PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3587377-1 1987 The triazolodiazepines brotizolam, triazolam and alprazolam inhibited PAF-induced human platelet aggregation in vitro (IC50 = 0.54, 7.6 and 13.7 microM, respectively) but showed only a weak or no effect against other aggregating agents (ADP, adrenaline, collagen, serotonin, arachidonic acid). Alprazolam 49-59 PCNA clamp associated factor Homo sapiens 70-73 8016392-11 1994 The PAF antagonist, alprazolam, increased gallbladder prostanoid production when administered alone and with LPS. Alprazolam 20-30 PCNA clamp associated factor Homo sapiens 4-7 8383168-7 1993 In both cell types, triazolam and alprazolam, two PAF antagonists, and the calcium channel blocker verapamil inhibited PAF-induced calcium mobilization. Alprazolam 34-44 PCNA clamp associated factor Homo sapiens 119-122 1325953-7 1992 The structurally dissimilar PAF receptor antagonists CV-6209 and alprazolam inhibited the CPAF-induced calcium changes at doses that competed with CPAF binding. Alprazolam 65-75 PCNA clamp associated factor Homo sapiens 28-31 2519888-6 1989 In decreasing order of potency, the following PAF-acether antagonists inhibited the change in platelet cytosolic free calcium elicited by 10 nM PAF-acether: L-652,731, kadsurenone, triazolam, diltiazem and alprazolam. Alprazolam 206-216 PCNA clamp associated factor Homo sapiens 46-49 2519888-6 1989 In decreasing order of potency, the following PAF-acether antagonists inhibited the change in platelet cytosolic free calcium elicited by 10 nM PAF-acether: L-652,731, kadsurenone, triazolam, diltiazem and alprazolam. Alprazolam 206-216 PCNA clamp associated factor Homo sapiens 144-147 3579913-2 1987 The benzodiazepines alprazolam and triazolam, but not diazepam (1-10 microM), inhibit PAF induced aggregation but have no effect on aggregation induced by other platelet agonists such as ADP, epinephrine and collagen. Alprazolam 20-30 PCNA clamp associated factor Homo sapiens 86-89 3579913-3 1987 The IC50 for aggregation by PAF (4 nM) in GFP is 1 microM for both alprazolam and triazolam. Alprazolam 67-77 PCNA clamp associated factor Homo sapiens 28-31 3579913-7 1987 Alprazolam and triazolam, but not diazepam, caused competitive displacement of 3H-PAF from specific binding sites of GFP. Alprazolam 0-10 PCNA clamp associated factor Homo sapiens 82-85 3579913-10 1987 These results are consistent with the interpretation that the specific inhibition of PAF induced platelet aggregation by alprazolam and triazolam, respectively, is due to competitive inhibition of binding of PAF to its receptor. Alprazolam 121-131 PCNA clamp associated factor Homo sapiens 85-88 3579913-10 1987 These results are consistent with the interpretation that the specific inhibition of PAF induced platelet aggregation by alprazolam and triazolam, respectively, is due to competitive inhibition of binding of PAF to its receptor. Alprazolam 121-131 PCNA clamp associated factor Homo sapiens 208-211 2893525-3 1987 We have found that the psychotropic triazolobenzodiazepine drugs, alprazolam and triazolam, potently (IC50 less than 1 microM) inhibit PAF-induced shape change, aggregation and secretion of human platelets. Alprazolam 66-76 PCNA clamp associated factor Homo sapiens 135-138 3694533-3 1987 The negative inotropic effect of PAF was, however, antagonized by drugs known to inhibit PAF-induced platelet aggregation: the order of relative potency was SRI 63-441 greater than CV-3988 greater than alprazolam greater than or equal to triazolam; i.e., the same order in which these compounds antagonize the effects of PAF on platelets. Alprazolam 202-212 PCNA clamp associated factor Homo sapiens 33-36 3694533-3 1987 The negative inotropic effect of PAF was, however, antagonized by drugs known to inhibit PAF-induced platelet aggregation: the order of relative potency was SRI 63-441 greater than CV-3988 greater than alprazolam greater than or equal to triazolam; i.e., the same order in which these compounds antagonize the effects of PAF on platelets. Alprazolam 202-212 PCNA clamp associated factor Homo sapiens 89-92 3694533-3 1987 The negative inotropic effect of PAF was, however, antagonized by drugs known to inhibit PAF-induced platelet aggregation: the order of relative potency was SRI 63-441 greater than CV-3988 greater than alprazolam greater than or equal to triazolam; i.e., the same order in which these compounds antagonize the effects of PAF on platelets. Alprazolam 202-212 PCNA clamp associated factor Homo sapiens 89-92 6150550-3 1984 It was found that in washed human platelets the psychotropic triazolobenzodiazepine drugs alprazolam and triazolam potently inhibited PAF-induced changes in shape, aggregation, and secretion. Alprazolam 90-100 PCNA clamp associated factor Homo sapiens 134-137