PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28152480-0 2017 Securinine enhances SMN2 exon 7 inclusion in spinal muscular atrophy cells. securinine 0-10 survival of motor neuron 2, centromeric Homo sapiens 20-24 28152480-7 2017 We found that securinine can increase luciferase activity, indicating that securinine promoted SMN2 exon 7 inclusion. securinine 75-85 survival of motor neuron 2, centromeric Homo sapiens 95-99 28152480-8 2017 In addition, securinine increased full-length SMN2 mRNA and SMN protein expression in SMA patient-derived lymphoid cell lines. securinine 13-23 survival of motor neuron 2, centromeric Homo sapiens 46-50 28152480-9 2017 To investigate the mechanism of securinine effect on SMN2 splicing, we compared the protein levels of relevant splicing factors between securinine-treated and untreated cells. securinine 32-42 survival of motor neuron 2, centromeric Homo sapiens 53-57