PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29154836-2 2018 So, in the present study, we have investigated the effect of S-Methylisothiourea Sulfate (selective iNOS inhibitor) and Citicoline, alone and in combination, on Type II diabetes mellitus induced neuropathic pain in wistar rats. S-methylisothiopseudouronium 61-88 nitric oxide synthase 2 Rattus norvegicus 100-104 27308268-4 2016 S-methylisothiourea hemisulfate (SMT) is a direct inhibitor of iNOS, and this study was designed to investigate the effect of SMT against kidney ID in iron overload rats. S-methylisothiopseudouronium 0-31 nitric oxide synthase 2 Rattus norvegicus 63-67 28757113-12 2017 SMT, an inducible NOS isoform (iNOS) inhibitor, promoted an increase in MAP and in the LF of SAP, in interbeat interval (IBI) parameters at LFnu and in LF/HF ratio of HRV in all groups, but the OVX+E had lower levels of NO when compared with the OVX group. S-methylisothiopseudouronium 0-3 nitric oxide synthase 2 Rattus norvegicus 31-35 27308268-0 2016 The role of S-methylisothiourea hemisulfate as inducible nitric oxide synthase inhibitor against kidney iron deposition in iron overload rats. S-methylisothiopseudouronium 12-43 nitric oxide synthase 2 Rattus norvegicus 47-78 27308268-4 2016 S-methylisothiourea hemisulfate (SMT) is a direct inhibitor of iNOS, and this study was designed to investigate the effect of SMT against kidney ID in iron overload rats. S-methylisothiopseudouronium 33-36 nitric oxide synthase 2 Rattus norvegicus 63-67 27069965-2 2016 OBJECTIVES: This study was designed to investigate the role of S-methylisothiourea (SMT) as selective inhibitor iNOS in renal IRI. S-methylisothiopseudouronium 63-82 nitric oxide synthase 2 Rattus norvegicus 112-116 27069965-2 2016 OBJECTIVES: This study was designed to investigate the role of S-methylisothiourea (SMT) as selective inhibitor iNOS in renal IRI. S-methylisothiopseudouronium 84-87 nitric oxide synthase 2 Rattus norvegicus 112-116 25595132-7 2015 Myocardial I/R was performed on isolated perfused hearts in the presence or absence of S-methyl-isothiourea (1 muM), a NOS inhibitor highly specific for iNOS. S-methylisothiopseudouronium 87-107 nitric oxide synthase 2 Rattus norvegicus 153-157 26598930-2 2016 The aim of this study was to investigate the effects and possible mechanism of action of iNOS on neuronal apoptosis in a rat model of cerebral focal ischemia and reperfusion injury in rats treated with S-methylisothiourea sulfate (SMT), a high-selective inhibitor of iNOS. S-methylisothiopseudouronium 202-229 nitric oxide synthase 2 Rattus norvegicus 89-93 26598930-2 2016 The aim of this study was to investigate the effects and possible mechanism of action of iNOS on neuronal apoptosis in a rat model of cerebral focal ischemia and reperfusion injury in rats treated with S-methylisothiourea sulfate (SMT), a high-selective inhibitor of iNOS. S-methylisothiopseudouronium 202-229 nitric oxide synthase 2 Rattus norvegicus 267-271 26598930-2 2016 The aim of this study was to investigate the effects and possible mechanism of action of iNOS on neuronal apoptosis in a rat model of cerebral focal ischemia and reperfusion injury in rats treated with S-methylisothiourea sulfate (SMT), a high-selective inhibitor of iNOS. S-methylisothiopseudouronium 231-234 nitric oxide synthase 2 Rattus norvegicus 89-93 25470921-1 2013 The aim of work was to study the influence of the highly selective blocker of the inducible NO-synthase (iNOS) of S-methylthiourea on the alteration of the endothelium-dependent vasodilation and alpha1-adrenoreactivity of the isolated rat aortic rings which underwent a short-term restriction of physical