PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22159869-8 2012 The ratio of unconjugated alprazolam to 4-hydroxyalprazolam was correlated with CRP levels (r(s) = 0.49, P = 0.01). Alprazolam 26-36 C-reactive protein Homo sapiens 80-83 22159869-11 2012 CONCLUSIONS: The correlation between CYP3A4 activity (assessed by alprazolam 4-hydroxylation) and CRP level suggests that inflammation may downregulate CYP3A4 activity. Alprazolam 66-76 C-reactive protein Homo sapiens 98-101