PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19932712-7	2010	Then, we also examined the expression of transcription factor, dopamine markers and oxidative stress marker in the hippocampus of sensitive strain C3H/HeN mice and found that the expression of CREB1 mRNA was significantly increased at 50 ppm toluene.	Toluene	242-249	cAMP responsive element binding protein 1	Mus musculus	193-198	
20804784-4	2010	NR2B, CaMKIV and CREB1 mRNAs increased significantly in the hippocampus of mice exposed to 50ppm toluene on PND 2-6.	Toluene	97-104	cAMP responsive element binding protein 1	Mus musculus	17-22	
16737738-4	2007	We observed that chronic exposure of mice to 50 ppm toluene for a longer period (12 weeks) caused a significant up-regulation of NMDA receptor subunit 2B (NMDA NR2B) expression associated with a simultaneous induction of CaMKIV, CREB-1, and FosB/DeltaFosB in the same hippocampal tissues.	Toluene	52-59	cAMP responsive element binding protein 1	Mus musculus	229-235	
18411703-5	2008	The influence of the cyclic AMP response element binding (CREB) protein expression following toluene inhalation was also examined.	Toluene	93-100	cAMP responsive element binding protein 1	Mus musculus	58-62	
18411703-9	2008	Furthermore, repeated toluene inhalation increased the levels of CREB proteins in the limbic forebrain.	Toluene	22-29	cAMP responsive element binding protein 1	Mus musculus	65-69	
17870172-6	2007	NMDA NR2A, calcium/calmodulin-dependent protein kinase IV (CaMKIV), cyclic AMP-responsive element binding protein 1 (CREB1), and BDNF were significantly up-regulated in the hippocampi of WT mice exposed to 9ppm of toluene, compared to the expressions observed in WT mice exposed to filtered air, but similar results were not observed in nude mice.	Toluene	214-221	cAMP responsive element binding protein 1	Mus musculus	117-122