PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22057034-5 2012 Splenic T lymphocyte subsets and mRNA expression levels of Th1 cytokine IL-12, transcription factor T-bet, and Foxp3 were significantly suppressed in PND 21 male mice exposed to toluene during PNDs 8-12. Toluene 178-185 forkhead box P3 Mus musculus 111-116 21601613-7 2011 In spleens from the allergic mouse model, the expressions of STAT3, STAT4, STAT5a, STAT6, GATA3 and Foxp3 mRNAs were significantly enhanced following exposure to 50ppm toluene for 6 weeks, but the expression of T-bet mRNA was not increased. Toluene 168-175 forkhead box P3 Mus musculus 100-105 20583897-6 2010 The expression of transcription factor forkhead box P3, signal transducers and activators of transcription (STAT)5 and STAT6 mRNAs was significantly increased in spleen from 5 ppm toluene-exposed, OVA-immunized B10.BR mice, but not in those of C57BL/10 mice. Toluene 180-187 forkhead box P3 Mus musculus 39-54 19645570-5 2009 Exposure of mice to 5 or 50 ppm toluene resulted in increased immunoglobulin (Ig) G1 and decreased IgG2a and IgE antibodies in the plasma; significantly decreased T-bet, GATA-3, and Foxp3 mRNA in the spleen; and a tendency toward decreased interferon (IFN)-gamma mRNA in spleen. Toluene 32-39 forkhead box P3 Mus musculus 182-187 19645570-6 2009 Exposure of mice to low-level toluene together with PGN stimulation resulted in decreased IgG1 as well as IgG2a antibodies in the plasma and Foxp3 mRNA in spleen as compared with control or PGN-treated mice. Toluene 30-37 forkhead box P3 Mus musculus 141-146 19571489-7 2009 On the other hand, splenic expression of transcription factor T-bet (Th1-specific), GATA-3 (Th2-specific) and Foxp3 (gene marker for regulatory CD4+CD25+ T-cells) mRNAs was suppressed in these mice, but not in the combination of 5 or 50 ppm toluene with PGN. Toluene 241-248 forkhead box P3 Mus musculus 110-115