activity. S-methylisothiopseudouronium 114-130 nitric oxide synthase 2 Rattus norvegicus 82-103 25111192-0 2014 Effect of S-methylisothiourea, an inducible nitric oxide synthase inhibitor, in joint pain and pathology in surgically induced model of osteoarthritis. S-methylisothiopseudouronium 10-29 nitric oxide synthase 2 Rattus norvegicus 34-65 25111192-1 2014 The aim of the present study was to evaluate in vivo modulatory effect of S-methylisothiourea (SMT), a preferential inhibitor of inducible nitric oxide synthase (iNOS) on pain and pathology in the surgical model of osteoarthritis (OA) in rats. S-methylisothiopseudouronium 74-93 nitric oxide synthase 2 Rattus norvegicus 129-160 25111192-1 2014 The aim of the present study was to evaluate in vivo modulatory effect of S-methylisothiourea (SMT), a preferential inhibitor of inducible nitric oxide synthase (iNOS) on pain and pathology in the surgical model of osteoarthritis (OA) in rats. S-methylisothiopseudouronium 74-93 nitric oxide synthase 2 Rattus norvegicus 162-166 25111192-1 2014 The aim of the present study was to evaluate in vivo modulatory effect of S-methylisothiourea (SMT), a preferential inhibitor of inducible nitric oxide synthase (iNOS) on pain and pathology in the surgical model of osteoarthritis (OA) in rats. S-methylisothiopseudouronium 95-98 nitric oxide synthase 2 Rattus norvegicus 129-160 25111192-1 2014 The aim of the present study was to evaluate in vivo modulatory effect of S-methylisothiourea (SMT), a preferential inhibitor of inducible nitric oxide synthase (iNOS) on pain and pathology in the surgical model of osteoarthritis (OA) in rats. S-methylisothiopseudouronium 95-98 nitric oxide synthase 2 Rattus norvegicus 162-166 25272454-2 2014 The intensity of these abnormalities in all experimental groups is significantly reduced with the supplement of the perfusate with inducible NO-synthase (iNOS) selective blocker S-methylisothiourea. S-methylisothiopseudouronium 178-197 nitric oxide synthase 2 Rattus norvegicus 131-152 25272454-2 2014 The intensity of these abnormalities in all experimental groups is significantly reduced with the supplement of the perfusate with inducible NO-synthase (iNOS) selective blocker S-methylisothiourea. S-methylisothiopseudouronium 178-197 nitric oxide synthase 2 Rattus norvegicus 154-158 25470921-1 2013 The aim of work was to study the influence of the highly selective blocker of the inducible NO-synthase (iNOS) of S-methylthiourea on the alteration of the endothelium-dependent vasodilation and alpha1-adrenoreactivity of the isolated rat aortic rings which underwent a short-term restriction of physical activity. S-methylisothiopseudouronium 114-130 nitric oxide synthase 2 Rattus norvegicus 105-109 25470921-8 2013 But both of these reaction types were eliminated by using highly selective inducible NO-synthase inhibitor with S-methylisothiourea. S-methylisothiopseudouronium 112-131 nitric oxide synthase 2 Rattus norvegicus 75-96 19535378-4 2009 METHODS AND RESULTS: In anaesthetized rats, the cardiovascular response to local or systemic injection of moxonidine was observed after treatment with the selective iNOS inhibitor S-methylisothiourea (SMT) in the brain. S-methylisothiopseudouronium 180-199 nitric oxide synthase 2 Rattus norvegicus 165-169 23719592-3 2013 This study evaluates the effects of S-methylisothiourea (SMT), a specific iNOS inhibitor, on lungs and pancreas of rats with AP receiving intravenous albumin. S-methylisothiopseudouronium 57-60 nitric oxide synthase 2 Rattus norvegicus 74-78 22885820-2 2012 The present study was undertaken to evaluate the effect of iNOS inhibitor S-methylisothiourea (SMT) in