelanocortin Homo sapiens 142-146 8381800-6 1993 After naloxone stimulation, the area under the plasma ACTH/time curves was significantly reduced by APZ, in both the 2 mg (P < 0.0005) and 0.5 mg (P < 0.005) doses, compared to their respective placebo studies; similar reductions in area under the plasma cortisol/time curves occurred after 2 mg (P < 0.00002) and 0.5 mg (P < 0.0005) APZ doses. Alprazolam 100-103 proopiomelanocortin Homo sapiens 54-58 8027217-2 1994 Because APZ inhibits CRH secretion from isolated rat hypothalami and inhibits the probable CRH-mediated effect of naloxone on ACTH release, it is likely APZ acts as an inhibitor of hypothalamic CRH release in humans. Alprazolam 8-11 proopiomelanocortin Homo sapiens 126-130 8027217-13 1994 This study also suggests that CRH/AVP synergy is an important physiological mechanism for ACTH release in humans, as indicated by the blunted ACTH response to AVP after APZ-mediated acute CRH deprivation. Alprazolam 169-172 proopiomelanocortin Homo sapiens 90-94 8082875-9 1994 The administration of alprazolam led to a highly significant attenuation of the ACTH increase following the stress interview. Alprazolam 22-32 proopiomelanocortin Homo sapiens 80-84 8082875-14 1994 Following administration of CRH, the ACTH augmentation was only slightly affected following alprazolam, while there were no changes in cortisol and prolactin secretion. Alprazolam 92-102 proopiomelanocortin Homo sapiens 37-41 8381800-6 1993 After naloxone stimulation, the area under the plasma ACTH/time curves was significantly reduced by APZ, in both the 2 mg (P < 0.0005) and 0.5 mg (P < 0.005) doses, compared to their respective placebo studies; similar reductions in area under the plasma cortisol/time curves occurred after 2 mg (P < 0.00002) and 0.5 mg (P < 0.0005) APZ doses. Alprazolam 346-349 proopiomelanocortin Homo sapiens 54-58 17097811-5 2006 Subjects pre-treated with alprazolam showed a strongly blunted response of ACTH as well as total and free cortisol to the TSST. Alprazolam 26-36 proopiomelanocortin Homo sapiens 75-79 2047572-1 1991 Chronic treatment with alprazolam reversed the effect of acute stress on the concentration of immunoreactive beta-endorphin (IR-BE) in the anterior pituitary (AP) and increased the amount of beta-endorphin (BE) relative to beta-lipotropin (B-LPH). Alprazolam 23-33 proopiomelanocortin Homo sapiens 109-123 2047572-1 1991 Chronic treatment with alprazolam reversed the effect of acute stress on the concentration of immunoreactive beta-endorphin (IR-BE) in the anterior pituitary (AP) and increased the amount of beta-endorphin (BE) relative to beta-lipotropin (B-LPH). Alprazolam 23-33 proopiomelanocortin Homo sapiens 191-205 2556727-5 1989 Alprazolam reduced ACTH and cortisol while increasing growth hormone. Alprazolam 0-10 proopiomelanocortin Homo sapiens 19-23 2556727-11 1989 Since alprazolam infusion affects three different measures (ACTH/cortisol, growth hormone, and plasma norepinephrine) thought to be dysregulated in depression, challenge with intravenous alprazolam may prove to be a useful "probe" in affective disorders. Alprazolam 6-16 proopiomelanocortin Homo sapiens 60-64 1334713-6 1992 Alprazolam significantly attenuated the 2DG-induced increases in plasma ACTH and epinephrine, but did not significantly effect plasma norepinephrine and DHPG. Alprazolam 0-10 proopiomelanocortin Homo sapiens 72-76 1329159-0 1992 [Changes in plasma cortisol and ACTH caused by diazepam, bromazepam, triazolam, and alprazolam in oral premedication]. Alprazolam 84-94 proopiomelanocortin Homo sapiens 32-36 21564163-1 2011 WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Alprazolam (ALP), a benzodiazepine activating GABAergic receptors, is involved in ACTH secretion. Alprazolam 44-54 proopiomelanocortin Homo sapiens 126-130 21564163-3 2011 AIMS: To establish the possible involvement of alprazolam (ALP) and/or opiates in the mechanism underlying the ACTH/cortisol response to physical exercise. Alprazolam 47-57 proopiomelanocortin Homo sapiens 111-115