PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18710030-4	2008	A high-fat diet enhanced reactions of biotransformation of amidopyrine, acetanilide, toluene, sulfadimezine, were catalyzed with CYP2E1, CYP3A and enzymes of conjugation, simultaneously it increased the hepatotoxicity of paracetamol.	Toluene	85-92	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	129-135	
7890112-2	1994	Toluene exposure induces CYP1A1/2, CYP2B1/2, CYP2E1 and CYP3A1, but decreases CYP2C11/6 and CYP2A1 in adult males.	Toluene	0-7	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	45-51	
15129551-0	2004	The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform.	Toluene	104-111	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	76-96	
10876999-1	2000	In this study we investigated cytochrome P450 (CYP) 2E1 expression using a probe drug, chlorzoxazone (CZX), whose metabolism can be used to monitor toluene exposure in rats.	Toluene	148-155	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	30-55	
10876999-4	2000	The total CYP and CYP2E1 content and the aniline and CZX hydroxylase activity (Vmax and CL(int)) increased depending on the dose of toluene administered.	Toluene	132-139	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	18-24	
10876999-5	2000	At the highest concentration (128 mM) of diethyldithiocarbamate, a specific inhibitor of CYP2E1, the production of 6-hydroxychlorzoxazone (HCZX) in microsomes from toluene-treated rats was reduced by about 80%.	Toluene	164-171	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	89-95	
10876999-7	2000	The production of HCZX and the activity of aniline hydroxylase in toluene-treated rats were correlated with the amount of rat CYP2E1 protein (r = 0.88 and r = 0.88, respectively).	Toluene	66-73	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	126-132	
10547960-5	1999	Anti-cytochrome P450 inhibitable activity of toluene metabolism and/or immunoblot analysis showed that CYP2E1 and CYP2B1/2 were induced by BB and DMF, but not by the other two chemicals; CYP2C11 was greatly decreased by all of the four toxicants; and CYP1A1/2 was slightly reduced by the four treatments.	Toluene	45-52	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	103-109	
12919724-10	2003	These results show that acute/subacute benzene and acute toluene treatments induce CYP2E1 expression probably through a similar mechanism which might be different from that of pyridine or acetone, in that the former increase mRNA levels, both in liver and in peripheral lymphocytes, whereas the latter stabilized the apo-protein.	Toluene	57-64	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	83-89	
8996725-7	1996	A 4 fold induction of CYP2E1 dependent chlorzoxazone hydroxylation after exposure to toluene and 2.5 fold after xylene corresponded to the enzyme levels of P45020E1 detected by immunoblotting.	Toluene	85-92	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	22-28	
8620572-4	1996	Anti-CYP2E1 and anti-CYP2B1/2 inhibitable activity of toluene side-chain oxidase was significantly enhanced in toluene-, benzene- and TRI-treated rats.	Toluene	54-61	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	5-11	
8620572-4	1996	Anti-CYP2E1 and anti-CYP2B1/2 inhibitable activity of toluene side-chain oxidase was significantly enhanced in toluene-, benzene- and TRI-treated rats.	Toluene	111-118	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	5-11	
8620572-7	1996	Western blot analysis revealed that the increase in peak area of bands recognized by anti-CYP2E1 was consistent with toluene inhibition results.	Toluene	117-124	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	90-96	
7890112-5	1994	Although structurally related chemicals of toluene also influence similar hepatic P450 isoenzymes, the degree of CYP2B1/2 induction increases, whilst that of CYP2E1 decreases with increasing molecular weight and aliphatic moieties.	Toluene	43-50	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	158-164	
8347164-3	1993	Anti-CYP2E1 significantly inhibited the metabolism of toluene to benzyl alcohol (BA) by about 50%, in microsomes from 1000 to 4000 ppm toluene-exposed rats, at low substrate concentration (0.2 mM).	Toluene	54-61	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	5-11	
8347164-6	1993	Immunoblot analysis with anti-CYP2E1 and anti-CYP2B1/2 revealed stronger immunoreactive bands in microsomes from rats exposed to more than 1000 and 2000 ppm of toluene, respectively.	Toluene	160-167	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	30-36	
8347164-8	1993	These results suggest that toluene induces CYP2E1, CYP2B1/2 and CYP3A1/2, but reduces CYP2C11/6, and has no effect on CYP1A1/2.	Toluene	27-34	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	43-49	
8347164-3	1993	Anti-CYP2E1 significantly inhibited the metabolism of toluene to benzyl alcohol (BA) by about 50%, in microsomes from 1000 to 4000 ppm toluene-exposed rats, at low substrate concentration (0.2 mM).	Toluene	135-142	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	5-11	
24386519-5	2013	The immunoblots indicated that the expression of CYP2E1 was considerably enhanced depending on the dosage of DMF and the CYP2E1 blot densities were significantly increased after treatment with both DMF and toluene, compared to treatment with DMF alone.	Toluene	206-213	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	49-55	
24386519-5	2013	The immunoblots indicated that the expression of CYP2E1 was considerably enhanced depending on the dosage of DMF and the CYP2E1 blot densities were significantly increased after treatment with both DMF and toluene, compared to treatment with DMF alone.	Toluene	206-213	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	121-127	
24386519-8	2013	These results suggest that the expression of CYP2E1 is induced by DMF and enhanced by toluene.	Toluene	86-93	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	45-51	
24949447-2	2014	Chloroform, dichloromethane, and toluene are primarily metabolized in liver by CYP2E1, producing reactive electrophilic metabolites, and may also produce oxidative stress via the uncoupled CYP2E1 catalytic cycle.	Toluene	33-40	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	79-85	
24949447-2	2014	Chloroform, dichloromethane, and toluene are primarily metabolized in liver by CYP2E1, producing reactive electrophilic metabolites, and may also produce oxidative stress via the uncoupled CYP2E1 catalytic cycle.	Toluene	33-40	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	189-195