APAP-induced hepatotoxicity in rats (1 g/kg, i.p.). S-methylisothiopseudouronium 74-93 nitric oxide synthase 2 Rattus norvegicus 59-63 22885820-2 2012 The present study was undertaken to evaluate the effect of iNOS inhibitor S-methylisothiourea (SMT) in APAP-induced hepatotoxicity in rats (1 g/kg, i.p.). S-methylisothiopseudouronium 95-98 nitric oxide synthase 2 Rattus norvegicus 59-63 22885820-10 2012 SMT 30 mg/kg dose has protected animals from APAP-induced hypotension and reduced iNOS gene expression. S-methylisothiopseudouronium 0-3 nitric oxide synthase 2 Rattus norvegicus 82-86 23719592-3 2013 This study evaluates the effects of S-methylisothiourea (SMT), a specific iNOS inhibitor, on lungs and pancreas of rats with AP receiving intravenous albumin. S-methylisothiopseudouronium 36-55 nitric oxide synthase 2 Rattus norvegicus 74-78 23287799-0 2013 Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. S-methylisothiopseudouronium 25-44 nitric oxide synthase 2 Rattus norvegicus 10-14 23287799-3 2013 The present study was undertaken in rats to investigate the effect of iNOS inhibitor S-methylisothiourea (SMT) in MIA-induced osteoathritic pain and disease progression in rats. S-methylisothiopseudouronium 85-104 nitric oxide synthase 2 Rattus norvegicus 70-74 23287799-3 2013 The present study was undertaken in rats to investigate the effect of iNOS inhibitor S-methylisothiourea (SMT) in MIA-induced osteoathritic pain and disease progression in rats. S-methylisothiopseudouronium 106-109 nitric oxide synthase 2 Rattus norvegicus 70-74 19836458-4 2010 We examined the neuroprotective effect of a preferential iNOS inhibitor s-methylisothiourea (SMT) at 0, 8, 24 and 48h as multiple injections (30 and 100mg/kg, i.p.) S-methylisothiopseudouronium 72-91 nitric oxide synthase 2 Rattus norvegicus 57-61 19535378-4 2009 METHODS AND RESULTS: In anaesthetized rats, the cardiovascular response to local or systemic injection of moxonidine was observed after treatment with the selective iNOS inhibitor S-methylisothiourea (SMT) in the brain. S-methylisothiopseudouronium 201-204 nitric oxide synthase 2 Rattus norvegicus 165-169 18524487-8 2008 Pretreatment with either S-methylisothiourea (S-MT), a selective iNOS inhibitor, or melatonin, a major secretory product of pineal gland, counteracted the over expression of iNOS induced by AMPH in a concentration-dependent manner. S-methylisothiopseudouronium 25-44 nitric oxide synthase 2 Rattus norvegicus 65-69 18927216-7 2009 S-methylisothiourea (an iNOS inhibitor) normalized endothelium-dependent relaxations and restored NO availability in arteries from 8-wk MMI-animals and partly ameliorated these alterations in 16-wk MMI rats. S-methylisothiopseudouronium 0-19 nitric oxide synthase 2 Rattus norvegicus 24-28 18573544-1 2008 OBJECTIVES: The aim of this study was to evaluate the efficiency of inducible nitric oxide synthase (iNOS) specific inhibitor, S-methylisothiourea sulfate (SMT) in preventing lung injury after different pulmonary aspiration materials in rats. S-methylisothiopseudouronium 127-154 nitric oxide synthase 2 Rattus norvegicus 68-99 18573544-1 2008 OBJECTIVES: The aim of this study was to evaluate the efficiency of inducible nitric oxide synthase (iNOS) specific inhibitor, S-methylisothiourea sulfate (SMT) in preventing lung injury after different pulmonary aspiration materials in rats. S-methylisothiopseudouronium 156-159 nitric oxide synthase 2 Rattus norvegicus 68-99 18573544-1 2008 OBJECTIVES: The aim of this study was to evaluate the efficiency of inducible nitric oxide synthase (iNOS) specific inhibitor, S-methylisothiourea sulfate (SMT) in preventing lung injury after different