PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21801798-11 2011 These results suggest that toluene, benzene and styrene induce production and secretion of PGE(2) and PGF(2alpha) in lung epithelial cells via p38 MAPK and COX-2 activation in a redox sensitive manner. Toluene 27-34 mitogen-activated protein kinase 14 Homo sapiens 143-146 21801798-0 2011 The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation. Toluene 40-47 mitogen-activated protein kinase 14 Homo sapiens 157-160 21801798-6 2011 In addition, we studied the potential role of oxidative stress and p38 MAPK activation in the toluene/benzene/styrene-dependent COX-2 induction. Toluene 94-101 mitogen-activated protein kinase 14 Homo sapiens 67-70 21801798-10 2011 Treatment of the cells with a specific p38 inhibitor (SB203580) or the antioxidant N-acetylcysteine (NAC) was able to prevent the toluene/benzene/styrene-dependent COX-2 activation, and subsequent increased PGE(2) and PGF(2alpha) secretion. Toluene 130-137 mitogen-activated protein kinase 14 Homo sapiens 39-42