PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17197224-5 2007 Immunoreactivity of glial fibrillary acidic protein (GFAP), a marker of astrocytes, was enhanced in the toluene-treated group. Toluene 104-111 glial fibrillary acidic protein Rattus norvegicus 20-51 17197224-5 2007 Immunoreactivity of glial fibrillary acidic protein (GFAP), a marker of astrocytes, was enhanced in the toluene-treated group. Toluene 104-111 glial fibrillary acidic protein Rattus norvegicus 53-57 9745935-0 1998 Decreases in brain glial fibrillary acidic protein (GFAP) are associated with increased serum corticosterone following inhalation exposure to toluene. Toluene 142-149 glial fibrillary acidic protein Rattus norvegicus 19-50 10978631-5 2000 Toluene exposure (1500 ppm for 4 h on 4-10 days) augmented glial fibrillary acidic protein (GFAP) immunoreactivity, particularly in the hippocampus and cerebellum. Toluene 0-7 glial fibrillary acidic protein Rattus norvegicus 59-90 10978631-5 2000 Toluene exposure (1500 ppm for 4 h on 4-10 days) augmented glial fibrillary acidic protein (GFAP) immunoreactivity, particularly in the hippocampus and cerebellum. Toluene 0-7 glial fibrillary acidic protein Rattus norvegicus 92-96 10978631-6 2000 Quantitative analysis showed that toluene inhalation markedly enhanced GFAP expression in the hippocampus and cerebellum. Toluene 34-41 glial fibrillary acidic protein Rattus norvegicus 71-75 10987130-1 2000 Toluene, a commonly used industrial solvent, is known to be toxic to both neuronal and glial cells, and has been shown to increase the immunoreactivity of glial fibrillary acidic protein (GFAP) in the brain. Toluene 0-7 glial fibrillary acidic protein Rattus norvegicus 155-186 10987130-1 2000 Toluene, a commonly used industrial solvent, is known to be toxic to both neuronal and glial cells, and has been shown to increase the immunoreactivity of glial fibrillary acidic protein (GFAP) in the brain. Toluene 0-7 glial fibrillary acidic protein Rattus norvegicus 188-192 10987130-2 2000 However, the mechanism of toluene-induced GFAP expression is poorly understood. Toluene 26-33 glial fibrillary acidic protein Rattus norvegicus 42-46 10987130-4 2000 Therefore, it seems possible that steroid hormones may play a potential role in the enhancement of GFAP expression observed following toluene exposure. Toluene 134-141 glial fibrillary acidic protein Rattus norvegicus 99-103 10987130-5 2000 To address this possibility, the effect of toluene inhalation on the expression of mRNAs encoding GFAP and steroidogenic enzymes in rat brain was examined. Toluene 43-50 glial fibrillary acidic protein Rattus norvegicus 98-102 10987130-6 2000 Toluene exposure increased GFAP protein contents without any significant alteration in GFAP mRNA levels in the hippocampus. Toluene 0-7 glial fibrillary acidic protein Rattus norvegicus 27-31 10987130-7 2000 In contrast, the elevation of both GFAP protein contents and its mRNA levels was observed in the cerebellum following toluene exposure. Toluene 118-125 glial fibrillary acidic protein Rattus norvegicus 35-39 10987130-8 2000 Further studies indicated that toluene exposure increased steroid 5 alpha-reductase (5 alpha-R) mRNA levels prior to the elevation of GFAP mRNA in the cerebellum, whereas neither 5 alpha-R nor GFAP mRNA levels in the hippocampus were significantly affected by toluene exposure. Toluene 31-38 glial fibrillary acidic protein Rattus norvegicus 134-138 10987130-9 2000 These results suggest that toluene inhalation may enhance GFAP gene expression in the rat cerebellum, and propose the possibility that the elevation of 5 alpha-R expression, and hence 5 alpha-reduced metabolites of steroid hormones, is presumably related to toluene-induced GFAP mRNA expression. Toluene 27-34 glial fibrillary acidic protein Rattus norvegicus 58-62 10987130-9 2000 These results suggest that toluene inhalation may enhance GFAP gene expression in the rat cerebellum, and propose the possibility that the elevation of 5 alpha-R expression, and hence 5 alpha-reduced metabolites of steroid hormones, is presumably related to toluene-induced GFAP mRNA expression. Toluene 27-34 glial fibrillary acidic protein Rattus norvegicus 274-278 9745935-0 1998 Decreases in brain glial fibrillary acidic protein (GFAP) are associated with increased serum corticosterone following inhalation exposure to toluene. Toluene 142-149 glial fibrillary acidic protein Rattus norvegicus 52-56 9745935-1 1998 Toluene and other neurotoxicants can cause both increases and decreases in the concentration of GFAP in the brain. Toluene 0-7 glial fibrillary acidic protein Rattus norvegicus 96-100 9745935-3 1998 In order to identify conditions under which inhalation exposure to toluene results in decreased GFAP concentration, rats were subjected to repeated inhalation of toluene for up to 7 days. Toluene 67-74 glial fibrillary acidic protein Rattus norvegicus 96-100 9745935-5 1998 This toluene exposure replicated the previously-observed decreases in GFAP in the thalamus. Toluene 5-12 glial fibrillary acidic protein Rattus norvegicus 70-74 9745935-9 1998 More research is needed to firmly establish cause and effect between increased serum glucocorticoid levels and GFAP decreases following toluene inhalation and to determine whether these decreases indicate toxicity or adaptive changes. Toluene 136-143 glial fibrillary acidic protein Rattus norvegicus 111-115 8834099-0 1996 Selective increase in astrocytic elements in the rat dentate gyrus after chronic toluene exposure studied by GFAP immunocytochemistry and electron microscopy. Toluene 81-88 glial fibrillary acidic protein Rattus norvegicus 109-113 8834099-2 1996 In toluene-treated rats, the numbers of GFAP-immunoreactive (IR) astrocytes were not changed, whereas the area and intensity of GFAP-IR processes were increased markedly in the dentate gyrus. Toluene 3-10 glial fibrillary acidic protein Rattus norvegicus 40-44 8834099-2 1996 In toluene-treated rats, the numbers of GFAP-immunoreactive (IR) astrocytes were not changed, whereas the area and intensity of GFAP-IR processes were increased markedly in the dentate gyrus. Toluene 3-10 glial fibrillary acidic protein Rattus norvegicus 128-132