pulmonary aspiration materials in rats. S-methylisothiopseudouronium 156-159 nitric oxide synthase 2 Rattus norvegicus 101-105 18524487-8 2008 Pretreatment with either S-methylisothiourea (S-MT), a selective iNOS inhibitor, or melatonin, a major secretory product of pineal gland, counteracted the over expression of iNOS induced by AMPH in a concentration-dependent manner. S-methylisothiopseudouronium 25-44 nitric oxide synthase 2 Rattus norvegicus 174-178 15763283-0 2005 Inhibition of iNOS with S-methylisothiourea was impaired in wound healing in caustic esophageal burn. S-methylisothiopseudouronium 24-43 nitric oxide synthase 2 Rattus norvegicus 14-18 16826982-4 2006 The beneficial effect of modLA was markedly attenuated by the prior administration of selective iNOS inhibitor S-methylisothiourea (SMT). S-methylisothiopseudouronium 111-130 nitric oxide synthase 2 Rattus norvegicus 96-100 16826982-4 2006 The beneficial effect of modLA was markedly attenuated by the prior administration of selective iNOS inhibitor S-methylisothiourea (SMT). S-methylisothiopseudouronium 132-135 nitric oxide synthase 2 Rattus norvegicus 96-100 15821434-1 2005 This study was designed to investigate the effects of inducible nitric oxide synthase (iNOS) inhibition with S-methylisothiourea (SMT) and L-N-(1-iminoethyl)-lysine (L-Nil) on the endotoxemia induced by intravenous lipopolysaccharide (LPS, 10 mg/kg) in conscious rats. S-methylisothiopseudouronium 109-128 nitric oxide synthase 2 Rattus norvegicus 54-85 15821434-1 2005 This study was designed to investigate the effects of inducible nitric oxide synthase (iNOS) inhibition with S-methylisothiourea (SMT) and L-N-(1-iminoethyl)-lysine (L-Nil) on the endotoxemia induced by intravenous lipopolysaccharide (LPS, 10 mg/kg) in conscious rats. S-methylisothiopseudouronium 109-128 nitric oxide synthase 2 Rattus norvegicus 87-91 15821434-1 2005 This study was designed to investigate the effects of inducible nitric oxide synthase (iNOS) inhibition with S-methylisothiourea (SMT) and L-N-(1-iminoethyl)-lysine (L-Nil) on the endotoxemia induced by intravenous lipopolysaccharide (LPS, 10 mg/kg) in conscious rats. S-methylisothiopseudouronium 130-133 nitric oxide synthase 2 Rattus norvegicus 54-85 15821434-1 2005 This study was designed to investigate the effects of inducible nitric oxide synthase (iNOS) inhibition with S-methylisothiourea (SMT) and L-N-(1-iminoethyl)-lysine (L-Nil) on the endotoxemia induced by intravenous lipopolysaccharide (LPS, 10 mg/kg) in conscious rats. S-methylisothiopseudouronium 130-133 nitric oxide synthase 2 Rattus norvegicus 87-91 15772520-4 2005 Rats were treated with the iNOS inhibitor S-methylisothiourea sulfate (SMT), 5 mg Kg day, i.p. S-methylisothiopseudouronium 42-69 nitric oxide synthase 2 Rattus norvegicus 27-31 15772520-4 2005 Rats were treated with the iNOS inhibitor S-methylisothiourea sulfate (SMT), 5 mg Kg day, i.p. S-methylisothiopseudouronium 71-74 nitric oxide synthase 2 Rattus norvegicus 27-31 15363445-6 2004 The selective iNOS inhibitor, S-methylisothiourea (MTU), suppressed hemorrhagic expression of renal iNOS mRNA and systemic NO products, suppressed the increases of serum creatinine and UN, and improved renal histological aggravations induced by hemorrhaging. S-methylisothiopseudouronium 30-49 nitric oxide synthase 2 Rattus norvegicus 14-18 15547110-10 2005 In vivo inducible nitric-oxide synthase (iNOS) inhibition by S-methylisothiourea partly attenuated LPS-induced endothelial dysfunction. S-methylisothiopseudouronium 61-80 nitric oxide synthase 2 Rattus norvegicus 8-39 15547110-10 2005 In vivo inducible nitric-oxide synthase (iNOS) inhibition by