PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12218154-9 2002 These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region. Alprazolam 81-91 RELA proto-oncogene, NF-kB subunit Homo sapiens 129-132 12218154-10 2002 In conclusion, a new action of alprazolam was elucidated, as shown in the inhibition of c-Rel/p65- and c-Rel/p50-regulated transcription. Alprazolam 31-41 RELA proto-oncogene, NF-kB subunit Homo sapiens 94-97 12218154-9 2002 These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region. Alprazolam 81-91 RELA proto-oncogene, NF-kB subunit Homo sapiens 269-272