PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22293356-2	2012	Involvement of inflammatory cytokines, particularly interleukin-1 (IL-1), in alterations of HMGR and Cyp7a1 gene expression during development of lead nitrate (LN)-induced hypercholesterolemia was examined in IL-1alpha/beta-knockout (IL-1-KO) and wild-type (WT) mice.	lead nitrate	146-158	interleukin 1 complex	Mus musculus	67-71	
22293356-2	2012	Involvement of inflammatory cytokines, particularly interleukin-1 (IL-1), in alterations of HMGR and Cyp7a1 gene expression during development of lead nitrate (LN)-induced hypercholesterolemia was examined in IL-1alpha/beta-knockout (IL-1-KO) and wild-type (WT) mice.	lead nitrate	160-162	interleukin 1 complex	Mus musculus	52-65	
22293356-2	2012	Involvement of inflammatory cytokines, particularly interleukin-1 (IL-1), in alterations of HMGR and Cyp7a1 gene expression during development of lead nitrate (LN)-induced hypercholesterolemia was examined in IL-1alpha/beta-knockout (IL-1-KO) and wild-type (WT) mice.	lead nitrate	160-162	interleukin 1 complex	Mus musculus	67-71	
22293356-2	2012	Involvement of inflammatory cytokines, particularly interleukin-1 (IL-1), in alterations of HMGR and Cyp7a1 gene expression during development of lead nitrate (LN)-induced hypercholesterolemia was examined in IL-1alpha/beta-knockout (IL-1-KO) and wild-type (WT) mice.	lead nitrate	160-162	interleukin 1 complex	Mus musculus	209-213	
22293356-3	2012	Lead nitrate treatment of WT mice led to not only a marked downregulation of the Cyp7a1 gene at 6-12 h, but also a significant upregulation of the HMGR gene at 12 h. However, such changes were not observed at significant levels in IL-1-KO mice, although a slight, transient downregulation of the Cyp7a1 gene and a minimal upregulation of the HMGR gene occurred at 6 h and 24 h, respectively.	lead nitrate	0-12	interleukin 1 complex	Mus musculus	231-235