S-methylisothiourea partly attenuated LPS-induced endothelial dysfunction. S-methylisothiopseudouronium 61-80 nitric oxide synthase 2 Rattus norvegicus 41-45 15591232-7 2005 Microinjection of aminoguanidine or S-methylisothiourea, iNOS inhibitors, or tempol, an antioxidant, significantly attenuated the pressor response evoked by iNOS gene transfer. S-methylisothiopseudouronium 36-55 nitric oxide synthase 2 Rattus norvegicus 157-161 15363445-6 2004 The selective iNOS inhibitor, S-methylisothiourea (MTU), suppressed hemorrhagic expression of renal iNOS mRNA and systemic NO products, suppressed the increases of serum creatinine and UN, and improved renal histological aggravations induced by hemorrhaging. S-methylisothiopseudouronium 30-49 nitric oxide synthase 2 Rattus norvegicus 100-104 15363445-6 2004 The selective iNOS inhibitor, S-methylisothiourea (MTU), suppressed hemorrhagic expression of renal iNOS mRNA and systemic NO products, suppressed the increases of serum creatinine and UN, and improved renal histological aggravations induced by hemorrhaging. S-methylisothiopseudouronium 51-54 nitric oxide synthase 2 Rattus norvegicus 14-18 15363445-6 2004 The selective iNOS inhibitor, S-methylisothiourea (MTU), suppressed hemorrhagic expression of renal iNOS mRNA and systemic NO products, suppressed the increases of serum creatinine and UN, and improved renal histological aggravations induced by hemorrhaging. S-methylisothiopseudouronium 51-54 nitric oxide synthase 2 Rattus norvegicus 100-104 12810755-6 2003 Pretreatment with microinjection of a selective iNOS inhibitor, S-methylisothiourea (250 pmol) bilaterally into the RVLM significantly reversed the reduction in both synthesis and activity of AT1R. S-methylisothiopseudouronium 64-83 nitric oxide synthase 2 Rattus norvegicus 48-52 15221344-2 2004 The aim of this study was to examine the effect of chronic administration of S-methylisothiourea (SMT), a selective NOS2 inhibitor, commenced one week after MI on hemodynamic parameters and left ventricular (LV) remodeling in rats. S-methylisothiopseudouronium 77-96 nitric oxide synthase 2 Rattus norvegicus 116-120 15221344-2 2004 The aim of this study was to examine the effect of chronic administration of S-methylisothiourea (SMT), a selective NOS2 inhibitor, commenced one week after MI on hemodynamic parameters and left ventricular (LV) remodeling in rats. S-methylisothiopseudouronium 98-101 nitric oxide synthase 2 Rattus norvegicus 116-120 15120566-6 2004 The selective iNOS inhibitors, S-methylthiourea (SMT) and aminoguanidine (AG), were administered in conjunction with opioid pretreatment or were also given 24 hours after opioid administration just prior to index ischemia. S-methylisothiopseudouronium 31-47 nitric oxide synthase 2 Rattus norvegicus 14-18 15120566-6 2004 The selective iNOS inhibitors, S-methylthiourea (SMT) and aminoguanidine (AG), were administered in conjunction with opioid pretreatment or were also given 24 hours after opioid administration just prior to index ischemia. S-methylisothiopseudouronium 49-52 nitric oxide synthase 2 Rattus norvegicus 14-18 11702011-7 2001 Hypotension and bradycardia promoted by Mev were significantly blunted on coadministration into the RVLM of the selective iNOS inhibitors S-methylisothiourea (250 pmol) or aminoguanidine (250 pmol). S-methylisothiopseudouronium 138-157 nitric oxide synthase 2 Rattus norvegicus 122-126 11976930-6 2002 Additionally, NO generation during hypoxia was reduced by 30% in the CH carotid body treated with S-methylisothiourea (SMT; 50 microM), a specific blocker of inducible NOS (iNOS). S-methylisothiopseudouronium 98-117 nitric oxide synthase 2 Rattus norvegicus 158-171 11976930-6 2002 Additionally, NO generation during hypoxia was reduced by 30% in the CH carotid body treated with S-methylisothiourea (SMT; 50 microM), a specific blocker of inducible NOS (iNOS). S-methylisothiopseudouronium 98-117 nitric oxide synthase 2 Rattus norvegicus 173-177 11976930-6 2002 Additionally, NO generation during hypoxia was reduced by 30% in the CH carotid body treated with S-methylisothiourea (SMT; 50 microM), a specific blocker of inducible NOS (iNOS). S-methylisothiopseudouronium 119-122 nitric oxide synthase 2 Rattus norvegicus 158-171 11976930-6 2002 Additionally, NO generation during hypoxia was reduced by 30% in the CH carotid body treated with S-methylisothiourea (SMT; 50 microM), a specific blocker of inducible NOS (iNOS). S-methylisothiopseudouronium 119-122 nitric oxide synthase 2 Rattus norvegicus 173-177 10903214-9 2000 However, pretreatment with the relatively selective inducible NOS (iNOS) inhibitor S-methylisothiourea sulfate (SMT) restored LV contractility. S-methylisothiopseudouronium 83-110 nitric oxide synthase 2 Rattus norvegicus 52-65 11581148-5 2001 All these effects of lipopolysaccharide (10 ng) were significantly blunted by coadministration of the selective iNOS inhibitor S-methylisothiourea (250 pmol). S-methylisothiopseudouronium 127-146 nitric oxide synthase 2 Rattus norvegicus 112-116 11368532-13 2001 Infusion of S-methylisothiourea (a selective iNOS inhibitor, 84 microg/sponge/24 h) successfully inhibited NO production (35.9 +/- 3.1 vs 49.6 +/- 3.6 microM, P < 0.05) and decreased sponge OHP content (385 +/- 60 vs 568 +/- 70 microg OHP/100 mg sponge, P < 0.05) without the toxic side effect (i.e., weight loss) seen with systemic administration. S-methylisothiopseudouronium 12-31 nitric oxide synthase 2 Rattus norvegicus 45-49 11284451-3 2001 The specific iNOS inhibitor, S-methylthiourea (MITU), produced marked inhibition (>90%) of CYP-induced increases in PPE associated with amelioration of tissue inflammatory changes. S-methylisothiopseudouronium 29-45 nitric oxide synthase 2 Rattus norvegicus 13-17 11164849-8 2001 A change in inducible NO synthase activity was not observed in normal myocardium 24 h after intestinal ischemia, but 30 min of coronary occlusion significantly increased the inducible NO synthase activity in the preconditioned group, which was abolished by aminoguanidine or S-methylisothiourea sulfate. S-methylisothiopseudouronium 275-302 nitric oxide synthase 2 Rattus norvegicus 12-33 11164849-8 2001 A change in inducible NO synthase activity was not observed in normal myocardium 24 h after intestinal ischemia, but 30 min of coronary occlusion significantly increased the inducible NO synthase activity in the preconditioned group, which was abolished by aminoguanidine or S-methylisothiourea sulfate. S-methylisothiopseudouronium 275-302 nitric oxide synthase 2 Rattus norvegicus 174-195 11220644-5 2001 In Experiment 2, S-methylisothiourea (SMT) was given (7.5 mg/kg, intraperitoneal immediately post-burn) to suppress iNOS activity. S-methylisothiopseudouronium 17-36 nitric oxide synthase 2 Rattus norvegicus 116-120 11220644-5 2001 In Experiment 2, S-methylisothiourea (SMT) was given (7.5 mg/kg, intraperitoneal immediately post-burn) to suppress iNOS activity. S-methylisothiopseudouronium 38-41 nitric oxide synthase 2 Rattus norvegicus 116-120 10903214-9 2000 However, pretreatment with the relatively selective inducible NOS (iNOS) inhibitor S-methylisothiourea sulfate (SMT) restored LV contractility. S-methylisothiopseudouronium 83-110 nitric oxide synthase 2 Rattus norvegicus 67-71 10903214-9 2000 However, pretreatment with the relatively selective inducible NOS (iNOS) inhibitor S-methylisothiourea sulfate (SMT) restored LV contractility. S-methylisothiopseudouronium 112-115 nitric oxide synthase 2 Rattus norvegicus 52-65 10903214-9 2000 However, pretreatment with the relatively selective inducible NOS (iNOS) inhibitor S-methylisothiourea sulfate (SMT) restored LV contractility. S-methylisothiopseudouronium 112-115 nitric oxide synthase 2 Rattus norvegicus 67-71 10657484-5 1999 Inducible nitric oxide synthase (iNOS) inhibitors, S-methylisothiourea sulfate (SMT) and N(G)-nitro-L-arginine (L-NNA), completely eliminated long-term depressant effect of CGRP. S-methylisothiopseudouronium 51-78 nitric oxide synthase 2 Rattus norvegicus 33-37 10775125-6 2000 In septic rats, arteriolar pretreatment with the "selective" iNOS blockers aminoguanidine (AG) or S-methylisothiourea sulfate (SMT) restored the responses to the control level. S-methylisothiopseudouronium 127-130 nitric oxide synthase 2 Rattus norvegicus 61-65 10932987-4 2000 The extent of the infarct area in the cerebral cortex and the production of 3-nitrotyrosine (a biomarker of peroxynitrite) were compared between the control pups and pups treated with S-methyl-isothiourea (a selective iNOS inhibitor). S-methylisothiopseudouronium 184-204 nitric oxide synthase 2 Rattus norvegicus 218-222 10670843-15 2000 Addition of S-methylisothiourea (SMT), an iNOS selective inhibitor, profoundly inhibited 66% of the induced iNOS activity (P < 0.05) and reduced 74% of the diet-induced increase in intestinal permeability (P < 0.05) in group II. S-methylisothiopseudouronium 12-31 nitric oxide synthase 2 Rattus norvegicus 42-46 10670843-15 2000 Addition of S-methylisothiourea (SMT), an iNOS selective inhibitor, profoundly inhibited 66% of the induced iNOS activity (P < 0.05) and reduced 74% of the diet-induced increase in intestinal permeability (P < 0.05) in group II. S-methylisothiopseudouronium 12-31 nitric oxide synthase 2 Rattus norvegicus 108-112 10670843-15 2000 Addition of S-methylisothiourea (SMT), an iNOS selective inhibitor, profoundly inhibited 66% of the induced iNOS activity (P < 0.05) and reduced 74% of the diet-induced increase in intestinal permeability (P < 0.05) in group II. S-methylisothiopseudouronium 33-36 nitric oxide synthase 2 Rattus norvegicus 42-46 10670843-15 2000 Addition of S-methylisothiourea (SMT), an iNOS selective inhibitor, profoundly inhibited 66% of the induced iNOS activity (P < 0.05) and reduced 74% of the diet-induced increase in intestinal permeability (P < 0.05) in group II. S-methylisothiopseudouronium 33-36 nitric oxide synthase 2 Rattus norvegicus 108-112 11450038-2 2000 For the iNOS inhibition, S-methylisothiourea (SMT) was administered to 12-week-old male SHRSP for 3 weeks. S-methylisothiopseudouronium 25-44 nitric oxide synthase 2 Rattus norvegicus 8-12 10554365-9 1999 To functionally assess the role of iNOS in colonic healing, rats were treated with a continuous intravenous infusion of S-methylisothiourea (a selective inhibitor of iNOS) at a dosage of 200 mg/kg/day for 5 days after anastomosis. S-methylisothiopseudouronium 120-139 nitric oxide synthase 2 Rattus norvegicus 166-170 10657484-5 1999 Inducible nitric oxide synthase (iNOS) inhibitors, S-methylisothiourea sulfate (SMT) and N(G)-nitro-L-arginine (L-NNA), completely eliminated long-term depressant effect of CGRP. S-methylisothiopseudouronium 80-83 nitric oxide synthase 2 Rattus norvegicus 0-31 10321717-6 1999 S-methylisothiourea sulfate (SMT), an iNOS inhibitor, completely blocked the depression of contraction caused by IL-1beta in intact aortic rings. S-methylisothiopseudouronium 0-27 nitric oxide synthase 2 Rattus norvegicus 38-42 10321717-6 1999 S-methylisothiourea sulfate (SMT), an iNOS inhibitor, completely blocked the depression of contraction caused by IL-1beta in intact aortic rings. S-methylisothiopseudouronium 29-32 nitric oxide synthase 2 Rattus norvegicus 38-42 9915669-6 1998 This study was designed to investigate the effect of iNOS specific inhibitor S-methylisothiourea (SMT) on the postburn intestinal mucosal barrier function and the possible mechanism of SMT"s action. S-methylisothiopseudouronium 77-96 nitric oxide synthase 2 Rattus norvegicus 53-57 9915669-6 1998 This study was designed to investigate the effect of iNOS specific inhibitor S-methylisothiourea (SMT) on the postburn intestinal mucosal barrier function and the possible mechanism of SMT"s action. S-methylisothiopseudouronium 98-101 nitric oxide synthase 2 Rattus norvegicus 53-57 9915669-11 1998 After thermal injury in rats, administration of SMT for 2 days decreased the intestinal mucosal iNOS activity/ tNOS activity ratio and the BT incidence. S-methylisothiopseudouronium 48-51 nitric oxide synthase 2 Rattus norvegicus 96-100 9840654-5 1998 Perfusion of hearts in vitro with the iNOS inhibitor S-methylisothiourea did not reverse the sepsis-induced contractile dysfunction. S-methylisothiopseudouronium 53-72 nitric oxide synthase 2 Rattus norvegicus 38-42 9840654-6 1998 However, treatment of animals with S-methylisothiourea or dexamethasone, a glucocorticoid that prevents the synthesis of the iNOS, at the time of induction of sepsis resulted in partial but not complete attenuation of myocardial contractile dysfunction induced by sepsis. S-methylisothiopseudouronium 35-54 nitric oxide synthase 2 Rattus norvegicus 125-129 9445295-1 1998 S-methyl-isothiourea (SMT) is a potent inhibitor of NO synthase (NOS) with relative selectivity towards the inducible isoform (iNOS). S-methylisothiopseudouronium 0-20 nitric oxide synthase 2 Rattus norvegicus 127-131 9445295-1 1998 S-methyl-isothiourea (SMT) is a potent inhibitor of NO synthase (NOS) with relative selectivity towards the inducible isoform (iNOS). S-methylisothiopseudouronium 22-25 nitric oxide synthase 2 Rattus norvegicus 127-131 9283697-19 1997 In contrast, the more selective iNOS inhibitor S-methyl-isothiourea (SMT) (10 micrograms ml-1) in drinking water) significantly reduced PMNs and lymphocyte influx in the sponge having no effect on monocyte influx. S-methylisothiopseudouronium 47-67 nitric oxide synthase 2 Rattus norvegicus 32-36 9322519-11 1997 LPS-induced intestinal hyperpermeability was ameliorated by both aminoguanidine and another selective iNOS inhibitor, S-methylisothiourea. S-methylisothiopseudouronium 118-137 nitric oxide synthase 2 Rattus norvegicus 102-106 9283697-19 1997 In contrast, the more selective iNOS inhibitor S-methyl-isothiourea (SMT) (10 micrograms ml-1) in drinking water) significantly reduced PMNs and lymphocyte influx in the sponge having no effect on monocyte influx. S-methylisothiopseudouronium 69-72 nitric oxide synthase 2 Rattus norvegicus 32-36 8863222-7 1996 Selective iNOS inhibition with either S-methyl isothiourea (SMT; 5 mg/kg IP) or aminoguanidine (AG; 20 mg/kg IP), administered 2 hours after LPS injection, significantly prevented the increase in PI associated with LPS injection. S-methylisothiopseudouronium 38-58 nitric oxide synthase 2 Rattus norvegicus 10-14 8863222-7 1996 Selective iNOS inhibition with either S-methyl isothiourea (SMT; 5 mg/kg IP) or aminoguanidine (AG; 20 mg/kg IP), administered 2 hours after LPS injection, significantly prevented the increase in PI associated with LPS injection. S-methylisothiopseudouronium 60-63 nitric oxide synthase 2 Rattus norvegicus 10-14